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Protein

Cdc42 homolog

Gene

Cdc42

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: FlyBase

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • actin cytoskeleton reorganization Source: FlyBase
  • actin filament polymerization Source: FlyBase
  • axon extension Source: FlyBase
  • axon guidance Source: FlyBase
  • axonogenesis Source: FlyBase
  • branching involved in open tracheal system development Source: FlyBase
  • cell projection assembly Source: FlyBase
  • cellularization Source: FlyBase
  • cortical actin cytoskeleton organization Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: FlyBase
  • encapsulation of foreign target Source: FlyBase
  • establishment of neuroblast polarity Source: FlyBase
  • exocyst localization Source: FlyBase
  • hemocyte migration Source: FlyBase
  • imaginal disc-derived wing hair outgrowth Source: FlyBase
  • JNK cascade Source: FlyBase
  • maintenance of cell polarity Source: FlyBase
  • maintenance of protein location Source: UniProtKB
  • melanotic encapsulation of foreign target Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • nephrocyte filtration Source: FlyBase
  • neuromuscular synaptic transmission Source: FlyBase
  • neuron projection development Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
  • positive regulation of lamellipodium assembly Source: FlyBase
  • positive regulation of protein kinase activity Source: UniProtKB
  • positive regulation of wound healing Source: FlyBase
  • protein localization to plasma membrane Source: FlyBase
  • regulation of actin filament polymerization Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • response to wounding Source: FlyBase
  • Rho protein signal transduction Source: FlyBase
  • sensory perception of touch Source: FlyBase
  • spermatid development Source: FlyBase
  • transforming growth factor beta receptor signaling pathway Source: FlyBase
  • vesicle-mediated transport Source: FlyBase
  • wound healing Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-114604 GPVI-mediated activation cascade
R-DME-182971 EGFR downregulation
R-DME-194840 Rho GTPase cycle
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-375170 CDO in myogenesis
R-DME-389359 CD28 dependent Vav1 pathway
R-DME-3928662 EPHB-mediated forward signaling
R-DME-416482 G alpha (12/13) signalling events
R-DME-418885 DCC mediated attractive signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-5627123 RHO GTPases activate PAKs
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-5663220 RHO GTPases Activate Formins
R-DME-5687128 MAPK6/MAPK4 signaling
R-DME-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP40793

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 homolog
Gene namesi
Name:Cdc42
ORF Names:CG12530
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0010341 Cdc42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12G → V: Enhances interaction with mbt. Coexpression with mbt slightly reduced the substrate phosphorylation ability of mbt. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989581 – 188Cdc42 homologAdd BLAST188
PropeptideiPRO_0000281288189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP40793
PRIDEiP40793

Expressioni

Gene expression databases

BgeeiFBgn0010341
ExpressionAtlasiP40793 baseline and differential
GenevisibleiP40793 DM

Interactioni

Subunit structurei

The GTP-bound but not the GDP-bound form interacts with mbt and gek.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • protein kinase binding Source: FlyBase

Protein-protein interaction databases

BioGridi59277, 60 interactors
DIPiDIP-31003N
IntActiP40793, 5 interactors
MINTiP40793
STRINGi7227.FBpp0301153

Structurei

3D structure databases

ProteinModelPortaliP40793
SMRiP40793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
InParanoidiP40793
KOiK04393
OMAiMQTLKCV
OrthoDBiEOG091G0KCM
PhylomeDBiP40793

Family and domain databases

CDDicd01874 Cdc42, 1 hit
InterProiView protein in InterPro
IPR037874 Cdc42
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE
110 120 130 140 150
ITHHCQKTPF LLVGTQIDLR DENSTLEKLA KNKQKPITME QGEKLAKELK
160 170 180 190
AVKYVECSAL TQKGLKNVFD EAILAALEPP EPTKKRKCKF L
Length:191
Mass (Da):21,403
Last modified:February 1, 1995 - v1
Checksum:i0AB96574ADC8E0E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10G → D in AAD43788 (PubMed:10772800).Curated1
Sequence conflicti65D → N in AAD43792 (PubMed:10772800).Curated1
Sequence conflicti83S → L in AAD43793 (PubMed:10772800).Curated1
Sequence conflicti114G → D in AAD43790 (PubMed:10772800).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11824 mRNA Translation: AAA62871.1
AF153423 Genomic DNA Translation: AAD43787.1
AF153424 Genomic DNA Translation: AAD43788.1
AF153425 Genomic DNA Translation: AAD43789.1
AF153426 Genomic DNA Translation: AAD43790.1
AF153427 Genomic DNA Translation: AAD43791.1
AF153428 Genomic DNA Translation: AAD43792.1
AF153429 Genomic DNA Translation: AAD43793.1
AE014298 Genomic DNA Translation: AAF49007.1
AY119570 mRNA Translation: AAM50224.1
PIRiI45716
RefSeqiNP_001245762.1, NM_001258833.3
NP_001245763.1, NM_001258834.3
NP_523414.1, NM_078690.4
UniGeneiDm.2867

Genome annotation databases

EnsemblMetazoaiFBtr0074751; FBpp0074520; FBgn0010341
FBtr0309214; FBpp0301153; FBgn0010341
FBtr0309215; FBpp0301154; FBgn0010341
GeneIDi32981
KEGGidme:Dmel_CG12530

Similar proteinsi

Entry informationi

Entry nameiCDC42_DROME
AccessioniPrimary (citable) accession number: P40793
Secondary accession number(s): Q540W4
, Q9U9S3, Q9U9S4, Q9U9S5, Q9U9S6, Q9V465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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