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UniProtKB - P40763 (STAT3_HUMAN)

Protein

Signal transducer and activator of transcription 3

Gene

STAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).By similarity8 Publications

Miscellaneous

Involved in the gp130-mediated signaling pathway.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1059683 Interleukin-6 signaling
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763 Downstream signal transduction
R-HSA-198745 Signalling to STAT3
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2586552 Signaling by Leptin
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8849474 PTK6 Activates STAT3
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8875791 MET activates STAT3
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9008059 Interleukin-37 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020956 Interleukin-27 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP40763
SIGNORiP40763

Protein family/group databases

MoonDBiP40763 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 3Imported
Alternative name(s):
Acute-phase response factor
Gene namesi
Name:STAT3Imported
Synonyms:APRFImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168610.14
HGNCiHGNC:11364 STAT3
MIMi102582 gene
neXtProtiNX_P40763

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
See also OMIM:147060
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037365382R → L in AD-HIES. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037366382R → Q in AD-HIES; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037367382R → W in AD-HIES; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar.1
Natural variantiVAR_037368384F → L in AD-HIES. 1 Publication1
Natural variantiVAR_037369384F → S in AD-HIES. 1 Publication1
Natural variantiVAR_037370389T → I in AD-HIES; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar.1
Natural variantiVAR_075414395N → Y in AD-HIES; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037371423R → Q in AD-HIES. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar.1
Natural variantiVAR_075415425N → Y in AD-HIES; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037372437H → Y in AD-HIES; loss of function. 1 Publication1
Natural variantiVAR_037373463Missing in AD-HIES; loss of function. 2 Publications1
Natural variantiVAR_037375611S → N in AD-HIES. 1 Publication1
Natural variantiVAR_037376621F → V in AD-HIES. 1 Publication1
Natural variantiVAR_037377622T → I in AD-HIES. 1 Publication1
Natural variantiVAR_037378637V → L in AD-HIES. 1 Publication1
Natural variantiVAR_037379637V → M in AD-HIES; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar.1
Natural variantiVAR_037380644Missing in AD-HIES. 1 Publication1
Natural variantiVAR_037381657Y → C in AD-HIES; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar.1
Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early childhood onset of a spectrum of autoimmune manifestations affecting multiple organs, including insulin-dependent diabetes mellitus and autoimmune enteropathy or celiac disease. Other features include short stature, non-specific dermatitis, hypothyroidism, autoimmune arthritis, and delayed puberty.
See also OMIM:615952
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078445330P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication1
Natural variantiVAR_071885392K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar.1
Natural variantiVAR_071886646N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar.1
Natural variantiVAR_071887658K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar.1
Natural variantiVAR_071888716T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi434 – 435EE → AA: Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. 2 Publications2
Mutagenesisi705Y → F: Inhibits leptin-mediated transactivation of CCND1 promoter. 1 Publication1

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi6774
GeneReviewsiSTAT3
MalaCardsiSTAT3
MIMi147060 phenotype
615952 phenotype
OpenTargetsiENSG00000168610
Orphaneti2314 Autosomal dominant hyper-IgE syndrome
PharmGKBiPA337

Chemistry databases

ChEMBLiCHEMBL4026

Polymorphism and mutation databases

BioMutaiSTAT3
DMDMi48429227

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001824172 – 770Signal transducer and activator of transcription 3Add BLAST769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei601Allysine; alternate1 Publication1
Modified residuei601N6-acetyllysine; alternate1 Publication1
Modified residuei615Allysine; alternate1 Publication1
Modified residuei615N6-acetyllysine; alternate1 Publication1
Modified residuei631Allysine; alternate1 Publication1
Modified residuei631N6-acetyllysine; alternate1 Publication1
Modified residuei685Allysine; alternate1 Publication1
Modified residuei685N6-acetyllysine; alternate1 Publication1
Modified residuei705Phosphotyrosine; by FER and PTK6Combined sources4 Publications1
Modified residuei707N6-acetyllysine1 Publication1
Modified residuei714PhosphothreonineCombined sources1
Modified residuei727Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCECombined sources7 Publications1
Isoform Del-701 (identifier: P40763-2)
Modified residuei704PhosphotyrosineCombined sources1

