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Protein

Pre-B-cell leukemia transcription factor 2

Gene

PBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi244 – 306Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP40425

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 2
Alternative name(s):
Homeobox protein PBX2
Protein G17
Gene namesi
Name:PBX2
Synonyms:G17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204304.11
HGNCiHGNC:8633 PBX2
MIMi176311 gene
neXtProtiNX_P40425

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5089
OpenTargetsiENSG00000204304
PharmGKBiPA32971

Polymorphism and mutation databases

BioMutaiPBX2
DMDMi1352729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492371 – 430Pre-B-cell leukemia transcription factor 2Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei330PhosphoserineCombined sources1
Modified residuei395PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP40425
MaxQBiP40425
PaxDbiP40425
PeptideAtlasiP40425
PRIDEiP40425
ProteomicsDBi55369

PTM databases

iPTMnetiP40425
PhosphoSitePlusiP40425

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000204304 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PBX2
ExpressionAtlasiP40425 baseline and differential
GenevisibleiP40425 HS

Organism-specific databases

HPAiHPA061478

Interactioni

Subunit structurei

Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111122, 37 interactors
CORUMiP40425
IntActiP40425, 43 interactors
MINTiP40425
STRINGi9606.ENSP00000364190

Structurei

3D structure databases

ProteinModelPortaliP40425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 145Poly-Ala9

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
HOVERGENiHBG000122
InParanoidiP40425
KOiK15609
OMAiGAGQMYS
OrthoDBiEOG091G10TD
PhylomeDBiP40425
TreeFamiTF314340

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40425-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK
60 70 80 90 100
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL
110 120 130 140 150
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV
160 170 180 190 200
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT
210 220 230 240 250
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN
260 270 280 290 300
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI
310 320 330 340 350
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS
360 370 380 390 400
GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR
410 420 430
ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN
Length:430
Mass (Da):45,881
Last modified:February 1, 1996 - v2
Checksum:iEF2FFA158C4DAF68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti393M → I in CAA42503 (PubMed:1682799).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59842 mRNA Translation: CAA42503.1
X80700 Genomic DNA Translation: CAA56717.1
D28769 Genomic DNA Translation: BAA05957.1
U89336 Genomic DNA Translation: AAB47490.1
AL662884 Genomic DNA No translation available.
AL662830 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03613.1
BC082261 mRNA Translation: AAH82261.1
CCDSiCCDS4748.1
PIRiA56002
RefSeqiNP_002577.2, NM_002586.4
UniGeneiHs.509545
Hs.718462

Genome annotation databases

EnsembliENST00000375050; ENSP00000364190; ENSG00000204304
ENST00000383270; ENSP00000372757; ENSG00000206315
ENST00000420432; ENSP00000410710; ENSG00000236353
ENST00000431537; ENSP00000390009; ENSG00000232005
ENST00000433552; ENSP00000391745; ENSG00000224952
ENST00000453487; ENSP00000403948; ENSG00000225987
ENST00000453961; ENSP00000397177; ENSG00000237344
GeneIDi5089
KEGGihsa:5089
UCSCiuc003oav.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59842 mRNA Translation: CAA42503.1
X80700 Genomic DNA Translation: CAA56717.1
D28769 Genomic DNA Translation: BAA05957.1
U89336 Genomic DNA Translation: AAB47490.1
AL662884 Genomic DNA No translation available.
AL662830 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03613.1
BC082261 mRNA Translation: AAH82261.1
CCDSiCCDS4748.1
PIRiA56002
RefSeqiNP_002577.2, NM_002586.4
UniGeneiHs.509545
Hs.718462

3D structure databases

ProteinModelPortaliP40425
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111122, 37 interactors
CORUMiP40425
IntActiP40425, 43 interactors
MINTiP40425
STRINGi9606.ENSP00000364190

PTM databases

iPTMnetiP40425
PhosphoSitePlusiP40425

Polymorphism and mutation databases

BioMutaiPBX2
DMDMi1352729

Proteomic databases

EPDiP40425
MaxQBiP40425
PaxDbiP40425
PeptideAtlasiP40425
PRIDEiP40425
ProteomicsDBi55369

Protocols and materials databases

DNASUi5089
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375050; ENSP00000364190; ENSG00000204304
ENST00000383270; ENSP00000372757; ENSG00000206315
ENST00000420432; ENSP00000410710; ENSG00000236353
ENST00000431537; ENSP00000390009; ENSG00000232005
ENST00000433552; ENSP00000391745; ENSG00000224952
ENST00000453487; ENSP00000403948; ENSG00000225987
ENST00000453961; ENSP00000397177; ENSG00000237344
GeneIDi5089
KEGGihsa:5089
UCSCiuc003oav.2 human

Organism-specific databases

CTDi5089
DisGeNETi5089
EuPathDBiHostDB:ENSG00000204304.11
GeneCardsiPBX2
HGNCiHGNC:8633 PBX2
HPAiHPA061478
MIMi176311 gene
neXtProtiNX_P40425
OpenTargetsiENSG00000204304
PharmGKBiPA32971
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
HOVERGENiHBG000122
InParanoidiP40425
KOiK15609
OMAiGAGQMYS
OrthoDBiEOG091G10TD
PhylomeDBiP40425
TreeFamiTF314340

Enzyme and pathway databases

SIGNORiP40425

Miscellaneous databases

ChiTaRSiPBX2 human
GeneWikiiPBX2
GenomeRNAii5089
PROiPR:P40425
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204304 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PBX2
ExpressionAtlasiP40425 baseline and differential
GenevisibleiP40425 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPBX2_HUMAN
AccessioniPrimary (citable) accession number: P40425
Secondary accession number(s): A2BFJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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