UniProtKB - P40645 (SOX6_MOUSE)

BLAST

>sp|P40645|SOX6_MOUSE Transcription factor SOX-6 OS=Mus musculus OX=10090 GN=Sox6 PE=1 SV=2
MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLV
STIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTP
ERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGT
PESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQ
QQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPG
DNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHS
YNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDET
TAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDI
LSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEK
ERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGAT
VAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKS
MSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEM
RQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYG
MKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN

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History
Entry version 155 (07 Nov 2018)
Sequence version 2 (01 Feb 1996)
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Protein

Transcription factor SOX-6

Gene

Sox6

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	620 – 688	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12446692
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 12446692
- 17084361
protein heterodimerization activity
Source: MGI
Inferred from physical interactionⁱ
- 9755172
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 16462943
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 16462943
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 16462943
transcription regulatory region DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17084361

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astrocyte differentiation Source: MGI
cardiac muscle cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 14530442
cartilage development
Source: MGI
Inferred from genetic interactionⁱ
- 15634692
cell fate commitment
Source: MGI
Inferred from genetic interactionⁱ
- 15634692
cell morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 16462943
cellular response to transforming growth factor beta stimulus Source: MGI
erythrocyte development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16462943
erythrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 20711497
gene silencing
Source: MGI
Inferred from mutant phenotypeⁱ
- 16462943
hemopoiesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 16462943
in utero embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17084361
muscle cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 14530442
negative regulation of cardiac muscle cell differentiation Source: MGI
negative regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 17084361
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 16462943
oligodendrocyte cell fate specification
Source: MGI
Inferred from mutant phenotypeⁱ
- 17084361
oligodendrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17084361
positive regulation of cartilage development Source: MGI
positive regulation of chondrocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 20940257
positive regulation of mesenchymal stem cell differentiation Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 17084361
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 9755172
post-embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16462943
regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 20711497
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 12446692

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Reactomeⁱ

R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-6 Alternative name(s): SOX-LZ
Gene namesⁱ	Name:Sox6 Synonyms:Sox-6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:98368 Sox6

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048730	1 – 827	Transcription factor SOX-6Add BLAST		827

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	119	PhosphothreonineCombined sources	1
Modified residueⁱ	399	PhosphoserineCombined sources	1
Modified residueⁱ	401	PhosphothreonineCombined sources	1
Cross-linkⁱ	404	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	417	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	439	PhosphoserineCombined sources	1
Modified residueⁱ	442	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Sumoylation inhibits the transcriptional activity.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P40645
PRIDEⁱ	P40645

PTM databases

iPTMnetⁱ	P40645
PhosphoSitePlusⁱ	P40645

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis.

Gene expression databases

Bgeeⁱ	ENSMUSG00000051910 Expressed in 268 organ(s), highest expression level in gastrocnemius medialis
CleanExⁱ	MM_SOX6
ExpressionAtlasⁱ	P40645 baseline and differential
Genevisibleⁱ	P40645 MM

Interactionⁱ

Subunit structureⁱ

Interacts with DAZAP2. May interact with CENPK.1 Publication

GO - Molecular functionⁱ

protein heterodimerization activity
Source: MGI
Inferred from physical interactionⁱ
- 9755172

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203410, 5 interactors
IntActⁱ	P40645, 1 interactor
STRINGⁱ	10090.ENSMUSP00000072583

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P40645
SMRⁱ	P40645
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	184 – 262	Sequence analysisAdd BLAST		79

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	233 – 261	Gln-richAdd BLAST	29
Compositional biasⁱ	240 – 243	Poly-Gln	4
Compositional biasⁱ	280 – 285	Poly-Ala	6
Compositional biasⁱ	313 – 317	Poly-Ala	5
Compositional biasⁱ	514 – 517	Poly-Gln	4

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0528 Eukaryota ENOG410YZNG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119274
HOGENOMⁱ	HOG000056455
HOVERGENⁱ	HBG003915
InParanoidⁱ	P40645
KEGG Orthology (KO) More...KOⁱ	K09269
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03D9
PhylomeDBⁱ	P40645
TreeFamⁱ	TF320471

