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Protein

Homeobox protein extradenticle

Gene

exd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi238 – 300Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP40427

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein extradenticle
Short name:
Dpbx
Gene namesi
Name:exd
ORF Names:CG8933
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000611 exd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Weak posterior-directed transformations in all 3 thoracic segments and in the anterior segments of the abdomen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488751 – 376Homeobox protein extradenticleAdd BLAST376

Proteomic databases

PaxDbiP40427
PRIDEiP40427

Expressioni

Tissue specificityi

Prior to full germband retraction it is ubiquitously present, after germband retraction, mostly present in the anterior portion of the ventral nerve cord.2 Publications

Developmental stagei

Expressed both maternally and zygotically at all stages of development.4 Publications

Gene expression databases

BgeeiFBgn0000611 Expressed in 76 organ(s), highest expression level in wing disc (Drosophila)
ExpressionAtlasiP40427 baseline and differential
GenevisibleiP40427 DM

Interactioni

Subunit structurei

Interacts with Ubx and hth.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi58911, 37 interactors
DIPiDIP-18773N
IntActiP40427, 11 interactors
MINTiP40427
STRINGi7227.FBpp0073940

Structurei

Secondary structure

1376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP40427
SMRiP40427
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40427

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi127 – 135Poly-Ala9

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
InParanoidiP40427
KOiK09355
OMAiSMQSLNG
OrthoDBiEOG091G10TD
PhylomeDBiP40427

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P40427-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDPNRMLAH TGGMMAPQGY GLSGQDDGQN AGSENEVRKQ KDIGEILQQI
60 70 80 90 100
MSISEQSLDE AQARKHTLNC HRMKPALFSV LCEIKEKTVL SIRNTQEEEP
110 120 130 140 150
PDPQLMRLDN MLIAEGVAGP EKGGGGAAAA SAAAASQGGS LSIDGADNAI
160 170 180 190 200
EHSDYRAKLA QIRQIYHQEL EKYEQACNEF TTHVMNLLRE QSRTRPITPK
210 220 230 240 250
EIERMVQIIH KKFSSIQMQL KQSTCEAVMI LRSRFLDARR KRRNFSKQAS
260 270 280 290 300
EILNEYFYSH LSNPYPSEEA KEELARKCGI TVSQVSNWFG NKRIRYKKNI
310 320 330 340 350
GKAQEEANLY AAKKAAGASP YSMAGPPSGT TTPMMSPAPP QDSMGYPMGS
360 370
GGYDQQQPYD NSMGGYDPNL HQDLSP
Length:376
Mass (Da):41,692
Last modified:February 1, 1995 - v1
Checksum:i79E3DC8F1F6B711F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PHV1M9PHV1_DROME
Extradenticle, isoform D
exd anon-EST:fe1H3, DExd, Dm-EXD, Dmel\CG8933, Dpbx exd anon-EST:fe1H3, DExd, Dm-EXD, Dmel\CG8933, Dpbx, EXD, Exd, l(1)IV, lincRNA.S9404, Pbx1, td48, CG8933, Dmel_CG8933
376Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98E → G in CAA79313 (PubMed:8100142).Curated1
Sequence conflicti344M → K in CAA79313 (PubMed:8100142).Curated1
Sequence conflicti363M → T in CAA79313 (PubMed:8100142).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33747 Genomic DNA Translation: AAC46903.1
L19295 mRNA Translation: AAC37182.1
AE014298 Genomic DNA Translation: AAF48555.1
AY061065 mRNA Translation: AAL28613.1
Z18864 mRNA Translation: CAA79313.1
PIRiA48840
RefSeqiNP_001259592.1, NM_001272663.2
NP_001259593.1, NM_001272664.1
NP_523360.1, NM_078636.5
NP_727923.1, NM_167478.3
UniGeneiDm.174

Genome annotation databases

EnsemblMetazoaiFBtr0074135; FBpp0073940; FBgn0000611
FBtr0074137; FBpp0073942; FBgn0000611
FBtr0333322; FBpp0305514; FBgn0000611
FBtr0333323; FBpp0305515; FBgn0000611
GeneIDi32567
KEGGidme:Dmel_CG8933
UCSCiCG8933-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33747 Genomic DNA Translation: AAC46903.1
L19295 mRNA Translation: AAC37182.1
AE014298 Genomic DNA Translation: AAF48555.1
AY061065 mRNA Translation: AAL28613.1
Z18864 mRNA Translation: CAA79313.1
PIRiA48840
RefSeqiNP_001259592.1, NM_001272663.2
NP_001259593.1, NM_001272664.1
NP_523360.1, NM_078636.5
NP_727923.1, NM_167478.3
UniGeneiDm.174

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8IX-ray2.40B238-300[»]
2R5YX-ray2.60B238-300[»]
2R5ZX-ray2.60B238-300[»]
4CYCX-ray2.36B238-312[»]
4UUSX-ray2.55B/F238-312[»]
5ZJQX-ray2.44B237-310[»]
5ZJRX-ray3.03B237-310[»]
5ZJSX-ray2.90B237-310[»]
5ZJTX-ray2.40B237-310[»]
ProteinModelPortaliP40427
SMRiP40427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58911, 37 interactors
DIPiDIP-18773N
IntActiP40427, 11 interactors
MINTiP40427
STRINGi7227.FBpp0073940

Proteomic databases

PaxDbiP40427
PRIDEiP40427

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074135; FBpp0073940; FBgn0000611
FBtr0074137; FBpp0073942; FBgn0000611
FBtr0333322; FBpp0305514; FBgn0000611
FBtr0333323; FBpp0305515; FBgn0000611
GeneIDi32567
KEGGidme:Dmel_CG8933
UCSCiCG8933-RA d. melanogaster

Organism-specific databases

CTDi32567
FlyBaseiFBgn0000611 exd

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
InParanoidiP40427
KOiK09355
OMAiSMQSLNG
OrthoDBiEOG091G10TD
PhylomeDBiP40427

Enzyme and pathway databases

SignaLinkiP40427

Miscellaneous databases

ChiTaRSiexd fly
EvolutionaryTraceiP40427
GenomeRNAii32567
PROiPR:P40427

Gene expression databases

BgeeiFBgn0000611 Expressed in 76 organ(s), highest expression level in wing disc (Drosophila)
ExpressionAtlasiP40427 baseline and differential
GenevisibleiP40427 DM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXD_DROME
AccessioniPrimary (citable) accession number: P40427
Secondary accession number(s): A4V4K5, Q0KHS1, Q9V3S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 10, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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