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UniProtKB - P40791 (MEF2_DROME)

Entry version 177 (02 Dec 2020)
Sequence version 3 (19 Oct 2011)
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Protein

Myocyte-specific enhancer factor 2

Gene

Mef2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers (PubMed:7839146, PubMed:8052612, PubMed:8202544). Essential for myoblast fusion and consequently muscle formation in adults (PubMed:25797154). During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription (PubMed:25797154).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi58 – 86Mef2-typeSequence analysisAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-525793, Myogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P40791

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2
Short name:
D-mef2
Alternative name(s):
MADS domain transcription factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mef2
ORF Names:CG1429
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0011656, Mef2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in pupae results in smaller muscle founder templates that display a reduced number of nuclei. No effect on the initiation of myoblast fusion.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001994271 – 540Myocyte-specific enhancer factor 2Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei95Phosphoserine1 Publication1
Modified residuei98Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P40791

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all presumptive mesoderm prior to the splitting process that generates the somatic and visceral/ heart mesoderm. After the subdivision, it is found in both the somatic and the visceral/heart mesoderm.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detectable in the presumptive mesoderm at late cellular blastoderm stage.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

TWI activity is required for MEF2 expression. SNA activity is needed for maintaining MEF2 expression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0011656, Expressed in spermathecum and 62 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P40791, differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P40791, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		61860, 26 interactors

Protein interaction database and analysis system

More...IntActi		P40791, 3 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0087529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P40791

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi377 – 431Gly-richAdd BLAST55
Compositional biasi380 – 386Poly-Ser7
Compositional biasi390 – 396Poly-Gly7
Compositional biasi419 – 428Poly-Gly10
Compositional biasi508 – 513Poly-Gln6
Compositional biasi516 – 519Poly-Gln4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0014, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000169350

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40791

Identification of Orthologs from Complete Genome Data

More...OMAi		LVMPNSR

Database for complete collections of gene phylogenies

More...PhylomeDBi		P40791

Family and domain databases

Conserved Domains Database

More...CDDi		cd00265, MADS_MEF2_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1810.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022102, HJURP_C
IPR033896, MADS_MEF2-like
IPR002100, TF_MADSbox
IPR036879, TF_MADSbox_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12347, HJURP_C, 1 hit
PF00319, SRF-TF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00404, MADSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00432, MADS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55455, SSF55455, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00350, MADS_BOX_1, 1 hit
PS50066, MADS_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform D (identifier: P40791-1) [UniParc]FASTAAdd to basket
Also known as: 1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKIQISR ITDERNRQVT FNKRKFGVMK KAYELSVLCD CEIALIIFSS 
        60         70         80         90        100
SNKLYQYAST DMDRVLLKYT EYNEPHESLT NKNIIEKENK NGVMSPDSPE 
       110        120        130        140        150
AETDYTLTPR TEAKYNKIDE EFQNMMQRNQ MAIGGAGAPR QLPNSSYTLP 
       160        170        180        190        200
VSVPVPGSYG DNLLQASPQM SHTNISPRPS SSETDSGGMS LIIYPSGSML 
       210        220        230        240        250
EMSNGYPHSH SPLVGSPSPG PSPGIAHHLS IKQQSPGSQN GRASNLRVVI 
       260        270        280        290        300
PPTIAPIPPN MSAPDDVGYA DQRQSQTSLN TPVVTLQTPI PALTSYSFGA 
       310        320        330        340        350
QDFSSSGVMN SADIMSLNTW HQGLVPHSSL SHLAVSNSTP PPATSPVSIK 
       360        370        380        390        400
VKAEPQSPPR DLSASGHQQN SNGSTGSGGS SSSTSSNASG GAGGGGAVSA 
       410        420        430        440        450
ANVITHLNNV SVLAGGPSGQ GGGGGGGGSN GNVEQATNLS VLSHAQQHHL 
       460        470        480        490        500
GMPNSRPSST GHITPTPGHD KYEGYPYRAL MGHNPRWNLN FAGAPSSDQD 
       510        520        530        540
VRLAAVAVQQ QQQQPHQQQQ LGDYDAPNHK RPRISGGWGT
Length:540
Mass (Da):57,172
Last modified:October 19, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B82D0C61EE1899E
GO
Isoform A (identifier: P40791-2) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     187-193: GGMSLII → V
     468-491: GHDKYEGYPYRALMGHNPRWNLNF → DFIILN

Show »
Length:516
Mass (Da):54,397
Checksum:i9514C616F8FCAA49
GO
Isoform B (identifier: P40791-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-193: GGMSLII → V
     469-493: Missing.

Show »
Length:509
Mass (Da):53,610
Checksum:iFDAC8DD1D4458F11
GO
Isoform C (identifier: P40791-4) [UniParc]FASTAAdd to basket
Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     469-493: Missing.

Show »
Length:515
Mass (Da):54,183
Checksum:iFC282A1CAAE3F614
GO
Isoform F (identifier: P40791-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-225: Missing.

