Fork head protein homolog 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• centromeric DNA binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A winged helix protein from yeast Saccharomyces cerevisiae recognizes centromere sequences."
    Myrich E., Shiyanova T., Liao X.
    Arch. Biochem. Biophys. 375:78-82(2000) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: SGDInferred from direct assayⁱ
  • "Fkh1 and Fkh2 bind multiple chromosomal elements in the S. cerevisiae genome with distinct specificities and cell cycle dynamics."
    Ostrow A.Z., Nellimoottil T., Knott S.R., Fox C.A., Tavare S., Aparicio O.M.
    PLoS ONE 9:e87647-e87647(2014) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: SGDInferred from direct assayⁱ
  • "Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth."
    Zhu G., Spellman P.T., Volpe T., Brown P.O., Botstein D., Davis T.N., Futcher B.
    Nature 406:90-94(2000) [PubMed] [Europe PMC] [Abstract]
  • "Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation."
    Hollenhorst P.C., Pietz G., Fox C.A.
    Genes Dev. 15:2445-2456(2001) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: SGDInferred from direct assayⁱ
  • "Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth."
    Zhu G., Spellman P.T., Volpe T., Brown P.O., Botstein D., Davis T.N., Futcher B.
    Nature 406:90-94(2000) [PubMed] [Europe PMC] [Abstract]
• DNA replication origin binding Source: SGDInferred from direct assayⁱ
  • "Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae."
    Knott S.R., Peace J.M., Ostrow A.Z., Gan Y., Rex A.E., Viggiani C.J., Tavare S., Aparicio O.M.
    Cell 148:99-111(2012) [PubMed] [Europe PMC] [Abstract]
  • "Fkh1 and Fkh2 bind multiple chromosomal elements in the S. cerevisiae genome with distinct specificities and cell cycle dynamics."
    Ostrow A.Z., Nellimoottil T., Knott S.R., Fox C.A., Tavare S., Aparicio O.M.
    PLoS ONE 9:e87647-e87647(2014) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGDInferred from direct assayⁱ
  • "Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth."
    Zhu G., Spellman P.T., Volpe T., Brown P.O., Botstein D., Davis T.N., Futcher B.
    Nature 406:90-94(2000) [PubMed] [Europe PMC] [Abstract]
  • "Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation."
    Hollenhorst P.C., Pietz G., Fox C.A.
    Genes Dev. 15:2445-2456(2001) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: SGDInferred from direct assayⁱ
  • "Fkh1 and Fkh2 bind multiple chromosomal elements in the S. cerevisiae genome with distinct specificities and cell cycle dynamics."
    Ostrow A.Z., Nellimoottil T., Knott S.R., Fox C.A., Tavare S., Aparicio O.M.
    PLoS ONE 9:e87647-e87647(2014) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to methylmercury Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Overexpression of Bop3 confers resistance to methylmercury in Saccharomyces cerevisiae through interaction with other proteins such as Fkh1, Rts1, and Msn2."
    Hwang G.-W., Furuoya Y., Hiroshima A., Furuchi T., Naganuma A.
    Biochem. Biophys. Res. Commun. 330:378-385(2005) [PubMed] [Europe PMC] [Abstract]
• chromatin remodeling Source: SGDInferred from mutant phenotypeⁱ
  • "The Isw2 chromatin-remodeling ATPase cooperates with the Fkh2 transcription factor to repress transcription of the B-type cyclin gene CLB2."
    Sherriff J.A., Kent N.A., Mellor J.
    Mol. Cell. Biol. 27:2848-2860(2007) [PubMed] [Europe PMC] [Abstract]
• donor selection Source: SGDInferred from mutant phenotypeⁱ
  • "Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer."
    Sun K., Coic E., Zhou Z., Durrens P., Haber J.E.
    Genes Dev. 16:2085-2096(2002) [PubMed] [Europe PMC] [Abstract]
  • "Cell cycle-dependent regulation of Saccharomyces cerevisiae donor preference during mating-type switching by SBF (Swi4/Swi6) and Fkh1."
    Coic E., Sun K., Wu C., Haber J.E.
    Mol. Cell. Biol. 26:5470-5480(2006) [PubMed] [Europe PMC] [Abstract]
  • "Binding of the Fkh1 Forkhead Associated Domain to a Phosphopeptide within the Mph1 DNA Helicase Regulates Mating-Type Switching in Budding Yeast."
    Dummer A.M., Su Z., Cherney R., Choi K., Denu J., Zhao X., Fox C.A.
    PLoS Genet. 12:e1006094-e1006094(2016) [PubMed] [Europe PMC] [Abstract]
• mRNA 3'-end processing Source: SGDInferred from mutant phenotypeⁱ
  • "Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast."
    Morillon A., O'Sullivan J., Azad A., Proudfoot N., Mellor J.
