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Entry version 138 (02 Jun 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Secreted protein CSS1

Gene

CSS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted protein that may be involved in cell wall organization and biosynthesis.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secreted protein CSS11 Publication
Alternative name(s):
Condition specific secretion protein 11 Publication
Haze protective factor 1'1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSS11 Publication
Synonyms:HPF1'
Ordered Locus Names:YIL169C
ORF Names:YI9402.07C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001431, CSS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YIL169C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreases haze protective activity in white wine.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001433024 – 995Secreted protein CSS1Add BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40442

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40442

PRoteomics IDEntifications database

More...
PRIDEi
P40442

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P40442

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40442

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced in both high and low pH environments.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34825, 20 interactors

Database of interacting proteins

More...
DIPi
DIP-3929N

Protein interaction database and analysis system

More...
IntActi
P40442, 2 interactors

Molecular INTeraction database

More...
MINTi
P40442

STRING: functional protein association networks

More...
STRINGi
4932.YIL169C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40442, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 253Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni98 – 276DisorderedSequence analysisAdd BLAST179

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRP1/TIP1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000179085

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016111_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40442

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDDNGCK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021031, Hyphal-reg_cell_wall_N
IPR004089, MCPsignal_dom
IPR000727, T_SNARE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11765, Hyphal_reg_CWP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P40442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNRLNKFQA ALALALYSQS ALGQYYSNST SISSNSSSTS VVSSSSGSVS
60 70 80 90 100
ISSSIAETSS SATDILSSIT QSASSTSGVS SSVGPSSSSV VSSSVSQSSS
110 120 130 140 150
SVSDVSSSVS QSSSSASDVS SSVSQSASST SDVSSSVSQS SSSASDVSSS
160 170 180 190 200
VSQSSSSASD VSSSVSQSAS SASDVSSSVS QSASSTSDVS SSVSQSSSSA
210 220 230 240 250
SDVSSSVSQS SSSASDVSSS VSQSASSTSD VSSSVSQSAS STSGVSSSGS
260 270 280 290 300
QSVSSASGSS SSFPQSTSSA STASGSATSN SLSSITSSAS SASATASNSL
310 320 330 340 350
SSSDGTIYLP TTTISGDLTL TGKVIATEGV VVAAGAKLTL LDGDKYSFSA
360 370 380 390 400
DLKVYGDLLV KKSKETYPGT EFDISGENFD VTGNFNAEES AATSASIYSF
410 420 430 440 450
TPSSFDNSGD ISLSLSKSKK GEVTFSPYSN SGAFSFSNAI LNGGSVSGLQ
460 470 480 490 500
RRDDTEGSVN NGEINLDNGS TYVIVEPVSG KGTVNIISGN LYLHYPDTFT
510 520 530 540 550
GQTVVFKGEG VLAVDPTETN ATPIPVVGYT GKNQIAITAD ITALSYDGTT
560 570 580 590 600
GVLTATQGNR QFSFAIGTGF SSSDFSVSEG IFAGAYAYYL NYNGVVATSA
610 620 630 640 650
ASSSTASGAS ASVTGSTSFG ASVTGSTAST SFGASVTGST ASTSFGASVT
660 670 680 690 700
GSTSVYTTTL DYVNATSTVV VSCSETTDSN GNVYTITTTV PCSSTTATIT
710 720 730 740 750
SCDETGCHVS TSTGAVVTET VSSKSYTTAT VTHCDDNGCN TKTVTSECSK
760 770 780 790 800
ETSATTASPK SYTTVTVTHC DDNGCNTKTV TSEAPEATTT TTVSSQSYTT
810 820 830 840 850
ATVTHCDDNG CKTKTVTSEA PEATTTTVSP KTYTTATVTQ CDDNGCSTKT
860 870 880 890 900
VTSECPEETS ATTTSPKSYT TVTVTHCDDN GCNTKTVTSE APEATTTTVS
910 920 930 940 950
PKTYTTATVT QCDDNGCSTK TVTSEAPKET SETSETSAAP KDIHYCHWLL
960 970 980 990
NGDDNGCNVK IITSKIPEAT STVTQLVLLQ SHTLLSLLRV LKQPH
Length:995
Mass (Da):99,736
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF63E287A03F137EC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z46921 Genomic DNA Translation: CAA87023.1
BK006942 Genomic DNA Translation: DAA08386.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50358

NCBI Reference Sequences

More...
RefSeqi
NP_012097.1, NM_001179517.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIL169C_mRNA; YIL169C; YIL169C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIL169C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46921 Genomic DNA Translation: CAA87023.1
BK006942 Genomic DNA Translation: DAA08386.1
PIRiS50358
RefSeqiNP_012097.1, NM_001179517.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34825, 20 interactors
DIPiDIP-3929N
IntActiP40442, 2 interactors
MINTiP40442
STRINGi4932.YIL169C

PTM databases

CarbonylDBiP40442
iPTMnetiP40442

Proteomic databases

MaxQBiP40442
PaxDbiP40442
PRIDEiP40442

Genome annotation databases

EnsemblFungiiYIL169C_mRNA; YIL169C; YIL169C
GeneIDi854637
KEGGisce:YIL169C

Organism-specific databases

SGDiS000001431, CSS1
VEuPathDBiFungiDB:YIL169C

Phylogenomic databases

eggNOGiKOG1216, Eukaryota
GeneTreeiENSGT00940000179085
HOGENOMiCLU_016111_1_0_1
InParanoidiP40442
OMAiCDDNGCK

Enzyme and pathway databases

ReactomeiR-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40442
RNActiP40442, protein

Family and domain databases

InterProiView protein in InterPro
IPR021031, Hyphal-reg_cell_wall_N
IPR004089, MCPsignal_dom
IPR000727, T_SNARE_dom
PfamiView protein in Pfam
PF11765, Hyphal_reg_CWP, 1 hit
PROSITEiView protein in PROSITE
PS50111, CHEMOTAXIS_TRANSDUC_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40442
Secondary accession number(s): D6VVC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 2, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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