UniProtKB - P40818 (UBP8_HUMAN)
Ubiquitin carboxyl-terminal hydrolase 8
USP8
Functioni
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 786 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1067 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cysteine-type endopeptidase activity Source: ProtInc
- SH3 domain binding Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
GO - Biological processi
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to nerve growth factor stimulus Source: Ensembl
- endosome organization Source: UniProtKB
- mitotic cytokinesis Source: MGI
- positive regulation of canonical Wnt signaling pathway Source: FlyBase
- protein deubiquitination Source: UniProtKB
- protein K48-linked deubiquitination Source: UniProtKB
- protein K63-linked deubiquitination Source: UniProtKB
- Ras protein signal transduction Source: GO_Central
- regulation of protein catabolic process at postsynapse, modulating synaptic transmission Source: Ensembl
- regulation of protein localization Source: UniProtKB
- regulation of protein stability Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Cell cycle, Ubl conjugation pathway |
Enzyme and pathway databases
BRENDAi | 3.4.19.12, 2681 |
PathwayCommonsi | P40818 |
Reactomei | R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling R-HSA-4641263, Regulation of FZD by ubiquitination R-HSA-5689880, Ub-specific processing proteases R-HSA-6807004, Negative regulation of MET activity |
SignaLinki | P40818 |
SIGNORi | P40818 |
Protein family/group databases
MEROPSi | C19.011 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolase 8Curated (EC:3.4.19.121 Publication)Alternative name(s): Deubiquitinating enzyme 8 Ubiquitin isopeptidase Y Short name: hUBPy Ubiquitin thioesterase 8 Ubiquitin-specific-processing protease 8 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138592.13 |
HGNCi | HGNC:12631, USP8 |
MIMi | 603158, gene |
neXtProti | NX_P40818 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein Curated
Nucleus
- Nucleus By similarity
Endosome
- Endosome membrane 2 Publications; Peripheral membrane protein Curated
Other locations
- Cytoplasm 4 Publications
Cytosol
- cytosol Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
- extrinsic component of endosome membrane Source: GO_Central
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- dendritic spine Source: GO_Central
- glutamatergic synapse Source: Ensembl
- midbody Source: MGI
- postsynaptic density Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endosome, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Pituitary adenoma 4, ACTH-secreting (PITA4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079717 | 718 – 723 | Missing in PITA4; somatic mutation; unknown pathological significance. 1 Publication | 6 | |
Natural variantiVAR_079718 | 718 | S → C in PITA4; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs672601308EnsemblClinVar. | 1 | |
Natural variantiVAR_079719 | 718 | S → P in PITA4; somatic mutation; unknown pathological significance; localizes to nucleus instead of cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs672601307EnsemblClinVar. | 1 | |
Natural variantiVAR_079720 | 718 | Missing in PITA4; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_079721 | 720 | P → R in PITA4; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs672601311EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 786 | C → S: Impairs deubiquitination activity and leads to endosome membrane accumulation. 1 Publication | 1 |
Keywords - Diseasei
Cushing syndrome, Disease mutationOrganism-specific databases
DisGeNETi | 9101 |
MalaCardsi | USP8 |
MIMi | 219090, phenotype |
OpenTargetsi | ENSG00000138592 |
Orphaneti | 401795, Autosomal recessive spastic paraplegia type 59 96253, Cushing disease |
PharmGKBi | PA37256 |
Miscellaneous databases
Pharosi | P40818, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2157854 |
Polymorphism and mutation databases
BioMutai | USP8 |
DMDMi | 731046 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080627 | 1 – 1118 | Ubiquitin carboxyl-terminal hydrolase 8Add BLAST | 1118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 160 | PhosphoserineCombined sources | 1 | |
Modified residuei | 392 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Modified residuei | 577 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 718 | PhosphoserineCombined sources | 1 | |
Modified residuei | 719 | PhosphoserineCombined sources | 1 | |
Modified residuei | 945 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1733 CPTAC-1734 |
EPDi | P40818 |
jPOSTi | P40818 |
MassIVEi | P40818 |
MaxQBi | P40818 |
PaxDbi | P40818 |
PeptideAtlasi | P40818 |
PRIDEi | P40818 |
ProteomicsDBi | 4442 55380 [P40818-1] |
PTM databases
iPTMneti | P40818 |
MetOSitei | P40818 |
PhosphoSitePlusi | P40818 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000138592, Expressed in sural nerve and 235 other tissues |
ExpressionAtlasi | P40818, baseline and differential |
Genevisiblei | P40818, HS |
Organism-specific databases
HPAi | ENSG00000138592, Low tissue specificity |
Interactioni
Subunit structurei
Forms a ternary complex with RNF128 and OTUB1.
