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UniProtKB - P40425 (PBX2_HUMAN)

Entry version 196 (25 May 2022)
Sequence version 2 (01 Feb 1996)
Previous versions | rss
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Protein

Pre-B-cell leukemia transcription factor 2

Gene

PBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi244 – 306Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P40425

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P40425

SIGNOR Signaling Network Open Resource

More...SIGNORi		P40425

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 2
Alternative name(s):
Homeobox protein PBX2
Protein G17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBX2
Synonyms:G17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8633, PBX2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176311, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P40425

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204304

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5089

Open Targets

More...OpenTargetsi		ENSG00000204304

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32971

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P40425, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PBX2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1352729

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000492371 – 430Pre-B-cell leukemia transcription factor 2Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei136PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei330PhosphoserineCombined sources1
Modified residuei395PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P40425

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P40425

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P40425

MaxQB - The MaxQuant DataBase

More...MaxQBi		P40425

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P40425

PeptideAtlas

More...PeptideAtlasi		P40425

PRoteomics IDEntifications database

More...PRIDEi		P40425

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55369

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P40425, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P40425

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P40425

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P40425

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204304, Expressed in left lobe of thyroid gland and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P40425, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P40425, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204304, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9.

Interacts with PBXIP1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111122, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P40425

Protein interaction database and analysis system

More...IntActi		P40425, 64 interactors

Molecular INTeraction database

More...MINTi		P40425

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364190

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P40425, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P40425

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P40425

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 243PBCPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni55 – 134PBC-APROSITE-ProRule annotationAdd BLAST80
Regioni137 – 243PBC-BPROSITE-ProRule annotationAdd BLAST107
Regioni326 – 347DisorderedSequence analysisAdd BLAST22
Regioni378 – 430DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi405 – 430Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0774, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041153_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40425

Identification of Orthologs from Complete Genome Data

More...OMAi		HALHEPP

Database of Orthologous Groups

More...OrthoDBi		804740at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P40425

TreeFam database of animal gene trees

More...TreeFami		TF314340

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR005542, PBX

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit
PF03792, PBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS51978, PBC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40425-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK 
        60         70         80         90        100
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL 
       110        120        130        140        150
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV 
       160        170        180        190        200
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT 
       210        220        230        240        250
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN 
       260        270        280        290        300
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 
       310        320        330        340        350
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS 
       360        370        380        390        400
GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR 
       410        420        430
ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN
Length:430
Mass (Da):45,881
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF2FFA158C4DAF68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti393M → I in CAA42503 (PubMed:1682799).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X59842 mRNA Translation: CAA42503.1
X80700 Genomic DNA Translation: CAA56717.1
D28769 Genomic DNA Translation: BAA05957.1
U89336 Genomic DNA Translation: AAB47490.1
AL662884 Genomic DNA No translation available.
AL662830 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03613.1
BC082261 mRNA Translation: AAH82261.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4748.1

Protein sequence database of the Protein Information Resource

More...PIRi		A56002

NCBI Reference Sequences

More...RefSeqi		NP_002577.2, NM_002586.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375050.6; ENSP00000364190.3; ENSG00000204304.12
ENST00000383270.4; ENSP00000372757.4; ENSG00000206315.9
ENST00000420432.2; ENSP00000410710.2; ENSG00000236353.7
ENST00000431537.2; ENSP00000390009.2; ENSG00000232005.7
ENST00000433552.2; ENSP00000391745.2; ENSG00000224952.7
ENST00000453487.2; ENSP00000403948.2; ENSG00000225987.7
ENST00000453961.2; ENSP00000397177.2; ENSG00000237344.7

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5089

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5089

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000375050.6; ENSP00000364190.3; NM_002586.5; NP_002577.2

UCSC genome browser

More...UCSCi		uc003oav.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59842 mRNA Translation: CAA42503.1
X80700 Genomic DNA Translation: CAA56717.1
D28769 Genomic DNA Translation: BAA05957.1
U89336 Genomic DNA Translation: AAB47490.1
AL662884 Genomic DNA No translation available.
AL662830 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03613.1
BC082261 mRNA Translation: AAH82261.1
CCDSiCCDS4748.1
PIRiA56002
RefSeqiNP_002577.2, NM_002586.4

3D structure databases

AlphaFoldDBiP40425
SMRiP40425
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111122, 62 interactors
CORUMiP40425
IntActiP40425, 64 interactors
MINTiP40425
STRINGi9606.ENSP00000364190

PTM databases

GlyGeniP40425, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP40425
MetOSiteiP40425
PhosphoSitePlusiP40425

Genetic variation databases

BioMutaiPBX2
DMDMi1352729

Proteomic databases

EPDiP40425
jPOSTiP40425
MassIVEiP40425
MaxQBiP40425
PaxDbiP40425
PeptideAtlasiP40425
PRIDEiP40425
ProteomicsDBi55369

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28518, 197 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		5089

Genome annotation databases

EnsembliENST00000375050.6; ENSP00000364190.3; ENSG00000204304.12
ENST00000383270.4; ENSP00000372757.4; ENSG00000206315.9
ENST00000420432.2; ENSP00000410710.2; ENSG00000236353.7
ENST00000431537.2; ENSP00000390009.2; ENSG00000232005.7
ENST00000433552.2; ENSP00000391745.2; ENSG00000224952.7
ENST00000453487.2; ENSP00000403948.2; ENSG00000225987.7
ENST00000453961.2; ENSP00000397177.2; ENSG00000237344.7
GeneIDi5089
KEGGihsa:5089
MANE-SelectiENST00000375050.6; ENSP00000364190.3; NM_002586.5; NP_002577.2
UCSCiuc003oav.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5089
DisGeNETi5089

GeneCards: human genes, protein and diseases

More...GeneCardsi		PBX2
HGNCiHGNC:8633, PBX2
HPAiENSG00000204304, Low tissue specificity
MIMi176311, gene
neXtProtiNX_P40425
OpenTargetsiENSG00000204304
PharmGKBiPA32971
VEuPathDBiHostDB:ENSG00000204304

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0774, Eukaryota
GeneTreeiENSGT00940000160293
HOGENOMiCLU_041153_0_0_1
InParanoidiP40425
OMAiHALHEPP
OrthoDBi804740at2759
PhylomeDBiP40425
TreeFamiTF314340

Enzyme and pathway databases

PathwayCommonsiP40425
SignaLinkiP40425
SIGNORiP40425

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5089, 26 hits in 1096 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PBX2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PBX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5089
PharosiP40425, Tbio

Protein Ontology

More...PROi		PR:P40425
RNActiP40425, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204304, Expressed in left lobe of thyroid gland and 233 other tissues
ExpressionAtlasiP40425, baseline and differential
GenevisibleiP40425, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR005542, PBX
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF03792, PBC, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS51978, PBC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPBX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40425
Secondary accession number(s): A2BFJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: May 25, 2022
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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