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UniProtKB - P40763 (STAT3_HUMAN)

Entry version 233 (25 May 2022)
Sequence version 2 (07 Jun 2004)
Previous versions | rss
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Protein

Signal transducer and activator of transcription 3

Gene

STAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:22306293, PubMed:23084476).

Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214).

May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986).

Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225).

Activated by IL31 through IL31RA (PubMed:15194700).

Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600).

Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214).

Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity).

May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580).

Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476).

Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

By similarity9 Publications

Miscellaneous

Involved in the gp130-mediated signaling pathway.

Caution

Was shown to be S-palmitoylated by ZDHHC19, leading to STAT3 homodimerization. However, this study was later retracted.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P40763

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1059683, Interleukin-6 signaling
R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-1266695, Interleukin-7 signaling
R-HSA-1433557, Signaling by SCF-KIT
R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763, Downstream signal transduction
R-HSA-198745, Signalling to STAT3
R-HSA-201556, Signaling by ALK
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2586552, Signaling by Leptin
R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis
R-HSA-452723, Transcriptional regulation of pluripotent stem cells
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-8849474, PTK6 Activates STAT3
R-HSA-8854691, Interleukin-20 family signaling
R-HSA-8875791, MET activates STAT3
R-HSA-8983432, Interleukin-15 signaling
R-HSA-8984722, Interleukin-35 Signalling
R-HSA-8985947, Interleukin-9 signaling
R-HSA-9008059, Interleukin-37 signaling
R-HSA-9020933, Interleukin-23 signaling
R-HSA-9020956, Interleukin-27 signaling
R-HSA-9020958, Interleukin-21 signaling
R-HSA-9616222, Transcriptional regulation of granulopoiesis
R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants
R-HSA-9674555, Signaling by CSF3 (G-CSF)
R-HSA-9701898, STAT3 nuclear events downstream of ALK signaling
R-HSA-9705462, Inactivation of CSF3 (G-CSF) signaling
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9725370, Signaling by ALK fusions and activated point mutants
R-HSA-9725371, Nuclear events stimulated by ALK signaling in cancer
R-HSA-982772, Growth hormone receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P40763

SIGNOR Signaling Network Open Resource

More...SIGNORi		P40763

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P40763, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and activator of transcription 3Imported
Alternative name(s):
Acute-phase response factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAT3Imported
Synonyms:APRFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11364, STAT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		102582, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P40763

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168610

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyper-IgE recurrent infection syndrome 1, autosomal dominant (HIES1)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037365382R → L in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037366382R → Q in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037367382R → W in HIES1; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar.1
Natural variantiVAR_037368384F → L in HIES1. 1 Publication1
Natural variantiVAR_037369384F → S in HIES1. 1 Publication1
Natural variantiVAR_037370389T → I in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar.1
Natural variantiVAR_075414395N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037371423R → Q in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar.1
Natural variantiVAR_075415425N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037372437H → Y in HIES1; loss of function. 1 Publication1
Natural variantiVAR_037373463Missing in HIES1; loss of function. 2 Publications1
Natural variantiVAR_037375611S → N in HIES1. 1 Publication1
Natural variantiVAR_037376621F → V in HIES1. 1 Publication1
Natural variantiVAR_037377622T → I in HIES1. 1 Publication1
Natural variantiVAR_037378637V → L in HIES1. 1 Publication1
Natural variantiVAR_037379637V → M in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar.1
Natural variantiVAR_037380644Missing in HIES1. 1 Publication1
Natural variantiVAR_037381657Y → C in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar.1
Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early childhood onset of a spectrum of autoimmune manifestations affecting multiple organs, including insulin-dependent diabetes mellitus and autoimmune enteropathy or celiac disease. Other features include short stature, non-specific dermatitis, hypothyroidism, autoimmune arthritis, and delayed puberty.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078445330P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication1
Natural variantiVAR_071885392K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar.1
Natural variantiVAR_071886646N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar.1
Natural variantiVAR_071887658K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar.1
Natural variantiVAR_071888716T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi434 – 435EE → AA: Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. 2 Publications2
Mutagenesisi705Y → F: Inhibits leptin-mediated transactivation of CCND1 promoter. Abolished phosphorylation by isoform M2 of PKM (PKM2). 2 Publications1

Keywords - Diseasei

Diabetes mellitus, Disease variant, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		6774

