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Entry version 151 (07 Apr 2021)
Sequence version 3 (28 Jul 2009)
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Protein

Polyketide synthase PksJ

Gene

pksJ

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.2 Publications

Miscellaneous

The acyl carrier 2 domain binds glycine.

Caution

Was originally thought to be two separate ORFs named pksJ and pksK.Curated

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 5 phosphopantetheines covalently.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1932For beta-ketoacyl synthase 1 activityPROSITE-ProRule annotation1
Active sitei3511For beta-ketoacyl synthase 2 activityPROSITE-ProRule annotation1
Active sitei4743For beta-ketoacyl synthase 3 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Ligase, Multifunctional enzyme, Transferase
Biological processAntibiotic biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU17180-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA01003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyketide synthase PksJ
Short name:
PKS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pksJ
Synonyms:pksK
Ordered Locus Names:BSU17180
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001931841 – 5043Polyketide synthase PksJAdd BLAST5043

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei627O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1689O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1 Publication1
Modified residuei3148O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3246O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4496O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40806

PRoteomics IDEntifications database

More...
PRIDEi
P40806

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-60662N

Protein interaction database and analysis system

More...
IntActi
P40806, 7 interactors

STRING: functional protein association networks

More...
STRINGi
224308.BSU17180

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

15043
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40806

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini590 – 667Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini1654 – 1729Carrier 2PROSITE-ProRule annotationAdd BLAST76
Domaini3114 – 3188Carrier 3PROSITE-ProRule annotationAdd BLAST75
Domaini3212 – 3286Carrier 4PROSITE-ProRule annotationAdd BLAST75
Domaini4459 – 4536Carrier 5PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni141 – 481Adenylation 1Add BLAST341
Regioni690 – 989CondensationBy similarityAdd BLAST300
Regioni1181 – 1578Adenylation 2By similarityAdd BLAST398
Regioni1763 – 2189Beta-ketoacyl synthase 1By similarityAdd BLAST427
Regioni3342 – 3782Beta-ketoacyl synthase 2By similarityAdd BLAST441
Regioni4591 – 4995Beta-ketoacyl synthase 3By similarityAdd BLAST405

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3839 – 3872Sequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0300, Bacteria
COG0318, Bacteria
COG1020, Bacteria
COG1028, Bacteria
COG3321, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40806