Post-translational modificationi

Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.By similarity13 Publications
Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).1 Publication
Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP40763
MaxQBiP40763
PaxDbiP40763
PeptideAtlasiP40763
PRIDEiP40763
ProteomicsDBi55378
55379 [P40763-2]

PTM databases

iPTMnetiP40763
PhosphoSitePlusiP40763

Miscellaneous databases

PMAP-CutDBiP40763

Expressioni

Tissue specificityi

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000168610 Expressed in 239 organ(s), highest expression level in upper lobe of lung
CleanExiHS_STAT3
ExpressionAtlasiP40763 baseline and differential
GenevisibleiP40763 HS

Organism-specific databases

HPAiCAB003859
CAB068241
CAB068242
HPA001671
HPA058603

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the 'Lys-129' acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with STAT3; the interaction is independent of STAT3 TYR-705 phosphorylation status (PubMed:25476455). Interacts with FGFR4 (PubMed:26675719). Interacts with OCAD1 (By similarity).By similarity20 Publications
(Microbial infection) Interacts with HCV core protein.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112651, 250 interactors
CORUMiP40763
DIPiDIP-33584N
ELMiP40763
IntActiP40763, 171 interactors
MINTiP40763
STRINGi9606.ENSP00000264657

Chemistry databases

BindingDBiP40763

Structurei

3D structure databases

ProteinModelPortaliP40763
SMRiP40763
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 670SH2PROSITE-ProRule annotationAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi150 – 162Essential for nuclear importAdd BLAST13

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000220792
HOVERGENiHBG055669
InParanoidiP40763
KOiK04692
OMAiECASSPM
OrthoDBiEOG091G03O3
PhylomeDBiP40763
TreeFamiTF318648

Family and domain databases

CDDicd10374 SH2_STAT3, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035855 STAT3_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40763-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720        730        740        750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG 
       760        770
QFESLTFDME LTSECATSPM
Length:770
Mass (Da):88,068
Last modified:June 7, 2004 - v2
Checksum:i6C00632211C8012D
GO
Isoform Del-701 (identifier: P40763-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: Missing.

Show »
Length:769
Mass (Da):87,981
Checksum:iA374A32AB9D28077
GO
Isoform 3 (identifier: P40763-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-722: TTCSNTI → FIDAVWK
     723-770: Missing.

