STAT3

Functionⁱ

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476, PubMed:31462771). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4⁺ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).By similarity8 Publications

Miscellaneous

Involved in the gp130-mediated signaling pathway.

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

PathwayCommonsⁱ	P40763
Reactomeⁱ	R-HSA-1059683, Interleukin-6 signaling R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-1266695, Interleukin-7 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763, Downstream signal transduction R-HSA-198745, Signalling to STAT3 R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2586552, Signaling by Leptin R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-452723, Transcriptional regulation of pluripotent stem cells R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8849474, PTK6 Activates STAT3 R-HSA-8854691, Interleukin-20 family signaling R-HSA-8875791, MET activates STAT3 R-HSA-8983432, Interleukin-15 signaling R-HSA-8984722, Interleukin-35 Signalling R-HSA-8985947, Interleukin-9 signaling R-HSA-9008059, Interleukin-37 signaling R-HSA-9020933, Interleukin-23 signaling R-HSA-9020956, Interleukin-27 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-982772, Growth hormone receptor signaling
SignaLinkⁱ	P40763
SIGNORⁱ	P40763

Protein family/group databases

MoonDBⁱ	P40763, Predicted

MoonDBⁱ

P40763, Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal transducer and activator of transcription 3Imported Alternative name(s): Acute-phase response factor
Gene namesⁱ	Name:STAT3Imported Synonyms:APRFImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168610.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11364, STAT3
MIMⁱ	102582, gene
neXtProtⁱ	NX_P40763

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyper-IgE recurrent infection syndrome 1, autosomal dominant (HIES1)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_037365	382	R → L in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar.	1
Natural variantⁱVAR_037366	382	R → Q in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar.	1
Natural variantⁱVAR_037367	382	R → W in HIES1; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar.	1
Natural variantⁱVAR_037368	384	F → L in HIES1. 1 Publication	1
Natural variantⁱVAR_037369	384	F → S in HIES1. 1 Publication	1
Natural variantⁱVAR_037370	389	T → I in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar.	1
Natural variantⁱVAR_075414	395	N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication	1
Natural variantⁱVAR_037371	423	R → Q in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar.	1
Natural variantⁱVAR_075415	425	N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication	1
Natural variantⁱVAR_037372	437	H → Y in HIES1; loss of function. 1 Publication	1
Natural variantⁱVAR_037373	463	Missing in HIES1; loss of function. 2 Publications	1
Natural variantⁱVAR_037375	611	S → N in HIES1. 1 Publication	1
Natural variantⁱVAR_037376	621	F → V in HIES1. 1 Publication	1
Natural variantⁱVAR_037377	622	T → I in HIES1. 1 Publication	1
Natural variantⁱVAR_037378	637	V → L in HIES1. 1 Publication	1
Natural variantⁱVAR_037379	637	V → M in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar.	1
Natural variantⁱVAR_037380	644	Missing in HIES1. 1 Publication	1
Natural variantⁱVAR_037381	657	Y → C in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar.	1

Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by early childhood onset of a spectrum of autoimmune manifestations affecting multiple organs, including insulin-dependent diabetes mellitus and autoimmune enteropathy or celiac disease. Other features include short stature, non-specific dermatitis, hypothyroidism, autoimmune arthritis, and delayed puberty.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078445	330	P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication	1
Natural variantⁱVAR_071885	392	K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar.	1
Natural variantⁱVAR_071886	646	N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar.	1
Natural variantⁱVAR_071887	658	K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar.	1
Natural variantⁱVAR_071888	716	T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	434 – 435	EE → AA: Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. 2 Publications	2
Mutagenesisⁱ	651	A → V: Modifies the lipid-binding pocket leading to reduction of palmitoylation levels and homodimerization. 1 Publication	1
Mutagenesisⁱ	687	C → S: Inhibits palmitoylation. 1 Publication	1
Mutagenesisⁱ	705	Y → F: Inhibits leptin-mediated transactivation of CCND1 promoter. Inhibits Phosphorylation. 2 Publications	1
Mutagenesisⁱ	712	C → S: Inhibits palmitoylation. 1 Publication	1

