UniProtKB - P40763 (STAT3_HUMAN)
Signal transducer and activator of transcription 3
STAT3
Functioni
Miscellaneous
Caution
GO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- nuclear receptor activity Source: BHF-UCL
- primary miRNA binding Source: ARUK-UCL
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- transcription factor binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- astrocyte differentiation Source: UniProtKB
- cellular response to cytokine stimulus Source: Reactome
- cellular response to hormone stimulus Source: BHF-UCL
- cellular response to leptin stimulus Source: UniProtKB
- cytokine-mediated signaling pathway Source: GO_Central
- defense response Source: GO_Central
- eating behavior Source: UniProtKB
- energy homeostasis Source: UniProtKB
- eye photoreceptor cell differentiation Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- growth hormone receptor signaling pathway Source: BHF-UCL
- growth hormone receptor signaling pathway via JAK-STAT Source: BHF-UCL
- inflammatory response Source: UniProtKB
- interleukin-15-mediated signaling pathway Source: Reactome
- interleukin-21-mediated signaling pathway Source: Reactome
- interleukin-23-mediated signaling pathway Source: Reactome
- interleukin-27-mediated signaling pathway Source: Reactome
- interleukin-35-mediated signaling pathway Source: Reactome
- interleukin-6-mediated signaling pathway Source: UniProtKB
- interleukin-7-mediated signaling pathway Source: Reactome
- interleukin-9-mediated signaling pathway Source: Reactome
- intracellular receptor signaling pathway Source: BHF-UCL
- leptin-mediated signaling pathway Source: UniProtKB
- negative regulation of autophagy Source: UniProtKB
- negative regulation of primary miRNA processing Source: ARUK-UCL
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- nervous system development Source: ProtInc
- phosphorylation Source: UniProtKB
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of gene silencing by miRNA Source: BHF-UCL
- positive regulation of interleukin-10 production Source: ARUK-UCL
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of interleukin-6 production Source: ARUK-UCL
- positive regulation of interleukin-8 production Source: ARUK-UCL
- positive regulation of metalloendopeptidase activity Source: BHF-UCL
- positive regulation of miRNA mediated inhibition of translation Source: BHF-UCL
- positive regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: Reactome
- protein import into nucleus Source: UniProtKB
- radial glial cell differentiation Source: UniProtKB
- receptor signaling pathway via JAK-STAT Source: GO_Central
- regulation of cell cycle Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of feeding behavior Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to estradiol Source: BHF-UCL
- response to leptin Source: UniProtKB
- response to peptide hormone Source: GO_Central
- sexual reproduction Source: UniProtKB
- signal transduction Source: ProtInc
- somatic stem cell population maintenance Source: Reactome
- temperature homeostasis Source: UniProtKB
- T-helper 17 cell lineage commitment Source: UniProtKB
- T-helper 17 type immune response Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P40763 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-1266695, Interleukin-7 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763, Downstream signal transduction R-HSA-198745, Signalling to STAT3 R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2586552, Signaling by Leptin R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-452723, Transcriptional regulation of pluripotent stem cells R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8849474, PTK6 Activates STAT3 R-HSA-8854691, Interleukin-20 family signaling R-HSA-8875791, MET activates STAT3 R-HSA-8983432, Interleukin-15 signaling R-HSA-8984722, Interleukin-35 Signalling R-HSA-8985947, Interleukin-9 signaling R-HSA-9008059, Interleukin-37 signaling R-HSA-9020933, Interleukin-23 signaling R-HSA-9020956, Interleukin-27 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-982772, Growth hormone receptor signaling |
SignaLinki | P40763 |
SIGNORi | P40763 |
Protein family/group databases
MoonDBi | P40763, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcription 3ImportedAlternative name(s): Acute-phase response factor |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11364, STAT3 |
MIMi | 102582, gene |
neXtProti | NX_P40763 |
VEuPathDBi | HostDB:ENSG00000168610.14 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Note: Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: BHF-UCL
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- chromatin Source: BHF-UCL
- cytoplasm Source: UniProtKB
- transcription regulator complex Source: ARUK-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Hyper-IgE recurrent infection syndrome 1, autosomal dominant (HIES1)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037365 | 382 | R → L in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar. | 1 | |