Interacts (via C-terminal UCH catalytic domain) with OTUB1 isoform 1.
Interacts with STAM2 (via SH3 domain).
Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ (By similarity).
Interacts with NBR1, RASGRF1, RNF41 and IST1. Associates with the ESCRT-0 complex and with microtubules (By similarity).
Interacts with BIRC6/bruce and KIF23/MKLP1.
By similarity5 Publications(Microbial infection) Interacts with Zika virus non-structural protein 1.
1 PublicationBinary interactionsi
Hide detailsP40818
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 114555, 100 interactors |
DIPi | DIP-40365N |
IntActi | P40818, 35 interactors |
MINTi | P40818 |
STRINGi | 9606.ENSP00000379721 |
Chemistry databases
BindingDBi | P40818 |
Miscellaneous databases
RNActi | P40818, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P40818 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P40818 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 116 | MITAdd BLAST | 84 | |
Domaini | 195 – 313 | RhodanesePROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 777 – 1109 | USPAdd BLAST | 333 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 405 – 413 | SH3-bindingBy similarity | 9 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH3-bindingPhylogenomic databases
eggNOGi | KOG1868, Eukaryota |
GeneTreei | ENSGT00940000157542 |
HOGENOMi | CLU_009980_0_0_1 |
InParanoidi | P40818 |
OMAi | LCVPEEA |
PhylomeDBi | P40818 |
TreeFami | TF106277 |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR015063, USP8_dimer IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00581, Rhodanese, 1 hit PF00443, UCH, 1 hit PF08969, USP8_dimer, 1 hit |
SUPFAMi | SSF52821, SSF52821, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC
60 70 80 90 100
RLDRDEERAY VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE
110 120 130 140 150
EAERLSESLK LRYEEAEVRK KLEEKDRQEE AQRLQQKRQE TGREDGGTLA
160 170 180 190 200
KGSLENVLDS KDKTQKSNGE KNEKCETKEK GAITAKELYT MMTDKNISLI
210 220 230 240 250
IMDARRMQDY QDSCILHSLS VPEEAISPGV TASWIEAHLP DDSKDTWKKR
260 270 280 290 300
GNVEYVVLLD WFSSAKDLQI GTTLRSLKDA LFKWESKTVL RNEPLVLEGG
310 320 330 340 350
YENWLLCYPQ YTTNAKVTPP PRRQNEEVSI SLDFTYPSLE ESIPSKPAAQ
360 370 380 390 400
TPPASIEVDE NIELISGQNE RMGPLNISTP VEPVAASKSD VSPIIQPVPS
410 420 430 440 450
IKNVPQIDRT KKPAVKLPEE HRIKSESTNH EQQSPQSGKV IPDRSTKPVV
460 470 480 490 500
FSPTLMLTDE EKARIHAETA LLMEKNKQEK ELRERQQEEQ KEKLRKEEQE
510 520 530 540 550
QKAKKKQEAE ENEITEKQQK AKEEMEKKES EQAKKEDKET SAKRGKEITG
560 570 580 590 600
VKRQSKSEHE TSDAKKSVED RGKRCPTPEI QKKSTGDVPH TSVTGDSGSG
610 620 630 640 650
KPFKIKGQPE SGILRTGTFR EDTDDTERNK AQREPLTRAR SEEMGRIVPG
660 670 680 690 700
LPSGWAKFLD PITGTFRYYH SPTNTVHMYP PEMAPSSAPP STPPTHKAKP
710 720 730 740 750
QIPAERDREP SKLKRSYSSP DITQAIQEEE KRKPTVTPTV NRENKPTCYP
760 770 780 790 800
KAEISRLSAS QIRNLNPVFG GSGPALTGLR NLGNTCYMNS ILQCLCNAPH
810 820 830 840 850
LADYFNRNCY QDDINRSNLL GHKGEVAEEF GIIMKALWTG QYRYISPKDF
860 870 880 890 900
KITIGKINDQ FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH
910 920 930 940 950
LDDFKAAEHA WQKHKQLNES IIVALFQGQF KSTVQCLTCH KKSRTFEAFM
960 970 980 990 1000
YLSLPLASTS KCTLQDCLRL FSKEEKLTDN NRFYCSHCRA RRDSLKKIEI
1010 1020 1030 1040 1050
WKLPPVLLVH LKRFSYDGRW KQKLQTSVDF PLENLDLSQY VIGPKNNLKK
1060 1070 1080 1090 1100
YNLFSVSNHY GGLDGGHYTA YCKNAARQRW FKFDDHEVSD ISVSSVKSSA
1110
AYILFYTSLG PRVTDVAT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A075B720 | A0A075B720_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 480 | Annotation score: | ||
