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Protein

Ubiquitin-like-specific protease 2

Gene

ULP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Insertion mutation in SMT4 confers temperature and benomyl sensitivity; high copy suppressor of a temperature sensitive mutation in MIF2.

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type peptidase activity Source: SGD
  • SUMO-specific isopeptidase activity Source: SGD

GO - Biological processi

  • chromosome condensation Source: SGD
  • mitotic spindle assembly checkpoint Source: SGD
  • plasmid maintenance Source: SGD
  • protein desumoylation Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31304-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.22.B67 984

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C48.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-like-specific protease 2 (EC:3.4.22.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ULP2
Synonyms:SMT4
Ordered Locus Names:YIL031W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001293 ULP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017321 – 1034Ubiquitin-like-specific protease 2Add BLAST1034

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei788PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei984PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40537

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40537

PRoteomics IDEntifications database

More...
PRIDEi
P40537

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40537

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34958, 335 interactors

Database of interacting proteins

More...
DIPi
DIP-5489N

Protein interaction database and analysis system

More...
IntActi
P40537, 10 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YIL031W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11034
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P40537

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40537

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154774

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40537

KEGG Orthology (KO)

More...
KOi
K08596

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSTHDIM

Database of Orthologous Groups

More...
OrthoDBi
EOG092C1210

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02902 Peptidase_C48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40537-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARKRKFNS LKPLDTLNSS RASSPRSSAS LPPKRYNTFR KDPKIVDHLN
60 70 80 90 100
NASTKDFLPV LSMNSESKRQ IELSDNDVDN NDEGEGVNSG CSDQDFEPLQ
110 120 130 140 150
SSPLKRHSSL KSTSNGLLFQ MSNNLGNGSP EPAVASTSPN GSIISTKLNL
160 170 180 190 200
NGQFSCVDSK TLRIYRHKAP CIMTFVSDHN HPKFSLYFQQ SVIYNSQVNL
210 220 230 240 250
LDDVELIILD KKNSFMAIIL KDLKKVKMIL DVNNSSININ TNILIWSTAS
260 270 280 290 300
SASNKKIKSI KRFLLMSYSS SIKVEILDHK EQILERLKHL IHPISSSSPS
310 320 330 340 350
LNMERAINST KNAFDSLRLK KTKLSTNDDE SPQIHTHFLS NKPHGLQSLT
360 370 380 390 400
KRTRIASLGK KEHSISVPKS NISPSDFYNT NGTETLQSHA VSQLRRSNRF
410 420 430 440 450
KDVSDPANSN SNSEFDDATT EFETPELFKP SLCYKFNDGS SYTITNQDFK
460 470 480 490 500
CLFNKDWVND SILDFFTKFY IESSIEKSII KREQVHLMSS FFYTKLISNP
510 520 530 540 550
ADYYSNVKKW VNNTDLFSKK YVVIPINISY HWFSCIITNL DAILDFHQNK
560 570 580 590 600
DKNDAINSDE ISINNPLVNI LTFDSLRQTH SREIDPIKEF LISYALDKYS
610 620 630 640 650
IQLDKTQIKM KTCPVPQQPN MSDCGVHVIL NIRKFFENPV ETIDVWKNSK
660 670 680 690 700
IKSKHFTAKM INKYFDKNER NSARKNLRHT LKLLQLNYIS YLKKENLYEE
710 720 730 740 750
VMQMEEKKST NINNNENYDD DDEEIQIIEN IDQSSKDNNA QLTSEPPCSR
760 770 780 790 800
SSSISTTERE PTELHNSVVR QPTGEIITDN EDPVRAASPE TASVSPPIRH
810 820 830 840 850
NILKSSSPFI SESANETEQE EFTSPYFGRP SLKTRAKQFE GVSSPIKNDQ
860 870 880 890 900
ALSSTHDIMM PSPKPKRIYP SKKIPQLSSH VQSLSTDSME RQSSPNNTNI
910 920 930 940 950
VISDTEQDSR LGVNSESKNT SGIVNRDDSD VNLIGSSLPN VAEKNHDNTQ
960 970 980 990 1000
ESNGNNDSLG KILQNVDKEL NEKLVDIDDV AFSSPTRGIP RTSATSKGSN
1010 1020 1030
AQLLSNYGDE NNQSQDSVWD EGRDNPILLE DEDP
Length:1,034
Mass (Da):116,883
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i782789B3B1DC37F6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z46861 Genomic DNA Translation: CAA86920.1
U27832 Genomic DNA Translation: AAA69556.1
BK006942 Genomic DNA Translation: DAA08516.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S49947

NCBI Reference Sequences

More...
RefSeqi
NP_012233.1, NM_001179381.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIL031W_mRNA; YIL031W_mRNA; YIL031W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIL031W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA Translation: CAA86920.1
U27832 Genomic DNA Translation: AAA69556.1
BK006942 Genomic DNA Translation: DAA08516.1
PIRiS49947
RefSeqiNP_012233.1, NM_001179381.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LNBX-ray2.30B411-710[»]
5V1AX-ray2.14B821-845[»]
ProteinModelPortaliP40537
SMRiP40537
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34958, 335 interactors
DIPiDIP-5489N
IntActiP40537, 10 interactors
STRINGi4932.YIL031W

Protein family/group databases

MEROPSiC48.005

PTM databases

iPTMnetiP40537

Proteomic databases

MaxQBiP40537
PaxDbiP40537
PRIDEiP40537

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL031W_mRNA; YIL031W_mRNA; YIL031W
GeneIDi854780
KEGGisce:YIL031W

Organism-specific databases

SGDiS000001293 ULP2

Phylogenomic databases

GeneTreeiENSGT00940000172065
HOGENOMiHOG000154774
InParanoidiP40537
KOiK08596
OMAiSSTHDIM
OrthoDBiEOG092C1210

Enzyme and pathway databases

BioCyciYEAST:G3O-31304-MONOMER
BRENDAi3.4.22.B67 984

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40537

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiULP2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40537
Secondary accession number(s): D6VVQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 5, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  5. Peptidase families
    Classification of peptidase families and list of entries
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