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		STAT3

MalaCards human disease database

More...MalaCardsi		STAT3
MIMi147060, phenotype
615952, phenotype

Open Targets

More...OpenTargetsi		ENSG00000168610

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		520, Acute promyelocytic leukemia
2314, Autosomal dominant hyper-IgE syndrome
512017, Chronic lymphoproliferative disorder of natural killer cells
99885, Isolated permanent neonatal diabetes mellitus
438159, STAT3-related early-onset multisystem autoimmune disease
86872, T-cell large granular lymphocyte leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA337

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P40763, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4026

Drug and drug target database

More...DrugBanki		DB05959, ENMD-1198
DB16630, OPB-111077

DrugCentral

More...DrugCentrali		P40763

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2994

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STAT3

Domain mapping of disease mutations (DMDM)

More...DMDMi		48429227

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001824172 – 770Signal transducer and activator of transcription 3Add BLAST769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei601Allysine; alternate1 Publication1
Modified residuei601N6-acetyllysine; alternate1 Publication1
Modified residuei615Allysine; alternate1 Publication1
Modified residuei615N6-acetyllysine; alternate1 Publication1
Modified residuei631Allysine; alternate1 Publication1
Modified residuei631N6-acetyllysine; alternate1 Publication1
Modified residuei685Allysine; alternate1 Publication1
Modified residuei685N6-acetyllysine; alternate1 Publication1
Modified residuei705Phosphotyrosine; by FER and PTK6Combined sources6 Publications1
Modified residuei707N6-acetyllysine1 Publication1
Modified residuei714PhosphothreonineCombined sources1
Modified residuei727Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCECombined sources8 Publications1
Isoform Del-701 (identifier: P40763-2)
Modified residuei704PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6, isoform M2 of PKM (PKM2) or FER leads to an increase of its transcriptional activity (PubMed:12763138, PubMed:16568091, PubMed:21135090, PubMed:22306293). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.By similarity14 Publications
Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).1 Publication
Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).1 Publication
(Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1275
CPTAC-1276
CPTAC-1751

Encyclopedia of Proteome Dynamics

More...EPDi		P40763

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P40763

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P40763

MaxQB - The MaxQuant DataBase

More...MaxQBi		P40763

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P40763

PeptideAtlas

More...PeptideAtlasi		P40763

PRoteomics IDEntifications database

More...PRIDEi		P40763

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55378 [P40763-1]
55379 [P40763-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P40763, 6 sites, 2 O-linked glycans (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P40763

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P40763

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P40763

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P40763

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4+ T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168610, Expressed in upper lobe of lung and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P40763, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P40763, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168610, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600).

Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (PubMed:15994929, PubMed:15194700, PubMed:17344214, PubMed:15677474, PubMed:15467733) (By similarity).

Interacts with IL23R in presence of IL23 (PubMed:12023369).

Interacts (via SH2 domain) with NLK.

Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).

Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity).

Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity).

Interacts with ARL2BP; interaction is enhanced with ARL2 (PubMed:18234692).

Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear (PubMed:17956865).

Interacts with BMX (PubMed:10688651).

Interacts with ZIPK/DAPK3 (PubMed:16219639).

Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3 (PubMed:9388184). In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (PubMed:17875724).

Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity).

Interacts with the 'Lys-129' acetylated form of BIRC5/survivin (PubMed:20826784).

Interacts with FER (PubMed:19147545).

Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (PubMed:23084476).

Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (PubMed:25476455).

Interacts with FGFR4 (PubMed:26675719).

Interacts with OCAD1 (By similarity).

Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB1 (PubMed:31899195).

Interacts and may form heterodimers with NHLH1 (By similarity).

By similarity22 Publications

(Microbial infection) Interacts with HCV core protein.

1 Publication

(Microbial infection) Interacts with S.typhimurium SarA.

