Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein peanut

Gene

pnut

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and possibly cellularization. Also acts as an enhancer of the sina gene, thus having a role in photoreceptor development.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183GTPBy similarity1
Binding sitei209GTP; via amide nitrogenBy similarity1
Binding sitei345GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei360GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 156GTPBy similarity8
Nucleotide bindingi288 – 296GTPBy similarity9

GO - Molecular functioni

  • actin binding Source: FlyBase
  • GTPase activity Source: FlyBase
  • GTP binding Source: FlyBase
  • microtubule binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • ubiquitin protein ligase binding Source: FlyBase

GO - Biological processi

  • actomyosin contractile ring assembly Source: FlyBase
  • apoptotic process Source: FlyBase
  • cellularization Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • positive regulation of apoptotic process Source: FlyBase

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein peanut
Gene namesi
Name:pnut
ORF Names:CG8705
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013726 pnut

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735101 – 539Protein peanutAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6Phosphoserine1 Publication1
Modified residuei13Phosphoserine1 Publication1
Modified residuei517Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40797
PRIDEiP40797

PTM databases

iPTMnetiP40797

Expressioni

Developmental stagei

Maternal gene products found in the early embryo prior to zygotic transcription.1 Publication

Gene expression databases

BgeeiFBgn0013726
GenevisibleiP40797 DM

Interactioni

Subunit structurei

Interacts with hil.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: FlyBase
  • microtubule binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • ubiquitin protein ligase binding Source: FlyBase

Protein-protein interaction databases

BioGridi61655, 25 interactors
DIPiDIP-60735N
IntActiP40797, 8 interactors
STRINGi7227.FBpp0087869

Structurei

3D structure databases

ProteinModelPortaliP40797
SMRiP40797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 411Septin-type GPROSITE-ProRule annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 156G1 motifPROSITE-ProRule annotation8
Regioni206 – 209G3 motifPROSITE-ProRule annotation4
Regioni287 – 290G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili420 – 516Sequence analysisAdd BLAST97

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
InParanoidiP40797
KOiK16944
OMAiFQFTAMV
OrthoDBiEOG091G07TS
PhylomeDBiP40797

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequencei

Sequence statusi: Complete.

P40797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPRSNAVN GGSGGAISAL PSTLAQLALR DKQQAASASA SSATNGSSGS
60 70 80 90 100
ESLVGVGGRP PNQPPSVPVA ASGKLDTSGG GASNGDSNKL THDLQEKEHQ
110 120 130 140 150
QAQKPQKPPL PVRQKPMEIA GYVGFANLPN QVYRKAVKRG FEFTLMVVGA
160 170 180 190 200
SGLGKSTLIN SMFLSDIYNA EQYPGPSLRK KKTVAVEATK VMLKENGVNL
210 220 230 240 250
TLTVVDTPGF GDAVDNSNCW VPILEYVDSK YEEYLTAESR VYRKTISDSR
260 270 280 290 300
VHCCLYFIAP SGHGLLPLDI ACMQSLSDKV NLVPVIAKAD TMTPDEVHLF
310 320 330 340 350
KKQILNEIAQ HKIKIYDFPA TLEDAAEEAK TTQNLRSRVP FAVVGANTII
360 370 380 390 400
EQDGKKVRGR RYPWGLVEVE NLTHCDFIAL RNMVIRTHLQ DLKDVTNNVH
410 420 430 440 450
YENYRCRKLS ELGLVDGKAR LSNKNPLTQM EEEKREHEQK MKKMEAEMEQ
460 470 480 490 500
VFDMKVKEKM QKLRDSELEL ARRHEERKKA LELQIRELEE KRREFEREKK
510 520 530
EWEDVNHVTL EELKRRSLGA NSSTDNVDGK KEKKKKGLF
Length:539
Mass (Da):60,143
Last modified:November 8, 2005 - v2
Checksum:iA8009F7E6F331A32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79G → S in AAA19603 (PubMed:8181057).Curated1
Sequence conflicti249S → N in AAA19603 (PubMed:8181057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08103 mRNA Translation: AAA19603.1
AE013599 Genomic DNA Translation: AAM68857.1
AY058663 mRNA Translation: AAL13892.1
PIRiA54294
RefSeqiNP_477064.1, NM_057716.4
NP_724659.1, NM_165597.2
UniGeneiDm.4132

Genome annotation databases

EnsemblMetazoaiFBtr0088792; FBpp0087869; FBgn0013726
FBtr0088793; FBpp0087870; FBgn0013726
GeneIDi35801
KEGGidme:Dmel_CG8705

Similar proteinsi

Entry informationi

Entry nameiPNUT_DROME
AccessioniPrimary (citable) accession number: P40797
Secondary accession number(s): Q0E9F5, Q9V385
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 8, 2005
Last modified: July 18, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health