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Protein

Mitochondrial nicotinamide adenine dinucleotide transporter 1

Gene

YIA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP.3 Publications

Caution

Was first identified as the mitochondrial pyruvate transporter (PubMed:12887330). However, later experiments showed that was a NAD+ transporter (PubMed:16291748).2 Publications

Kineticsi

  1. KM=0.38 mM for NAD+1 Publication
  1. Vmax=617 nmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • NAD transmembrane transporter activity Source: SGD
  • pyruvate secondary active transmembrane transporter activity Source: SGD

GO - Biological processi

  • mitochondrial pyruvate transmembrane transport Source: SGD
  • NAD transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31285-MONOMER
ReactomeiR-SCE-196757 Metabolism of folate and pterines
R-SCE-389599 Alpha-oxidation of phytanate

Protein family/group databases

TCDBi2.A.29.10.5 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial nicotinamide adenine dinucleotide transporter 1
Alternative name(s):
Mitochondrial NAD(+) transporter 1
Gene namesi
Name:YIA6
Synonyms:NDT1
Ordered Locus Names:YIL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL006W
SGDiS000001268 YIA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 80Mitochondrial matrixSequence analysisAdd BLAST80
Transmembranei81 – 101Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini102 – 141Mitochondrial intermembraneSequence analysisAdd BLAST40
Transmembranei142 – 162Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini163 – 176Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei177 – 199Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini200 – 235Mitochondrial intermembraneSequence analysisAdd BLAST36
Transmembranei236 – 256Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini257 – 280Mitochondrial matrixSequence analysisAdd BLAST24
Transmembranei281 – 297Helical; Name=5Sequence analysisAdd BLAST17
Topological domaini298 – 335Mitochondrial intermembraneSequence analysisAdd BLAST38
Transmembranei336 – 358Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini359 – 373Mitochondrial matrixSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906981 – 373Mitochondrial nicotinamide adenine dinucleotide transporter 1Add BLAST373

Proteomic databases

PaxDbiP40556
PRIDEiP40556

Interactioni

Protein-protein interaction databases

BioGridi34986, 136 interactors
DIPiDIP-4960N
IntActiP40556, 2 interactors
STRINGi4932.YIL006W

Structurei

3D structure databases

ProteinModelPortaliP40556
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 166Solcar 1Add BLAST92
Repeati174 – 263Solcar 2Add BLAST90
Repeati276 – 364Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149129
HOGENOMiHOG000188210
InParanoidiP40556
KOiK15115
OMAiTHVAVQF
OrthoDBiEOG092C43EV

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P40556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTDNPVPN CGLLPEQQYC SADHEEPLLL HEEQLIFPDH SSQLSSADII
60 70 80 90 100
EPIKMNSSTE SIIGTTLRKK WVPLSSTQIT ALSGAFAGFL SGVAVCPLDV
110 120 130 140 150
AKTRLQAQGL QTRFENPYYR GIMGTLSTIV RDEGPRGLYK GLVPIVLGYF
160 170 180 190 200
PTWMIYFSVY EFSKKFFHGI FPQFDFVAQS CAAITAGAAS TTLTNPIWVV
210 220 230 240 250
KTRLMLQSNL GEHPTHYKGT FDAFRKLFYQ EGFKALYAGL VPSLLGLFHV
260 270 280 290 300
AIHFPIYEDL KVRFHCYSRE NNTNSINLQR LIMASSVSKM IASAVTYPHE
310 320 330 340 350
ILRTRMQLKS DIPDSIQRRL FPLIKATYAQ EGLKGFYSGF TTNLVRTIPA
360 370
SAITLVSFEY FRNRLENIST MVI
Length:373
Mass (Da):41,954
Last modified:February 1, 1995 - v1
Checksum:i976C767C1D40E8DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38113 Genomic DNA Translation: CAA86245.1
BK006942 Genomic DNA Translation: DAA08540.1
PIRiS48451
RefSeqiNP_012260.1, NM_001179356.1

Genome annotation databases

EnsemblFungiiYIL006W; YIL006W; YIL006W
GeneIDi854811
KEGGisce:YIL006W

Similar proteinsi

Entry informationi

Entry nameiYIA6_YEAST
AccessioniPrimary (citable) accession number: P40556
Secondary accession number(s): D6VVS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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