1 Publication

(Microbial infection) Interacts with human cytomegalovirus (HHV-5) immediate early protein IE1; this interaction leads to STAT3 nuclear accumulation and disruption of IL6-induced STAT3 phosphorylation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P40763
With#Exp.IntAct
BCKDK [O14874]2EBI-518675,EBI-1046765
BICD1 [Q96G01]2EBI-518675,EBI-1104509
BLK [P51451]9EBI-518675,EBI-2105445
BMX [P51813]8EBI-518675,EBI-696657
CAPN1 [P07384]2EBI-518675,EBI-1542113
CDK9 [P50750]2EBI-518675,EBI-1383449
CORO1A [P31146]2EBI-518675,EBI-1046676
CSF3R [Q99062]4EBI-518675,EBI-7331284
DAXX [Q9UER7]4EBI-518675,EBI-77321
DIRAS3 [O95661]3EBI-518675,EBI-6139214
ECH1 [Q13011]2EBI-518675,EBI-711968
ECHS1 [P30084]3EBI-518675,EBI-719602
EGFR [P00533]15EBI-518675,EBI-297353
ERBB2 [P04626]9EBI-518675,EBI-641062
EZH2 [Q15910]5EBI-518675,EBI-530054
GADD45GIP1 [Q8TAE8]4EBI-518675,EBI-372506
GNL3 [Q9BVP2]2EBI-518675,EBI-641642
IMPDH2 [P12268]3EBI-518675,EBI-353389
JAK1 [P23458]2EBI-518675,EBI-1383438
KHDRBS1 [Q07666]2EBI-518675,EBI-1364
LMO2 [P25791]3EBI-518675,EBI-739696
MAP3K7 [O43318]4EBI-518675,EBI-358684
MAPK13 [O15264]2EBI-518675,EBI-2116951
MAPK9 [P45984]2EBI-518675,EBI-713568
MAPK9 - isoform Alpha-2 [P45984-1]3EBI-518675,EBI-713586
MORC4 [Q8TE76]2EBI-518675,EBI-3940432
MRPS31 [Q92665]2EBI-518675,EBI-720602
NFE2L2 [Q16236]5EBI-518675,EBI-2007911
NFIX - isoform 3 [Q14938-3]3EBI-518675,EBI-20559045
NFIX - isoform 4 [Q14938-4]3EBI-518675,EBI-20558886
NR4A1 [P22736]3EBI-518675,EBI-721550
OGDHL [Q9ULD0]2EBI-518675,EBI-3940481
PGR [P06401]3EBI-518675,EBI-78539
POM121 - isoform 2 [Q96HA1-2]3EBI-518675,EBI-11956563
PRDX2 [P32119]4EBI-518675,EBI-1266300
PTPN1 [P18031]2EBI-518675,EBI-968788
RELA [Q04206]4EBI-518675,EBI-73886
RET [P07949]3EBI-518675,EBI-2480756
ROCK2 [O75116]3EBI-518675,EBI-366288
RPS9 [P46781]2EBI-518675,EBI-351206
SOX1 [O00570]2EBI-518675,EBI-2935583
SP1 [P08047]4EBI-518675,EBI-298336
SRI [P30626]3EBI-518675,EBI-750459
STAT1 [P42224]8EBI-518675,EBI-1057697
itself8EBI-518675,EBI-518675
SULT2A1 [Q06520]2EBI-518675,EBI-3921363
SYK [P43405]10EBI-518675,EBI-78302
Zdhhc19 [Q810M5] from Mus musculus.4EBI-518675,EBI-22225085
Q9DUM3 from Human herpesvirus 8.4EBI-518675,EBI-7971837
Isoform Del-701 [P40763-2]
With#Exp.IntAct
APP [P05067]3EBI-10692009,EBI-77613

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112651, 363 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6041, STAT1/STAT3 complex
CPX-6043, STAT3/STAT5A complex
CPX-6044, STAT3/STAT5B complex
CPX-6046, STAT3/STAT4 complex
CPX-6049, STAT3 homodimer

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P40763

Database of interacting proteins

More...DIPi		DIP-33584N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P40763

Protein interaction database and analysis system

More...IntActi		P40763, 246 interactors

Molecular INTeraction database

More...MINTi		P40763

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264657

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P40763

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P40763, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1770
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P40763

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P40763

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini580 – 670SH2PROSITE-ProRule annotationAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi150 – 162Essential for nuclear importAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3667, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234663

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014189_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40763

Database of Orthologous Groups

More...OrthoDBi		327469at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P40763

TreeFam database of animal gene trees

More...TreeFami		TF318648

Family and domain databases

Conserved Domains Database

More...CDDi		cd10374, SH2_STAT3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR035855, STAT3_SH2
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction

The PANTHER Classification System

More...PANTHERi		PTHR11801, PTHR11801, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00017, SH2, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00964, STAT_int, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47655, SSF47655, 1 hit
SSF48092, SSF48092, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40763-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720        730        740        750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG 
       760        770
QFESLTFDME LTSECATSPM
Length:770
Mass (Da):88,068
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C00632211C8012D
GO
Isoform Del-701 (identifier: P40763-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: Missing.

Show »
Length:769
Mass (Da):87,981
Checksum:iA374A32AB9D28077
GO
Isoform 3 (identifier: P40763-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-722: TTCSNTI → FIDAVWK
     723-770: Missing.