Natural variantiVAR_037366 | 382 | R → Q in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar. | 1 | |
Natural variantiVAR_037367 | 382 | R → W in HIES1; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar. | 1 | |
Natural variantiVAR_037368 | 384 | F → L in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037369 | 384 | F → S in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037370 | 389 | T → I in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar. | 1 | |
Natural variantiVAR_075414 | 395 | N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication | 1 | |
Natural variantiVAR_037371 | 423 | R → Q in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar. | 1 | |
Natural variantiVAR_075415 | 425 | N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication | 1 | |
Natural variantiVAR_037372 | 437 | H → Y in HIES1; loss of function. 1 Publication | 1 | |
Natural variantiVAR_037373 | 463 | Missing in HIES1; loss of function. 2 Publications | 1 | |
Natural variantiVAR_037375 | 611 | S → N in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037376 | 621 | F → V in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037377 | 622 | T → I in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037378 | 637 | V → L in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037379 | 637 | V → M in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar. | 1 | |
Natural variantiVAR_037380 | 644 | Missing in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037381 | 657 | Y → C in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar. | 1 |
Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078445 | 330 | P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication | 1 | |
Natural variantiVAR_071885 | 392 | K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar. | 1 | |
Natural variantiVAR_071886 | 646 | N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar. | 1 | |
Natural variantiVAR_071887 | 658 | K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar. | 1 | |
Natural variantiVAR_071888 | 716 | T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 434 – 435 | EE → AA: Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. 2 Publications | 2 | |
Mutagenesisi | 705 | Y → F: Inhibits leptin-mediated transactivation of CCND1 promoter. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 6774 |
GeneReviewsi | STAT3 |
MalaCardsi | STAT3 |
MIMi | 147060, phenotype 615952, phenotype |
OpenTargetsi | ENSG00000168610 |
Orphaneti | 520, Acute promyelocytic leukemia 2314, Autosomal dominant hyper-IgE syndrome 512017, Chronic lymphoproliferative disorder of natural killer cells 99885, Permanent neonatal diabetes mellitus 438159, STAT3-related early-onset multisystem autoimmune disease 86872, T-cell large granular lymphocyte leukemia |
PharmGKBi | PA337 |
Miscellaneous databases
Pharosi | P40763, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4026 |
DrugBanki | DB05959, ENMD-1198 |
DrugCentrali | P40763 |
GuidetoPHARMACOLOGYi | 2994 |
Genetic variation databases
BioMutai | STAT3 |
DMDMi | 48429227 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000182417 | 2 – 770 | Signal transducer and activator of transcription 3Add BLAST | 769 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 601 | Allysine; alternate1 Publication | 1 | ||
Modified residuei | 601 | N6-acetyllysine; alternate1 Publication | 1 | ||
Modified residuei | 615 | Allysine; alternate1 Publication | 1 | ||
Modified residuei | 615 | N6-acetyllysine; alternate1 Publication | 1 | ||
Modified residuei | 631 | Allysine; alternate1 Publication | 1 | ||
Modified residuei | 631 | N6-acetyllysine; alternate1 Publication | 1 | ||
Modified residuei | 685 | Allysine; alternate1 Publication | 1 | ||
Modified residuei | 685 | N6-acetyllysine; alternate1 Publication | 1 | ||
Modified residuei | 705 | Phosphotyrosine; by FER and PTK6Combined sources5 Publications | 1 | ||
Modified residuei | 707 | N6-acetyllysine1 Publication | 1 | ||
Modified residuei | 714 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 727 | Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCECombined sources8 Publications | 1 | ||
Isoform Del-701 (identifier: P40763-2) | |||||
Modified residuei | 704 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1275 CPTAC-1276 CPTAC-1751 |
EPDi | P40763 |
jPOSTi | P40763 |
MassIVEi | P40763 |
MaxQBi | P40763 |
PaxDbi | P40763 |
PeptideAtlasi | P40763 |
PRIDEi | P40763 |
ProteomicsDBi | 55378 [P40763-1] 55379 [P40763-2] |
PTM databases
GlyGeni | P40763, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P40763 |
MetOSitei | P40763 |
PhosphoSitePlusi | P40763 |
SwissPalmi | P40763 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000168610, Expressed in upper lobe of lung and 250 other tissues |
ExpressionAtlasi | P40763, baseline and differential |
Genevisiblei | P40763, HS |
Organism-specific databases
HPAi | ENSG00000168610, Low tissue specificity |
Interactioni
Subunit structurei
Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600).
Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (PubMed:15994929, PubMed:15194700, PubMed:17344214, PubMed:15677474, PubMed:15467733) (By similarity).
Interacts with IL23R in presence of IL23 (PubMed:12023369).
Interacts (via SH2 domain) with NLK.
Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).
Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity).
Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity).
Interacts with ARL2BP; interaction is enhanced with ARL2 (PubMed:18234692).
Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear (PubMed:17956865).
Interacts with BMX (PubMed:10688651).
Interacts with ZIPK/DAPK3 (PubMed:16219639).
Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3 (PubMed:9388184). In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (PubMed:17875724).
Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity).
Interacts with the 'Lys-129' acetylated form of BIRC5/survivin (PubMed:20826784).
Interacts with FER (PubMed:19147545).
Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (PubMed:23084476).
Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (PubMed:25476455).
Interacts with FGFR4 (PubMed:26675719).
Interacts with OCAD1 (By similarity).
Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB (PubMed:31899195).
Interacts and may form heterodimers with NHLH1 (By similarity).
By similarity22 Publications(Microbial infection) Interacts with HCV core protein.
1 Publication(Microbial infection) Interacts with S.typhimurium SarA.
1 PublicationBinary interactionsi
Hide detailsP40763
Isoform Del-701 [P40763-2]
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-10692009,EBI-77613 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112651, 303 interactors |
ComplexPortali | CPX-6041, STAT1/STAT3 complex CPX-6043, STAT3/STAT5A complex CPX-6044, STAT3/STAT5B complex CPX-6046, STAT3/STAT4 complex CPX-6049, STAT3 homodimer |
CORUMi | P40763 |
DIPi | DIP-33584N |
ELMi | P40763 |
IntActi | P40763, 216 interactors |
MINTi | P40763 |
STRINGi | 9606.ENSP00000264657 |
Chemistry databases
BindingDBi | P40763 |
Miscellaneous databases
RNActi | P40763, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P40763 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 580 – 670 | SH2PROSITE-ProRule annotationAdd BLAST | 91 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 150 – 162 | Essential for nuclear importAdd BLAST | 13 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | P40763 |
OMAi | GKYCRSE |
OrthoDBi | 327469at2759 |
PhylomeDBi | P40763 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL
460 470 480 490 500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT
510 520 530 540 550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC
560 570 580 590 600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF
660 670 680 690 700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG
710 720 730 740 750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG
760 770
QFESLTFDME LTSECATSPM
The sequence of this isoform differs from the canonical sequence as follows:
701-701: Missing.