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFFEHET

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P40806

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 5 hits
3.10.129.110, 1 hit
3.30.559.10, 1 hit
3.40.47.10, 3 hits
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 1 hit
PF16197, KAsynt_C_assoc, 2 hits
PF00109, ketoacyl-synt, 3 hits
PF02801, Ketoacyl-synt_C, 3 hits
PF08659, KR, 2 hits
PF00550, PP-binding, 5 hits
PF14765, PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 3 hits
SM00823, PKS_PP, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 5 hits
SSF51735, SSF51735, 3 hits
SSF53901, SSF53901, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS00606, B_KETOACYL_SYNTHASE, 2 hits
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNNDNIRIL TNPSVSHGEP LHISEKQPAT IPEVLYRTAT ELGDTKGIIY
60 70 80 90 100
LQPDGTEVYQ SYRRLWDDGL RIAKGLRQSG LKAKQSVILQ LGDNSQLLPA
110 120 130 140 150
FWGCVLTGVV PAPLAVPPTY AESSSGTQKL KDAWTLLDKP AVITDRGMHQ
160 170 180 190 200
EMLDWAKEQG LEGFRAIIVE DLLSAEADTD WHQSSPEDLA LLLLTSGSTG
210 220 230 240 250
TPKAVMLNHR NIMSMVKGII QMQGFTREDI TFNWMPFDHV GGIGMLHLRD
260 270 280 290 300
VYLGCQEINV SSETILMEPL KWLDWIDHYR ASVTWAPNFA FGLVTDFAEE
310 320 330 340 350
IKDKKWDLSS MRYMLNGGEA MVAKVGRRIL ELLEPHGLPA DAIRPAWGMS
360 370 380 390 400
ETSSGVIFSH EFTRAGTSDD DHFVEIGSPI PGFSMRIVND HNELVEEGEI
410 420 430 440 450
GRFQVSGLSV TSGYYQRPDL NESVFTEDGW FETGDLGFLR NGRLTITGRT
460 470 480 490 500
KDAIIINGIN YYSHAIESAV EELPEIETSY TAACAVRLGQ NSTDQLAIFF
510 520 530 540 550
VTSAKLNDEQ MSQLLRNIQS HVSQVIGVTP EYLLPVQKEE IPKTAIGKIQ
560 570 580 590 600
RTQLKTSFEN GEFDHLLHKP NRMNDAVQDE GIQQADQVKR VREEIQKHLL
610 620 630 640 650
TCLTEELHVS HDWVEPNANI QSLGVNSIKM MKLIRSIEKN YHIKLTAREI
660 670 680 690 700
HQYPTIERLA SYLSEHEDLS SLSADKKGTD TYKTEPERSQ ATFQPLSEVQ
710 720 730 740 750
KGLWTLQKMS PEKSAYHVPL CFKFSSGLHH ETFQQAFGLV LNQHPILKHV
760 770 780 790 800
IQEKDGVPFL KNEPALSIEI KTENISSLKE SDIPAFLRKK VKEPYVKENS
810 820 830 840 850
PLVRVMSFSR SEQEHFLLVV IHHLIFDGVS SVTFIRSLFD TYQLLLKGQQ
860 870 880 890 900
PEKAVSPAIY HDFAAWEKNM LAGKDGVKHR TYWQKQLSGT LPNLQLPNVS
910 920 930 940 950
ASSVDSQFRE DTYTRRLSSG FMNQVRTFAK EHSVNVTTVF LSCYMMLLGR
960 970 980 990 1000
YTGQKEQIVG MPAMVRPEER FDDAIGHFLN MLPIRSELNP ADTFSSFISK
1010 1020 1030 1040 1050
LQLTILDGLD HAAYPFPKMV RDLNIPRSQA GSPVFQTAFF YQNFLQSGSY
1060 1070 1080 1090 1100
QSLLSRYADF FSVDFVEYIH QEGEYELVFE LWETEEKMEL NIKYNTGLFD
1110 1120 1130 1140 1150
AASISAMFDH FVYVTEQAML NPSQPLKEYS LLPEAEKQMI LKTWNATGKT
1160 1170 1180 1190 1200
YPYITFHELF EQQAKKTPDR AAVSYEGQTL TYRELDEKST QLAIYLQAHG
1210 1220 1230 1240 1250
VGPDRLAGIY VDRSLDMLVG LLAILKAGGA YVPLDPSYPA ERLEYMLEDS
1260 1270 1280 1290 1300
EVFITLTTSE LVNTLSWNGV TTALLDQDWD EIAQTASDRK VLTRTVTPEN
1310 1320 1330 1340 1350
LAYVIYTSGS TGKPKGVMIP HKALTNFLVS MGETPGLTAE DKMLAVTTYC
1360 1370 1380 1390 1400
FDIAALELFL PLIKGAHCYI CQTEHTKDVE KLKRDIRAIK PTVMQATPAT
1410 1420 1430 1440 1450
WKMLFYSGWE NEESVKILCG GEALPETLKR YFLDTGSEAW NMFGPTETTI
1460 1470 1480 1490 1500
WSAVQRINVE CSHATIGRPI ANTQIYITDS QLAPVPAGVP GELCIAGDGV
1510 1520 1530 1540 1550