Show »
Length:722
Mass (Da):83,126
Checksum:i09226A697966D947
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLH9G8JLH9_HUMAN
Signal transducer and activator of ...
STAT3
672Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4R3A0A7I2V4R3_HUMAN
Signal transducer and activator of ...
STAT3
738Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V395A0A7I2V395_HUMAN
Signal transducer and activator of ...
STAT3
721Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3V0A0A7I2V3V0_HUMAN
Signal transducer and activator of ...
STAT3
802Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V2G1A0A7I2V2G1_HUMAN
Signal transducer and activator of ...
STAT3
765Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V444A0A7I2V444_HUMAN
Signal transducer and activator of ...
STAT3
763Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V4R2A0A7I2V4R2_HUMAN
Signal transducer and activator of ...
STAT3
727Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V552A0A7I2V552_HUMAN
Signal transducer and activator of ...
STAT3
737Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQD2A0A7I2YQD2_HUMAN
Signal transducer and activator of ...
STAT3
726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQI1A0A7I2YQI1_HUMAN
Signal transducer and activator of ...
STAT3
760Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133T → A in BAF84622 (PubMed:14702039).Curated1
Sequence conflicti288Q → H in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti460P → S in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti548K → N in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti652E → V in BAF84622 (PubMed:14702039).Curated1
Sequence conflicti667V → L in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti730T → A in AAA58374 (PubMed:7512451).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01868332Q → K. Corresponds to variant dbSNP:rs1803125Ensembl.1
Natural variantiVAR_018679143M → I1 PublicationCorresponds to variant dbSNP:rs17878478Ensembl.1
Natural variantiVAR_078445330P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication1
Natural variantiVAR_037365382R → L in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037366382R → Q in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037367382R → W in HIES1; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar.1
Natural variantiVAR_037368384F → L in HIES1. 1 Publication1
Natural variantiVAR_037369384F → S in HIES1. 1 Publication1
Natural variantiVAR_037370389T → I in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar.1
Natural variantiVAR_071885392K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar.1
Natural variantiVAR_075414395N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037371423R → Q in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar.1
Natural variantiVAR_075415425N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037372437H → Y in HIES1; loss of function. 1 Publication1
Natural variantiVAR_037373463Missing in HIES1; loss of function. 2 Publications1
Natural variantiVAR_037374561F → Y1 PublicationCorresponds to variant dbSNP:rs1064116Ensembl.1
Natural variantiVAR_037375611S → N in HIES1. 1 Publication1
Natural variantiVAR_037376621F → V in HIES1. 1 Publication1
Natural variantiVAR_037377622T → I in HIES1. 1 Publication1
Natural variantiVAR_037378637V → L in HIES1. 1 Publication1
Natural variantiVAR_037379637V → M in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar.1
Natural variantiVAR_037380644Missing in HIES1. 1 Publication1
Natural variantiVAR_071886646N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar.1
Natural variantiVAR_037381657Y → C in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar.1
Natural variantiVAR_071887658K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar.1
Natural variantiVAR_071888716T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010474701Missing in isoform Del-701. 1 Publication1
Alternative sequenceiVSP_055918716 – 722TTCSNTI → FIDAVWK in isoform 3. 1 Publication7
Alternative sequenceiVSP_055919723 – 770Missing in isoform 3. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L29277 mRNA Translation: AAA58374.1
AJ012463 mRNA Translation: CAA10032.1
JB252046 mRNA No translation available.
AK291933 mRNA Translation: BAF84622.1
AY572796 Genomic DNA Translation: AAS66986.1
AC087691 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60822.1
BC000627 mRNA Translation: AAH00627.1
BC014482 mRNA Translation: AAH14482.1
AF029311 mRNA Translation: AAB84254.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32656.1 [P40763-1]
CCDS32657.1 [P40763-2]
CCDS59288.1 [P40763-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A54444

