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UniProtKB - P40735 (ECFA1_BACSU)
Protein
Energy-coupling factor transporter ATP-binding protein EcfA1
Gene
ecfA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
UniRule annotationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 168 | Proton acceptorSequence analysis | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 42 – 49 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU01450-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Energy-coupling factor transporter ATP-binding protein EcfA1UniRule annotation (EC:7.-.-.-UniRule annotation)Short name: ECF transporter A component EcfAUniRule annotation |
Gene namesi | Name:ecfAUniRule annotation Synonyms:cbiO1, ybaD, ybxA Ordered Locus Names:BSU01450 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091986 | 1 – 281 | Energy-coupling factor transporter ATP-binding protein EcfA1Add BLAST | 281 |
Proteomic databases
PaxDbi | P40735 |
Interactioni
Subunit structurei
Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
UniRule annotationProtein-protein interaction databases
STRINGi | 224308.BSU01450 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 242 | ABC transporterUniRule annotationAdd BLAST | 236 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1122, Bacteria |
InParanoidi | P40735 |
OMAi | RMKDFDA |
PhylomeDBi | P40735 |
Family and domain databases
CDDi | cd03225, ABC_cobalt_CbiO_domain1, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR015856, ABC_transpr_CbiO/EcfA_su IPR030947, EcfA_1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR04520, ECF_ATPase_1, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51246, CBIO, 1 hit |
i Sequence
Sequence statusi: Complete.
P40735-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQNQLISVE DIVFRYRKDA ERRALDGVSL QVYEGEWLAI VGHNGSGKST
60 70 80 90 100
LARALNGLIL PESGDIEVAG IQLTEESVWE VRKKIGMVFQ NPDNQFVGTT
110 120 130 140 150
VRDDVAFGLE NNGVPREEMI ERVDWAVKQV NMQDFLDQEP HHLSGGQKQR
160 170 180 190 200
VAIAGVIAAR PDIIILDEAT SMLDPIGREE VLETVRHLKE QGMATVISIT
210 220 230 240 250
HDLNEAAKAD RIIVMNGGKK YAEGPPEEIF KLNKELVRIG LDLPFSFQLS
260 270 280
QLLRENGLAL EENHLTQEGL VKELWTLQSK M
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 97 | V → F in BAA10983 (PubMed:8969501).Curated | 1 | |
Sequence conflicti | 235 | E → G in BAA10983 (PubMed:8969501).Curated | 1 | |
Sequence conflicti | 279 | S → L in BAA10983 (PubMed:8969501).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D64126 Genomic DNA Translation: BAA10983.1 AL009126 Genomic DNA Translation: CAB11921.2 M26414 Genomic DNA Translation: AAA22219.1 |
PIRi | E69751 |
RefSeqi | NP_388026.2, NC_000964.3 WP_004399689.1, NZ_JNCM01000029.1 |
Genome annotation databases
EnsemblBacteriai | CAB11921; CAB11921; BSU_01450 |
GeneIDi | 938925 |
KEGGi | bsu:BSU01450 |
PATRICi | fig|224308.179.peg.149 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D64126 Genomic DNA Translation: BAA10983.1 AL009126 Genomic DNA Translation: CAB11921.2 M26414 Genomic DNA Translation: AAA22219.1 |
PIRi | E69751 |
RefSeqi | NP_388026.2, NC_000964.3 WP_004399689.1, NZ_JNCM01000029.1 |
3D structure databases
AlphaFoldDBi | P40735 |
SMRi | P40735 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU01450 |
Proteomic databases
PaxDbi | P40735 |
Genome annotation databases
EnsemblBacteriai | CAB11921; CAB11921; BSU_01450 |
GeneIDi | 938925 |
KEGGi | bsu:BSU01450 |
PATRICi | fig|224308.179.peg.149 |
Phylogenomic databases
eggNOGi | COG1122, Bacteria |
InParanoidi | P40735 |
OMAi | RMKDFDA |
PhylomeDBi | P40735 |
Enzyme and pathway databases
BioCyci | BSUB:BSU01450-MONOMER |
Family and domain databases
CDDi | cd03225, ABC_cobalt_CbiO_domain1, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR015856, ABC_transpr_CbiO/EcfA_su IPR030947, EcfA_1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR04520, ECF_ATPase_1, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51246, CBIO, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ECFA1_BACSU | |
Accessioni | P40735Primary (citable) accession number: P40735 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | June 16, 2009 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families