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UniProtKB - P40517 (YRB2_YEAST)
Protein
Ran-specific GTPase-activating protein 2
Gene
YRB2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.
1 PublicationMiscellaneous
Present with 3620 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
GO - Biological processi
- protein export from nucleus Source: SGD
- ribosomal small subunit export from nucleus Source: SGD
Keywordsi
Molecular function | GTPase activation |
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Ran-specific GTPase-activating protein 2Alternative name(s): Ran-binding protein 2 Short name: RANBP2 |
Gene namesi | Name:YRB2 Ordered Locus Names:YIL063C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001325, YRB2 |
VEuPathDBi | FungiDB:YIL063C |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: SGD
Nucleus
- nuclear pore Source: GO_Central
- nucleus Source: SGD
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213671 | 1 – 327 | Ran-specific GTPase-activating protein 2Add BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 179 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P40517 |
PaxDbi | P40517 |
PRIDEi | P40517 |
PTM databases
iPTMneti | P40517 |
Interactioni
Subunit structurei
Interacts with GSP1, XPO1 and SRM1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 34929, 45 interactors |
DIPi | DIP-2243N |
IntActi | P40517, 6 interactors |
MINTi | P40517 |
STRINGi | 4932.YIL063C |
Miscellaneous databases
RNActi | P40517, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P40517 |
SMRi | P40517 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 191 – 327 | RanBD1PROSITE-ProRule annotationAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 96 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 109 – 205 | DisorderedSequence analysisAdd BLAST | 97 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 27 – 96 | Basic and acidic residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 160 – 180 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 187 – 205 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Domaini
Contains X-F-X-F-G repeats.
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
HOGENOMi | CLU_052718_0_0_1 |
InParanoidi | P40517 |
OMAi | CMNSIDE |
Family and domain databases
DisProti | DP01079 |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID50276 |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom IPR045255, RanBP1-like |
PANTHERi | PTHR23138, PTHR23138, 1 hit |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
i Sequence
Sequence statusi: Complete.
P40517-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSETNGGNAA RENSEVKQTA VENPIDKLDG TPKRPREKDQ DEQAEETSDK
60 70 80 90 100
SEAPNKNDEE KKEEGKKDQE PSHKKIKVDD GKTVESGIVE DDKKEDKFVF
110 120 130 140 150
GAASKFGTGF GVAKKDTKDG DATTSTESLP ASDSKTKKPF AFGSGLSFGS
160 170 180 190 200
GFNILKNKTE NNSESEKKAT DVDKDKVHSG SEQLANASED TKDKPKPLKL
210 220 230 240 250
QKQEVKSGEE SEECIYQVNA KLYQLSNIKE GWKERGVGII KINKSKDDVE
260 270 280 290 300
KTRIVMRSRG ILKVILNIQL VKGFTVQKGF TGSLQSEKFI RLLAVDDNGD
310 320
PAQYAIKTGK KETTDELYNI IVKSVPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38060 Genomic DNA Translation: CAA86160.1 AY557879 Genomic DNA Translation: AAS56205.1 BK006942 Genomic DNA Translation: DAA08487.1 |
PIRi | S48416 |
RefSeqi | NP_012201.1, NM_001179413.1 |
Genome annotation databases
EnsemblFungii | YIL063C_mRNA; YIL063C; YIL063C |
GeneIDi | 854747 |
KEGGi | sce:YIL063C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38060 Genomic DNA Translation: CAA86160.1 AY557879 Genomic DNA Translation: AAS56205.1 BK006942 Genomic DNA Translation: DAA08487.1 |
PIRi | S48416 |
RefSeqi | NP_012201.1, NM_001179413.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3WYF | X-ray | 2.22 | B/E | 90-327 | [»] | |
AlphaFoldDBi | P40517 | |||||
SMRi | P40517 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34929, 45 interactors |
DIPi | DIP-2243N |
IntActi | P40517, 6 interactors |
MINTi | P40517 |
STRINGi | 4932.YIL063C |
PTM databases
iPTMneti | P40517 |
Proteomic databases
MaxQBi | P40517 |
PaxDbi | P40517 |
PRIDEi | P40517 |
Genome annotation databases
EnsemblFungii | YIL063C_mRNA; YIL063C; YIL063C |
GeneIDi | 854747 |
KEGGi | sce:YIL063C |
Organism-specific databases
SGDi | S000001325, YRB2 |
VEuPathDBi | FungiDB:YIL063C |
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
HOGENOMi | CLU_052718_0_0_1 |
InParanoidi | P40517 |
OMAi | CMNSIDE |
Miscellaneous databases
PROi | PR:P40517 |
RNActi | P40517, protein |
Family and domain databases
DisProti | DP01079 |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID50276 |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom IPR045255, RanBP1-like |
PANTHERi | PTHR23138, PTHR23138, 1 hit |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YRB2_YEAST | |
Accessioni | P40517Primary (citable) accession number: P40517 Secondary accession number(s): D6VVM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references