Show »
Length:722
Mass (Da):83,126
Checksum:i09226A697966D947
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLH9G8JLH9_HUMAN
Signal transducer and activator of ...
STAT3
672Annotation score:
K7EP08K7EP08_HUMAN
Signal transducer and activator of ...
STAT3
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133T → A in BAF84622 (PubMed:14702039).Curated1
Sequence conflicti288Q → H in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti460P → S in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti548K → N in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti652E → V in BAF84622 (PubMed:14702039).Curated1
Sequence conflicti667V → L in AAA58374 (PubMed:7512451).Curated1
Sequence conflicti730T → A in AAA58374 (PubMed:7512451).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01868332Q → K. Corresponds to variant dbSNP:rs1803125Ensembl.1
Natural variantiVAR_018679143M → I1 PublicationCorresponds to variant dbSNP:rs17878478Ensembl.1
Natural variantiVAR_078445330P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication1
Natural variantiVAR_037365382R → L in AD-HIES. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037366382R → Q in AD-HIES; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar.1
Natural variantiVAR_037367382R → W in AD-HIES; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar.1
Natural variantiVAR_037368384F → L in AD-HIES. 1 Publication1
Natural variantiVAR_037369384F → S in AD-HIES. 1 Publication1
Natural variantiVAR_037370389T → I in AD-HIES; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar.1
Natural variantiVAR_071885392K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar.1
Natural variantiVAR_075414395N → Y in AD-HIES; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037371423R → Q in AD-HIES. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar.1
Natural variantiVAR_075415425N → Y in AD-HIES; unknown pathological significance; reduced DNA-binding ability. 1 Publication1
Natural variantiVAR_037372437H → Y in AD-HIES; loss of function. 1 Publication1
Natural variantiVAR_037373463Missing in AD-HIES; loss of function. 2 Publications1
Natural variantiVAR_037374561F → Y1 PublicationCorresponds to variant dbSNP:rs1064116Ensembl.1
Natural variantiVAR_037375611S → N in AD-HIES. 1 Publication1
Natural variantiVAR_037376621F → V in AD-HIES. 1 Publication1
Natural variantiVAR_037377622T → I in AD-HIES. 1 Publication1
Natural variantiVAR_037378637V → L in AD-HIES. 1 Publication1
Natural variantiVAR_037379637V → M in AD-HIES; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar.1
Natural variantiVAR_037380644Missing in AD-HIES. 1 Publication1
Natural variantiVAR_071886646N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar.1
Natural variantiVAR_037381657Y → C in AD-HIES; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar.1
Natural variantiVAR_071887658K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar.1
Natural variantiVAR_071888716T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010474701Missing in isoform Del-701. 1 Publication1
Alternative sequenceiVSP_055918716 – 722TTCSNTI → FIDAVWK in isoform 3. 1 Publication7
Alternative sequenceiVSP_055919723 – 770Missing in isoform 3. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29277 mRNA Translation: AAA58374.1
AJ012463 mRNA Translation: CAA10032.1
JB252046 mRNA No translation available.
AK291933 mRNA Translation: BAF84622.1
AY572796 Genomic DNA Translation: AAS66986.1
AC087691 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60822.1
BC000627 mRNA Translation: AAH00627.1
BC014482 mRNA Translation: AAH14482.1
AF029311 mRNA Translation: AAB84254.1
CCDSiCCDS32656.1 [P40763-1]
CCDS32657.1 [P40763-2]
CCDS59288.1 [P40763-3]
PIRiA54444
RefSeqiNP_003141.2, NM_003150.3 [P40763-2]
NP_644805.1, NM_139276.2 [P40763-1]
NP_998827.1, NM_213662.1 [P40763-3]
XP_005257673.2, XM_005257616.3 [P40763-2]
XP_005257674.2, XM_005257617.3 [P40763-1]
XP_011523447.1, XM_011525145.2 [P40763-1]
XP_011523448.1, XM_011525146.2 [P40763-3]
XP_016880461.1, XM_017024972.1 [P40763-3]
XP_016880464.1, XM_017024975.1 [P40763-2]
UniGeneiHs.463059

Genome annotation databases

EnsembliENST00000264657; ENSP00000264657; ENSG00000168610 [P40763-1]
ENST00000404395; ENSP00000384943; ENSG00000168610 [P40763-2]
ENST00000585517; ENSP00000467000; ENSG00000168610 [P40763-3]
ENST00000588969; ENSP00000467985; ENSG00000168610 [P40763-1]
GeneIDi6774
KEGGihsa:6774
UCSCiuc002hzl.2 human [P40763-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