AKGYYKKEEL TDSRFIDNPF EPGSKLYRTG DMARWLTGGR IEYIGRIDNQ
1560 1570 1580 1590 1600
VKIRGFRIEL GDIESRLSEH PGILECVVVA DMDNLAAYYT AKHANASLTA
1610 1620 1630 1640 1650
RELRHFVKNA LPAYMVPSYF IQLDHMPLTP NGKIDRNSLK NIDLSGEQLK
1660 1670 1680 1690 1700
QRQTSPKNIQ DTVFTIWQEV LKTSDIEWDD GFFDVGGDSL LAVTVADRIK
1710 1720 1730 1740 1750
HELSCEFSVT DLFEYSTIKN ISQYITEQRM GDASDHIPTD PAAHIEDQST
1760 1770 1780 1790 1800
EMSDLPDYYD DSVAIIGISC EFPGAKNHDE FWENLRDGKE SIAFFNKEEL
1810 1820 1830 1840 1850
QRFGISKEIA ENADYVPAKA SIDGKDRFDP SFFQISPKDA EFMDPQLRML
1860 1870 1880 1890 1900
LTHSWKAIED AGYAARQIPQ TSVFMSASNN SYRALLPSDT TESLETPDGY
1910 1920 1930 1940 1950
VSWVLAQSGT IPTMISHKLG LRGPSYFVHA NCSSSLIGLH SAYKSLLSGE
1960 1970 1980 1990 2000
SDYALVGGAT LHTESNIGYV HQPGLNFSSD GHIKAFDASA DGMIGGEGVA
2010 2020 2030 2040 2050
VVLLKKAADA VKDGDHIYAL LRGIGVNNDG ADKVGFYAPS VKGQADVVQQ
2060 2070 2080 2090 2100
VMNQTKVQPE SICYVEAHGT GTKLGDPIEL AALTNVYRQY TNKTQFCGIG
2110 2120 2130 2140 2150
SVKTNIGHLD TAAGLAGCIK VVMSLYHQEL APSVNYKEPN PNTDLASSPF
2160 2170 2180 2190 2200
YVVDQKKTLS REIKTHRAAL SSFGLGGTNT HAIFEQFKRD SDKGKIDGTC
2210 2220 2230 2240 2250
IVPISAKNKE RLQEYAEDIL AYLERRGFEN SQLPDFAYTL QVGREAMEHR
2260 2270 2280 2290 2300
VVFIADHVNE LKQRLTDFIN GNTAIEGCFQ GSKHNAREVS WLTEDEDSAE
2310 2320 2330 2340 2350
LIRKWMAKGK VNKLAEMWSK GAHIDWMQLY KGERPNRMSL PTYPFAKERY
2360 2370 2380 2390 2400
WPSQDDRKPV AQISGNQTGI GSIHPLLHQN TSDFSEQKFS SVFTGDEFFL
2410 2420 2430 2440 2450
RDHVVRGKPV LPGVAYLEMA YAAINQAAGS EIGQDVRIRL NHTVWVQPVV
2460 2470 2480 2490 2500
VDRHSAQVDI SLFPEEDGKI TFDIYSTQED GDDPVIHSQG SAELASAAET
2510 2520 2530 2540 2550
PVADLTEMSR RCGKGKMSPD QFYEEGRSRG MFHGPAFQGI KNVNIGNREV
2560 2570 2580 2590 2600
LAQLQLPEIV SGTNEQFVLH PSIMDSALQT ATICIMQELT DQKLILPFAL
2610 2620 2630 2640 2650
EELEVIKGCS SSMWAYARLS DSDHSGGVVQ KADIDVIDES GTVCVRIKGF
2660 2670 2680 2690 2700
STRVLEGEVH TSKPSTRHER LMLEPVWEKQ NEEREDEDLS YTEHIIVLFE
2710 2720 2730 2740 2750
TERSVTDSIA SHMKDARVIT LNEAVGHIAE RYQCYMQNIF ELLQSKVRKL
2760 2770 2780 2790 2800
SAGRIIIQAI VPLEKEKQLF AGVSGLFKTA EIEFSKLTAQ VIEIEKPEEM
2810 2820 2830 2840 2850
IDLHLKLKDD SRRPFDKQIR YEAGYRFVKG WREMVLPSAD TLHMPWRDEG
2860 2870 2880 2890 2900
VYLITGGAGS LGLLFAKEIA NRTGRSTIVL TGRSVLSEDK ENELEALRSI
2910 2920 2930 2940 2950
GAEVVYREAD VSDQHAVRHL LEEIKERYGT LNGIIHGAGS SKDRFIIHKT
2960 2970 2980 2990 3000
NEEFQEVLQP KVSGLLHVDE CSKDFPLDFF IFFSSVSGCL GNAGQADYAA
3010 3020 3030 3040 3050
ANSFMDAFAE YRRSLAASKK RFGSTISFNW PLWEEGGMQV GAEDEKRMLK
3060 3070 3080 3090 3100
TTGMVPMPTD SGLKAFYQGI VSDKPQVFVM EGQLQKMKQK LLSAGSKAKR
3110 3120 3130 3140 3150
NDQRKADQDQ GQTRKLEAAL IQMVGAILKV NTDDIDVNTE LSEYGFDSVT
3160 3170 3180 3190 3200
FTVFTNKINE KFQLELTPTI FFEYGSVQSL AEYVVAAYQG EWNQDATAKG
3210 3220 3230 3240 3250
KDERTNLVHS LSSLEASLSN MVSAILKVNS EDIDVNTELS EYGFDSVTFT
3260 3270 3280 3290 3300
VFTNKINEEF QLELTPTIFF EYGSLHSLAE YLTVEHGDTL VQEREKPEGQ
3310 3320 3330 3340 3350
EELQTKSSEA PKITSRRKRR FTQPIIAKAE RNKKQAADFE PVAIVGISGR
3360 3370 3380 3390 3400
FPGAMDIDEF WKNLEEGKDS ITEVPKDRWD WREHYGNPDT DVNKTDIKWG
3410 3420 3430 3440 3450
GFIDGVAEFD PLFFGISPRE ADYVDPQQRL LMTYVWKALE DAGCSPQSLS
3460 3470 3480 3490 3500
