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Entry version 171 (22 Apr 2020)
Sequence version 1 (01 Feb 1995)
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Protein

DNA repair/transcription protein MET18/MMS19

Gene

MET18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as RAD3/XPD and DNA2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription.5 Publications

Miscellaneous

Present with 3150 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Transcription

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31379-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-SCE-2564818 Cytosolic iron-sulfur cluster assembly (yeast)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair/transcription protein MET18/MMS19
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MET18
Synonyms:MMS19
Ordered Locus Names:YIL128W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YIL128W

Saccharomyces Genome Database

More...
SGDi
S000001390 MET18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000964451 – 1032DNA repair/transcription protein MET18/MMS19Add BLAST1032

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40469

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40469

PRoteomics IDEntifications database

More...
PRIDEi
P40469

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P40469

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40469

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34863, 286 interactors

Database of interacting proteins

More...
DIPi
DIP-1438N

Protein interaction database and analysis system

More...
IntActi
P40469, 42 interactors

Molecular INTeraction database

More...
MINTi
P40469

STRING: functional protein association networks

More...
STRINGi
4932.YIL128W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40469 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati862 – 901HEAT 1Add BLAST40
Repeati905 – 943HEAT 2Add BLAST39
Repeati946 – 988HEAT 3Add BLAST43
Repeati991 – 1029HEAT 4Add BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi628 – 635Poly-Asn8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MET18/MMS19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005943_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40469

KEGG Orthology (KO)

More...
KOi
K15075

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEIFACY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039920 MET18/MMS19
IPR024687 MMS19_C
IPR029240 MMS19_N

The PANTHER Classification System

More...
PANTHERi
PTHR12891 PTHR12891, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12460 MMS19_C, 1 hit
PF14500 MMS19_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPDELNSAV VTFMANLNID DSKANETAST VTDSIVHRSI KLLEVVVALK
60 70 80 90 100
DYFLSENEVE RKKALTCLTT ILAKTPKDHL SKNECSVIFQ FYQSKLDDQA
110 120 130 140 150
LAKEVLEGFA ALAPMKYVSI NEIAQLLRLL LDNYQQGQHL ASTRLWPFKI
160 170 180 190 200
LRKIFDRFFV NGSSTEQVKR INDLFIETFL HVANGEKDPR NLLLSFALNK
210 220 230 240 250
SITSSLQNVE NFKEDLFDVL FCYFPITFKP PKHDPYKISN QDLKTALRSA
260 270 280 290 300
ITATPLFAED AYSNLLDKLT ASSPVVKNDT LLTLLECVRK FGGSSILENW
310 320 330 340 350
TLLWNALKFE IMQNSEGNEN TLLNPYNKDQ QSDDVGQYTN YDACLKIINL
360 370 380 390 400
MALQLYNFDK VSFEKFFTHV LDELKPNFKY EKDLKQTCQI LSAIGSGNVE
410 420 430 440 450
IFNKVISSTF PLFLINTSEV AKLKLLIMNF SFFVDSYIDL FGRTSKESLG
460 470 480 490 500
TPVPNNKMAE YKDEIIMILS MALTRSSKAE VTIRTLSVIQ FTKMIKMKGF
510 520 530 540 550
LTPEEVSLII QYFTEEILTD NNKNIYYACL EGLKTISEIY EDLVFEISLK
560 570 580 590 600
KLLDLLPDCF EEKIRVNDEE NIHIETILKI ILDFTTSRHI LVKESITFLA
610 620 630 640 650
TKLNRVAKIS KSREYCFLLI STIYSLFNNN NQNENVLNEE DALALKNAIE
660 670 680 690 700
PKLFEIITQE SAIVSDNYNL TLLSNVLFFT NLKIPQAAHQ EELDRYNELF
710 720 730 740 750
ISEGKIRILD TPNVLAISYA KILSALNKNC QFPQKFTVLF GTVQLLKKHA
760 770 780 790 800
PRMTETEKLG YLELLLVLSN KFVSEKDVIG LFDWKDLSVI NLEVMVWLTK
810 820 830 840 850
GLIMQNSLES SEIAKKFIDL LSNEEIGSLV SKLFEVFVMD ISSLKKFKGI
860 870 880 890 900
SWNNNVKILY KQKFFGDIFQ TLVSNYKNTV DMTIKCNYLT ALSLVLKHTP
910 920 930 940 950
SQSVGPFIND LFPLLLQALD MPDPEVRVSA LETLKDTTDK HHTLITEHVS
960 970 980 990 1000
TIVPLLLSLS LPHKYNSVSV RLIALQLLEM ITTVVPLNYC LSYQDDVLSA
1010 1020 1030
LIPVLSDKKR IIRKQCVDTR QVYYELGQIP FE
Length:1,032
Mass (Da):117,883
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD05DCC488E098814
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230P → Q in AAB38865 (PubMed:8943333).Curated1
Sequence conflicti329D → G in AAB38865 (PubMed:8943333).Curated1
Sequence conflicti335V → M in AAB38865 (PubMed:8943333).Curated1
Sequence conflicti361V → I in AAB38865 (PubMed:8943333).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti111 – 112AL → SF in strain: SK1. 2
Natural varianti329D → G in strain: SK1. 1 Publication1
Natural varianti335V → M in strain: SK1. 1 Publication1
Natural varianti444T → I in strain: SK1. 1 Publication1
Natural varianti697N → S in strain: SK1. 1 Publication1
Natural varianti814A → S in strain: SK1. 1 Publication1
Natural varianti816K → M in strain: SK1. 1
Natural varianti930A → T in strain: SK1. 1
Natural varianti963H → Q in strain: SK1. 1
Natural varianti969S → C in strain: SK1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70559 Genomic DNA Translation: AAB38865.1
DQ115392 Genomic DNA Translation: AAZ22499.1
Z38059 Genomic DNA Translation: CAA86150.1
Z46833 Genomic DNA Translation: CAA86864.1
BK006942 Genomic DNA Translation: DAA08425.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53571

