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Protein

Aspartic proteinase yapsin-6

Gene

YPS6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves proteins C-terminally to mono- and paired-basic residues (By similarity). Required for cell wall integrity.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85PROSITE-ProRule annotation1
Active sitei324PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: SGD

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciYEAST:G3O-31451-MONOMER

Protein family/group databases

MEROPSiA01.A62

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-6 (EC:3.4.23.-)
Gene namesi
Name:YPS6
Ordered Locus Names:YIR039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR039C
SGDiS000001478 YPS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000002584425 – 52Sequence analysisAdd BLAST28
ChainiPRO_000002584553 – 515Aspartic proteinase yapsin-6Add BLAST463
PropeptideiPRO_0000025846516 – 537Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi515GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, GPI-anchor, Lipoprotein, Zymogen

Proteomic databases

MaxQBiP40583
PaxDbiP40583
PRIDEiP40583

Interactioni

Protein-protein interaction databases

BioGridi35030, 68 interactors
DIPiDIP-2688N
IntActiP40583, 3 interactors
MINTiP40583
STRINGi4932.YIR039C

Structurei

3D structure databases

ProteinModelPortaliP40583
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 426Peptidase A1PROSITE-ProRule annotationAdd BLAST360

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00550000075429
HOGENOMiHOG000248646
InParanoidiP40583
OMAiADIINIC
OrthoDBiEOG092C3KPP

Family and domain databases

CDDicd05474 SAP_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR033876 SAP-like
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 2 hits
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLISILSLL SSLMCSLTVL GSSASSYVKF PVQKLADIIN ICTQDVSTVF
60 70 80 90 100
KRNEVLNTTV INGIGVYVVK MEIGTPPQTL YLQLDTGSSD MIVNNADIAY
110 120 130 140 150
CKSMSDGSDY ASTDNYELTA TFNGLPSTTI SSEAYNTLCS YWGTFDASNS
160 170 180 190 200
STFENNATFF NNTYGDGTYY AGTYGTDVVS FENITLNDFT FGVSNDTIGN
210 220 230 240 250
PSGILGISLP IAEFTDGIEY ALALNRTPFI YDNFPMELKN QGKINKIAYS
260 270 280 290 300
LFLNGPDAHF GSILFGAVDK SKYTGQLYTL PMLQAFNTLG SNPGMIITAQ
310 320 330 340 350
SVAILDSESG NKTVSDIQFP VMLDSGTTFS YLPTEIAEAI GKSFDGEYSS
360 370 380 390 400
DDQGYIFDCS KVNDTLLSVD FGGFNISANI SNFVTSAKDR CVLNVKQSES
410 420 430 440 450
TYMLGDAFLV DAYVVYDLEN YEISIAQASF NNQEEDIEVI SDTVPGATPA
460 470 480 490 500
PGYFSTWVYK PGSPIGTGDF INVSWTSYSE FSQYKSLLAT AAQSDDASSF
510 520 530
SSSGGSSEST TKKQNAGYKY RSSFSFSLLS FISYFLL
Length:537
Mass (Da):58,214
Last modified:February 1, 1995 - v1
Checksum:i80C14D25D49D32CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA Translation: CAA86199.1
Z46902 Genomic DNA Translation: CAA86998.1
BK006942 Genomic DNA Translation: DAA08586.1
PIRiS50344
RefSeqiNP_012305.3, NM_001179561.3

Genome annotation databases

EnsemblFungiiYIR039C; YIR039C; YIR039C
GeneIDi854857
KEGGisce:YIR039C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA Translation: CAA86199.1
Z46902 Genomic DNA Translation: CAA86998.1
BK006942 Genomic DNA Translation: DAA08586.1
PIRiS50344
RefSeqiNP_012305.3, NM_001179561.3

3D structure databases

ProteinModelPortaliP40583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35030, 68 interactors
DIPiDIP-2688N
IntActiP40583, 3 interactors
MINTiP40583
STRINGi4932.YIR039C

Protein family/group databases

MEROPSiA01.A62

Proteomic databases

MaxQBiP40583
PaxDbiP40583
PRIDEiP40583

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR039C; YIR039C; YIR039C
GeneIDi854857
KEGGisce:YIR039C

Organism-specific databases

EuPathDBiFungiDB:YIR039C
SGDiS000001478 YPS6

Phylogenomic databases

GeneTreeiENSGT00550000075429
HOGENOMiHOG000248646
InParanoidiP40583
OMAiADIINIC
OrthoDBiEOG092C3KPP

Enzyme and pathway databases

BioCyciYEAST:G3O-31451-MONOMER

Miscellaneous databases

PROiPR:P40583

Family and domain databases

CDDicd05474 SAP_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR033876 SAP-like
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 2 hits
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYPS6_YEAST
AccessioniPrimary (citable) accession number: P40583
Secondary accession number(s): D6VVX0, E9PAD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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