PBX2

Functionⁱ

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	244 – 306	Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST		63

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12054735
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18973687

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

embryonic limb morphogenesis Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 19356220
proximal/distal pattern formation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P40425

SIGNORⁱ

P40425

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pre-B-cell leukemia transcription factor 2 Alternative name(s): Homeobox protein PBX2 Protein G17
Gene namesⁱ	Name:PBX2 Synonyms:G17
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204304.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8633 PBX2
MIMⁱ	176311 gene
neXtProtⁱ	NX_P40425

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5089
Open Targets More...OpenTargetsⁱ	ENSG00000204304
PharmGKBⁱ	PA32971

Polymorphism and mutation databases

BioMutaⁱ	PBX2
DMDMⁱ	1352729

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049237	1 – 430	Pre-B-cell leukemia transcription factor 2Add BLAST		430

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	136	PhosphoserineCombined sources	1
Modified residueⁱ	151	PhosphoserineCombined sources	1
Modified residueⁱ	159	PhosphoserineBy similarity	1
Modified residueⁱ	330	PhosphoserineCombined sources	1
Modified residueⁱ	395	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P40425
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40425
PaxDbⁱ	P40425
PeptideAtlas More...PeptideAtlasⁱ	P40425
PRIDEⁱ	P40425
ProteomicsDBⁱ	55369

PTM databases

iPTMnetⁱ	P40425
PhosphoSitePlusⁱ	P40425

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.

Gene expression databases

Bgeeⁱ	ENSG00000204304 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_PBX2
ExpressionAtlasⁱ	P40425 baseline and differential
Genevisibleⁱ	P40425 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA061478

HPAⁱ

HPA061478

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CARD9	Q9H257	3	EBI-348489,EBI-751319
HOXA1	P49639	3	EBI-348489,EBI-740785

GO - Molecular functionⁱ

transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18973687

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111122, 37 interactors
CORUMⁱ	P40425
IntActⁱ	P40425, 43 interactors
Molecular INTeraction database More...MINTⁱ	P40425
STRINGⁱ	9606.ENSP00000364190

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P40425
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	137 – 145	Poly-Ala		9

Sequence similaritiesⁱ

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0774 Eukaryota ENOG410XRVF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016426
HOVERGENⁱ	HBG000122
InParanoidⁱ	P40425
KEGG Orthology (KO) More...KOⁱ	K15609
OMAⁱ	GAGQMYS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10TD
PhylomeDBⁱ	P40425
TreeFamⁱ	TF314340

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR005542 PBX
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03792 PBC, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P40425-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK 
        60         70         80         90        100
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL 
       110        120        130        140        150
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV 
       160        170        180        190        200
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT 
       210        220        230        240        250
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN 
       260        270        280        290        300
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 
       310        320        330        340        350
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS 
       360        370        380        390        400
GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR 
       410        420        430
ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN

Length:430

Mass (Da):45,881

Last modified:February 1, 1996 - v2

Checksum:ⁱEF2FFA158C4DAF68

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	393	M → I in CAA42503 (PubMed:1682799).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59842 mRNA Translation: CAA42503.1 X80700 Genomic DNA Translation: CAA56717.1 D28769 Genomic DNA Translation: BAA05957.1 U89336 Genomic DNA Translation: AAB47490.1 AL662884 Genomic DNA No translation available. AL662830 Genomic DNA No translation available. AL845464 Genomic DNA No translation available. BX284686 Genomic DNA No translation available. BX927239 Genomic DNA No translation available. CR933878 Genomic DNA No translation available. CR812478 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03613.1 BC082261 mRNA Translation: AAH82261.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4748.1
PIRⁱ	A56002
NCBI Reference Sequences More...RefSeqⁱ	NP_002577.2, NM_002586.4
UniGeneⁱ	Hs.509545 Hs.718462

Genome annotation databases

Ensemblⁱ	ENST00000375050; ENSP00000364190; ENSG00000204304 ENST00000383270; ENSP00000372757; ENSG00000206315 ENST00000420432; ENSP00000410710; ENSG00000236353 ENST00000431537; ENSP00000390009; ENSG00000232005 ENST00000433552; ENSP00000391745; ENSG00000224952 ENST00000453487; ENSP00000403948; ENSG00000225987 ENST00000453961; ENSP00000397177; ENSG00000237344
GeneIDⁱ	5089
KEGGⁱ	hsa:5089
UCSC genome browser More...UCSCⁱ	uc003oav.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P40425	HCG2039588		HUMAN		430	UniRef100_P40425
PBX homeobox 2		PANTR		430
PBX homeobox 2		GORGO		403
pre-B-cell leukemia transcription factor 2		TARSY		370
Uncharacterized protein		PANPA		370