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG8JLH9 | G8JLH9_HUMAN | Signal transducer and activator of ... | STAT3 | 672 | Annotation score: | ||
A0A7I2V2G1 | A0A7I2V2G1_HUMAN | Signal transducer and activator of ... | STAT3 | 765 | Annotation score: | ||
A0A7I2V2T1 | A0A7I2V2T1_HUMAN | Signal transducer and activator of ... | STAT3 | 575 | Annotation score: | ||
A0A7I2V395 | A0A7I2V395_HUMAN | Signal transducer and activator of ... | STAT3 | 721 | Annotation score: | ||
A0A7I2V3V0 | A0A7I2V3V0_HUMAN | Signal transducer and activator of ... | STAT3 | 802 | Annotation score: | ||
A0A7I2V444 | A0A7I2V444_HUMAN | Signal transducer and activator of ... | STAT3 | 763 | Annotation score: | ||
A0A7I2V4C8 | A0A7I2V4C8_HUMAN | Signal transducer and activator of ... | STAT3 | 742 | Annotation score: | ||
A0A7I2V4F6 | A0A7I2V4F6_HUMAN | Signal transducer and activator of ... | STAT3 | 458 | Annotation score: | ||
A0A7I2V4R2 | A0A7I2V4R2_HUMAN | Signal transducer and activator of ... | STAT3 | 727 | Annotation score: | ||
A0A7I2V4R3 | A0A7I2V4R3_HUMAN | Signal transducer and activator of ... | STAT3 | 738 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | T → A in BAF84622 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 288 | Q → H in AAA58374 (PubMed:7512451).Curated | 1 | |
Sequence conflicti | 460 | P → S in AAA58374 (PubMed:7512451).Curated | 1 | |
Sequence conflicti | 548 | K → N in AAA58374 (PubMed:7512451).Curated | 1 | |
Sequence conflicti | 652 | E → V in BAF84622 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 667 | V → L in AAA58374 (PubMed:7512451).Curated | 1 | |
Sequence conflicti | 730 | T → A in AAA58374 (PubMed:7512451).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018683 | 32 | Q → K. Corresponds to variant dbSNP:rs1803125Ensembl. | 1 | |
Natural variantiVAR_018679 | 143 | M → I1 PublicationCorresponds to variant dbSNP:rs17878478Ensembl. | 1 | |
Natural variantiVAR_078445 | 330 | P → S in ADMIO1; increases transcriptional activity; increases binding to ISL1 promoter region; decreases glucose stimulated insulin secretion. 1 Publication | 1 | |
Natural variantiVAR_037365 | 382 | R → L in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994136EnsemblClinVar. | 1 | |
Natural variantiVAR_037366 | 382 | R → Q in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs113994136EnsemblClinVar. | 1 | |
Natural variantiVAR_037367 | 382 | R → W in HIES1; loss of function; reduced DNA-binding ability. 3 PublicationsCorresponds to variant dbSNP:rs113994135EnsemblClinVar. | 1 | |
Natural variantiVAR_037368 | 384 | F → L in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037369 | 384 | F → S in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037370 | 389 | T → I in HIES1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs397514766EnsemblClinVar. | 1 | |
Natural variantiVAR_071885 | 392 | K → R in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777648EnsemblClinVar. | 1 | |
Natural variantiVAR_075414 | 395 | N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication | 1 | |
Natural variantiVAR_037371 | 423 | R → Q in HIES1. 1 PublicationCorresponds to variant dbSNP:rs113994137EnsemblClinVar. | 1 | |
Natural variantiVAR_075415 | 425 | N → Y in HIES1; unknown pathological significance; reduced DNA-binding ability. 1 Publication | 1 | |
Natural variantiVAR_037372 | 437 | H → Y in HIES1; loss of function. 1 Publication | 1 | |
Natural variantiVAR_037373 | 463 | Missing in HIES1; loss of function. 2 Publications | 1 | |
Natural variantiVAR_037374 | 561 | F → Y1 PublicationCorresponds to variant dbSNP:rs1064116Ensembl. | 1 | |