NCBI Reference Sequences

More...RefSeqi		NP_003141.2, NM_003150.3 [P40763-2]
NP_644805.1, NM_139276.2 [P40763-1]
NP_998827.1, NM_213662.1 [P40763-3]
XP_005257673.2, XM_005257616.3
XP_005257674.2, XM_005257617.3
XP_011523447.1, XM_011525145.2
XP_011523448.1, XM_011525146.2
XP_016880461.1, XM_017024972.1
XP_016880464.1, XM_017024975.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264657.10; ENSP00000264657.4; ENSG00000168610.16
ENST00000404395.3; ENSP00000384943.3; ENSG00000168610.16 [P40763-2]
ENST00000585517.5; ENSP00000467000.1; ENSG00000168610.16 [P40763-3]
ENST00000588969.5; ENSP00000467985.1; ENSG00000168610.16
ENST00000677030.1; ENSP00000503662.1; ENSG00000168610.16 [P40763-3]
ENST00000677723.1; ENSP00000503574.1; ENSG00000168610.16 [P40763-2]
ENST00000678044.1; ENSP00000503102.1; ENSG00000168610.16
ENST00000678827.1; ENSP00000503634.1; ENSG00000168610.16 [P40763-3]
ENST00000678906.1; ENSP00000504184.1; ENSG00000168610.16
ENST00000678960.1; ENSP00000503181.1; ENSG00000168610.16
ENST00000679014.1; ENSP00000503237.1; ENSG00000168610.16 [P40763-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6774

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6774

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000264657.10; ENSP00000264657.4; NM_139276.3; NP_644805.1

UCSC genome browser

More...UCSCi		uc002hzl.2, human [P40763-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

STAT3 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology
STAT3base

STAT3 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29277 mRNA Translation: AAA58374.1
AJ012463 mRNA Translation: CAA10032.1
JB252046 mRNA No translation available.
AK291933 mRNA Translation: BAF84622.1
AY572796 Genomic DNA Translation: AAS66986.1
AC087691 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60822.1
BC000627 mRNA Translation: AAH00627.1
BC014482 mRNA Translation: AAH14482.1
AF029311 mRNA Translation: AAB84254.1
CCDSiCCDS32656.1 [P40763-1]
CCDS32657.1 [P40763-2]
CCDS59288.1 [P40763-3]
PIRiA54444
RefSeqiNP_003141.2, NM_003150.3 [P40763-2]
NP_644805.1, NM_139276.2 [P40763-1]
NP_998827.1, NM_213662.1 [P40763-3]
XP_005257673.2, XM_005257616.3
XP_005257674.2, XM_005257617.3
XP_011523447.1, XM_011525145.2
XP_011523448.1, XM_011525146.2
XP_016880461.1, XM_017024972.1
XP_016880464.1, XM_017024975.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AX3X-ray2.98B571-582[»]
5U5SNMR-B81-92[»]
6NJSX-ray2.70A127-688[»]
6NUQX-ray3.15A127-688[»]
6QHDX-ray2.85A/B127-715[»]
6TLCX-ray2.90A/B127-722[»]
AlphaFoldDBiP40763
SMRiP40763
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112651, 363 interactors
ComplexPortaliCPX-6041, STAT1/STAT3 complex
CPX-6043, STAT3/STAT5A complex
CPX-6044, STAT3/STAT5B complex
CPX-6046, STAT3/STAT4 complex
CPX-6049, STAT3 homodimer
CORUMiP40763
DIPiDIP-33584N
ELMiP40763
IntActiP40763, 246 interactors
MINTiP40763
STRINGi9606.ENSP00000264657

Chemistry databases

BindingDBiP40763
ChEMBLiCHEMBL4026
DrugBankiDB05959, ENMD-1198
DB16630, OPB-111077
DrugCentraliP40763
GuidetoPHARMACOLOGYi2994

Protein family/group databases

MoonDBiP40763, Predicted

PTM databases

GlyGeniP40763, 6 sites, 2 O-linked glycans (6 sites)
iPTMnetiP40763
MetOSiteiP40763
PhosphoSitePlusiP40763
SwissPalmiP40763

Genetic variation databases

BioMutaiSTAT3
DMDMi48429227

Proteomic databases

CPTACiCPTAC-1275
CPTAC-1276
CPTAC-1751
EPDiP40763
jPOSTiP40763
MassIVEiP40763
MaxQBiP40763
PaxDbiP40763
PeptideAtlasiP40763
PRIDEiP40763
ProteomicsDBi55378 [P40763-1]
55379 [P40763-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P40763, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		660, 2514 antibodies from 55 providers