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6774
GeneReviewsⁱ	STAT3
MalaCards human disease database More...MalaCardsⁱ	STAT3
MIMⁱ	147060, phenotype 615952, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000168610
Orphanetⁱ	520, Acute promyelocytic leukemia 2314, Autosomal dominant hyper-IgE syndrome 512017, Chronic lymphoproliferative disorder of natural killer cells 99885, Permanent neonatal diabetes mellitus 438159, STAT3-related early-onset multisystem autoimmune disease 86872, T-cell large granular lymphocyte leukemia
PharmGKBⁱ	PA337

Miscellaneous databases

Pharosⁱ	P40763, Tchem

Pharosⁱ

P40763, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL4026
Drug and drug target database More...DrugBankⁱ	DB05959, ENMD-1198
DrugCentral More...DrugCentralⁱ	P40763
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2994

Polymorphism and mutation databases

BioMutaⁱ	STAT3
DMDMⁱ	48429227

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000182417	2 – 770	Signal transducer and activator of transcription 3Add BLAST		769

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	601	Allysine; alternate1 Publication	1
Modified residueⁱ	601	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	615	Allysine; alternate1 Publication	1
Modified residueⁱ	615	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	631	Allysine; alternate1 Publication	1
Modified residueⁱ	631	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	685	Allysine; alternate1 Publication	1
Modified residueⁱ	685	N6-acetyllysine; alternate1 Publication	1
Lipidationⁱ	687	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	705	Phosphotyrosine; by FER and PTK6Combined sources6 Publications	1
Modified residueⁱ	707	N6-acetyllysine1 Publication	1
Lipidationⁱ	712	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	714	PhosphothreonineCombined sources	1
Modified residueⁱ	727	Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCECombined sources8 Publications	1
Isoform Del-701 (identifier: P40763-2)
Modified residueⁱ	704	PhosphotyrosineCombined sources	1

Post-translational modificationⁱ

Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity (PubMed:12763138, PubMed:16568091, PubMed:21135090, PubMed:31462771). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.By similarity14 Publications

Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).1 Publication

Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).1 Publication

(Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA.1 Publication

S-palmitoylated by ZDHHC19 in SH2 putative lipid-binding pockets, leading to homodimerization (PubMed:31462771). Nuclear STAT3 is highly palmitoylated (about 75%) compared with cytoplasmic STAT3 (about 20%) (PubMed:31462771).1 Publication

S-stearoylated, probably by ZDHHC19.1 Publication1 Publication

Keywords - PTMⁱ

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-1275 CPTAC-1276 CPTAC-1751
EPDⁱ	P40763
jPOSTⁱ	P40763
MassIVEⁱ	P40763
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40763
PaxDbⁱ	P40763
PeptideAtlas More...PeptideAtlasⁱ	P40763
PRIDEⁱ	P40763
ProteomicsDBⁱ	55378 [P40763-1] 55379 [P40763-2]

PTM databases

GlyGenⁱ	P40763, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetⁱ	P40763
MetOSiteⁱ	P40763
PhosphoSitePlusⁱ	P40763
SwissPalmⁱ	P40763

Expressionⁱ

Tissue specificityⁱ

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4⁺ T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).1 Publication

Inductionⁱ

Positive feedback loop through phosphorylation and palmitoylation in response to stimulation with palmitic acid and cytokines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168610, Expressed in upper lobe of lung and 250 other tissues
ExpressionAtlasⁱ	P40763, baseline and differential
Genevisibleⁱ	P40763, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000168610, Low tissue specificity

HPAⁱ

ENSG00000168610, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600).

Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (PubMed:15994929, PubMed:15194700, PubMed:17344214, PubMed:15677474, PubMed:15467733) (By similarity).

Interacts with IL23R in presence of IL23 (PubMed:12023369).

Interacts (via SH2 domain) with NLK.

Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).

Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity).

Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity).

Interacts with ARL2BP; interaction is enhanced with ARL2 (PubMed:18234692).

Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear (PubMed:17956865).

Interacts with BMX (PubMed:10688651).

Interacts with ZIPK/DAPK3 (PubMed:16219639).

Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3 (PubMed:9388184). In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3.

Interacts with STMN3, antagonizing its microtubule-destabilizing activity.

Interacts with the 'Lys-129' acetylated form of BIRC5/survivin (PubMed:20826784).

Interacts with FER (PubMed:19147545).

Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (PubMed:23084476).

Interacts with STAT3; the interaction is independent of STAT3 Tyr-705 phosphorylation status (PubMed:25476455).

Interacts with FGFR4 (PubMed:26675719).

Interacts with OCAD1 (By similarity).

Interacts with ZDHHC19, leading to palmitoylation which promotes homodimerization and activation (PubMed:31462771).

Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB (PubMed:31899195).

By similarity23 Publications

(Microbial infection) Interacts with HCV core protein.

1 Publication

(Microbial infection) Interacts with S.typhimurium SarA.

1 Publication

Binary interactionsⁱ

Hide details

P40763

With	#Exp.	IntAct
BCKDK [O14874]	2	EBI-518675,EBI-1046765
BICD1 [Q96G01]	2	EBI-518675,EBI-1104509
BLK [P51451]	9	EBI-518675,EBI-2105445
BMX [P51813]	8	EBI-518675,EBI-696657
CAPN1 [P07384]	2	EBI-518675,EBI-1542113
CDK9 [P50750]	2	EBI-518675,EBI-1383449
CORO1A [P31146]	2	EBI-518675,EBI-1046676
CSF3R [Q99062]	4	EBI-518675,EBI-7331284
DAXX [Q9UER7]	4	EBI-518675,EBI-77321
DIRAS3 [O95661]	3	EBI-518675,EBI-6139214
ECH1 [Q13011]	2	EBI-518675,EBI-711968
ECHS1 [P30084]	3	EBI-518675,EBI-719602
EGFR [P00533]	15	EBI-518675,EBI-297353
ERBB2 [P04626]	9	EBI-518675,EBI-641062
EZH2 [Q15910]	5	EBI-518675,EBI-530054
GADD45GIP1 [Q8TAE8]	4	EBI-518675,EBI-372506
GNL3 [Q9BVP2]	2	EBI-518675,EBI-641642
IMPDH2 [P12268]	3	EBI-518675,EBI-353389
JAK1 [P23458]	2	EBI-518675,EBI-1383438
KHDRBS1 [Q07666]	2	EBI-518675,EBI-1364
LMO2 [P25791]	3	EBI-518675,EBI-739696
MAP3K7 [O43318]	4	EBI-518675,EBI-358684
MAPK9 [P45984]	2	EBI-518675,EBI-713568
MAPK9 - isoform Alpha-2 [P45984-1]	3	EBI-518675,EBI-713586
MORC4 [Q8TE76]	2	EBI-518675,EBI-3940432
MRPS31 [Q92665]	2	EBI-518675,EBI-720602
NFIX - isoform 3 [Q14938-3]	3	EBI-518675,EBI-20559045
NFIX - isoform 4 [Q14938-4]	3	EBI-518675,EBI-20558886
NR4A1 [P22736]	3	EBI-518675,EBI-721550
OGDHL [Q9ULD0]	2	EBI-518675,EBI-3940481
PGR [P06401]	3	EBI-518675,EBI-78539
POM121 - isoform 2 [Q96HA1-2]	3	EBI-518675,EBI-11956563
PRDX2 [P32119]	4	EBI-518675,EBI-1266300
PTPN1 [P18031]	2	EBI-518675,EBI-968788
RELA [Q04206]	4	EBI-518675,EBI-73886
RET [P07949]	3	EBI-518675,EBI-2480756
ROCK2 [O75116]	3	EBI-518675,EBI-366288
RPS9 [P46781]	2	EBI-518675,EBI-351206
SOX1 [O00570]	2	EBI-518675,EBI-2935583
SP1 [P08047]	4	EBI-518675,EBI-298336
SRI [P30626]	3	EBI-518675,EBI-750459
STAT1 [P42224]	5	EBI-518675,EBI-1057697
itself	8	EBI-518675,EBI-518675
SULT2A1 [Q06520]	2	EBI-518675,EBI-3921363
SYK [P43405]	10	EBI-518675,EBI-78302
Zdhhc19 [Q810M5] from Mus musculus.	4	EBI-518675,EBI-22225085
Q9DUM3 from Human herpesvirus 8.	4	EBI-518675,EBI-7971837

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	112651, 285 interactors
CORUMⁱ	P40763
Database of interacting proteins More...DIPⁱ	DIP-33584N
ELMⁱ	P40763
IntActⁱ	P40763, 208 interactors
Molecular INTeraction database More...MINTⁱ	P40763
STRINGⁱ	9606.ENSP00000264657