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR027153 SOX-6
PANTHERⁱ	PTHR10270:SF89 PTHR10270:SF89, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P40645-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKQATSPF ACTADGEEAM TQDLTSREKE EGSDQHPASH LPLHPIMHNK 
        60         70         80         90        100
PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH 
       110        120        130        140        150
KPDEGSRERE IMNSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS 
       160        170        180        190        200
SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS 
       210        220        230        240        250
LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK 
       260        270        280        290        300
INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 
       310        320        330        340        350
DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINPRLK GISDRFGRNL 
       360        370        380        390        400
DPSEHGGGHS YNHRQIEQLY AAQLASMQVS PGAKMPSTPQ PPNSAGAVSP 
       410        420        430        440        450
TGIKNEKRGT SPVTQVKDET TAQPLNLSSR PKTAEPVKSP TSPTQNLFPA 
       460        470        480        490        500
SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI 
       510        520        530        540        550
QEARKMREQI QREQQQQPHG VDGKLSSMNN MGLSNCRTEK ERTRFENLGP 
       560        570        580        590        600
QLTGKSSEDG KLGPGVIDLT RPEDAEGSKA MNGSAAKLQQ YYCWPTGGAT 
       610        620        630        640        650
VAEARVYRDA RGRASSEPHI KRPMNAFMVW AKDERRKILQ AFPDMHNSNI 
       660        670        680        690        700
SKILGSRWKS MSNQEKQPYY EEQARLSKIH LEKYPNYKYK PRPKRTCIVD 
       710        720        730        740        750
GKKLRIGEYK QLMRSRRQEM RQFFTVGQQP QMPITTGTGV VYPGAITMAT 
       760        770        780        790        800
TTPSPQMTSD CSSTSASPEP SLPVIQSTYG MKMDGASLAG NDMINGEDEM 
       810        820 
EAYDDYEDDP KSDYSSENEA PEPVSAN

Length:827

Mass (Da):91,803

Last modified:February 1, 1996 - v2

Checksum:ⁱF777BAB7CFB1E93B

Isoform 2 (identifier: P40645-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
327-367: Missing.

« Hide

        10         20         30         40         50
MSSKQATSPF ACTADGEEAM TQDLTSREKE EGSDQHPASH LPLHPIMHNK 
        60         70         80         90        100
PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH 
       110        120        130        140        150
KPDEGSRERE IMNSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS 
       160        170        180        190        200
SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS 
       210        220        230        240        250
LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK 
       260        270        280        290        300
INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 
       310        320        330        340        350
DNYPVQFIPS TMAAAAASGL SPLQLQQLYA AQLASMQVSP GAKMPSTPQP 
       360        370        380        390        400
PNSAGAVSPT GIKNEKRGTS PVTQVKDETT AQPLNLSSRP KTAEPVKSPT 
       410        420        430        440        450
SPTQNLFPAS KTSPVNLPNK SSIPSPIGGS LGRGSSLDIL SSLNSPALFG 
       460        470        480        490        500
DQDTVMKAIQ EARKMREQIQ REQQQQPHGV DGKLSSMNNM GLSNCRTEKE 
       510        520        530        540        550
RTRFENLGPQ LTGKSSEDGK LGPGVIDLTR PEDAEGSKAM NGSAAKLQQY 
       560        570        580        590        600
YCWPTGGATV AEARVYRDAR GRASSEPHIK RPMNAFMVWA KDERRKILQA 
       610        620        630        640        650
FPDMHNSNIS KILGSRWKSM SNQEKQPYYE EQARLSKIHL EKYPNYKYKP 
       660        670        680        690        700
RPKRTCIVDG KKLRIGEYKQ LMRSRRQEMR QFFTVGQQPQ MPITTGTGVV 
       710        720        730        740        750
YPGAITMATT TPSPQMTSDC SSTSASPEPS LPVIQSTYGM KMDGASLAGN 
       760        770        780 
DMINGEDEME AYDDYEDDPK SDYSSENEAP EPVSAN

Show »

Length:786

Mass (Da):87,192

Checksum:ⁱEFC8E350AEC84653

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8BSS6	Q8BSS6_MOUSE	Transcription factor SOX-6 Transcription factor SOX-6	Sox6	785	Annotation score:
A0A0U1RPC1	A0A0U1RPC1_MOUSE	Transcription factor SOX-6 Transcription factor SOX-6	Sox6	786	Annotation score:
E9PUW0	E9PUW0_MOUSE	Transcription factor SOX-6 Transcription factor SOX-6	Sox6	787	Annotation score:
A0A0U1RNW8	A0A0U1RNW8_MOUSE	Transcription factor SOX-6 Transcription factor SOX-6	Sox6	828	Annotation score:
A0A0U1RNH0	A0A0U1RNH0_MOUSE	Transcription factor SOX-6 Transcription factor SOX-6	Sox6	111	Annotation score:
A0A0U1RNI3	A0A0U1RNI3_MOUSE	Transcription factor SOX-6 Transcription factor SOX-6	Sox6	125	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	312 – 313	MA → SS in BAA09618 (PubMed:7791783).Curated		2
Sequence conflictⁱ	632	K → R in CAA46610 (PubMed:1614875).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002198	327 – 367	Missing in isoform 2. 1 PublicationAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32614 mRNA Translation: AAC52263.1 D61689 mRNA Translation: BAA09618.1 AJ010605 mRNA Translation: CAA09270.1 X65659 mRNA Translation: CAA46610.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40098.1 [P40645-1]
PIRⁱ	S22944 S59121
NCBI Reference Sequences More...RefSeqⁱ	NP_001264255.1, NM_001277326.1 [P40645-1] NP_001264257.1, NM_001277328.1 [P40645-2] NP_035575.1, NM_011445.4 [P40645-1] XP_011240009.1, XM_011241707.2 [P40645-1] XP_011240013.1, XM_011241711.2 [P40645-2]
UniGeneⁱ	Mm.323365 Mm.487065