The CPTC Antibody Portal

More...CPTCi		P40763, 1 antibody

The DNASU plasmid repository

More...DNASUi		6774

Genome annotation databases

EnsembliENST00000264657.10; ENSP00000264657.4; ENSG00000168610.16
ENST00000404395.3; ENSP00000384943.3; ENSG00000168610.16 [P40763-2]
ENST00000585517.5; ENSP00000467000.1; ENSG00000168610.16 [P40763-3]
ENST00000588969.5; ENSP00000467985.1; ENSG00000168610.16
ENST00000677030.1; ENSP00000503662.1; ENSG00000168610.16 [P40763-3]
ENST00000677723.1; ENSP00000503574.1; ENSG00000168610.16 [P40763-2]
ENST00000678044.1; ENSP00000503102.1; ENSG00000168610.16
ENST00000678827.1; ENSP00000503634.1; ENSG00000168610.16 [P40763-3]
ENST00000678906.1; ENSP00000504184.1; ENSG00000168610.16
ENST00000678960.1; ENSP00000503181.1; ENSG00000168610.16
ENST00000679014.1; ENSP00000503237.1; ENSG00000168610.16 [P40763-2]
GeneIDi6774
KEGGihsa:6774
MANE-SelectiENST00000264657.10; ENSP00000264657.4; NM_139276.3; NP_644805.1
UCSCiuc002hzl.2, human [P40763-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6774
DisGeNETi6774

GeneCards: human genes, protein and diseases

More...GeneCardsi		STAT3
GeneReviewsiSTAT3
HGNCiHGNC:11364, STAT3
HPAiENSG00000168610, Low tissue specificity
MalaCardsiSTAT3
MIMi102582, gene
147060, phenotype
615952, phenotype
neXtProtiNX_P40763
OpenTargetsiENSG00000168610
Orphaneti520, Acute promyelocytic leukemia
2314, Autosomal dominant hyper-IgE syndrome
512017, Chronic lymphoproliferative disorder of natural killer cells
99885, Isolated permanent neonatal diabetes mellitus
438159, STAT3-related early-onset multisystem autoimmune disease
86872, T-cell large granular lymphocyte leukemia
PharmGKBiPA337
VEuPathDBiHostDB:ENSG00000168610

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3667, Eukaryota
GeneTreeiENSGT01030000234663
HOGENOMiCLU_014189_3_0_1
InParanoidiP40763
OrthoDBi327469at2759
PhylomeDBiP40763
TreeFamiTF318648

Enzyme and pathway databases

PathwayCommonsiP40763
ReactomeiR-HSA-1059683, Interleukin-6 signaling
R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-1266695, Interleukin-7 signaling
R-HSA-1433557, Signaling by SCF-KIT
R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763, Downstream signal transduction
R-HSA-198745, Signalling to STAT3
R-HSA-201556, Signaling by ALK
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2586552, Signaling by Leptin
R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis
R-HSA-452723, Transcriptional regulation of pluripotent stem cells
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-8849474, PTK6 Activates STAT3
R-HSA-8854691, Interleukin-20 family signaling
R-HSA-8875791, MET activates STAT3
R-HSA-8983432, Interleukin-15 signaling
R-HSA-8984722, Interleukin-35 Signalling
R-HSA-8985947, Interleukin-9 signaling
R-HSA-9008059, Interleukin-37 signaling
R-HSA-9020933, Interleukin-23 signaling
R-HSA-9020956, Interleukin-27 signaling
R-HSA-9020958, Interleukin-21 signaling
R-HSA-9616222, Transcriptional regulation of granulopoiesis
R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants
R-HSA-9674555, Signaling by CSF3 (G-CSF)
R-HSA-9701898, STAT3 nuclear events downstream of ALK signaling
R-HSA-9705462, Inactivation of CSF3 (G-CSF) signaling
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9725370, Signaling by ALK fusions and activated point mutants
R-HSA-9725371, Nuclear events stimulated by ALK signaling in cancer
R-HSA-982772, Growth hormone receptor signaling
SignaLinkiP40763
SIGNORiP40763

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6774, 38 hits in 1117 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STAT3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STAT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6774
PharosiP40763, Tchem

Protein Ontology

More...PROi		PR:P40763
RNActiP40763, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168610, Expressed in upper lobe of lung and 251 other tissues
ExpressionAtlasiP40763, baseline and differential
GenevisibleiP40763, HS

Family and domain databases

CDDicd10374, SH2_STAT3, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR035855, STAT3_SH2
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction
PANTHERiPTHR11801, PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit
SMARTiView protein in SMART
SM00964, STAT_int, 1 hit
SUPFAMiSSF47655, SSF47655, 1 hit
SSF48092, SSF48092, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40763
Secondary accession number(s): A8K7B8
, K7ENL3, O14916, Q9BW54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 7, 2004
Last modified: May 25, 2022
This is version 233 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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