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UniProtKB - P40532 (APQ12_YEAST)
Protein
Nuclear membrane organization protein APQ12
Gene
APQ12
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in the regulation of lipid homeostasis in the endoplasmic reticulum, thereby impacting nuclear pore complex biogenesis and localization, and nucleocytoplasmic mRNA transport.
3 PublicationsGO - Biological processi
- lipid homeostasis Source: SGD
- mRNA transport Source: UniProtKB-KW
- nuclear envelope organization Source: SGD
Keywordsi
Biological process | mRNA transport, Transport |
Protein family/group databases
TCDBi | 9.A.34.1.1, the nuclear pore complex biogenesis (npc-b) family |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear membrane organization protein APQ12 |
Gene namesi | Name:APQ12 Ordered Locus Names:YIL040W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001302, APQ12 |
VEuPathDBi | FungiDB:YIL040W |
Subcellular locationi
Nucleus
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear envelope Source: SGD
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 58 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 59 – 67 | Perinuclear spaceSequence analysis | 9 | |
Transmembranei | 68 – 84 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 85 – 138 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202992 | 1 – 138 | Nuclear membrane organization protein APQ12Add BLAST | 138 |
Proteomic databases
MaxQBi | P40532 |
PaxDbi | P40532 |
PRIDEi | P40532 |
TopDownProteomicsi | P40532 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34950, 500 interactors |
DIPi | DIP-5412N |
STRINGi | 4932.YIL040W |
Miscellaneous databases
RNActi | P40532, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the APQ12 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_1856860_0_0_1 |
InParanoidi | P40532 |
OMAi | TCIGIYM |
Family and domain databases
InterProi | View protein in InterPro IPR024316, APQ12 |
Pfami | View protein in Pfam PF12716, Apq12, 1 hit |
i Sequence
Sequence statusi: Complete.
P40532-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDATQPQYEL SVVTQCLKSA IDVIQWLIPT ITKFSQSHPL VFQLLFIFFT
60 70 80 90 100
FYVFYKLLMN FITLVKRFLY LTLVVTCIGI YMRGSQQFLT VDLLNFYNFV
110 120 130
MSNRYYAFKI YTLFINALER EINTVYHLAQ MKMEQLLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46861 Genomic DNA Translation: CAA86911.1 BK006942 Genomic DNA Translation: DAA08508.1 |
PIRi | S49938 |
RefSeqi | NP_012224.1, NM_001179390.1 |
Genome annotation databases
EnsemblFungii | YIL040W_mRNA; YIL040W; YIL040W |
GeneIDi | 854771 |
KEGGi | sce:YIL040W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46861 Genomic DNA Translation: CAA86911.1 BK006942 Genomic DNA Translation: DAA08508.1 |
PIRi | S49938 |
RefSeqi | NP_012224.1, NM_001179390.1 |
3D structure databases
SMRi | P40532 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34950, 500 interactors |
DIPi | DIP-5412N |
STRINGi | 4932.YIL040W |
Protein family/group databases
TCDBi | 9.A.34.1.1, the nuclear pore complex biogenesis (npc-b) family |
Proteomic databases
MaxQBi | P40532 |
PaxDbi | P40532 |
PRIDEi | P40532 |
TopDownProteomicsi | P40532 |
Genome annotation databases
EnsemblFungii | YIL040W_mRNA; YIL040W; YIL040W |
GeneIDi | 854771 |
KEGGi | sce:YIL040W |
Organism-specific databases
SGDi | S000001302, APQ12 |
VEuPathDBi | FungiDB:YIL040W |
Phylogenomic databases
HOGENOMi | CLU_1856860_0_0_1 |
InParanoidi | P40532 |
OMAi | TCIGIYM |
Miscellaneous databases
PROi | PR:P40532 |
RNActi | P40532, protein |
Family and domain databases
InterProi | View protein in InterPro IPR024316, APQ12 |
Pfami | View protein in Pfam PF12716, Apq12, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APQ12_YEAST | |
Accessioni | P40532Primary (citable) accession number: P40532 Secondary accession number(s): D6VVP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - SIMILARITY comments
Index of protein domains and families