Protein	Similar proteins		Species	Score	Length	Source
P40425	Pre-B-cell leukemia transcription factor 2		MOUSE		430	UniRef90_P40425
HCG2039588		HUMAN		430
PBX homeobox 2		PANTR		430
PBX homeobox 2		GORGO		403
pre-B-cell leukemia transcription factor 2		TARSY		370
+118

Protein	Similar proteins		Species	Score	Length	Source
P40425	Pre-B-cell leukemia transcription factor 2		MOUSE		430	UniRef50_P40425
Pre-B-cell leukemia transcription factor 3		HUMAN		434
Pre-B-cell leukemia transcription factor 2		XENLA		445
PBX homeobox 2		PANTR		430
PBX homeobox 2		GORGO		403
+313

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59842 mRNA Translation: CAA42503.1 X80700 Genomic DNA Translation: CAA56717.1 D28769 Genomic DNA Translation: BAA05957.1 U89336 Genomic DNA Translation: AAB47490.1 AL662884 Genomic DNA No translation available. AL662830 Genomic DNA No translation available. AL845464 Genomic DNA No translation available. BX284686 Genomic DNA No translation available. BX927239 Genomic DNA No translation available. CR933878 Genomic DNA No translation available. CR812478 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03613.1 BC082261 mRNA Translation: AAH82261.1
CCDSⁱ	CCDS4748.1
PIRⁱ	A56002
RefSeqⁱ	NP_002577.2, NM_002586.4
UniGeneⁱ	Hs.509545 Hs.718462

3D structure databases

ProteinModelPortalⁱ	P40425
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111122, 37 interactors
CORUMⁱ	P40425
IntActⁱ	P40425, 43 interactors
MINTⁱ	P40425
STRINGⁱ	9606.ENSP00000364190

PTM databases

iPTMnetⁱ	P40425
PhosphoSitePlusⁱ	P40425

Polymorphism and mutation databases

BioMutaⁱ	PBX2
DMDMⁱ	1352729

Proteomic databases

EPDⁱ	P40425
MaxQBⁱ	P40425
PaxDbⁱ	P40425
PeptideAtlasⁱ	P40425
PRIDEⁱ	P40425
ProteomicsDBⁱ	55369

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5089
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375050; ENSP00000364190; ENSG00000204304 ENST00000383270; ENSP00000372757; ENSG00000206315 ENST00000420432; ENSP00000410710; ENSG00000236353 ENST00000431537; ENSP00000390009; ENSG00000232005 ENST00000433552; ENSP00000391745; ENSG00000224952 ENST00000453487; ENSP00000403948; ENSG00000225987 ENST00000453961; ENSP00000397177; ENSG00000237344
GeneIDⁱ	5089
KEGGⁱ	hsa:5089
UCSCⁱ	uc003oav.2 human

Organism-specific databases

CTDⁱ	5089
DisGeNETⁱ	5089
EuPathDBⁱ	HostDB:ENSG00000204304.11
GeneCardsⁱ	PBX2
HGNCⁱ	HGNC:8633 PBX2
HPAⁱ	HPA061478
MIMⁱ	176311 gene
neXtProtⁱ	NX_P40425
OpenTargetsⁱ	ENSG00000204304
PharmGKBⁱ	PA32971
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0774 Eukaryota ENOG410XRVF LUCA
GeneTreeⁱ	ENSGT00390000016426
HOVERGENⁱ	HBG000122
InParanoidⁱ	P40425
KOⁱ	K15609
OMAⁱ	GAGQMYS
OrthoDBⁱ	EOG091G10TD
PhylomeDBⁱ	P40425
TreeFamⁱ	TF314340

Enzyme and pathway databases

SIGNORⁱ	P40425

SIGNORⁱ

P40425

Miscellaneous databases

ChiTaRSⁱ	PBX2 human
GeneWikiⁱ	PBX2
GenomeRNAiⁱ	5089
Protein Ontology More...PROⁱ	PR:P40425
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204304 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_PBX2
ExpressionAtlasⁱ	P40425 baseline and differential
Genevisibleⁱ	P40425 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR005542 PBX
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03792 PBC, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PBX2_HUMAN
Accessionⁱ	P40425Primary (citable) accession number: P40425 Secondary accession number(s): A2BFJ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P40425 (PBX2_HUMAN)

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Pre-B-cell leukemia transcription factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