NCBI Reference Sequences

More...
RefSeqi
NP_012138.1, NM_001179476.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIL128W_mRNA; YIL128W; YIL128W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIL128W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70559 Genomic DNA Translation: AAB38865.1
DQ115392 Genomic DNA Translation: AAZ22499.1
Z38059 Genomic DNA Translation: CAA86150.1
Z46833 Genomic DNA Translation: CAA86864.1
BK006942 Genomic DNA Translation: DAA08425.1
PIRiS53571
RefSeqiNP_012138.1, NM_001179476.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi34863, 286 interactors
DIPiDIP-1438N
IntActiP40469, 42 interactors
MINTiP40469
STRINGi4932.YIL128W

PTM databases

CarbonylDBiP40469
iPTMnetiP40469

Proteomic databases

MaxQBiP40469
PaxDbiP40469
PRIDEiP40469

Genome annotation databases

EnsemblFungiiYIL128W_mRNA; YIL128W; YIL128W
GeneIDi854678
KEGGisce:YIL128W

Organism-specific databases

EuPathDBiFungiDB:YIL128W
SGDiS000001390 MET18

Phylogenomic databases

HOGENOMiCLU_005943_1_0_1
InParanoidiP40469
KOiK15075
OMAiFEIFACY

Enzyme and pathway databases

BioCyciYEAST:G3O-31379-MONOMER
ReactomeiR-SCE-2564818 Cytosolic iron-sulfur cluster assembly (yeast)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40469
RNActiP40469 protein

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039920 MET18/MMS19
IPR024687 MMS19_C
IPR029240 MMS19_N
PANTHERiPTHR12891 PTHR12891, 1 hit
PfamiView protein in Pfam
PF12460 MMS19_C, 1 hit
PF14500 MMS19_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMET18_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40469
Secondary accession number(s): D6VVF9, P89106, Q45U11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 22, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
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