Chemistry databases

BindingDBⁱ

P40763

Miscellaneous databases

RNActⁱ	P40763, protein

RNActⁱ

P40763, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	139 – 177	Combined sources	39
Helixⁱ	194 – 237	Combined sources	44
Helixⁱ	239 – 251	Combined sources	13
Helixⁱ	261 – 290	Combined sources	30
Helixⁱ	297 – 320	Combined sources	24
Beta strandⁱ	321 – 328	Combined sources	8
Beta strandⁱ	338 – 340	Combined sources	3
Beta strandⁱ	345 – 353	Combined sources	9
Helixⁱ	356 – 358	Combined sources	3
Turnⁱ	359 – 361	Combined sources	3
Beta strandⁱ	363 – 368	Combined sources	6
Beta strandⁱ	373 – 376	Combined sources	4
Beta strandⁱ	384 – 388	Combined sources	5
Beta strandⁱ	391 – 393	Combined sources	3
Turnⁱ	398 – 401	Combined sources	4
Beta strandⁱ	404 – 415	Combined sources	12
Helixⁱ	432 – 434	Combined sources	3
Beta strandⁱ	439 – 447	Combined sources	9
Beta strandⁱ	450 – 457	Combined sources	8
Beta strandⁱ	461 – 466	Combined sources	6
Helixⁱ	467 – 469	Combined sources	3
Helixⁱ	470 – 483	Combined sources	14
Turnⁱ	490 – 494	Combined sources	5
Helixⁱ	501 – 513	Combined sources	13
Helixⁱ	522 – 533	Combined sources	12
Helixⁱ	546 – 549	Combined sources	4
Beta strandⁱ	557 – 559	Combined sources	3
Helixⁱ	561 – 574	Combined sources	14
Helixⁱ	577 – 582	Combined sources	6
Helixⁱ	591 – 600	Combined sources	10
Beta strandⁱ	605 – 610	Combined sources	6
Beta strandⁱ	619 – 626	Combined sources	8
Beta strandⁱ	632 – 636	Combined sources	5
Helixⁱ	642 – 645	Combined sources	4
Helixⁱ	650 – 656	Combined sources	7
Turnⁱ	674 – 676	Combined sources	3
Helixⁱ	679 – 683	Combined sources	5
Helixⁱ	684 – 686	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P40763
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	580 – 670	SH2PROSITE-ProRule annotationAdd BLAST		91

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	150 – 162	Essential for nuclear importAdd BLAST		13

Sequence similaritiesⁱ

Belongs to the transcription factor STAT family.Curated

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG3667, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00990000203599
HOGENOMⁱ	CLU_014189_3_0_1
InParanoidⁱ	P40763
KEGG Orthology (KO) More...KOⁱ	K04692
OMAⁱ	GKYCRSE
Database of Orthologous Groups More...OrthoDBⁱ	327469at2759
PhylomeDBⁱ	P40763
TreeFamⁱ	TF318648

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10374, SH2_STAT3, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801, PTHR11801, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00964, STAT_int, 1 hit
SUPFAMⁱ	SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P40763-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720        730        740        750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG 
       760        770
QFESLTFDME LTSECATSPM

Length:770

Mass (Da):88,068

Last modified:June 7, 2004 - v2

Checksum:ⁱ6C00632211C8012D

GO

Isoform Del-701 (identifier: P40763-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
701-701: Missing.

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720        730        740        750
AAPYLKTKFI CVTPTTCSNT IDLPMSPRTL DSLMQFGNNG EGAEPSAGGQ 
       760 
FESLTFDMEL TSECATSPM

Show »

Length:769

Mass (Da):87,981

Checksum:ⁱA374A32AB9D28077

GO

Isoform 3 (identifier: P40763-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
716-722: TTCSNTI → FIDAVWK
723-770: Missing.

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720 
SAAPYLKTKF ICVTPFIDAV WK

Show »