H0YNL5 | H0YNL5_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 135 | Annotation score: | ||
H0YM17 | H0YM17_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 73 | Annotation score: | ||
H0YM47 | H0YM47_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 125 | Annotation score: | ||
H0YKV1 | H0YKV1_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 136 | Annotation score: | ||
H0YLH2 | H0YLH2_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 96 | Annotation score: | ||
H0YLS3 | H0YLS3_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP8 | 62 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 526 | E → G in CAD97662 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 717 | Y → H in CAD97662 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 945 | T → A in CAD97662 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077850 | 310 | Q → K Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777201EnsemblClinVar. | 1 | |
Natural variantiVAR_017796 | 443 | D → G. Corresponds to variant dbSNP:rs3743044EnsemblClinVar. | 1 | |
Natural variantiVAR_079717 | 718 – 723 | Missing in PITA4; somatic mutation; unknown pathological significance. 1 Publication | 6 | |
Natural variantiVAR_079718 | 718 | S → C in PITA4; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs672601308EnsemblClinVar. | 1 | |
Natural variantiVAR_079719 | 718 | S → P in PITA4; somatic mutation; unknown pathological significance; localizes to nucleus instead of cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs672601307EnsemblClinVar. | 1 | |
Natural variantiVAR_079720 | 718 | Missing in PITA4; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_079721 | 720 | P → R in PITA4; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs672601311EnsemblClinVar. | 1 | |
Natural variantiVAR_051525 | 739 | T → A. Corresponds to variant dbSNP:rs11638390Ensembl. | 1 | |
Natural variantiVAR_017797 | 827 | A → G. Corresponds to variant dbSNP:rs1056577Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054594 | 35 – 111 | Missing in isoform 2. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_054595 | 601 – 629 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D29956 mRNA Translation: BAA06225.2 AK296480 mRNA Translation: BAG59120.1 BX537420 mRNA Translation: CAD97662.1 AC012170 Genomic DNA No translation available. BC038801 mRNA Translation: AAH38801.1 Sequence problems. BC051345 mRNA Translation: AAH51345.1 Sequence problems. BC110590 mRNA Translation: AAI10591.1 |
CCDSi | CCDS10137.1 [P40818-1] CCDS61632.1 [P40818-2] |
RefSeqi | NP_001122082.1, NM_001128610.2 [P40818-1] NP_001269978.1, NM_001283049.1 [P40818-2] NP_005145.3, NM_005154.4 [P40818-1] XP_006720824.1, XM_006720761.3 [P40818-1] XP_011520495.1, XM_011522193.2 [P40818-1] |
Genome annotation databases
Ensembli | ENST00000307179; ENSP00000302239; ENSG00000138592 [P40818-1] ENST00000396444; ENSP00000379721; ENSG00000138592 [P40818-1] ENST00000425032; ENSP00000412682; ENSG00000138592 [P40818-2] |
GeneIDi | 9101 |
KEGGi | hsa:9101 |
UCSCi | uc001zyl.6, human [P40818-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D29956 mRNA Translation: BAA06225.2 AK296480 mRNA Translation: BAG59120.1 BX537420 mRNA Translation: CAD97662.1 AC012170 Genomic DNA No translation available. BC038801 mRNA Translation: AAH38801.1 Sequence problems. BC051345 mRNA Translation: AAH51345.1 Sequence problems. BC110590 mRNA Translation: AAI10591.1 |
CCDSi | CCDS10137.1 [P40818-1] CCDS61632.1 [P40818-2] |
