Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Esculentin-1A

Gene
N/A
Organism
Pelophylax esculentus (Edible frog) (Rana esculenta)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Esculentin-1A
OrganismiPelophylax esculentus (Edible frog) (Rana esculenta)
Taxonomic identifieri8401 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001653671 – 46Esculentin-1AAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 461 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.

Structurei

Secondary structure

146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15

3D structure databases

SMRiP40843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005608

Family and domain databases

InterProiView protein in InterPro
IPR012521 Antimicrobial_frog_2
PfamiView protein in Pfam
PF08023 Antimicrobial_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GIFSKLAGKK IKNLLISGLK NVGKEVGMDV VRTGIDIAGC KIKGEC
Length:46
Mass (Da):4,803
Last modified:February 1, 1995 - v1
Checksum:iCDD607B576AF98EF
GO

Sequence databases

PIRiG53578

Similar proteinsi

Entry informationi

Entry nameiES1A_PELES
AccessioniPrimary (citable) accession number: P40843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health