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Protein

ADP-ribosylation factor-like protein 4A

Gene

ARL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • vesicle-mediated transport Source: GO_Central

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4A
Gene namesi
Name:ARL4A
Synonyms:ARL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122644.12
HGNCiHGNC:695 ARL4A
MIMi604786 gene
neXtProtiNX_P40617

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34T → N: Inhibits relocalization of CYTH2 to the plasma membrane. Strongly localized in the nucleolus. 2 Publications1
Mutagenesisi79Q → L: Localized in the nucleus and nucleolus. 2 Publications1

Organism-specific databases

DisGeNETi10124
OpenTargetsiENSG00000122644
PharmGKBiPA24988

Polymorphism and mutation databases

BioMutaiARL4A
DMDMi1168495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074592 – 200ADP-ribosylation factor-like protein 4AAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Myristoylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP40617
PaxDbiP40617
PeptideAtlasiP40617
PRIDEiP40617
ProteomicsDBi55376

PTM databases

iPTMnetiP40617
PhosphoSitePlusiP40617

Expressioni

Gene expression databases

BgeeiENSG00000122644 Expressed in 94 organ(s), highest expression level in right testis
CleanExiHS_ARL4A
ExpressionAtlasiP40617 baseline and differential
GenevisibleiP40617 HS

Organism-specific databases

HPAiHPA064513

Interactioni

Subunit structurei

Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115428, 12 interactors
IntActiP40617, 9 interactors
STRINGi9606.ENSP00000349250

Structurei

3D structure databases

ProteinModelPortaliP40617
SMRiP40617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP40617
KOiK07945
OMAiCFHIVIL
OrthoDBiEOG091G0LK5
PhylomeDBiP40617
TreeFamiTF105464

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P40617-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP
60 70 80 90 100
TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV
110 120 130 140 150
DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL
160 170 180 190 200
LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR
Length:200
Mass (Da):22,615
Last modified:November 1, 1995 - v2
Checksum:i8D93A8C003BD16CF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7Q9C9J7Q9_HUMAN
ADP-ribosylation factor-like protei...
ARL4A
50Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73960 mRNA Translation: AAB39713.1
AK313233 mRNA Translation: BAG36044.1
AF493890 mRNA Translation: AAM12604.1
CH236948 Genomic DNA Translation: EAL24295.1
CH471073 Genomic DNA Translation: EAW93650.1
BC001111 mRNA Translation: AAH01111.1
BC003027 mRNA Translation: AAH03027.1
CCDSiCCDS5359.1
RefSeqiNP_001032241.1, NM_001037164.2
NP_001182325.1, NM_001195396.1
NP_005729.1, NM_005738.4
NP_997625.1, NM_212460.3
UniGeneiHs.245540

Genome annotation databases

EnsembliENST00000356797; ENSP00000349250; ENSG00000122644
ENST00000396662; ENSP00000379897; ENSG00000122644
ENST00000396663; ENSP00000379898; ENSG00000122644
ENST00000396664; ENSP00000379899; ENSG00000122644
ENST00000404894; ENSP00000385236; ENSG00000122644
GeneIDi10124
KEGGihsa:10124
UCSCiuc003ssp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73960 mRNA Translation: AAB39713.1
AK313233 mRNA Translation: BAG36044.1
AF493890 mRNA Translation: AAM12604.1
CH236948 Genomic DNA Translation: EAL24295.1
CH471073 Genomic DNA Translation: EAW93650.1
BC001111 mRNA Translation: AAH01111.1
BC003027 mRNA Translation: AAH03027.1
CCDSiCCDS5359.1
RefSeqiNP_001032241.1, NM_001037164.2
NP_001182325.1, NM_001195396.1
NP_005729.1, NM_005738.4
NP_997625.1, NM_212460.3
UniGeneiHs.245540

3D structure databases

ProteinModelPortaliP40617
SMRiP40617
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115428, 12 interactors
IntActiP40617, 9 interactors
STRINGi9606.ENSP00000349250

PTM databases

iPTMnetiP40617
PhosphoSitePlusiP40617

Polymorphism and mutation databases

BioMutaiARL4A
DMDMi1168495

Proteomic databases

EPDiP40617
PaxDbiP40617
PeptideAtlasiP40617
PRIDEiP40617
ProteomicsDBi55376

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356797; ENSP00000349250; ENSG00000122644
ENST00000396662; ENSP00000379897; ENSG00000122644
ENST00000396663; ENSP00000379898; ENSG00000122644
ENST00000396664; ENSP00000379899; ENSG00000122644
ENST00000404894; ENSP00000385236; ENSG00000122644
GeneIDi10124
KEGGihsa:10124
UCSCiuc003ssp.4 human

Organism-specific databases

CTDi10124
DisGeNETi10124
EuPathDBiHostDB:ENSG00000122644.12
GeneCardsiARL4A
HGNCiHGNC:695 ARL4A
HPAiHPA064513
MIMi604786 gene
neXtProtiNX_P40617
OpenTargetsiENSG00000122644
PharmGKBiPA24988
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP40617
KOiK07945
OMAiCFHIVIL
OrthoDBiEOG091G0LK5
PhylomeDBiP40617
TreeFamiTF105464

Miscellaneous databases

GeneWikiiARL4A
GenomeRNAii10124
PROiPR:P40617
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122644 Expressed in 94 organ(s), highest expression level in right testis
CleanExiHS_ARL4A
ExpressionAtlasiP40617 baseline and differential
GenevisibleiP40617 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL4A_HUMAN
AccessioniPrimary (citable) accession number: P40617
Secondary accession number(s): A4D119, P80418, Q49AF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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