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Entry version 162 (12 Aug 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Activator of stress genes 1

Gene

ASG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor involved in the stress response.1 Publication

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi21 – 47Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processStress response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31381-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activator of stress genes 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASG1
Ordered Locus Names:YIL130W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YIL130W

Saccharomyces Genome Database

More...
SGDi
S000001392, ASG1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No growth on non-fermentable carbon sources like glycerol and lactate and sensitivity to calcofluor white.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149971 – 964Activator of stress genes 1Add BLAST964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei166Phosphoserine; by ATM or ATRCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40467

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40467

PRoteomics IDEntifications database

More...
PRIDEi
P40467

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P40467

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40467

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34861, 65 interactors

Database of interacting proteins

More...
DIPi
DIP-820N

Protein interaction database and analysis system

More...
IntActi
P40467, 4 interactors

Molecular INTeraction database

More...
MINTi
P40467

STRING: functional protein association networks

More...
STRINGi
4932.YIL130W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40467, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40467

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi832 – 837Poly-Asn6
Compositional biasi840 – 869Poly-AsnAdd BLAST30
Compositional biasi875 – 887Poly-AsnAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ASG1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSY2, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010084_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40467

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTIYKMD

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00067, GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00906, Fungal_trans, 1 hit
SM00066, GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701, SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEQAQQGEQ SVKRRRVTRA CDECRKKKVK CDGQQPCIHC TVYSYECTYK
60 70 80 90 100
KPTKRTQNSG NSGVLTLGNV TTGPSSSTVV AAAASNPNKL LSNIKTERAI
110 120 130 140 150
LPGASTIPAS NNPSKPRKYK TKSTRLQSKI DRYKQIFDEV FPQLPDIDNL
160 170 180 190 200
DIPVFLQIFH NFKRDSQSFL DDTVKEYTLI VNDSSSPIQP VLSSNSKNST
210 220 230 240 250
PDEFLPNMKS DSNSASSNRE QDSVDTYSNI PVGREIKIIL PPKAIALQFV
260 270 280 290 300
KSTWEHCCVL LRFYHRPSFI RQLDELYETD PNNYTSKQMQ FLPLCYAAIA
310 320 330 340 350
VGALFSKSIV SNDSSREKFL QDEGYKYFIA ARKLIDITNA RDLNSIQAIL
360 370 380 390 400
MLIIFLQCSA RLSTCYTYIG VAMRSALRAG FHRKLSPNSG FSPIEIEMRK
410 420 430 440 450
RLFYTIYKLD VYINAMLGLP RSISPDDFDQ TLPLDLSDEN ITEVAYLPEN
460 470 480 490 500
QHSVLSSTGI SNEHTKLFLI LNEIISELYP IKKTSNIISH ETVTSLELKL
510 520 530 540 550
RNWLDSLPKE LIPNAENIDP EYERANRLLH LSFLHVQIIL YRPFIHYLSR
560 570 580 590 600
NMNAENVDPL CYRRARNSIA VARTVIKLAK EMVSNNLLTG SYWYACYTIF
610 620 630 640 650
YSVAGLLFYI HEAQLPDKDS AREYYDILKD AETGRSVLIQ LKDSSMAASR
660 670 680 690 700
TYNLLNQIFE KLNSKTIQLT ALHSSPSNES AFLVTNNSSA LKPHLGDSLQ
710 720 730 740 750
PPVFFSSQDT KNSFSLAKSE ESTNDYAMAN YLNNTPISEN PLNEAQQQDQ
760 770 780 790 800
VSQGTTNMSN ERDPNNFLSI DIRLDNNGQS NILDATDDVF IRNDGDIPTN
810 820 830 840 850
SAFDFSSSKS NASNNSNPDT INNNYNNVSG KNNNNNNITN NSNNNHNNNN
860 870 880 890 900
NDNNNNNNNN NNNNNNNNNS GNSSNNNNNN NNNKNNNDFG IKIDNNSPSY
910 920 930 940 950
EGFPQLQIPL SQDNLNIEDK EEMSPNIEIK NEQNMTDSND ILGVFDQLDA
960
QLFGKYLPLN YPSE
Length:964
Mass (Da):108,781
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD5ABE59E4B022CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti77S → N in strain: SK1. 1 Publication1
Natural varianti149N → S in strain: SK1. 1 Publication1
Natural varianti353I → F in strain: SK1. 1 Publication1
Natural varianti682F → S in strain: SK1. 1 Publication1
Natural varianti707S → F in strain: SK1. 1 Publication1
Natural varianti770I → T in strain: SK1. 1 Publication1
Natural varianti811N → S in strain: SK1. 1 Publication1
Natural varianti852D → NDNNN in strain: SK1. 1
Natural varianti887N → NN in strain: SK1. 1 Publication1
Natural varianti926 – 933Missing in strain: SK1. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ115392 Genomic DNA Translation: AAZ22497.1
Z38059 Genomic DNA Translation: CAA86148.1
BK006942 Genomic DNA Translation: DAA08423.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48404

NCBI Reference Sequences

More...
RefSeqi
NP_012136.1, NM_001179478.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIL130W_mRNA; YIL130W; YIL130W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIL130W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115392 Genomic DNA Translation: AAZ22497.1
Z38059 Genomic DNA Translation: CAA86148.1
BK006942 Genomic DNA Translation: DAA08423.1
PIRiS48404
RefSeqiNP_012136.1, NM_001179478.1

3D structure databases

SMRiP40467
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi34861, 65 interactors
DIPiDIP-820N
IntActiP40467, 4 interactors
MINTiP40467
STRINGi4932.YIL130W

PTM databases

iPTMnetiP40467

Proteomic databases

MaxQBiP40467
PaxDbiP40467
PRIDEiP40467
TopDownProteomicsiP40467

Genome annotation databases

EnsemblFungiiYIL130W_mRNA; YIL130W; YIL130W
GeneIDi854676
KEGGisce:YIL130W

Organism-specific databases

EuPathDBiFungiDB:YIL130W
SGDiS000001392, ASG1

Phylogenomic databases

eggNOGiENOG502QSY2, Eukaryota
GeneTreeiENSGT00940000176737
HOGENOMiCLU_010084_1_0_1
InParanoidiP40467
OMAiYTIYKMD

Enzyme and pathway databases

BioCyciYEAST:G3O-31381-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40467
RNActiP40467, protein

Family and domain databases

CDDicd00067, GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906, Fungal_trans, 1 hit
SM00066, GAL4, 1 hit
SUPFAMiSSF57701, SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASG1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40467
Secondary accession number(s): D6VVF7, Q45U13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 12, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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