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Protein

Mitochondrial FAD carrier protein FLX1

Gene

FLX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transport of FAD from the cytosol to the mitochondrial matrix.

GO - Molecular functioni

  • FAD transmembrane transporter activity Source: SGD
  • folic acid transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • FAD transport Source: SGD
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31385-MONOMER

Protein family/group databases

TCDBi2.A.29.10.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial FAD carrier protein FLX1
Gene namesi
Name:FLX1
Ordered Locus Names:YIL134W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL134W
SGDiS000001396 FLX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei129 – 149Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906821 – 311Mitochondrial FAD carrier protein FLX1Add BLAST311

Proteomic databases

PaxDbiP40464
PRIDEiP40464

PTM databases

CarbonylDBiP40464

Interactioni

Protein-protein interaction databases

BioGridi34857, 303 interactors
DIPiDIP-5662N
IntActiP40464, 3 interactors
MINTiP40464
STRINGi4932.YIL134W

Structurei

3D structure databases

ProteinModelPortaliP40464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 101Solcar 1Add BLAST95
Repeati123 – 210Solcar 2Add BLAST88
Repeati224 – 310Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149145
HOGENOMiHOG000188210
InParanoidiP40464
KOiK15115
OMAiLRPKYKG
OrthoDBiEOG092C43EV

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P40464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDHQWTPLQ KEVISGLSAG SVTTLVVHPL DLLKVRLQLS ATSAQKAHYG
60 70 80 90 100
PFMVIKEIIR SSANSGRSVT NELYRGLSIN LFGNAIAWGV YFGLYGVTKE
110 120 130 140 150
LIYKSVAKPG ETQLKGVGND HKMNSLIYLS AGASSGLMTA ILTNPIWVIK
160 170 180 190 200
TRIMSTSKGA QGAYTSMYNG VQQLLRTDGF QGLWKGLVPA LFGVSQGALY
210 220 230 240 250
FAVYDTLKQR KLRRKRENGL DIHLTNLETI EITSLGKMVS VTLVYPFQLL
260 270 280 290 300
KSNLQSFRAN EQKFRLFPLI KLIIANDGFV GLYKGLSANL VRAIPSTCIT
310
FCVYENLKHR L
Length:311
Mass (Da):34,409
Last modified:February 1, 1995 - v1
Checksum:i9309FFD0E3BCBEE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA Translation: CAA86144.1
L41168 Genomic DNA Translation: AAA64973.1
AY692757 Genomic DNA Translation: AAT92776.1
BK006942 Genomic DNA Translation: DAA08419.1
PIRiS48400
RefSeqiNP_012132.3, NM_001179482.3

Genome annotation databases

EnsemblFungiiYIL134W; YIL134W; YIL134W
GeneIDi854672
KEGGisce:YIL134W

Similar proteinsi

Entry informationi

Entry nameiFLX1_YEAST
AccessioniPrimary (citable) accession number: P40464
Secondary accession number(s): D6VVF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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