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Protein

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

Gene

INP51

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth.8 Publications

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

Enzyme regulationi

IRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: SGD

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • phosphatidylinositol dephosphorylation Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processEndocytosis, Lipid metabolism, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:YIL002C-MONOMER
ReactomeiR-SCE-1660499 Synthesis of PIPs at the plasma membrane
R-SCE-1660514 Synthesis of PIPs at the Golgi membrane
R-SCE-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-SCE-1855204 Synthesis of IP3 and IP4 in the cytosol
R-SCE-194840 Rho GTPase cycle
R-SCE-202424 Downstream TCR signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51 (EC:3.1.3.36)
Alternative name(s):
Synaptojanin-like protein 1
Gene namesi
Name:INP51
Synonyms:SJL1
Ordered Locus Names:YIL002C
ORF Names:YIA2C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL002C
SGDiS000001264 INP51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097411 – 946Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51Add BLAST946

Proteomic databases

MaxQBiP40559
PaxDbiP40559
PRIDEiP40559

PTM databases

iPTMnetiP40559

Interactioni

Subunit structurei

Interacts with IRS4 and TAX4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34990, 127 interactors
DIPiDIP-2677N
ELMiP40559
IntActiP40559, 18 interactors
MINTiP40559
STRINGi4932.YIL002C

Structurei

3D structure databases

ProteinModelPortaliP40559
SMRiP40559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 480SACPROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119075
HOGENOMiHOG000179717
InParanoidiP40559
KOiK20279
OMAiPLFGDWG
OrthoDBiEOG092C1610

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
IPR002013 SAC_dom
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PF02383 Syja_N, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50275 SAC, 1 hit

Sequencei

Sequence statusi: Complete.

P40559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFIGRRSR SIVISSNNYC LSFQRLRSIP GASSQQRQLS KTPSVTIKSY
60 70 80 90 100
PDTDLSSDSN YLEVKSCIFN GLLGLVCLNG DIYVAVISGV QNVGFPRWKL
110 120 130 140 150
IDHQVRPSES IYKVLDVDFY SLENDVFDYL LCERSEQNYD KLIHEHPCGP
160 170 180 190 200
LKKLFSDGTF YYSRDFDISN IVKNHGLSHN LEYTVDNQDL SFIWNANLAS
210 220 230 240 250
EVINWRSKIS NEEKQLFANA GFLTFVIRGY CKTALIEDGP NTASITIISR
260 270 280 290 300
ISTESKQDTL ELEGISEDGR VSLFVETEIV VTTEKFIFSY TQVNGSIPLF
310 320 330 340 350
WESVESQLLY GKKIKVTKDS IEAQGAFDRH FDNLTSKYGV VSIVNIIKPK
360 370 380 390 400
SESQEKLALT YKDCAESKGI KITNIEYSSS VLTKSPHKLL YLLKQDIYEF
410 420 430 440 450
GAFAYDISRG IYFAKQTGVL RISAFDSIEK PNTVERLVSK EVLELTTNEI
460 470 480 490 500
DVFELTSPFL DAHDKLWSEN YYWLDRTYTK HTKNSGKYTK VYSKLFGSRV
510 520 530 540 550
RLYDPLHIYI SQYLKQLRSK YTFEKDISIF AGTFNISGKI PKDDIKDWIF
560 570 580 590 600
PKSMSKEDEM ADLYVIGLEE VVELTPGHML ATDPYVRQFW EKKILTLLNG
610 620 630 640 650
PGRKKKYIRL WSTQLGGILL LLFMNETEYS KVKHIEGDVK KTGFGGMASN
660 670 680 690 700
KGAVAVSFKY SATRFCVLVS HLAAGLENVE QRHNDYKTIA KSIRFSKGLR
710 720 730 740 750
IKDHDAIIWM GDFNYRILMS NEDVRRKIVS KEYASLFEKD QLNQQMIAGE
760 770 780 790 800
SFPYFHEMAI DFPPTYKFDP GTKNYDTSEK MRIPAWTDRI LSRGEVLEQL
810 820 830 840 850
EYKCCEDILF SDHRPVYAIF RARVTVVDEQ KKTTLGTQIY EKIMERLEGL
860 870 880 890 900
DDDEKIAVLS DDAFVIESFE GSDSIAGPTH SPTPIPEPKR GRKLPPPSSD
910 920 930 940
LKKWWIGSGK QVKVVLDVDP AVYMINPKRD PNPFVENEDE PLFIER
Length:946
Mass (Da):108,430
Last modified:February 1, 1995 - v1
Checksum:iA833C39B0A62543F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79743 Genomic DNA No translation available.
Z38062 Genomic DNA Translation: CAA86201.1
BK006942 Genomic DNA Translation: DAA08545.1
PIRiS48433
RefSeqiNP_012264.3, NM_001179352.3

Genome annotation databases

EnsemblFungiiYIL002C; YIL002C; YIL002C
GeneIDi854815
KEGGisce:YIL002C

Similar proteinsi

Entry informationi

Entry nameiINP51_YEAST
AccessioniPrimary (citable) accession number: P40559
Secondary accession number(s): D6VVS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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