Length:722

Mass (Da):83,126

Checksum:ⁱ09226A697966D947

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G8JLH9	G8JLH9_HUMAN	Signal transducer and activator of ... Signal transducer and activator of transcription	STAT3	672	Annotation score:
K7EP08	K7EP08_HUMAN	Signal transducer and activator of ... Signal transducer and activator of transcription 3	STAT3	84	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	133	T → A in BAF84622 (PubMed:14702039).Curated	1
Sequence conflictⁱ	288	Q → H in AAA58374 (PubMed:7512451).Curated	1
Sequence conflictⁱ	460	P → S in AAA58374 (PubMed:7512451).Curated	1
Sequence conflictⁱ	548	K → N in AAA58374 (PubMed:7512451).Curated	1
Sequence conflictⁱ	652	E → V in BAF84622 (PubMed:14702039).Curated	1
Sequence conflictⁱ	667	V → L in AAA58374 (PubMed:7512451).Curated	1
Sequence conflictⁱ	730	T → A in AAA58374 (PubMed:7512451).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018683	32	Q → K. Corresponds to variant dbSNP:rs1803125Ensembl.	1
Natural variantⁱVAR_018679	143	M → I1 PublicationCorresponds to variant dbSNP:rs17878478Ensembl.	1
Natural variantⁱVAR_078445	330	P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication	1
Natural variantⁱVAR_037365	382	R → L in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar.	1
Natural variantⁱVAR_037366	382	R → Q in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar.	1
Natural variantⁱVAR_037367	382	R → W in HIES1; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar.	1
Natural variantⁱVAR_037368	384	F → L in HIES1. 1 Publication	1
Natural variantⁱVAR_037369	384	F → S in HIES1. 1 Publication	1
Natural variantⁱVAR_037370	389	T → I in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar.	1
Natural variantⁱVAR_071885	392	K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar.	1
Natural variantⁱVAR_075414	395	N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication	1
Natural variantⁱVAR_037371	423	R → Q in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar.	1
Natural variantⁱVAR_075415	425	N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication	1
Natural variantⁱVAR_037372	437	H → Y in HIES1; loss of function. 1 Publication	1
Natural variantⁱVAR_037373	463	Missing in HIES1; loss of function. 2 Publications	1
Natural variantⁱVAR_037374	561	F → Y1 PublicationCorresponds to variant dbSNP:rs1064116Ensembl.	1
Natural variantⁱVAR_037375	611	S → N in HIES1. 1 Publication	1
Natural variantⁱVAR_037376	621	F → V in HIES1. 1 Publication	1
Natural variantⁱVAR_037377	622	T → I in HIES1. 1 Publication	1
Natural variantⁱVAR_037378	637	V → L in HIES1. 1 Publication	1
Natural variantⁱVAR_037379	637	V → M in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar.	1
Natural variantⁱVAR_037380	644	Missing in HIES1. 1 Publication	1
Natural variantⁱVAR_071886	646	N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar.	1
Natural variantⁱVAR_037381	657	Y → C in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar.	1
Natural variantⁱVAR_071887	658	K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar.	1
Natural variantⁱVAR_071888	716	T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010474	701	Missing in isoform Del-701. 1 Publication	1
Alternative sequenceⁱVSP_055918	716 – 722	TTCSNTI → FIDAVWK in isoform 3. 1 Publication	7
Alternative sequenceⁱVSP_055919	723 – 770	Missing in isoform 3. 1 PublicationAdd BLAST	48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29277 mRNA Translation: AAA58374.1 AJ012463 mRNA Translation: CAA10032.1 JB252046 mRNA No translation available. AK291933 mRNA Translation: BAF84622.1 AY572796 Genomic DNA Translation: AAS66986.1 AC087691 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60822.1 BC000627 mRNA Translation: AAH00627.1 BC014482 mRNA Translation: AAH14482.1 AF029311 mRNA Translation: AAB84254.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32656.1 [P40763-1] CCDS32657.1 [P40763-2] CCDS59288.1 [P40763-3]
PIRⁱ	A54444
NCBI Reference Sequences More...RefSeqⁱ	NP_003141.2, NM_003150.3 [P40763-2] NP_644805.1, NM_139276.2 [P40763-1] NP_998827.1, NM_213662.1 [P40763-3] XP_005257673.2, XM_005257616.3 XP_005257674.2, XM_005257617.3 XP_011523447.1, XM_011525145.2 XP_011523448.1, XM_011525146.2 XP_016880461.1, XM_017024972.1 XP_016880464.1, XM_017024975.1