STAT3 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology
STAT3base

STAT3 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29277 mRNA Translation: AAA58374.1
AJ012463 mRNA Translation: CAA10032.1
JB252046 mRNA No translation available.
AK291933 mRNA Translation: BAF84622.1
AY572796 Genomic DNA Translation: AAS66986.1
AC087691 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60822.1
BC000627 mRNA Translation: AAH00627.1
BC014482 mRNA Translation: AAH14482.1
AF029311 mRNA Translation: AAB84254.1
CCDSiCCDS32656.1 [P40763-1]
CCDS32657.1 [P40763-2]
CCDS59288.1 [P40763-3]
PIRiA54444
RefSeqiNP_003141.2, NM_003150.3 [P40763-2]
NP_644805.1, NM_139276.2 [P40763-1]
NP_998827.1, NM_213662.1 [P40763-3]
XP_005257673.2, XM_005257616.3 [P40763-2]
XP_005257674.2, XM_005257617.3 [P40763-1]
XP_011523447.1, XM_011525145.2 [P40763-1]
XP_011523448.1, XM_011525146.2 [P40763-3]
XP_016880461.1, XM_017024972.1 [P40763-3]
XP_016880464.1, XM_017024975.1 [P40763-2]
UniGeneiHs.463059

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AX3X-ray2.98B571-582[»]
5U5SNMR-B81-92[»]
ProteinModelPortaliP40763
SMRiP40763
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112651, 250 interactors
CORUMiP40763
DIPiDIP-33584N
ELMiP40763
IntActiP40763, 171 interactors
MINTiP40763
STRINGi9606.ENSP00000264657

Chemistry databases

BindingDBiP40763
ChEMBLiCHEMBL4026

Protein family/group databases

MoonDBiP40763 Predicted

PTM databases

iPTMnetiP40763
PhosphoSitePlusiP40763

Polymorphism and mutation databases

BioMutaiSTAT3
DMDMi48429227

Proteomic databases

EPDiP40763
MaxQBiP40763
PaxDbiP40763
PeptideAtlasiP40763
PRIDEiP40763
ProteomicsDBi55378
55379 [P40763-2]

Protocols and materials databases

DNASUi6774
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264657; ENSP00000264657; ENSG00000168610 [P40763-1]
ENST00000404395; ENSP00000384943; ENSG00000168610 [P40763-2]
ENST00000585517; ENSP00000467000; ENSG00000168610 [P40763-3]
ENST00000588969; ENSP00000467985; ENSG00000168610 [P40763-1]
GeneIDi6774
KEGGihsa:6774
UCSCiuc002hzl.2 human [P40763-1]

Organism-specific databases

CTDi6774
DisGeNETi6774
EuPathDBiHostDB:ENSG00000168610.14
GeneCardsiSTAT3
GeneReviewsiSTAT3
HGNCiHGNC:11364 STAT3
HPAiCAB003859
CAB068241
CAB068242
HPA001671
HPA058603
MalaCardsiSTAT3
MIMi102582 gene
147060 phenotype
615952 phenotype
neXtProtiNX_P40763
OpenTargetsiENSG00000168610
Orphaneti2314 Autosomal dominant hyper-IgE syndrome
PharmGKBiPA337
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000220792
HOVERGENiHBG055669
InParanoidiP40763
KOiK04692
OMAiECASSPM
OrthoDBiEOG091G03O3
PhylomeDBiP40763
TreeFamiTF318648

Enzyme and pathway databases

ReactomeiR-HSA-1059683 Interleukin-6 signaling
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763 Downstream signal transduction
R-HSA-198745 Signalling to STAT3
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2586552 Signaling by Leptin
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8849474 PTK6 Activates STAT3
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8875791 MET activates STAT3
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9008059 Interleukin-37 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020956 Interleukin-27 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP40763
SIGNORiP40763

Miscellaneous databases

ChiTaRSiSTAT3 human
GeneWikiiSTAT3
GenomeRNAii6774
PMAP-CutDBiP40763
PROiPR:P40763
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168610 Expressed in 239 organ(s), highest expression level in upper lobe of lung
CleanExiHS_STAT3
ExpressionAtlasiP40763 baseline and differential
GenevisibleiP40763 HS

Family and domain databases

CDDicd10374 SH2_STAT3, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035855 STAT3_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAT3_HUMAN
AccessioniPrimary (citable) accession number: P40763
Secondary accession number(s): A8K7B8
, K7ENL3, O14916, Q9BW54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 7, 2004
Last modified: October 10, 2018
This is version 208 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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