    Science 300:492-495(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of pseudohyphal growth Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae."
    Hollenhorst P.C., Bose M.E., Mielke M.R., Muller U., Fox C.A.
    Genetics 154:1533-1548(2000) [PubMed] [Europe PMC] [Abstract]
  • "Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth."
    Zhu G., Spellman P.T., Volpe T., Brown P.O., Botstein D., Davis T.N., Futcher B.
    Nature 406:90-94(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription elongation from RNA polymerase II promoter Source: SGDInferred from mutant phenotypeⁱ
  • "Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast."
    Morillon A., O'Sullivan J., Azad A., Proudfoot N., Mellor J.
    Science 300:492-495(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGDInferred from genetic interactionⁱ
  • "Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth."
    Zhu G., Spellman P.T., Volpe T., Brown P.O., Botstein D., Davis T.N., Futcher B.
    Nature 406:90-94(2000) [PubMed] [Europe PMC] [Abstract]
  • "Forkhead proteins control the outcome of transcription factor binding by antiactivation."
    Voth W.P., Yu Y., Takahata S., Kretschmann K.L., Lieb J.D., Parker R.L., Milash B., Stillman D.J.
    EMBO J. 26:4324-4334(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGDInferred from mutant phenotypeⁱ
  • "Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae."
    Hollenhorst P.C., Bose M.E., Mielke M.R., Muller U., Fox C.A.
    Genetics 154:1533-1548(2000) [PubMed] [Europe PMC] [Abstract]
  • "Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin."
    Casey L., Patterson E.E., Muller U., Fox C.A.
    Mol. Biol. Cell 19:608-622(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of chromatin silencing at silent mating-type cassette Source: SGDInferred from mutant phenotypeⁱ
  • "Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae."
    Hollenhorst P.C., Bose M.E., Mielke M.R., Muller U., Fox C.A.
    Genetics 154:1533-1548(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-dependent DNA replication initiation Source: SGDInferred from mutant phenotypeⁱ
  • "Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae."
    Knott S.R., Peace J.M., Ostrow A.Z., Gan Y., Rex A.E., Viggiani C.J., Tavare S., Aparicio O.M.
    Cell 148:99-111(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA replication initiation Source: SGDInferred from mutant phenotypeⁱ
  • "Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase."
    Peace J.M., Villwock S.K., Zeytounian J.L., Gan Y., Aparicio O.M.
    Genome Res. 26:365-375(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGDInferred from genetic interactionⁱ
  • "Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae."
    Hollenhorst P.C., Bose M.E., Mielke M.R., Muller U., Fox C.A.
    Genetics 154:1533-1548(2000) [PubMed] [Europe PMC] [Abstract]
  • "Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth."
    Zhu G., Spellman P.T., Volpe T., Brown P.O., Botstein D., Davis T.N., Futcher B.
    Nature 406:90-94(2000) [PubMed] [Europe PMC] [Abstract]
  • "Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase."
    Kumar R., Reynolds D.M., Shevchenko A., Shevchenko A., Goldstone S.D., Dalton S.
    Curr. Biol. 10:896-906(2000) [PubMed] [Europe PMC] [Abstract]
  • "Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation."
    Hollenhorst P.C., Pietz G., Fox C.A.
    Genes Dev. 15:2445-2456(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• termination of RNA polymerase II transcription Source: SGDInferred from mutant phenotypeⁱ
  • "Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast."
    Morillon A., O'Sullivan J., Azad A., Proudfoot N., Mellor J.
    Science 300:492-495(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL 
        60         70         80         90        100
SIAREVNAYA KIAGCDWTYY VQKLEVTIGR NTDSLNLNAV PGTVVKKNID 
       110        120        130        140        150
IDLGPAKIVS RKHAAIRFNL ESGSWELQIF GRNGAKVNFR RIPTGPDSPP 
       160        170        180        190        200
TVLQSGCIID IGGVQMIFIL PEQETIISDY CLNHLMPKLL STYGTNGNNN 
       210        220        230        240        250
PLLRNIIEGS TYLREQRLQE EARLQQLDHL HTPLSSSSDV NPIGDPHGDT 
       260        270        280        290        300
IMMEEDEEDE NYTRGGIRPN TYTSSSNNAV TNGNVPHIEN PSDLSLDENR 
       310        320        330        340        350
YIKPPQSYAS MITQAILSTP EGSISLADIY KFISDNYAFY RFSQMAWQNS 
       360        370        380        390        400
VRHNLSLNKA FEKVPKRAGQ QGKGMNWKIS DEVRRDFLNK WNAGKLSKIR 
       410        420        430        440        450
RGASVTRQLQ LHMSKFGEIP APESSSIDPR GIKAQKVKKS LQATSSILGE 
       460        470        480 
SAPQLQRTQL TGQISTTTSM DVTTNANVNN SSLS                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome IX
   Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names