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UniProtKB - P40425 (PBX2_HUMAN)
Protein
Pre-B-cell leukemia transcription factor 2
Gene
PBX2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 244 – 306 | Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST | 63 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- brain development Source: GO_Central
- embryonic limb morphogenesis Source: Ensembl
- embryonic organ development Source: GO_Central
- eye development Source: GO_Central
- neuron development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- proximal/distal pattern formation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P40425 |
SignaLinki | P40425 |
SIGNORi | P40425 |
Names & Taxonomyi
Protein namesi | Recommended name: Pre-B-cell leukemia transcription factor 2Alternative name(s): Homeobox protein PBX2 Protein G17 |
Gene namesi | Name:PBX2 Synonyms:G17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8633, PBX2 |
MIMi | 176311, gene |
neXtProti | NX_P40425 |
VEuPathDBi | HostDB:ENSG00000204304 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5089 |
OpenTargetsi | ENSG00000204304 |
PharmGKBi | PA32971 |
Miscellaneous databases
Pharosi | P40425, Tbio |
Genetic variation databases
BioMutai | PBX2 |
DMDMi | 1352729 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049237 | 1 – 430 | Pre-B-cell leukemia transcription factor 2Add BLAST | 430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 136 | PhosphoserineCombined sources | 1 | |
Modified residuei | 151 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphoserineBy similarity | 1 | |
Modified residuei | 330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P40425 |
jPOSTi | P40425 |
MassIVEi | P40425 |
MaxQBi | P40425 |
PaxDbi | P40425 |
PeptideAtlasi | P40425 |
PRIDEi | P40425 |
ProteomicsDBi | 55369 |
PTM databases
GlyGeni | P40425, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P40425 |
MetOSitei | P40425 |
PhosphoSitePlusi | P40425 |
Expressioni
Tissue specificityi
Ubiquitously expressed.
Gene expression databases
Bgeei | ENSG00000204304, Expressed in left lobe of thyroid gland and 233 other tissues |
ExpressionAtlasi | P40425, baseline and differential |
Genevisiblei | P40425, HS |
Organism-specific databases
HPAi | ENSG00000204304, Low tissue specificity |
Interactioni
Subunit structurei
Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9.
Interacts with PBXIP1.
2 PublicationsBinary interactionsi
P40425
GO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111122, 62 interactors |
CORUMi | P40425 |
IntActi | P40425, 64 interactors |
MINTi | P40425 |
STRINGi | 9606.ENSP00000364190 |
Miscellaneous databases
RNActi | P40425, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 243 | PBCPROSITE-ProRule annotationAdd BLAST | 196 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 55 – 134 | PBC-APROSITE-ProRule annotationAdd BLAST | 80 | |
Regioni | 137 – 243 | PBC-BPROSITE-ProRule annotationAdd BLAST | 107 | |
Regioni | 326 – 347 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 378 – 430 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 405 – 430 | Polar residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the TALE/PBX homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0774, Eukaryota |
GeneTreei | ENSGT00940000160293 |
HOGENOMi | CLU_041153_0_0_1 |
InParanoidi | P40425 |
OMAi | HALHEPP |
OrthoDBi | 804740at2759 |
PhylomeDBi | P40425 |
TreeFami | TF314340 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR005542, PBX |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03792, PBC, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS51978, PBC, 1 hit |
i Sequence
Sequence statusi: Complete.
P40425-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK
60 70 80 90 100
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL
110 120 130 140 150
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV
160 170 180 190 200
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT
210 220 230 240 250
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN
260 270 280 290 300
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI
310 320 330 340 350
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS
360 370 380 390 400
GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR
410 420 430
ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 393 | M → I in CAA42503 (PubMed:1682799).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59842 mRNA Translation: CAA42503.1 X80700 Genomic DNA Translation: CAA56717.1 D28769 Genomic DNA Translation: BAA05957.1 U89336 Genomic DNA Translation: AAB47490.1 AL662884 Genomic DNA No translation available. AL662830 Genomic DNA No translation available. AL845464 Genomic DNA No translation available. BX284686 Genomic DNA No translation available. BX927239 Genomic DNA No translation available. CR933878 Genomic DNA No translation available. CR812478 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03613.1 BC082261 mRNA Translation: AAH82261.1 |
CCDSi | CCDS4748.1 |
PIRi | A56002 |
RefSeqi | NP_002577.2, NM_002586.4 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59842 mRNA Translation: CAA42503.1 X80700 Genomic DNA Translation: CAA56717.1 D28769 Genomic DNA Translation: BAA05957.1 U89336 Genomic DNA Translation: AAB47490.1 AL662884 Genomic DNA No translation available. AL662830 Genomic DNA No translation available. AL845464 Genomic DNA No translation available. BX284686 Genomic DNA No translation available. BX927239 Genomic DNA No translation available. CR933878 Genomic DNA No translation available. CR812478 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03613.1 BC082261 mRNA Translation: AAH82261.1 |
CCDSi | CCDS4748.1 |
PIRi | A56002 |
RefSeqi | NP_002577.2, NM_002586.4 |
3D structure databases
AlphaFoldDBi | P40425 |
SMRi | P40425 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111122, 62 interactors |
CORUMi | P40425 |
IntActi | P40425, 64 interactors |
MINTi | P40425 |
STRINGi | 9606.ENSP00000364190 |
PTM databases
GlyGeni | P40425, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P40425 |
MetOSitei | P40425 |
PhosphoSitePlusi | P40425 |
Genetic variation databases
BioMutai | PBX2 |
DMDMi | 1352729 |
Proteomic databases
EPDi | P40425 |
jPOSTi | P40425 |
MassIVEi | P40425 |
MaxQBi | P40425 |
PaxDbi | P40425 |
PeptideAtlasi | P40425 |
PRIDEi | P40425 |
ProteomicsDBi | 55369 |
Protocols and materials databases
Antibodypediai | 28518, 197 antibodies from 25 providers |
DNASUi | 5089 |
Genome annotation databases
Organism-specific databases
CTDi | 5089 |
DisGeNETi | 5089 |
GeneCardsi | PBX2 |
HGNCi | HGNC:8633, PBX2 |
HPAi | ENSG00000204304, Low tissue specificity |
MIMi | 176311, gene |
neXtProti | NX_P40425 |
OpenTargetsi | ENSG00000204304 |
PharmGKBi | PA32971 |
VEuPathDBi | HostDB:ENSG00000204304 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0774, Eukaryota |
GeneTreei | ENSGT00940000160293 |
HOGENOMi | CLU_041153_0_0_1 |
InParanoidi | P40425 |
OMAi | HALHEPP |
OrthoDBi | 804740at2759 |
PhylomeDBi | P40425 |
TreeFami | TF314340 |
Enzyme and pathway databases
PathwayCommonsi | P40425 |
SignaLinki | P40425 |
SIGNORi | P40425 |
Miscellaneous databases
BioGRID-ORCSi | 5089, 26 hits in 1096 CRISPR screens |
ChiTaRSi | PBX2, human |
GeneWikii | PBX2 |
GenomeRNAii | 5089 |
Pharosi | P40425, Tbio |
PROi | PR:P40425 |
RNActi | P40425, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204304, Expressed in left lobe of thyroid gland and 233 other tissues |
ExpressionAtlasi | P40425, baseline and differential |
Genevisiblei | P40425, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR005542, PBX |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03792, PBC, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS51978, PBC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PBX2_HUMAN | |
Accessioni | P40425Primary (citable) accession number: P40425 Secondary accession number(s): A2BFJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families