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UniProtKB - P40481 (HPM1_YEAST)
Protein
Histidine protein methyltransferase 1
Gene
HPM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Protein-histidine N-methyltransferase that mediates methylation of RPL3 at 'His-243' (PubMed:20864530, PubMed:24865971).
Methylates ribosome-associated RPL3, but not free RPL3, thereby regulating 60S subunit assembly (PubMed:24865971, PubMed:26826131).
In addition to RPL3, mediates His methylation of other proteins (PubMed:26826131).
3 PublicationsCatalytic activityi
- L-histidyl-[protein] + S-adenosyl-L-methionine = H+ + Nτ-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine1 PublicationEC:2.1.1.851 Publication
GO - Molecular functioni
- protein-L-histidine N-tele-methyltransferase activity Source: UniProtKB
GO - Biological processi
- peptidyl-histidine methylation, to form tele-methylhistidine Source: UniProtKB
- positive regulation of translational fidelity Source: SGD
- ribosomal large subunit assembly Source: SGD
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Histidine protein methyltransferase 11 Publication (EC:2.1.1.851 Publication)Alternative name(s): Mitotic exit network interactor 1 |
Gene namesi | Ordered Locus Names:YIL110W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001372, HPM1 |
VEuPathDBi | FungiDB:YIL110W |
Pathology & Biotechi
Disruption phenotypei
Loss of Protein-histidine methylation (PubMed:24865971). Impaired early rRNA processing, resulting in a deficiency of 60S subunits and translation initiation defects (PubMed:24865971). A haploid deletion mutant leads to hypersensitivity to echinocandin-like antifungal lipopeptide caspofungin, a 1,3-beta-glucan synthase inhibitor. Deletion confers sensitivity to the synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) (PubMed:15166135).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202964 | 1 – 377 | Histidine protein methyltransferase 1Add BLAST | 377 |
Proteomic databases
MaxQBi | P40481 |
PaxDbi | P40481 |
PRIDEi | P40481 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34881, 151 interactors |
DIPi | DIP-4710N |
IntActi | P40481, 1 interactor |
STRINGi | 4932.YIL110W |
Miscellaneous databases
RNActi | P40481, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2920, Eukaryota |
GeneTreei | ENSGT00390000000464 |
HOGENOMi | CLU_038704_1_1_1 |
InParanoidi | P40481 |
OMAi | WRTFLPL |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR019410, Methyltransf_16 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR14614, PTHR14614, 1 hit |
i Sequence
Sequence statusi: Complete.
P40481-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFSFGFTSN DFDDDELVAQ PETFVESSKE NENTTAYINP LDSDFLSQAG
60 70 80 90 100
VVQPNVEDLG TILESLKDVR LTFEEFQSPI YRKPLIKREL FDVKHQLMLE
110 120 130 140 150
TDAQSNNNST ELDILLGDTS EDLRKNIYEG GLKSWECSYD LVDLLSENVD
160 170 180 190 200
RISNDIDAVV EIGCGTALPS EFLFRSALLR NDRSKGLKFV LTDYNASVLR
210 220 230 240 250
LVTIPNLVIT WAKTVLTKEQ WYALQKDECE DIPINNEELL LTSKLLAAFY
260 270 280 290 300
DDVQSRNISV TLISGSWGRK FSNLIHEVLS GSQKVLSLSS ETIYQPDNLP
310 320 330 340 350
VIAETILDIH NLPQTDVKTY VAAKDIYFGV GGSITEFEAY LDDKINSEHL
360 370
PIHSERFKVN SGLKRSIICI ETNKAIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38125 Genomic DNA Translation: CAA86270.1 AY558076 Genomic DNA Translation: AAS56402.1 BK006942 Genomic DNA Translation: DAA08443.1 |
PIRi | S48462 |
RefSeqi | NP_012156.1, NM_001179458.1 |
Genome annotation databases
EnsemblFungii | YIL110W_mRNA; YIL110W; YIL110W |
GeneIDi | 854696 |
KEGGi | sce:YIL110W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38125 Genomic DNA Translation: CAA86270.1 AY558076 Genomic DNA Translation: AAS56402.1 BK006942 Genomic DNA Translation: DAA08443.1 |
PIRi | S48462 |
RefSeqi | NP_012156.1, NM_001179458.1 |
3D structure databases
AlphaFoldDBi | P40481 |
SMRi | P40481 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34881, 151 interactors |
DIPi | DIP-4710N |
IntActi | P40481, 1 interactor |
STRINGi | 4932.YIL110W |
Proteomic databases
MaxQBi | P40481 |
PaxDbi | P40481 |
PRIDEi | P40481 |
Genome annotation databases
EnsemblFungii | YIL110W_mRNA; YIL110W; YIL110W |
GeneIDi | 854696 |
KEGGi | sce:YIL110W |
Organism-specific databases
SGDi | S000001372, HPM1 |
VEuPathDBi | FungiDB:YIL110W |
Phylogenomic databases
eggNOGi | KOG2920, Eukaryota |
GeneTreei | ENSGT00390000000464 |
HOGENOMi | CLU_038704_1_1_1 |
InParanoidi | P40481 |
OMAi | WRTFLPL |
Miscellaneous databases
PROi | PR:P40481 |
RNActi | P40481, protein |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR019410, Methyltransf_16 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR14614, PTHR14614, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HPM1_YEAST | |
Accessioni | P40481Primary (citable) accession number: P40481 Secondary accession number(s): D6VVH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - SIMILARITY comments
Index of protein domains and families