Natural variantiVAR_037375 | 611 | S → N in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037376 | 621 | F → V in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037377 | 622 | T → I in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037378 | 637 | V → L in HIES1. 1 Publication | 1 | |
Natural variantiVAR_037379 | 637 | V → M in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs113994139EnsemblClinVar. | 1 | |
Natural variantiVAR_037380 | 644 | Missing in HIES1. 1 Publication | 1 | |
Natural variantiVAR_071886 | 646 | N → K in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777649EnsemblClinVar. | 1 | |
Natural variantiVAR_037381 | 657 | Y → C in HIES1; reduced DNA-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs193922721EnsemblClinVar. | 1 | |
Natural variantiVAR_071887 | 658 | K → N in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs587777650EnsemblClinVar. | 1 | |
Natural variantiVAR_071888 | 716 | T → M in ADMIO1. 1 PublicationCorresponds to variant dbSNP:rs869312892EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010474 | 701 | Missing in isoform Del-701. 1 Publication | 1 | |
Alternative sequenceiVSP_055918 | 716 – 722 | TTCSNTI → FIDAVWK in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_055919 | 723 – 770 | Missing in isoform 3. 1 PublicationAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29277 mRNA Translation: AAA58374.1 AJ012463 mRNA Translation: CAA10032.1 JB252046 mRNA No translation available. AK291933 mRNA Translation: BAF84622.1 AY572796 Genomic DNA Translation: AAS66986.1 AC087691 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60822.1 BC000627 mRNA Translation: AAH00627.1 BC014482 mRNA Translation: AAH14482.1 AF029311 mRNA Translation: AAB84254.1 |
CCDSi | CCDS32656.1 [P40763-1] CCDS32657.1 [P40763-2] CCDS59288.1 [P40763-3] |
PIRi | A54444 |
RefSeqi | NP_003141.2, NM_003150.3 [P40763-2] NP_644805.1, NM_139276.2 [P40763-1] NP_998827.1, NM_213662.1 [P40763-3] XP_005257673.2, XM_005257616.3 XP_005257674.2, XM_005257617.3 XP_011523447.1, XM_011525145.2 XP_011523448.1, XM_011525146.2 XP_016880461.1, XM_017024972.1 XP_016880464.1, XM_017024975.1 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia STAT3 entry |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
STAT3base STAT3 mutation db |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29277 mRNA Translation: AAA58374.1 AJ012463 mRNA Translation: CAA10032.1 JB252046 mRNA No translation available. AK291933 mRNA Translation: BAF84622.1 AY572796 Genomic DNA Translation: AAS66986.1 AC087691 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60822.1 BC000627 mRNA Translation: AAH00627.1 BC014482 mRNA Translation: AAH14482.1 AF029311 mRNA Translation: AAB84254.1 |
CCDSi | CCDS32656.1 [P40763-1] CCDS32657.1 [P40763-2] CCDS59288.1 [P40763-3] |
PIRi | A54444 |
RefSeqi | NP_003141.2, NM_003150.3 [P40763-2] NP_644805.1, NM_139276.2 [P40763-1] NP_998827.1, NM_213662.1 [P40763-3] XP_005257673.2, XM_005257616.3 XP_005257674.2, XM_005257617.3 XP_011523447.1, XM_011525145.2 XP_011523448.1, XM_011525146.2 XP_016880461.1, XM_017024972.1 XP_016880464.1, XM_017024975.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5AX3 | X-ray | 2.98 | B | 571-582 | [»] | |
5U5S | NMR | - | B | 81-92 | [»] | |
6NJS | X-ray | 2.70 | A | 127-688 | [»] | |
6NUQ | X-ray | 3.15 | A | 127-688 | [»] | |
6QHD | X-ray | 2.85 | A/B | 127-715 | [»] | |
6TLC | X-ray | 2.90 | A/B | 127-722 | [»] | |
SMRi | P40763 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112651, 303 interactors |
ComplexPortali | CPX-6041, STAT1/STAT3 complex CPX-6043, STAT3/STAT5A complex CPX-6044, STAT3/STAT5B complex CPX-6046, STAT3/STAT4 complex CPX-6049, STAT3 homodimer |