RefSeqi | NP_001122082.1, NM_001128610.2 [P40818-1] NP_001269978.1, NM_001283049.1 [P40818-2] NP_005145.3, NM_005154.4 [P40818-1] XP_006720824.1, XM_006720761.3 [P40818-1] XP_011520495.1, XM_011522193.2 [P40818-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WHB | NMR | - | A | 174-317 | [»] | |
2A9U | X-ray | 2.10 | A/B | 1-142 | [»] | |
2GFO | X-ray | 2.00 | A | 734-1110 | [»] | |
2GWF | X-ray | 2.30 | A/C/E | 181-318 | [»] | |
3N3K | X-ray | 2.60 | A | 734-1110 | [»] | |
6F09 | X-ray | 1.59 | A/B/C/D | 712-724 | [»] | |
SMRi | P40818 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114555, 100 interactors |
DIPi | DIP-40365N |
IntActi | P40818, 35 interactors |
MINTi | P40818 |
STRINGi | 9606.ENSP00000379721 |
Chemistry databases
BindingDBi | P40818 |
ChEMBLi | CHEMBL2157854 |
Protein family/group databases
MEROPSi | C19.011 |
PTM databases
iPTMneti | P40818 |
MetOSitei | P40818 |
PhosphoSitePlusi | P40818 |
Polymorphism and mutation databases
BioMutai | USP8 |
DMDMi | 731046 |
Proteomic databases
CPTACi | CPTAC-1733 CPTAC-1734 |
EPDi | P40818 |
jPOSTi | P40818 |
MassIVEi | P40818 |
MaxQBi | P40818 |
PaxDbi | P40818 |
PeptideAtlasi | P40818 |
PRIDEi | P40818 |
ProteomicsDBi | 4442 55380 [P40818-1] |
Protocols and materials databases
Antibodypediai | 1385, 260 antibodies |
Genome annotation databases
Ensembli | ENST00000307179; ENSP00000302239; ENSG00000138592 [P40818-1] ENST00000396444; ENSP00000379721; ENSG00000138592 [P40818-1] ENST00000425032; ENSP00000412682; ENSG00000138592 [P40818-2] |
GeneIDi | 9101 |
KEGGi | hsa:9101 |
UCSCi | uc001zyl.6, human [P40818-1] |
Organism-specific databases
CTDi | 9101 |
DisGeNETi | 9101 |
EuPathDBi | HostDB:ENSG00000138592.13 |
GeneCardsi | USP8 |
HGNCi | HGNC:12631, USP8 |
HPAi | ENSG00000138592, Low tissue specificity |
MalaCardsi | USP8 |
MIMi | 219090, phenotype 603158, gene |
neXtProti | NX_P40818 |
OpenTargetsi | ENSG00000138592 |
Orphaneti | 401795, Autosomal recessive spastic paraplegia type 59 96253, Cushing disease |
PharmGKBi | PA37256 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1868, Eukaryota |
GeneTreei | ENSGT00940000157542 |
HOGENOMi | CLU_009980_0_0_1 |
InParanoidi | P40818 |
OMAi | LCVPEEA |
PhylomeDBi | P40818 |
TreeFami | TF106277 |
Enzyme and pathway databases
BRENDAi | 3.4.19.12, 2681 |
PathwayCommonsi | P40818 |
Reactomei | R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling R-HSA-4641263, Regulation of FZD by ubiquitination R-HSA-5689880, Ub-specific processing proteases R-HSA-6807004, Negative regulation of MET activity |
SignaLinki | P40818 |
SIGNORi | P40818 |
Miscellaneous databases
BioGRID-ORCSi | 9101, 524 hits in 856 CRISPR screens |
ChiTaRSi | USP8, human |
EvolutionaryTracei | P40818 |
GeneWikii | USP8 |
GenomeRNAii | 9101 |
Pharosi | P40818, Tbio |
PROi | PR:P40818 |
RNActi | P40818, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138592, Expressed in sural nerve and 235 other tissues |
ExpressionAtlasi | P40818, baseline and differential |
Genevisiblei | P40818, HS |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR015063, USP8_dimer IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00581, Rhodanese, 1 hit PF00443, UCH, 1 hit PF08969, USP8_dimer, 1 hit |
SUPFAMi | SSF52821, SSF52821, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBP8_HUMAN | |
Accessioni | P40818Primary (citable) accession number: P40818 Secondary accession number(s): B4DKA8 Q8IWI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 218 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries