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UniProtKB - P40475 (QDR1_YEAST)
Protein
Quinidine resistance protein 1
Gene
QDR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole.
1 PublicationGO - Molecular functioni
- efflux transmembrane transporter activity Source: SGD
- xenobiotic transmembrane transporter activity Source: GO_Central
GO - Biological processi
- ascospore wall assembly Source: SGD
- transmembrane transport Source: SGD
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: GO_Central
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Quinidine resistance protein 1 |
Gene namesi | Name:QDR1 Ordered Locus Names:YIL120W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001382, QDR1 |
VEuPathDBi | FungiDB:YIL120W |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 75 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 108 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 135 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 157 – 165 | ExtracellularSequence analysis | 9 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 195 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 224 | ExtracellularSequence analysis | 8 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 296 | CytoplasmicSequence analysisAdd BLAST | 51 | |
Transmembranei | 297 – 317 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 318 – 341 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 421 | CytoplasmicSequence analysisAdd BLAST | 59 | |
Transmembranei | 422 – 442 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 443 – 445 | ExtracellularSequence analysis | 3 | |
Transmembranei | 446 – 466 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 467 – 481 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 482 – 502 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 503 – 511 | ExtracellularSequence analysis | 9 | |
Transmembranei | 512 – 532 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 533 – 563 | CytoplasmicSequence analysisAdd BLAST | 31 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173441 | 1 – 563 | Quinidine resistance protein 1Add BLAST | 563 |
Proteomic databases
PaxDbi | P40475 |
PRIDEi | P40475 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34871, 37 interactors |
DIPi | DIP-8146N |
IntActi | P40475, 1 interactor |
STRINGi | 4932.YIL120W |
Miscellaneous databases
RNActi | P40475, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 49 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00940000176391 |
HOGENOMi | CLU_008455_8_4_1 |
InParanoidi | P40475 |
OMAi | QGITPMF |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P40475-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKQQTSVMR NASIAKEERE GSDNNNVDRS SSDAISDNDA ERSNSHSEID
60 70 80 90 100
NESNFDMVPY SRFSHKQKML LVVQCAFTGF FSTVAGSIYY PVLTIIERKF
110 120 130 140 150
NITEELANVT IVVYFIFQGV APSIMGGLAD TFGRRPIVLW AILAYFCACI
160 170 180 190 200
GLACAHNYAQ ILALRCLQAA GISPVIAINS GIMGDVTTKV ERGGYVGLVA
210 220 230 240 250
GFQVVGTAFG ALIGAGLSSK WGWRAIFWFL AIGSGICLVF STLLMPETKR
260 270 280 290 300
TLVGNGSVTP RSFLNRSLIL HVGSVKKTLH LDDPDPETLE PRTSVDFLAP
310 320 330 340 350
LKILHIREID ILLSIAGLQF STWTTHQTAL TIVLSKKYNL SVAKIGLCFL
360 370 380 390 400
PAGISTLTSI ISAGRYLNWS YRTRKVKYNR WIKEQELQLM EKYKGDKNKV
410 420 430 440 450
AELIHSNSHY AFNLVEARLH PAFVTLLLSS IGFTAFGWCI SVKTPLAAVL
460 470 480 490 500
CTSAFASLFS NCILTFSTTL IVDLFPSKAS TATGCLNLFR CLLSAIFIAA
510 520 530 540 550
LTKMVEKMRY GGVFTFLSAI TSSSSLLLFY LLKNGKQLSF DRIRANDKSA
560
GRSVGKNSEK VST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46833 Genomic DNA Translation: CAA86872.1 BK006942 Genomic DNA Translation: DAA08433.1 |
PIRi | S49889 |
RefSeqi | NP_012146.1, NM_001179468.1 |
Genome annotation databases
EnsemblFungii | YIL120W_mRNA; YIL120W; YIL120W |
GeneIDi | 854686 |
KEGGi | sce:YIL120W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46833 Genomic DNA Translation: CAA86872.1 BK006942 Genomic DNA Translation: DAA08433.1 |
PIRi | S49889 |
RefSeqi | NP_012146.1, NM_001179468.1 |
3D structure databases
SMRi | P40475 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34871, 37 interactors |
DIPi | DIP-8146N |
IntActi | P40475, 1 interactor |
STRINGi | 4932.YIL120W |
Proteomic databases
PaxDbi | P40475 |
PRIDEi | P40475 |
Genome annotation databases
EnsemblFungii | YIL120W_mRNA; YIL120W; YIL120W |
GeneIDi | 854686 |
KEGGi | sce:YIL120W |
Organism-specific databases
SGDi | S000001382, QDR1 |
VEuPathDBi | FungiDB:YIL120W |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00940000176391 |
HOGENOMi | CLU_008455_8_4_1 |
InParanoidi | P40475 |
OMAi | QGITPMF |
Miscellaneous databases
PROi | PR:P40475 |
RNActi | P40475, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QDR1_YEAST | |
Accessioni | P40475Primary (citable) accession number: P40475 Secondary accession number(s): D6VVG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - SIMILARITY comments
Index of protein domains and families