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Protein

Sensor protein QseC

Gene

qseC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

  • phosphorelay signal transduction system Source: GO_Central

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12658-MONOMER
BRENDAi2.7.13.3 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein QseC (EC:2.7.13.3)
Gene namesi
Name:qseC
Synonyms:ygiY
Ordered Locus Names:b3026, JW2994
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13027 qseC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 156PeriplasmicSequence analysisAdd BLAST123
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 449CytoplasmicSequence analysisAdd BLAST272

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747031 – 449Sensor protein QseCAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40719
PRIDEiP40719

PTM databases

iPTMnetiP40719

Expressioni

Inductioni

By the signal autoinducer AI-2, through MqsR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259459, 16 interactors
IntActiP40719, 6 interactors
STRINGi316385.ECDH10B_3200

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00774
ProteinModelPortaliP40719
SMRiP40719
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40719

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 449Histidine kinasePROSITE-ProRule annotationAdd BLAST207

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHQ Bacteria
ENOG410XS4R LUCA
HOGENOMiHOG000223178
InParanoidiP40719
KOiK07645
PhylomeDBiP40719

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR013727 2CSK_N
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF08521 2CSK_N, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

P40719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFTQRLSLR VRLTLIFLIL ASVTWLLSSF VAWKQTTDNV DELFDTQLML
60 70 80 90 100
FAKRLSTLDL NEINAADRMA QTPNRLKHGH VDDDALTFAI FTHDGRMVLN
110 120 130 140 150
DGDNGEDIPY SYQREGFADG QLVGEDDPWR FVWMTSPDGK YRIVVGQEWE
160 170 180 190 200
YREDMALAIV AGQLIPWLVA LPIMLIIMMV LLGRELAPLN KLALALRMRD
210 220 230 240 250
PDSEKPLNAT GVPSEVRPLV ESLNQLFART HAMMVRERRF TSDAAHELRS
260 270 280 290 300
PLTALKVQTE VAQLSDDDPQ ARKKALLQLH SGIDRATRLV DQLLTLSRLD
310 320 330 340 350
SLDNLQDVAE IPLEDLLQSS VMDIYHTAQQ AKIDVRLTLN AHSIKRTGQP
360 370 380 390 400
LLLSLLVRNL LDNAVRYSPQ GSVVDVTLNA DNFIVRDNGP GVTPEALARI
410 420 430 440
GERFYRPPGQ TATGSGLGLS IVQRIAKLHG MNVEFGNAEQ GGFEAKVSW
Length:449
Mass (Da):50,282
Last modified:October 1, 1996 - v2
Checksum:i9F00CB507FDFA715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69194.1
U00096 Genomic DNA Translation: AAC76062.1
AP009048 Genomic DNA Translation: BAE77082.1
U18656 Genomic DNA No translation available.
PIRiH65089
RefSeqiNP_417498.1, NC_000913.3
WP_000673402.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76062; AAC76062; b3026
BAE77082; BAE77082; BAE77082
GeneIDi947174
KEGGiecj:JW2994
eco:b3026
PATRICifig|1411691.4.peg.3704

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69194.1
U00096 Genomic DNA Translation: AAC76062.1
AP009048 Genomic DNA Translation: BAE77082.1
U18656 Genomic DNA No translation available.
PIRiH65089
RefSeqiNP_417498.1, NC_000913.3
WP_000673402.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSENMR-A2-185[»]
3JZ3X-ray2.50A/B236-449[»]
DisProtiDP00774
ProteinModelPortaliP40719
SMRiP40719
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259459, 16 interactors
IntActiP40719, 6 interactors
STRINGi316385.ECDH10B_3200

PTM databases

iPTMnetiP40719

Proteomic databases

PaxDbiP40719
PRIDEiP40719

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76062; AAC76062; b3026
BAE77082; BAE77082; BAE77082
GeneIDi947174
KEGGiecj:JW2994
eco:b3026
PATRICifig|1411691.4.peg.3704

Organism-specific databases

EchoBASEiEB2845
EcoGeneiEG13027 qseC

Phylogenomic databases

eggNOGiENOG4105DHQ Bacteria
ENOG410XS4R LUCA
HOGENOMiHOG000223178
InParanoidiP40719
KOiK07645
PhylomeDBiP40719

Enzyme and pathway databases

BioCyciEcoCyc:EG12658-MONOMER
BRENDAi2.7.13.3 2026

Miscellaneous databases

EvolutionaryTraceiP40719
PROiPR:P40719

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR013727 2CSK_N
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF08521 2CSK_N, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQSEC_ECOLI
AccessioniPrimary (citable) accession number: P40719
Secondary accession number(s): Q2M9H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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