Genome annotation databases

Ensemblⁱ	ENSMUST00000072804; ENSMUSP00000072583; ENSMUSG00000051910 [P40645-1] ENSMUST00000166207; ENSMUSP00000129027; ENSMUSG00000051910 [P40645-1]
GeneIDⁱ	20679
KEGGⁱ	mmu:20679
UCSC genome browser More...UCSCⁱ	uc009jin.2 mouse [P40645-2] uc009jip.2 mouse [P40645-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P40645	MCG141507, isoform CRA_a		MOUSE		827	UniRef100_P40645
UPI000A318AF4		MUSCR		634

Protein	Similar proteins		Species	Score	Length	Source
P40645	Transcription factor SOX-6		HUMAN		828	UniRef90_P40645
MCG141507, isoform CRA_a		MOUSE		827
transcription factor SOX-6 isoform X1		Florida manatee		860
SRY-box 6		CAVPO		859
transcription factor SOX-6 isoform X1		URSMA		856
+388
P40645-2	Transcription factor SOX-6		PONAB		787	UniRef90_P40645-2
SRY-box 6		MUSPF		814
transcription factor SOX-6 isoform X3		MESAU		814
transcription factor SOX-6 isoform X1		Yangtze finless porpoise		808
transcription factor SOX-6 isoform X2		DELLE		801
+287

Protein	Similar proteins		Species	Score	Length	Source
P40645	Transcription factor SOX-6		HUMAN		828	UniRef50_P40645
Transcription factor Sox-6		XENTR		777
Transcription factor SOX-6		PONAB		787
MCG141507, isoform CRA_a		MOUSE		827
transcription factor SOX-6 isoform X1		Florida manatee		860
+1204

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32614 mRNA Translation: AAC52263.1 D61689 mRNA Translation: BAA09618.1 AJ010605 mRNA Translation: CAA09270.1 X65659 mRNA Translation: CAA46610.1
CCDSⁱ	CCDS40098.1 [P40645-1]
PIRⁱ	S22944 S59121
RefSeqⁱ	NP_001264255.1, NM_001277326.1 [P40645-1] NP_001264257.1, NM_001277328.1 [P40645-2] NP_035575.1, NM_011445.4 [P40645-1] XP_011240009.1, XM_011241707.2 [P40645-1] XP_011240013.1, XM_011241711.2 [P40645-2]
UniGeneⁱ	Mm.323365 Mm.487065

3D structure databases

ProteinModelPortalⁱ	P40645
SMRⁱ	P40645
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203410, 5 interactors
IntActⁱ	P40645, 1 interactor
STRINGⁱ	10090.ENSMUSP00000072583

PTM databases

iPTMnetⁱ	P40645
PhosphoSitePlusⁱ	P40645

Proteomic databases

PaxDbⁱ	P40645
PRIDEⁱ	P40645

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000072804; ENSMUSP00000072583; ENSMUSG00000051910 [P40645-1] ENSMUST00000166207; ENSMUSP00000129027; ENSMUSG00000051910 [P40645-1]
GeneIDⁱ	20679
KEGGⁱ	mmu:20679
UCSCⁱ	uc009jin.2 mouse [P40645-2] uc009jip.2 mouse [P40645-1]

Organism-specific databases

CTDⁱ	55553
MGIⁱ	MGI:98368 Sox6

Phylogenomic databases

eggNOGⁱ	KOG0528 Eukaryota ENOG410YZNG LUCA
GeneTreeⁱ	ENSGT00760000119274
HOGENOMⁱ	HOG000056455
HOVERGENⁱ	HBG003915
InParanoidⁱ	P40645
KOⁱ	K09269
OrthoDBⁱ	EOG091G03D9
PhylomeDBⁱ	P40645
TreeFamⁱ	TF320471

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Reactomeⁱ

R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSⁱ	Sox6 mouse
Protein Ontology More...PROⁱ	PR:P40645
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000051910 Expressed in 268 organ(s), highest expression level in gastrocnemius medialis
CleanExⁱ	MM_SOX6
ExpressionAtlasⁱ	P40645 baseline and differential
Genevisibleⁱ	P40645 MM

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR027153 SOX-6
PANTHERⁱ	PTHR10270:SF89 PTHR10270:SF89, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX6_MOUSE
Accessionⁱ	P40645Primary (citable) accession number: P40645 Secondary accession number(s): Q62250, Q9QWS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P40645 (SOX6_MOUSE)

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Transcription factor SOX-6

Sox6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