Genome annotation databases

Ensemblⁱ	ENST00000264657; ENSP00000264657; ENSG00000168610 [P40763-1] ENST00000404395; ENSP00000384943; ENSG00000168610 [P40763-2] ENST00000585517; ENSP00000467000; ENSG00000168610 [P40763-3] ENST00000588969; ENSP00000467985; ENSG00000168610 [P40763-1]
GeneIDⁱ	6774
KEGGⁱ	hsa:6774
UCSC genome browser More...UCSCⁱ	uc002hzl.2, human [P40763-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P40763	Signal transducer and activator of transcription		ICTTR		679	UniRef100_P40763
signal transducer and activator of transcription 3 isoform X1		ACIJB		770
signal transducer and activator of transcription 3 isoform X1		VICPA		770
Signal transducer and activator of transcription		PONAB		770
Signal transducer and activator of transcription		PANTR		770
+32
P40763-2	Signal transducer and activator of transcription		PONAB		769	UniRef100_P40763-2
signal transducer and activator of transcription 3 isoform X2		VICPA		769
signal transducer and activator of transcription 3 isoform X2		ACIJB		769
Signal transducer and activator of transcription		PANTR		769
Signal transducer and activator of transcription		PHYMC		769
+6
P40763-3	Signal transducer and activator of transcription		MOUSE		722	UniRef100_Q6GU23
Signal transducer and activator of transcription		MACMU		722
signal transducer and activator of transcription 3 isoform X3		VICPA		722
Signal transducer and activator of transcription		CALJA		722
Signal transducer and activator of transcription		PANTR		722
+11

Protein	Similar proteins		Species	Score	Length	Source
P40763	Signal transducer and activator of transcription		ICTTR		679	UniRef90_P40763
signal transducer and activator of transcription 3 isoform X1		ACIJB		770
signal transducer and activator of transcription 3 isoform X1		VICPA		770
Signal transducer and activator of transcription		PONAB		770
Signal transducer and activator of transcription		PANTR		770
+69

Protein	Similar proteins		Species	Score	Length	Source
P40763	Signal transducer and activator of transcription 3		CHICK		771	UniRef50_P40763
Signal transducer and activator of transcription 3		PIG		770
Signal transducer and activator of transcription 3		BOVIN		770
Signal transducer and activator of transcription 3		RAT		770
Signal transducer and activator of transcription 3	)	MOUSE		770
+1159

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

STAT3 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

STAT3base

STAT3 mutation db

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29277 mRNA Translation: AAA58374.1 AJ012463 mRNA Translation: CAA10032.1 JB252046 mRNA No translation available. AK291933 mRNA Translation: BAF84622.1 AY572796 Genomic DNA Translation: AAS66986.1 AC087691 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60822.1 BC000627 mRNA Translation: AAH00627.1 BC014482 mRNA Translation: AAH14482.1 AF029311 mRNA Translation: AAB84254.1
CCDSⁱ	CCDS32656.1 [P40763-1] CCDS32657.1 [P40763-2] CCDS59288.1 [P40763-3]
PIRⁱ	A54444
RefSeqⁱ	NP_003141.2, NM_003150.3 [P40763-2] NP_644805.1, NM_139276.2 [P40763-1] NP_998827.1, NM_213662.1 [P40763-3] XP_005257673.2, XM_005257616.3 XP_005257674.2, XM_005257617.3 XP_011523447.1, XM_011525145.2 XP_011523448.1, XM_011525146.2 XP_016880461.1, XM_017024972.1 XP_016880464.1, XM_017024975.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5AX3	X-ray	2.98	B	571-582	[»]
	5U5S	NMR	-	B	81-92	[»]
	6NJS	X-ray	2.70	A	127-688	[»]
	6NUQ	X-ray	3.15	A	127-688	[»]
	6QHD	X-ray	2.85	A/B	127-715	[»]
	6TLC	X-ray	2.90	A/B	127-722	[»]
SMRⁱ	P40763
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	112651, 285 interactors
CORUMⁱ	P40763
DIPⁱ	DIP-33584N
ELMⁱ	P40763
IntActⁱ	P40763, 208 interactors
MINTⁱ	P40763
STRINGⁱ	9606.ENSP00000264657

Chemistry databases

BindingDBⁱ	P40763
ChEMBLⁱ	CHEMBL4026
DrugBankⁱ	DB05959, ENMD-1198
DrugCentralⁱ	P40763
GuidetoPHARMACOLOGYⁱ	2994

Protein family/group databases

MoonDBⁱ	P40763, Predicted

MoonDBⁱ

P40763, Predicted

PTM databases

GlyGenⁱ	P40763, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetⁱ	P40763
MetOSiteⁱ	P40763
PhosphoSitePlusⁱ	P40763
SwissPalmⁱ	P40763

