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Protein

Synaptotagmin-4

Gene

Syt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Plays a role in dendrite formation by melanocytes.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184Calcium 1By similarity1
Metal bindingi184Calcium 2By similarity1
Metal bindingi191Calcium 1By similarity1
Metal bindingi245Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi246Calcium 1By similarity1
Metal bindingi246Calcium 2By similarity1
Metal bindingi246Calcium 3By similarity1
Metal bindingi249Calcium 3By similarity1
Metal bindingi252Calcium 2By similarity1
Metal bindingi252Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-4
Alternative name(s):
Synaptotagmin IV
Short name:
SytIV
Gene namesi
Name:Syt4
Synonyms:Syt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:101759 Syt4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16VesicularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 425CytoplasmicSequence analysisAdd BLAST388

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839491 – 425Synaptotagmin-4Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40749
PaxDbiP40749
PRIDEiP40749

PTM databases

iPTMnetiP40749
PhosphoSitePlusiP40749

Expressioni

Tissue specificityi

Expressed in many regions of the nervous system but is undetectable in extra neural tissues (PubMed:8058779).1 Publication

Gene expression databases

BgeeiENSMUSG00000024261 Expressed in 170 organ(s), highest expression level in pituitary gland
CleanExiMM_SYT3
MM_SYT4
GenevisibleiP40749 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203614, 2 interactors
STRINGi10090.ENSMUSP00000025110

Structurei

3D structure databases

ProteinModelPortaliP40749
SMRiP40749
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 258C2 1PROSITE-ProRule annotationAdd BLAST104
Domaini289 – 392C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 297Phospholipid bindingCuratedAdd BLAST151

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOVERGENiHBG005010
InParanoidiP40749
KOiK19904
OMAiQIAKWHM
OrthoDBiEOG091G09ZN
PhylomeDBiP40749
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028683 SYT4
PANTHERiPTHR10024:SF114 PTHR10024:SF114, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

P40749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPITTSRVE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR RSAKSNKTPP
60 70 80 90 100
YKFVHVLKGV DIYPENLSSK KKFGGDDKSE VKGKAALPNL SLHLDLEKRD
110 120 130 140 150
LNGNFPKANP KAGSSSDLEN VTPKLFTETE KEANSPESLK SSTSLTSEEK
160 170 180 190 200
QEKLGTLFLS LEYNFEKKAF VVNIKEAQGL PAMDEQSMTS DPYIKMTILP
210 220 230 240 250
EKKHRVKTRV LRKTLDPVFD ETFTFYGIPY PHIQELSLHF TVLSFDRFSR
260 270 280 290 300
DDVIGEVLIP LSGIELSDGK MLMTREIIKR NAKKSSGRGE LLVSLCYQST
310 320 330 340 350
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP
360 370 380 390 400
NAVFNELFVF DIPCESLEEI SVEFLVLDSE RGSRNEVIGR LVLGATAEGS
410 420
GGGHWKEICD FPRRQIAKWH MLCDG
Length:425
Mass (Da):47,659
Last modified:July 11, 2003 - v2
Checksum:i9A01144898CDFCEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70K → Q in AAA20971 (PubMed:8058779).Curated1
Sequence conflicti85A → T in AAA20971 (PubMed:8058779).Curated1
Sequence conflicti220D → G in AAA20971 (PubMed:8058779).Curated1
Sequence conflicti246D → N in BAC31726 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10355 mRNA Translation: AAA20971.1
AK032106 mRNA Translation: BAC27705.1
AK043985 mRNA Translation: BAC31726.1
AK050515 mRNA Translation: BAC34301.1
AK083960 mRNA Translation: BAC39080.1
AK148681 mRNA Translation: BAE28640.1
BC058208 mRNA Translation: AAH58208.1
CCDSiCCDS29109.1
RefSeqiNP_033334.2, NM_009308.3
UniGeneiMm.233846

Genome annotation databases

EnsembliENSMUST00000025110; ENSMUSP00000025110; ENSMUSG00000024261
GeneIDi20983
KEGGimmu:20983
UCSCiuc008ehy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10355 mRNA Translation: AAA20971.1
AK032106 mRNA Translation: BAC27705.1
AK043985 mRNA Translation: BAC31726.1
AK050515 mRNA Translation: BAC34301.1
AK083960 mRNA Translation: BAC39080.1
AK148681 mRNA Translation: BAE28640.1
BC058208 mRNA Translation: AAH58208.1
CCDSiCCDS29109.1
RefSeqiNP_033334.2, NM_009308.3
UniGeneiMm.233846

3D structure databases

ProteinModelPortaliP40749
SMRiP40749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203614, 2 interactors
STRINGi10090.ENSMUSP00000025110

PTM databases

iPTMnetiP40749
PhosphoSitePlusiP40749

Proteomic databases

MaxQBiP40749
PaxDbiP40749
PRIDEiP40749

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025110; ENSMUSP00000025110; ENSMUSG00000024261
GeneIDi20983
KEGGimmu:20983
UCSCiuc008ehy.1 mouse

Organism-specific databases

CTDi6860
MGIiMGI:101759 Syt4

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOVERGENiHBG005010
InParanoidiP40749
KOiK19904
OMAiQIAKWHM
OrthoDBiEOG091G09ZN
PhylomeDBiP40749
TreeFamiTF315600

Miscellaneous databases

PROiPR:P40749
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024261 Expressed in 170 organ(s), highest expression level in pituitary gland
CleanExiMM_SYT3
MM_SYT4
GenevisibleiP40749 MM

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028683 SYT4
PANTHERiPTHR10024:SF114 PTHR10024:SF114, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSYT4_MOUSE
AccessioniPrimary (citable) accession number: P40749
Secondary accession number(s): Q3UFC1, Q8BGH3, Q8BRL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 11, 2003
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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