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UniProtKB - P40556 (YIA6_YEAST)
Protein
Mitochondrial nicotinamide adenine dinucleotide transporter 1
Gene
YIA6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Mitochondrial inner membrane carrier protein that mediates the import of NAD+ into mitochondria (PubMed:16291748, PubMed:32906142, PubMed:33087354).
Can transport NAD+ by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP (PubMed:16291748).
Also able to transport NAD+ by exchange with AMP, GMP or deamido-NAD (+) in vitro (PubMed:16291748).
3 PublicationsCaution
Was first identified as the mitochondrial pyruvate transporter (PubMed:12887330). However, later experiments showed that was a NAD+ transporter (PubMed:16291748).2 Publications
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=0.38 mM for NAD+1 Publication
- Vmax=617 nmol/min/mg enzyme1 Publication
GO - Molecular functioni
- NAD transmembrane transporter activity Source: UniProtKB
- pyruvate secondary active transmembrane transporter activity Source: SGD
GO - Biological processi
- mitochondrial NAD transmembrane transport Source: UniProtKB
- mitochondrial pyruvate transmembrane transport Source: SGD
- NAD transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.29.10.5, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial nicotinamide adenine dinucleotide transporter 1CuratedAlternative name(s): Mitochondrial NAD(+) transporter 1 |
Gene namesi | Name:YIA6 Synonyms:NDT12 Publications Ordered Locus Names:YIL006W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001268, YIA6 |
VEuPathDBi | FungiDB:YIL006W |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 80 | Mitochondrial matrixSequence analysisAdd BLAST | 80 | |
Transmembranei | 81 – 101 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 141 | Mitochondrial intermembraneSequence analysisAdd BLAST | 40 | |
Transmembranei | 142 – 162 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 176 | Mitochondrial matrixSequence analysisAdd BLAST | 14 | |
Transmembranei | 177 – 199 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 200 – 235 | Mitochondrial intermembraneSequence analysisAdd BLAST | 36 | |
Transmembranei | 236 – 256 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 280 | Mitochondrial matrixSequence analysisAdd BLAST | 24 | |
Transmembranei | 281 – 297 | Helical; Name=5Sequence analysisAdd BLAST | 17 | |
Topological domaini | 298 – 335 | Mitochondrial intermembraneSequence analysisAdd BLAST | 38 | |
Transmembranei | 336 – 358 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 359 – 373 | Mitochondrial matrixSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090698 | 1 – 373 | Mitochondrial nicotinamide adenine dinucleotide transporter 1Add BLAST | 373 |
Proteomic databases
PaxDbi | P40556 |
PRIDEi | P40556 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34986, 137 interactors |
DIPi | DIP-4960N |
IntActi | P40556, 1 interactor |
STRINGi | 4932.YIL006W |
Miscellaneous databases
RNActi | P40556, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 75 – 166 | Solcar 1Sequence analysisAdd BLAST | 92 | |
Repeati | 174 – 263 | Solcar 2Sequence analysisAdd BLAST | 90 | |
Repeati | 276 – 364 | Solcar 3Sequence analysisAdd BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0764, Eukaryota |
GeneTreei | ENSGT00940000176809 |
HOGENOMi | CLU_015166_6_1_1 |
InParanoidi | P40556 |
OMAi | MPNRPRY |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR044712, SLC25A32-like |
PANTHERi | PTHR45683, PTHR45683, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
P40556-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQTDNPVPN CGLLPEQQYC SADHEEPLLL HEEQLIFPDH SSQLSSADII
60 70 80 90 100
EPIKMNSSTE SIIGTTLRKK WVPLSSTQIT ALSGAFAGFL SGVAVCPLDV
110 120 130 140 150
AKTRLQAQGL QTRFENPYYR GIMGTLSTIV RDEGPRGLYK GLVPIVLGYF
160 170 180 190 200
PTWMIYFSVY EFSKKFFHGI FPQFDFVAQS CAAITAGAAS TTLTNPIWVV
210 220 230 240 250
KTRLMLQSNL GEHPTHYKGT FDAFRKLFYQ EGFKALYAGL VPSLLGLFHV
260 270 280 290 300
AIHFPIYEDL KVRFHCYSRE NNTNSINLQR LIMASSVSKM IASAVTYPHE
310 320 330 340 350
ILRTRMQLKS DIPDSIQRRL FPLIKATYAQ EGLKGFYSGF TTNLVRTIPA
360 370
SAITLVSFEY FRNRLENIST MVI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38113 Genomic DNA Translation: CAA86245.1 BK006942 Genomic DNA Translation: DAA08540.1 |
PIRi | S48451 |
RefSeqi | NP_012260.1, NM_001179356.1 |
Genome annotation databases
EnsemblFungii | YIL006W_mRNA; YIL006W; YIL006W |
GeneIDi | 854811 |
KEGGi | sce:YIL006W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38113 Genomic DNA Translation: CAA86245.1 BK006942 Genomic DNA Translation: DAA08540.1 |
PIRi | S48451 |
RefSeqi | NP_012260.1, NM_001179356.1 |
3D structure databases
SMRi | P40556 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34986, 137 interactors |
DIPi | DIP-4960N |
IntActi | P40556, 1 interactor |
STRINGi | 4932.YIL006W |
Protein family/group databases
TCDBi | 2.A.29.10.5, the mitochondrial carrier (mc) family |
Proteomic databases
PaxDbi | P40556 |
PRIDEi | P40556 |
Genome annotation databases
EnsemblFungii | YIL006W_mRNA; YIL006W; YIL006W |
GeneIDi | 854811 |
KEGGi | sce:YIL006W |
Organism-specific databases
SGDi | S000001268, YIA6 |
VEuPathDBi | FungiDB:YIL006W |
Phylogenomic databases
eggNOGi | KOG0764, Eukaryota |
GeneTreei | ENSGT00940000176809 |
HOGENOMi | CLU_015166_6_1_1 |
InParanoidi | P40556 |
OMAi | MPNRPRY |
Miscellaneous databases
PROi | PR:P40556 |
RNActi | P40556, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR044712, SLC25A32-like |
PANTHERi | PTHR45683, PTHR45683, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | YIA6_YEAST | |
Accessioni | P40556Primary (citable) accession number: P40556 Secondary accession number(s): D6VVS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - SIMILARITY comments
Index of protein domains and families