CORUMi | P40763 |
DIPi | DIP-33584N |
ELMi | P40763 |
IntActi | P40763, 216 interactors |
MINTi | P40763 |
STRINGi | 9606.ENSP00000264657 |
Chemistry databases
BindingDBi | P40763 |
ChEMBLi | CHEMBL4026 |
DrugBanki | DB05959, ENMD-1198 |
DrugCentrali | P40763 |
GuidetoPHARMACOLOGYi | 2994 |
Protein family/group databases
MoonDBi | P40763, Predicted |
PTM databases
GlyGeni | P40763, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P40763 |
MetOSitei | P40763 |
PhosphoSitePlusi | P40763 |
SwissPalmi | P40763 |
Genetic variation databases
BioMutai | STAT3 |
DMDMi | 48429227 |
Proteomic databases
CPTACi | CPTAC-1275 CPTAC-1276 CPTAC-1751 |
EPDi | P40763 |
jPOSTi | P40763 |
MassIVEi | P40763 |
MaxQBi | P40763 |
PaxDbi | P40763 |
PeptideAtlasi | P40763 |
PRIDEi | P40763 |
ProteomicsDBi | 55378 [P40763-1] 55379 [P40763-2] |
Protocols and materials databases
ABCDi | P40763, 1 sequenced antibody |
Antibodypediai | 660, 2425 antibodies |
CPTCi | P40763, 1 antibody |
DNASUi | 6774 |
Genome annotation databases
Organism-specific databases
CTDi | 6774 |
DisGeNETi | 6774 |
GeneCardsi | STAT3 |
GeneReviewsi | STAT3 |
HGNCi | HGNC:11364, STAT3 |
HPAi | ENSG00000168610, Low tissue specificity |
MalaCardsi | STAT3 |
MIMi | 102582, gene 147060, phenotype 615952, phenotype |
neXtProti | NX_P40763 |
OpenTargetsi | ENSG00000168610 |
Orphaneti | 520, Acute promyelocytic leukemia 2314, Autosomal dominant hyper-IgE syndrome 512017, Chronic lymphoproliferative disorder of natural killer cells 99885, Permanent neonatal diabetes mellitus 438159, STAT3-related early-onset multisystem autoimmune disease 86872, T-cell large granular lymphocyte leukemia |
PharmGKBi | PA337 |
VEuPathDBi | HostDB:ENSG00000168610.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | P40763 |
OMAi | GKYCRSE |
OrthoDBi | 327469at2759 |
PhylomeDBi | P40763 |
TreeFami | TF318648 |
Enzyme and pathway databases
PathwayCommonsi | P40763 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-1266695, Interleukin-7 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763, Downstream signal transduction R-HSA-198745, Signalling to STAT3 R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2586552, Signaling by Leptin R-HSA-2892247, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-452723, Transcriptional regulation of pluripotent stem cells R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8849474, PTK6 Activates STAT3 R-HSA-8854691, Interleukin-20 family signaling R-HSA-8875791, MET activates STAT3 R-HSA-8983432, Interleukin-15 signaling R-HSA-8984722, Interleukin-35 Signalling R-HSA-8985947, Interleukin-9 signaling R-HSA-9008059, Interleukin-37 signaling R-HSA-9020933, Interleukin-23 signaling R-HSA-9020956, Interleukin-27 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-982772, Growth hormone receptor signaling |
SignaLinki | P40763 |
SIGNORi | P40763 |
Miscellaneous databases
BioGRID-ORCSi | 6774, 31 hits in 1034 CRISPR screens |
ChiTaRSi | STAT3, human |
GeneWikii | STAT3 |
GenomeRNAii | 6774 |
Pharosi | P40763, Tchem |
PROi | PR:P40763 |
RNActi | P40763, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168610, Expressed in upper lobe of lung and 250 other tissues |
ExpressionAtlasi | P40763, baseline and differential |
Genevisiblei | P40763, HS |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAT3_HUMAN | |
Accessioni | P40763Primary (citable) accession number: P40763 Secondary accession number(s): A8K7B8 Q9BW54 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | June 7, 2004 | |
Last modified: | April 7, 2021 | |
This is version 229 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families