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Entry version 140 (02 Jun 2021)
Sequence version 1 (01 Feb 1995)
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Protein

EST/SMG-like protein 1

Gene

ESL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of gene expression responses of environment-sensing pathways.

1 Publication

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EST/SMG-like protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESL11 Publication
Ordered Locus Names:YIL151CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001413, ESL1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YIL151C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002029571 – 1118EST/SMG-like protein 1Add BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei170PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40456

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40456

PRoteomics IDEntifications database

More...
PRIDEi
P40456

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40456

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34841, 78 interactors

Database of interacting proteins

More...
DIPi
DIP-1904N

Protein interaction database and analysis system

More...
IntActi
P40456, 6 interactors

Molecular INTeraction database

More...
MINTi
P40456

STRING: functional protein association networks

More...
STRINGi
4932.YIL151C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40456, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P40456

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini947 – 1087PINcSequence analysisAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62DisorderedSequence analysisAdd BLAST62
Regioni77 – 119DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 31Polar residuesSequence analysisAdd BLAST20
Compositional biasi77 – 95Polar residuesSequence analysisAdd BLAST19
Compositional biasi102 – 119Polar residuesSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQKF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006407_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40456

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHIATVQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002716, PIN_dom
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13638, PIN_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00670, PINc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40456-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDLMVPAND DPSNETDYSR SNNNHTHIVS DMRPTSAAFL HQKRHSSSSH
60 70 80 90 100
NDTPESSFAK RRVPGIVDPV GKGFIDGITN SQISAQNTPS KTDDASRRPS
110 120 130 140 150
ISRKVMESTP QVKTSSIPTM DVPKSPYYVN RTMLARNMKV VSRDTYEDNA
160 170 180 190 200
NPQMRADEPL VASNGIYSNS QPQSQVTLSD IRRAPVVAAS PPPMIRQLPS
210 220 230 240 250
AQPNQTFIKK LQEIYKIIVV QETELQQRCL YLTTSQTTEL KSLWAIYRLN
260 270 280 290 300
TELIKNYINF IITALLTTQP INDLIMGQEI LDIYRIEKRL WVYGIITFLD
310 320 330 340 350
VLKNFSNFMD PEVCCQFIIY AFISVSNMLE DIPLKYSILW RQRLGDLSRM
360 370 380 390 400
AISLYPSGFI DWRLSAEYWY TESMKYIYGC GKLYYHIATV QQNSLEAFVN
410 420 430 440 450
LGKSVFCQDP FTPSQQTLQL LIENIYQSAF IDRSSGSANN NEIAHRNSQL
460 470 480 490 500
IDYLKHTEVM LLPSFLENMD LQHVVLMYFK DKFGKDFNGN DVFDTKDMFC
510 520 530 540 550
QNPESLRYYF RHAPAFAESQ LLQLIGFGNP KNPFALLFQL PKYLKLKKDK
560 570 580 590 600
REKKRSEATE TSSYTDPFDV QISSESYFQN IDALNSSFND IPTNLNIWLD
610 620 630 640 650
SLNHINMTSI QCSIHVLTKF LHAPLVVALP HFLTWLHFIV AILKKLEMVN
660 670 680 690 700
SKQVVAFWIH FLRRTMPWNS IVTLGNVLVC YMLDNLHPFL KKELEKFYSL
710 720 730 740 750
ELDDLIEYYN ENENLPEIWK CWGTLWFDAI KKCDVMEIPG VQDHLFFDSP
760 770 780 790 800
LDGIVFDEKD EVGEKFWMRS VRAVLLLKGI AKKFPDLGLK VSFQASVFCR
810 820 830 840 850
RNDIPPDYFL KNLTFKLDAY DEDNYNDNNE LDDLYDTIEI NEEIEAVNMD
860 870 880 890 900
PQATPNLSVV SGESIFEYTG YTRLAPDYHC FDKNGGFNSA FIYSQWSNVG
910 920 930 940 950
NGVTLDVSGE SIYDVANNNL SLHWEKIFFD KIAAASKGSD ENYNCTLYFV
960 970 980 990 1000
IDATSWLRHF AHIFKLAKNN TLKFAICLTT FQELRYLRGS KDDTVVEAAT
1010 1020 1030 1040 1050
RSVITIRQLY DEKKIIPMRF TGNIATHVEE NLEFEEQITW KTHVDEFVID
1060 1070 1080 1090 1100
AIAKLNQRFQ AERLTDENKN KGKEFAVLVT DDDNMNQKAK DRMIKTCNTK
1110
YLFSLGSKLG INSGLCTN
Length:1,118
Mass (Da):128,735
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F80F3A5E95C6CC3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z38059 Genomic DNA Translation: CAA86127.1
BK006942 Genomic DNA Translation: DAA08402.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48383

NCBI Reference Sequences

More...
RefSeqi
NP_012115.1, NM_001179499.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIL151C_mRNA; YIL151C; YIL151C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIL151C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA Translation: CAA86127.1
BK006942 Genomic DNA Translation: DAA08402.1
PIRiS48383
RefSeqiNP_012115.1, NM_001179499.1

3D structure databases

SMRiP40456
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi34841, 78 interactors
DIPiDIP-1904N
IntActiP40456, 6 interactors
MINTiP40456
STRINGi4932.YIL151C

PTM databases

iPTMnetiP40456

Proteomic databases

MaxQBiP40456
PaxDbiP40456
PRIDEiP40456

Genome annotation databases

EnsemblFungiiYIL151C_mRNA; YIL151C; YIL151C
GeneIDi854655
KEGGisce:YIL151C

Organism-specific databases

SGDiS000001413, ESL1
VEuPathDBiFungiDB:YIL151C

Phylogenomic databases

eggNOGiENOG502QQKF, Eukaryota
GeneTreeiENSGT00940000176784
HOGENOMiCLU_006407_0_0_1
InParanoidiP40456
OMAiYHIATVQ

Enzyme and pathway databases

ReactomeiR-SCE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40456
RNActiP40456, protein

Family and domain databases

InterProiView protein in InterPro
IPR002716, PIN_dom
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13638, PIN_4, 1 hit
SMARTiView protein in SMART
SM00670, PINc, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESL1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40456
Secondary accession number(s): D6VVD6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 2, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
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