Show »
Length:501
Mass (Da):53,294
Checksum:i15E435B57713126C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KEP4A0A0B4KEP4_DROME
Myocyte enhancer factor 2, isoform ...
Mef2 22.21, BEST:SD04091, C, D-MEF2, D-Mef2
511Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFI1A0A0B4KFI1_DROME
Myocyte enhancer factor 2, isoform ...
Mef2 22.21, BEST:SD04091, C, D-MEF2, D-Mef2
606Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL28644 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM48340 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 3MGR → WAA in AAL28644 (PubMed:12537569).Curated3
Sequence conflicti1 – 3MGR → WAA in AAM48340 (PubMed:12537569).Curated3
Sequence conflicti97D → E in AAF06817 (PubMed:7839146).Curated1
Sequence conflicti101A → G in AAF06817 (PubMed:7839146).Curated1
Sequence conflicti112 – 114EAK → GGM in AAF06817 (PubMed:7839146).Curated3
Sequence conflicti338S → R in AAA20463 (PubMed:8052612).Curated1
Sequence conflicti364 – 377ASGHQ…GSTGS → PAVISRIAMVPRAG in AAA19957 (PubMed:8202544).CuratedAdd BLAST14
Sequence conflicti364 – 377ASGHQ…GSTGS → PAVISRIAMVPRAG in AAF06817 (PubMed:7839146).CuratedAdd BLAST14
Sequence conflicti429S → T in AAF06817 (PubMed:7839146).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041851187 – 225Missing in isoform F. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_006237187 – 193GGMSLII → V in isoform A and isoform B. 1 Publication7
Alternative sequenceiVSP_006238468 – 491GHDKY…WNLNF → DFIILN in isoform A. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_006239469 – 493Missing in isoform B and isoform C. 4 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U03292 mRNA Translation: AAA19957.1
U07422 mRNA Translation: AAA20463.1
X83527 mRNA Translation: CAA58508.1
U19493 Genomic DNA Translation: AAF06817.1
AE013599 Genomic DNA Translation: AAF58872.1
AE013599 Genomic DNA Translation: AAM71042.1
AE013599 Genomic DNA Translation: AAM71043.1
AE013599 Genomic DNA Translation: AAM71044.1
AE013599 Genomic DNA Translation: AAS64881.1
AY061096 mRNA Translation: AAL28644.1 Different initiation.
AY061589 mRNA Translation: AAL29137.1
AY118311 mRNA Translation: AAM48340.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_477018.1, NM_057670.5 [P40791-4]
NP_477019.1, NM_057671.5 [P40791-3]
NP_477020.1, NM_057672.5 [P40791-1]
NP_477021.1, NM_057673.5 [P40791-2]
NP_995789.1, NM_206067.4 [P40791-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088443; FBpp0087529; FBgn0011656 [P40791-1]
FBtr0088444; FBpp0087530; FBgn0011656 [P40791-2]
FBtr0088445; FBpp0087531; FBgn0011656 [P40791-4]
FBtr0088446; FBpp0087532; FBgn0011656 [P40791-3]
FBtr0088447; FBpp0089303; FBgn0011656 [P40791-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1429

UCSC genome browser

More...UCSCi		CG1429-RF, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03292 mRNA Translation: AAA19957.1
U07422 mRNA Translation: AAA20463.1
X83527 mRNA Translation: CAA58508.1
U19493 Genomic DNA Translation: AAF06817.1
AE013599 Genomic DNA Translation: AAF58872.1
AE013599 Genomic DNA Translation: AAM71042.1
AE013599 Genomic DNA Translation: AAM71043.1
AE013599 Genomic DNA Translation: AAM71044.1
AE013599 Genomic DNA Translation: AAS64881.1
AY061096 mRNA Translation: AAL28644.1 Different initiation.
AY061589 mRNA Translation: AAL29137.1
AY118311 mRNA Translation: AAM48340.1 Different initiation.
RefSeqiNP_477018.1, NM_057670.5 [P40791-4]
NP_477019.1, NM_057671.5 [P40791-3]
NP_477020.1, NM_057672.5 [P40791-1]
NP_477021.1, NM_057673.5 [P40791-2]
NP_995789.1, NM_206067.4 [P40791-6]

3D structure databases

SMRiP40791
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61860, 26 interactors
IntActiP40791, 3 interactors
STRINGi7227.FBpp0087529

PTM databases

iPTMnetiP40791

Genome annotation databases

EnsemblMetazoaiFBtr0088443; FBpp0087529; FBgn0011656 [P40791-1]
FBtr0088444; FBpp0087530; FBgn0011656 [P40791-2]
FBtr0088445; FBpp0087531; FBgn0011656 [P40791-4]
FBtr0088446; FBpp0087532; FBgn0011656 [P40791-3]
FBtr0088447; FBpp0089303; FBgn0011656 [P40791-6]
GeneIDi36032
KEGGidme:Dmel_CG1429
UCSCiCG1429-RF, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		36032
FlyBaseiFBgn0011656, Mef2

Phylogenomic databases

eggNOGiKOG0014, Eukaryota
GeneTreeiENSGT00940000169350
InParanoidiP40791
OMAiLVMPNSR
PhylomeDBiP40791

Enzyme and pathway databases

ReactomeiR-DME-525793, Myogenesis
SignaLinkiP40791

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36032, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36032

Protein Ontology

More...PROi		PR:P40791

Gene expression databases

BgeeiFBgn0011656, Expressed in spermathecum and 62 other tissues
ExpressionAtlasiP40791, differential
GenevisibleiP40791, DM

Family and domain databases

CDDicd00265, MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR022102, HJURP_C
IPR033896, MADS_MEF2-like
IPR002100, TF_MADSbox
IPR036879, TF_MADSbox_sf
PfamiView protein in Pfam
PF12347, HJURP_C, 1 hit
PF00319, SRF-TF, 1 hit
PRINTSiPR00404, MADSDOMAIN
SMARTiView protein in SMART
SM00432, MADS, 1 hit
SUPFAMiSSF55455, SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS00350, MADS_BOX_1, 1 hit
PS50066, MADS_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEF2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40791
Secondary accession number(s): A1Z821
, Q24394, Q8MT88, Q95R70, Q95RW1, Q9U5I8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 19, 2011
Last modified: December 2, 2020
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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