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Protein

Cyprosin

Gene

CYPRO1

Organism
Cynara cardunculus (Cardoon)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69PROSITE-ProRule annotation1
Active sitei256PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.A02

Names & Taxonomyi

Protein namesi
Recommended name:
Cyprosin (EC:3.4.23.-)
Gene namesi
Name:CYPRO1
OrganismiCynara cardunculus (Cardoon)
Taxonomic identifieri4265 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeCarduoideaeCardueaeCarduinaeCynara

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000025899‹1 – 33Activation peptideSequence analysisAdd BLAST›33
ChainiPRO_000002590034 – 473CyprosinAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 88PROSITE-ProRule annotation
Disulfide bondi247 ↔ 251PROSITE-ProRule annotation
Disulfide bondi286 ↔ 378PROSITE-ProRule annotation
Disulfide bondi311 ↔ 350PROSITE-ProRule annotation
Disulfide bondi317 ↔ 347PROSITE-ProRule annotation
Glycosylationi364N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi392 ↔ 429PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiP40782

Expressioni

Tissue specificityi

Mostly present in the violet parts of styles and corollas of mature flowers.

Developmental stagei

Expressed in early stages of floral development and switched off at maturation of the flower.

Structurei

3D structure databases

ProteinModelPortaliP40782
SMRiP40782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 470Peptidase A1PROSITE-ProRule annotationAdd BLAST420
Domaini281 – 384Saposin B-typePROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Family and domain databases

CDDicd06098 phytepsin, 1 hit
Gene3Di2.40.70.10, 3 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR033869 Phytepsin
IPR007856 SapB_1
IPR008138 SapB_2
IPR011001 Saposin-like
IPR008139 SaposinB_dom
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PF05184 SapB_1, 1 hit
PF03489 SapB_2, 1 hit
PRINTSiPR00792 PEPSIN
SMARTiView protein in SMART
SM00741 SapB, 1 hit
SUPFAMiSSF47862 SSF47862, 1 hit
SSF50630 SSF50630, 2 hits
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit
PS50015 SAP_B, 2 hits

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LKKRKVNILN HPGEHAGSND ANARRKYGVR GNFRDSDGEL IALKNYMDAQ
60 70 80 90 100
YFGEIGIGTP PQKFTVIFDT GSSNLWVPSS KCYFSVACLF HSKYRSTDST
110 120 130 140 150
TYKKNGKSAA IQYGTGSISG FFSQDSVKLG DLLVKEQDFI EATKEPGITF
160 170 180 190 200
LAAKFDGILG LGFQEISVGD AVPVWYTMLN QGLVQEPVFS FWLNRNADEQ
210 220 230 240 250
EGGELVFGGV DPNHFKGEHT YVPVTQKGYW QFEMGDVLIG DKTTGFCASG
260 270 280 290 300
CAAIADSGTS LLAGTTTIVT QINQAIGAAG VMSQQCKSLV DQYGKSMIEM
310 320 330 340 350
LLSEEQPEKI CSQMKLCSFD GSHDTSMIIE SVVDKSKGKS SGLPMRCVPC
360 370 380 390 400
ARWVVWMQNQ IRQNETEENI INYVDKLCER LPSPMGESAV DCSSLSSMPN
410 420 430 440 450
IAFTVGGKTF NLSPEQYVLK VGEGATAQCI SGFTAMDVAP PHGPLWILGD
460 470
VFMGQYHTVF DYGNLRVGFA EAA
Length:473
Mass (Da):51,564
Last modified:November 1, 1995 - v2
Checksum:i65F3232EBD06CB56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69193 mRNA Translation: CAA48939.1 Sequence problems.
PIRiS47096
T12049

Similar proteinsi

Entry informationi

Entry nameiCYPR1_CYNCA
AccessioniPrimary (citable) accession number: P40782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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