GTGTGIFIGT GNTGYKDLFH RANLPIEGHA ATGHMIPSVG PNRMSYFLNI
3510 3520 3530 3540 3550
HGPSEPVETA CSSSLVAIHR AVTAMQNGDC EMAIAGGVNT ILTEEAHISY
3560 3570 3580 3590 3600
SKAGMLSTDG RCKTFSADAN GYVRGEGVGM VMLKKLEDAE RDGNHIYGVI
3610 3620 3630 3640 3650
RGTAENHGGR ANTLTSPNPK AQADLLVRAY RQADIDPSTV TYIEAHGTGT
3660 3670 3680 3690 3700
ELGDPIEING LKAAFKELSN MRGESQPDVP DHRCGIGSVK SNIGHLELAA
3710 3720 3730 3740 3750
GISGLIKVLL QMKHKTLVKS LHCETLNPYL QLTDSPFYIV QEKQEWKSVT
3760 3770 3780 3790 3800
DRDGNELPRR AGISSFGIGG VNAHIVIEEY MPKANSEHTA TEQPNVIVLS
3810 3820 3830 3840 3850
AKNKSRLIDR ASQLLEVIRN KKYTDQDLHR IAYTLQVGRE EMDERLACVA
3860 3870 3880 3890 3900
GTMQELEEKL QAFVDGKEET DEFFRGQSHR NKETQTIFTA DEDMALALDA
3910 3920 3930 3940 3950
WIRKRKYAKL ADLWVKGVSI QWNTLYGETK PRLISLPSYP FAKDHYWVPA
3960 3970 3980 3990 4000
KEHSERDKKE LVNAIEDRAA CFLTKQWSLS PIGSAVPGTR TVAILCCQET
4010 4020 4030 4040 4050
ADLAAEVSSY FPNHLLIDVS RIENDQSDID WKEFDGLVDV IGCGWDDEGR
4060 4070 4080 4090 4100
LDWIEWVQRL VEFGHKEGLR LLCVTKGLES FQNTSVRMAG ASRAGLYRML
4110 4120 4130 4140 4150
QCEYSHLISR HMDAEEVTDH RRLAKLIADE FYSDSYDAEV CYRDGLRYQA
4160 4170 4180 4190 4200
FLKAHPETGK ATEQSAVFPK DHVLLITGGT RGIGLLCARH FAECYGVKKL
4210 4220 4230 4240 4250
VLTGREQLPP REEWARFKTS NTSLAEKIQA VRELEAKGVQ VEMLSLTLSD
4260 4270 4280 4290 4300
DAQVEQTLQH IKRTLGPIGG VIHCAGLTDM DTLAFIRKTS DDIQRVLEPK
4310 4320 4330 4340 4350
VSGLTTLYRH VCNEPLQFFV LFSSVSAIIP ELSAGQADYA MANSYMDYFA
4360 4370 4380 4390 4400
EAHQKHAPII SVQWPNWKET GMGEVTNQAY RDSGLLSITN SEGLRFLDQI
4410 4420 4430 4440 4450
VSKKFGPVVL PAMANQTNWE PELLMKRRKP HEGGLQEAAL QSPPARDIEE
4460 4470 4480 4490 4500
ADEVSKCDGL LSETQSWLID LFTEELRIDR EDFEIDGLFQ DYGVDSIILA
4510 4520 4530 4540 4550
QVLQRINRKL EAALDPSILY EYPTIQRFAD WLIGSYSERL SALFGGRISD
4560 4570 4580 4590 4600
ASAPLENKIE AEASVPGKDR ALTPQIQAPA ILSPDSHAEG IAVVGLSCRF
4610 4620 4630 4640 4650
PGAETLESYW SLLSEGRSSI GPIPAERWGC KTPYYAGVID GVSYFDPDFF
4660 4670 4680 4690 4700
LLHEEDVRAM DPQALLVLEE CLKLLYHAGY TPEEIKGKPV GVYIGGRSQH
4710 4720 4730 4740 4750
KPDEDSLDHA KNPIVTVGQN YLAANLSQFF DVRGPSVVVD TACSSALVGM
4760 4770 4780 4790 4800
NMAIQALRGG DIQSAIVGGV SLLSSDASHR LFDRRGILSK HSSFHVFDER
4810 4820 4830 4840 4850
ADGVVLGEGV GMVMLKTVKQ ALEDGDIIYA VVKAASVNND GRTAGPATPN
4860 4870 4880 4890 4900
LEAQKEVMKD ALFKSGKKPE DISYLEANGS GSIVTDLLEL KAIQSVYRSG
4910 4920 4930 4940 4950
HSSPLSLGSI KPNIGHPLCA EGIASFIKVV LMLKERRFVP FLSGEKEMAH
4960 4970 4980 4990 5000
FDQQKANITF SRALEKWTDS QPTAAINCFA DGGTNAHVIV EAWEKDEKHA
5010 5020 5030 5040
IKRSPISPPQ LKKRMLSPGE PKLEAETSKM TAANIWDTYE VEV
Length:5,043
Mass (Da):562,814
Last modified:July 28, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6E8A8533D518DE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87V → W in AAA85143 (PubMed:7704258).Curated1
Sequence conflicti619N → NAN in AAA85144 (PubMed:7704258).Curated1
Sequence conflicti4981D → G in AAA85144 (PubMed:7704258).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U11039 Genomic DNA Translation: AAA85143.1 Sequence problems.
U11039 Genomic DNA Translation: AAA85144.1 Sequence problems.
AL009126 Genomic DNA Translation: CAB13589.3

