We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P40452 (COA1_YEAST)
Protein
Cytochrome c oxidase assembly factor 1
Gene
COA1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.
2 PublicationsMiscellaneous
Present with 1680 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- mitochondrial cytochrome c oxidase assembly Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase assembly factor 1 |
Gene namesi | Name:COA1 Synonyms:FMP35 Ordered Locus Names:YIL157C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001419, COA1 |
VEuPathDBi | FungiDB:YIL157C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane Curated; Single-pass membrane protein Curated
Mitochondrion
- integral component of mitochondrial inner membrane Source: SGD
- integral component of mitochondrial membrane Source: SGD
- mitochondrion Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 73 | Mitochondrial matrixSequence analysisAdd BLAST | 73 | |
Transmembranei | 74 – 94 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 197 | Mitochondrial intermembraneSequence analysisAdd BLAST | 103 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202954 | 1 – 197 | Cytochrome c oxidase assembly factor 1Add BLAST | 197 |
Proteomic databases
MaxQBi | P40452 |
PaxDbi | P40452 |
PRIDEi | P40452 |
PTM databases
iPTMneti | P40452 |
Interactioni
Subunit structurei
Interacts with COX1, COX14, MSS51 and SHY1.
2 PublicationsBinary interactionsi
P40452
With | #Exp. | IntAct |
---|---|---|
COX14 [P39103] | 2 | EBI-25287,EBI-5113 |
MSS51 [P32335] | 3 | EBI-25287,EBI-11318 |
SHY1 [P53266] | 5 | EBI-25287,EBI-17111 |
Protein-protein interaction databases
BioGRIDi | 34835, 92 interactors |
DIPi | DIP-4708N |
IntActi | P40452, 6 interactors |
MINTi | P40452 |
STRINGi | 4932.YIL157C |
Miscellaneous databases
RNActi | P40452, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the COA1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZQV, Eukaryota |
HOGENOMi | CLU_092488_2_1_1 |
InParanoidi | P40452 |
OMAi | EFLIHEW |
Family and domain databases
InterProi | View protein in InterPro IPR014807, Coa1 IPR042432, Coa1_fungi |
PANTHERi | PTHR28523, PTHR28523, 1 hit |
Pfami | View protein in Pfam PF08695, Coa1, 1 hit |
i Sequence
Sequence statusi: Complete.
P40452-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLRLVTKGL PKVTPSAAKA VLVRGSLLHS FSTSARFNNS VAEDEAKIVL
60 70 80 90 100
KDKNRPLRID RELPDPTTER RKRIAGFLLF SVAIGSALSL IFNYEKTESP
110 120 130 140 150
IISNTLYYIR RSPATKNILG ESIEFDGIIP WVYGELNSVK GRINITFYIK
160 170 180 190
GDKNVTGTVR LVADRNTHDE EFLIHEWSVT AAGQKIDLLA ENTKTPI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38059 Genomic DNA Translation: CAA86121.1 BK006942 Genomic DNA Translation: DAA08395.1 |
PIRi | S48377 |
RefSeqi | NP_012109.1, NM_001179505.1 |
Genome annotation databases
EnsemblFungii | YIL157C_mRNA; YIL157C; YIL157C |
GeneIDi | 854649 |
KEGGi | sce:YIL157C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38059 Genomic DNA Translation: CAA86121.1 BK006942 Genomic DNA Translation: DAA08395.1 |
PIRi | S48377 |
RefSeqi | NP_012109.1, NM_001179505.1 |
3D structure databases
SMRi | P40452 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34835, 92 interactors |
DIPi | DIP-4708N |
IntActi | P40452, 6 interactors |
MINTi | P40452 |
STRINGi | 4932.YIL157C |
PTM databases
iPTMneti | P40452 |
Proteomic databases
MaxQBi | P40452 |
PaxDbi | P40452 |
PRIDEi | P40452 |
Genome annotation databases
EnsemblFungii | YIL157C_mRNA; YIL157C; YIL157C |
GeneIDi | 854649 |
KEGGi | sce:YIL157C |
Organism-specific databases
SGDi | S000001419, COA1 |
VEuPathDBi | FungiDB:YIL157C |
Phylogenomic databases
eggNOGi | ENOG502RZQV, Eukaryota |
HOGENOMi | CLU_092488_2_1_1 |
InParanoidi | P40452 |
OMAi | EFLIHEW |
Miscellaneous databases
PROi | PR:P40452 |
RNActi | P40452, protein |
Family and domain databases
InterProi | View protein in InterPro IPR014807, Coa1 IPR042432, Coa1_fungi |
PANTHERi | PTHR28523, PTHR28523, 1 hit |
Pfami | View protein in Pfam PF08695, Coa1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COA1_YEAST | |
Accessioni | P40452Primary (citable) accession number: P40452 Secondary accession number(s): D6VVC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - SIMILARITY comments
Index of protein domains and families