Polymorphism and mutation databases

BioMutaⁱ	STAT3
DMDMⁱ	48429227

Proteomic databases

CPTACⁱ	CPTAC-1275 CPTAC-1276 CPTAC-1751
EPDⁱ	P40763
jPOSTⁱ	P40763
MassIVEⁱ	P40763
MaxQBⁱ	P40763
PaxDbⁱ	P40763
PeptideAtlasⁱ	P40763
PRIDEⁱ	P40763
ProteomicsDBⁱ	55378 [P40763-1] 55379 [P40763-2]

Protocols and materials databases

Antibodypediaⁱ	660, 2384 antibodies
The DNASU plasmid repository More...DNASUⁱ	6774

Genome annotation databases

Ensemblⁱ	ENST00000264657; ENSP00000264657; ENSG00000168610 [P40763-1] ENST00000404395; ENSP00000384943; ENSG00000168610 [P40763-2] ENST00000585517; ENSP00000467000; ENSG00000168610 [P40763-3] ENST00000588969; ENSP00000467985; ENSG00000168610 [P40763-1]
GeneIDⁱ	6774
KEGGⁱ	hsa:6774
UCSCⁱ	uc002hzl.2, human [P40763-1]

Organism-specific databases

CTDⁱ	6774
DisGeNETⁱ	6774
EuPathDBⁱ	HostDB:ENSG00000168610.14
GeneCardsⁱ	STAT3
GeneReviewsⁱ	STAT3
HGNCⁱ	HGNC:11364, STAT3
HPAⁱ	ENSG00000168610, Low tissue specificity
MalaCardsⁱ	STAT3
MIMⁱ	102582, gene 147060, phenotype 615952, phenotype
neXtProtⁱ	NX_P40763
OpenTargetsⁱ	ENSG00000168610
Orphanetⁱ	520, Acute promyelocytic leukemia 2314, Autosomal dominant hyper-IgE syndrome 512017, Chronic lymphoproliferative disorder of natural killer cells 99885, Permanent neonatal diabetes mellitus 438159, STAT3-related early-onset multisystem autoimmune disease 86872, T-cell large granular lymphocyte leukemia
PharmGKBⁱ	PA337
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3667, Eukaryota
GeneTreeⁱ	ENSGT00990000203599
HOGENOMⁱ	CLU_014189_3_0_1
InParanoidⁱ	P40763
KOⁱ	K04692
OMAⁱ	GKYCRSE
OrthoDBⁱ	327469at2759
PhylomeDBⁱ	P40763
TreeFamⁱ	TF318648

Enzyme and pathway databases

PathwayCommonsⁱ	P40763
Reactomeⁱ	R-HSA-1059683, Interleukin-6 signaling R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-1266695, Interleukin-7 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763, Downstream signal transduction R-HSA-198745, Signalling to STAT3 R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2586552, Signaling by Leptin R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-452723, Transcriptional regulation of pluripotent stem cells R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8849474, PTK6 Activates STAT3 R-HSA-8854691, Interleukin-20 family signaling R-HSA-8875791, MET activates STAT3 R-HSA-8983432, Interleukin-15 signaling R-HSA-8984722, Interleukin-35 Signalling R-HSA-8985947, Interleukin-9 signaling R-HSA-9008059, Interleukin-37 signaling R-HSA-9020933, Interleukin-23 signaling R-HSA-9020956, Interleukin-27 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-982772, Growth hormone receptor signaling
SignaLinkⁱ	P40763
SIGNORⁱ	P40763

Miscellaneous databases

BioGRID-ORCSⁱ	6774, 20 hits in 906 CRISPR screens
ChiTaRSⁱ	STAT3, human
GeneWikiⁱ	STAT3
GenomeRNAiⁱ	6774
Pharosⁱ	P40763, Tchem
Protein Ontology More...PROⁱ	PR:P40763
RNActⁱ	P40763, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168610, Expressed in upper lobe of lung and 250 other tissues
ExpressionAtlasⁱ	P40763, baseline and differential
Genevisibleⁱ	P40763, HS

Family and domain databases

CDDⁱ	cd10374, SH2_STAT3, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801, PTHR11801, 1 hit
Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00964, STAT_int, 1 hit
SUPFAMⁱ	SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAT3_HUMAN
Accessionⁱ	P40763Primary (citable) accession number: P40763 Secondary accession number(s): A8K7B8 , K7ENL3, O14916, Q9BW54
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	June 7, 2004
	Last modified:	October 7, 2020
	This is version 226 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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Supporting data

UniProtKB - P40763 (STAT3_HUMAN)

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Signal transducer and activator of transcription 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P40763

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