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UniProtKB - P40574 (YAP5_YEAST)
Protein
AP-1-like transcription factor YAP5
Gene
YAP5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6).
3 PublicationsMiscellaneous
One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities.
Present with 238 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: SGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to iron Source: SGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: AP-1-like transcription factor YAP5 |
Gene namesi | Name:YAP5 Ordered Locus Names:YIR018W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001457, YAP5 |
VEuPathDBi | FungiDB:YIR018W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076525 | 1 – 245 | AP-1-like transcription factor YAP5Add BLAST | 245 |
Proteomic databases
PaxDbi | P40574 |
PRIDEi | P40574 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 35010, 44 interactors |
DIPi | DIP-2994N |
IntActi | P40574, 5 interactors |
MINTi | P40574 |
STRINGi | 4932.YIR018W |
Miscellaneous databases
RNActi | P40574, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 121 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 77 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 63 – 82 | Basic motifPROSITE-ProRule annotationAdd BLAST | 20 | |
Regioni | 86 – 114 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 77 | Basic and acidic residuesSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QUE5, Eukaryota |
HOGENOMi | CLU_963771_0_0_1 |
InParanoidi | P40574 |
OMAi | NFKPMDA |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
P40574-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE
60 70 80 90 100
DYETEENDEE LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY
110 120 130 140 150
ETKLNRLQNE LQAKESENHA LKQKLETLTL KQASVPAQDP ILQNLIENFK
160 170 180 190 200
PMKAIPIKYN TAIKRHQHST ELPSSVKCGF CNDNTTCVCK ELETDHRKSD
210 220 230 240
DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI RSIIH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | P → S in AAC49426 (PubMed:8665859).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17015 Genomic DNA Translation: AAC49426.1 Z37996 Genomic DNA Translation: CAA86089.1 AY558238 Genomic DNA Translation: AAS56564.1 BK006942 Genomic DNA Translation: DAA08564.1 |
PIRi | S48363 |
RefSeqi | NP_012283.1, NM_001179540.1 |
Genome annotation databases
EnsemblFungii | YIR018W_mRNA; YIR018W; YIR018W |
GeneIDi | 854835 |
KEGGi | sce:YIR018W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17015 Genomic DNA Translation: AAC49426.1 Z37996 Genomic DNA Translation: CAA86089.1 AY558238 Genomic DNA Translation: AAS56564.1 BK006942 Genomic DNA Translation: DAA08564.1 |
PIRi | S48363 |
RefSeqi | NP_012283.1, NM_001179540.1 |
3D structure databases
SMRi | P40574 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35010, 44 interactors |
DIPi | DIP-2994N |
IntActi | P40574, 5 interactors |
MINTi | P40574 |
STRINGi | 4932.YIR018W |
Proteomic databases
PaxDbi | P40574 |
PRIDEi | P40574 |
Genome annotation databases
EnsemblFungii | YIR018W_mRNA; YIR018W; YIR018W |
GeneIDi | 854835 |
KEGGi | sce:YIR018W |
Organism-specific databases
SGDi | S000001457, YAP5 |
VEuPathDBi | FungiDB:YIR018W |
Phylogenomic databases
eggNOGi | ENOG502QUE5, Eukaryota |
HOGENOMi | CLU_963771_0_0_1 |
InParanoidi | P40574 |
OMAi | NFKPMDA |
Miscellaneous databases
PROi | PR:P40574 |
RNActi | P40574, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YAP5_YEAST | |
Accessioni | P40574Primary (citable) accession number: P40574 Secondary accession number(s): D6VVU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - SIMILARITY comments
Index of protein domains and families