Protein sequence database of the Protein Information Resource

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PIRi
A69679
H69678

NCBI Reference Sequences

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RefSeqi
NP_389598.3, NC_000964.3
WP_003245563.1, NZ_JNCM01000035.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
CAB13589; CAB13589; BSU_17180

Database of genes from NCBI RefSeq genomes

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GeneIDi
940043

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
bsu:BSU17180

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|224308.179.peg.1863

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11039 Genomic DNA Translation: AAA85143.1 Sequence problems.
U11039 Genomic DNA Translation: AAA85144.1 Sequence problems.
AL009126 Genomic DNA Translation: CAB13589.3
PIRiA69679
H69678
RefSeqiNP_389598.3, NC_000964.3
WP_003245563.1, NZ_JNCM01000035.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J1QX-ray2.35A2669-3111[»]
4J1SX-ray3.01A2669-3111[»]
4NA1X-ray1.95A/B3336-3951[»]
4NA2X-ray2.30A/B3336-3951[»]
4NA3X-ray2.89A/B3336-3951[»]
5KTKX-ray1.98A3954-4472[»]
SMRiP40806
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-60662N
IntActiP40806, 7 interactors
STRINGi224308.BSU17180

Proteomic databases

PaxDbiP40806
PRIDEiP40806

Genome annotation databases

EnsemblBacteriaiCAB13589; CAB13589; BSU_17180
GeneIDi940043
KEGGibsu:BSU17180
PATRICifig|224308.179.peg.1863

Phylogenomic databases

eggNOGiCOG0300, Bacteria
COG0318, Bacteria
COG1020, Bacteria
COG1028, Bacteria
COG3321, Bacteria
InParanoidiP40806
OMAiLFFEHET
PhylomeDBiP40806

Enzyme and pathway databases

UniPathwayiUPA01003
BioCyciBSUB:BSU17180-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 5 hits
3.10.129.110, 1 hit
3.30.559.10, 1 hit
3.40.47.10, 3 hits
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 1 hit
PF16197, KAsynt_C_assoc, 2 hits
PF00109, ketoacyl-synt, 3 hits
PF02801, Ketoacyl-synt_C, 3 hits
PF08659, KR, 2 hits
PF00550, PP-binding, 5 hits
PF14765, PS-DH, 1 hit
SMARTiView protein in SMART
SM00826, PKS_DH, 1 hit
SM00825, PKS_KS, 3 hits
SM00823, PKS_PP, 5 hits
SUPFAMiSSF47336, SSF47336, 5 hits
SSF51735, SSF51735, 3 hits
SSF53901, SSF53901, 3 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS00606, B_KETOACYL_SYNTHASE, 2 hits
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKSJ_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40806
Secondary accession number(s): P40803
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 28, 2009
Last modified: April 7, 2021
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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