UniProtKB - P40796 (LA_DROME)
Protein
La protein homolog
Gene
La
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development.
GO - Molecular functioni
- 5S rRNA primary transcript binding Source: FlyBase
- DNA binding Source: UniProtKB-KW
- mRNA binding Source: FlyBase
GO - Biological processi
- RNA processing Source: InterPro
Keywordsi
Molecular function | DNA-binding, RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: La protein homologAlternative name(s): La autoantigen homolog La ribonucleoprotein |
Gene namesi | Name:La ORF Names:CG10922 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011638, La |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: FlyBase
Other locations
- euchromatin Source: FlyBase
- ribonucleoprotein complex Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207606 | 1 – 390 | La protein homologAdd BLAST | 390 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 9 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P40796 |
PRIDEi | P40796 |
PTM databases
iPTMneti | P40796 |
Expressioni
Developmental stagei
Expressed throughout embryonic, larval, pupal, and adult development. Expression throughout the embryo is followed by a restricted pattern of mesodermal expression that is later confined to the visceral mesoderm, gonads, gut, and salivary glands.
Gene expression databases
Bgeei | FBgn0011638, Expressed in adult abdomen (Drosophila) and 74 other tissues |
ExpressionAtlasi | P40796, baseline and differential |
Genevisiblei | P40796, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 61271, 9 interactors |
DIPi | DIP-19001N |
IntActi | P40796, 10 interactors |
STRINGi | 7227.FBpp0080905 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 137 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 149 – 234 | RRMPROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 259 – 386 | xRRMPROSITE-ProRule annotationAdd BLAST | 128 |
Phylogenomic databases
eggNOGi | KOG4213, Eukaryota |
GeneTreei | ENSGT00830000128380 |
HOGENOMi | CLU_042341_1_1_1 |
InParanoidi | P40796 |
OMAi | PEHNEER |
OrthoDBi | 882725at2759 |
PhylomeDBi | P40796 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
i Sequence
Sequence statusi: Complete.
P40796-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEVAETPSV EAQEEVAQPA EAQVLEAKNG DAKKDPAPAA EEAAGGFTKQ
60 70 80 90 100
ERAIIRQVEY YFGDANLNRD KFLREQIGKN EDGWVPLSVL VTFKRLASLS
110 120 130 140 150
TDLSEIVAAL NKSEEGLVEI SEDKLSLRRH PERPIPEHNE ERRKEIQERT
160 170 180 190 200
AYAKGFPLDS QISELLDFAA NYDKVVNLTM RKHYDKPTKS YKFKGSIFLT
210 220 230 240 250
FETKDQAKAF LEQEKIVYKE RELLRKWQVD YLKEKQEEYA QKNEKRKNKK
260 270 280 290 300
EAKPEPAFEL PKNAIVVFEG APETSSREEI REAFEKIKDF EVAYIEFAKG
310 320 330 340 350
ETKGSVRLTE ADAAEKYIAK VEEGKLKFKD EVSLSLRKAT EEEEKEFIDK
360 370 380 390
AIEFMKKRRD FTRNKGKRFN RKRHGGNDHK HGGGKKARGD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 169 | A → T in AAA20518 (PubMed:8035794).Curated | 1 | |
Sequence conflicti | 182 – 183 | KH → NS in AAA20518 (PubMed:8035794).Curated | 2 | |
Sequence conflicti | 283 | A → R in AAA20518 (PubMed:8035794).Curated | 1 | |
Sequence conflicti | 329 | K → N in AAA20518 (PubMed:8035794).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07652 mRNA Translation: AAA20518.1 L32988 mRNA Translation: AAA21776.1 AE014134 Genomic DNA Translation: AAF53885.1 |
PIRi | A53773 A53781 |
RefSeqi | NP_477014.1, NM_057666.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0081374; FBpp0080906; FBgn0011638 |
GeneIDi | 35305 |
KEGGi | dme:Dmel_CG10922 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07652 mRNA Translation: AAA20518.1 L32988 mRNA Translation: AAA21776.1 AE014134 Genomic DNA Translation: AAF53885.1 |
PIRi | A53773 A53781 |
RefSeqi | NP_477014.1, NM_057666.5 |
3D structure databases
SMRi | P40796 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 61271, 9 interactors |
DIPi | DIP-19001N |
IntActi | P40796, 10 interactors |
STRINGi | 7227.FBpp0080905 |
PTM databases
iPTMneti | P40796 |
Proteomic databases
PaxDbi | P40796 |
PRIDEi | P40796 |
Genome annotation databases
EnsemblMetazoai | FBtr0081374; FBpp0080906; FBgn0011638 |
GeneIDi | 35305 |
KEGGi | dme:Dmel_CG10922 |
Organism-specific databases
CTDi | 35305 |
FlyBasei | FBgn0011638, La |
Phylogenomic databases
eggNOGi | KOG4213, Eukaryota |
GeneTreei | ENSGT00830000128380 |
HOGENOMi | CLU_042341_1_1_1 |
InParanoidi | P40796 |
OMAi | PEHNEER |
OrthoDBi | 882725at2759 |
PhylomeDBi | P40796 |
Miscellaneous databases
BioGRID-ORCSi | 35305, 1 hit in 1 CRISPR screen |
GenomeRNAii | 35305 |
PROi | PR:P40796 |
Gene expression databases
Bgeei | FBgn0011638, Expressed in adult abdomen (Drosophila) and 74 other tissues |
ExpressionAtlasi | P40796, baseline and differential |
Genevisiblei | P40796, DM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LA_DROME | |
Accessioni | P40796Primary (citable) accession number: P40796 Secondary accession number(s): Q24375, Q9VIN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase