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Entry version 205 (10 Feb 2021)
Sequence version 3 (18 Sep 2013)
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Protein

Mitogen-activated protein kinase ERK-A

Gene

rl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues (PubMed:8157002, PubMed:19965758, PubMed:22140578, PubMed:27552662). Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways (PubMed:8157002). Required for embryonic epithelial tissue repair (PubMed:22140578). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei67ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei162Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi44 – 52ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.24, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110056, MAPK3 (ERK1) activation
R-DME-112409, RAF-independent MAPK1/3 activation
R-DME-112411, MAPK1 (ERK2) activation
R-DME-1169408, ISG15 antiviral mechanism
R-DME-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-DME-170968, Frs2-mediated activation
R-DME-198753, ERK/MAPK targets
R-DME-202670, ERKs are inactivated
R-DME-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DME-2559580, Oxidative Stress Induced Senescence
R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-DME-2559585, Oncogene Induced Senescence
R-DME-2871796, FCERI mediated MAPK activation
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-375165, NCAM signaling for neurite out-growth
R-DME-437239, Recycling pathway of L1
R-DME-445144, Signal transduction by L1
R-DME-450341, Activation of the AP-1 family of transcription factors
R-DME-5654726, Negative regulation of FGFR1 signaling
R-DME-5654727, Negative regulation of FGFR2 signaling
R-DME-5654732, Negative regulation of FGFR3 signaling
R-DME-5654733, Negative regulation of FGFR4 signaling
R-DME-5663213, RHO GTPases Activate WASPs and WAVEs
R-DME-5673001, RAF/MAP kinase cascade
R-DME-5674135, MAP2K and MAPK activation
R-DME-5674499, Negative feedback regulation of MAPK pathway
R-DME-5675221, Negative regulation of MAPK pathway
R-DME-6798695, Neutrophil degranulation
R-DME-74749, Signal attenuation
R-DME-881907, Gastrin-CREB signalling pathway via PKC and MAPK
R-DME-9627069, Regulation of the apoptosome activity
R-DME-9634635, Estrogen-stimulated signaling through PRKCZ
R-DME-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P40417

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase ERK-A (EC:2.7.11.24)
Alternative name(s):
Extracellular-regulated kinase A
Protein rolled
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rl1 PublicationImported
Synonyms:ERKa1 Publication, MAPK1 Publication
ORF Names:CG12559Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003256, rl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic wound healing defects (PubMed:22140578). RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage and increases adult weight (PubMed:19965758).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001863091 – 376Mitogen-activated protein kinase ERK-AAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei198Phosphothreonine1 Publication1
Modified residuei200Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Dually phosphorylated on Thr-198 and Tyr-200, which activates the enzyme (By similarity). Phosphorylated on tyrosine residue(s) in response to insulin.By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40417

PRoteomics IDEntifications database

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PRIDEi
P40417

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P40417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In third instar larvae, expressed in eye imaginal disks. In adults, expressed in head and body.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Embryos, larvae and adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003256, Expressed in embryo and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P40417, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P40417, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
78013, 85 interactors

Database of interacting proteins

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DIPi
DIP-17266N

Protein interaction database and analysis system

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IntActi
P40417, 13 interactors

Molecular INTeraction database

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MINTi
P40417

STRING: functional protein association networks

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STRINGi
7227.FBpp0112426

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P40417

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 326Protein kinasePROSITE-ProRule annotationAdd BLAST289

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi198 – 200TXY3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0660, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156771

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P40417

Identification of Orthologs from Complete Genome Data

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OMAi
DIYIVQC

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR003527, MAP_kinase_CS
IPR008349, MAPK_ERK1/2
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01770, ERK1ERK2MAPK

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01351, MAPK, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform C (identifier: P40417-3) [UniParc]FASTAAdd to basket
Also known as: D, E

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEFNSSGSV VNGTGSTEVP QSNAEVIRGQ IFEVGPRYIK LAYIGEGAYG
60 70 80 90 100
MVVSADDTLT NQRVAIKKIS PFEHQTYCQR TLREITILTR FKHENIIDIR
110 120 130 140 150
DILRVDSIDQ MRDVYIVQCL METDLYKLLK TQRLSNDHIC YFLYQILRGL
160 170 180 190 200
KYIHSANVLH RDLKPSNLLL NKTCDLKICD FGLARIADPE HDHTGFLTEY
210 220 230 240 250
VATRWYRAPE IMLNSKGYTK SIDIWSVGCI LAEMLSNRPI FPGKHYLDQL
260 270 280 290 300
NHILGVLGSP SRDDLECIIN EKARNYLESL PFKPNVPWAK LFPNADALAL
310 320 330 340 350
DLLGKMLTFN PHKRIPVEEA LAHPYLEQYY DPGDEPVAEV PFRINMENDD
360 370
ISRDALKSLI FEETLKFKER QPDNAP
Length:376
Mass (Da):43,151
Last modified:September 18, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2642B3CBB0F234D2
GO
Isoform H (identifier: P40417-1) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:266
Mass (Da):30,778
Checksum:iFF3E31EA7A9EDC24
GO
Isoform G (identifier: P40417-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.
     46-53: EGAYGMVV → MESALVIR

Show »
Length:331
Mass (Da):38,430
Checksum:iB4BC3B8FE279331A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y4W5A8Y4W5_DROME
RE73195p
rl 12559, 2, BcDNA:RE08694, CG18732, CT34260
190Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0477921 – 110Missing in isoform H. CuratedAdd BLAST110
Alternative sequenceiVSP_0477931 – 45Missing in isoform G. CuratedAdd BLAST45
Alternative sequenceiVSP_04779446 – 53EGAYGMVV → MESALVIR in isoform G. Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M95124 mRNA Translation: AAA28677.1
AE013599 Genomic DNA Translation: EAA46310.2
AE013599 Genomic DNA Translation: EAA46311.2
AE013599 Genomic DNA Translation: EAA46312.4
AE013599 Genomic DNA Translation: EDP28106.2
AE013599 Genomic DNA Translation: EDP28107.1
AE013599 Genomic DNA Translation: EYR77323.1
AY070996 mRNA Translation: AAL48618.1

Protein sequence database of the Protein Information Resource

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PIRi
A46036
B46036

NCBI Reference Sequences

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RefSeqi
NP_001015121.3, NM_001015121.3 [P40417-2]
NP_001015122.1, NM_001015122.3 [P40417-3]
NP_001015123.1, NM_001015123.3 [P40417-3]
NP_001104348.2, NM_001110878.4 [P40417-1]
NP_001104349.1, NM_001110879.2 [P40417-3]
NP_001287635.1, NM_001300706.2 [P40417-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0113700; FBpp0112423; FBgn0003256 [P40417-3]
FBtr0113702; FBpp0112425; FBgn0003256 [P40417-3]
FBtr0113703; FBpp0112426; FBgn0003256 [P40417-3]
FBtr0329919; FBpp0302952; FBgn0003256 [P40417-2]
FBtr0329920; FBpp0302953; FBgn0003256 [P40417-1]
FBtr0345337; FBpp0311493; FBgn0003256 [P40417-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3354888

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG12559

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95124 mRNA Translation: AAA28677.1
AE013599 Genomic DNA Translation: EAA46310.2
AE013599 Genomic DNA Translation: EAA46311.2
AE013599 Genomic DNA Translation: EAA46312.4
AE013599 Genomic DNA Translation: EDP28106.2
AE013599 Genomic DNA Translation: EDP28107.1
AE013599 Genomic DNA Translation: EYR77323.1
AY070996 mRNA Translation: AAL48618.1
PIRiA46036
B46036
RefSeqiNP_001015121.3, NM_001015121.3 [P40417-2]
NP_001015122.1, NM_001015122.3 [P40417-3]
NP_001015123.1, NM_001015123.3 [P40417-3]
NP_001104348.2, NM_001110878.4 [P40417-1]
NP_001104349.1, NM_001110879.2 [P40417-3]
NP_001287635.1, NM_001300706.2 [P40417-3]

3D structure databases

SMRiP40417
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi78013, 85 interactors
DIPiDIP-17266N
IntActiP40417, 13 interactors
MINTiP40417
STRINGi7227.FBpp0112426

PTM databases

iPTMnetiP40417

Proteomic databases

PaxDbiP40417
PRIDEiP40417

Genome annotation databases

EnsemblMetazoaiFBtr0113700; FBpp0112423; FBgn0003256 [P40417-3]
FBtr0113702; FBpp0112425; FBgn0003256 [P40417-3]
FBtr0113703; FBpp0112426; FBgn0003256 [P40417-3]
FBtr0329919; FBpp0302952; FBgn0003256 [P40417-2]
FBtr0329920; FBpp0302953; FBgn0003256 [P40417-1]
FBtr0345337; FBpp0311493; FBgn0003256 [P40417-3]
GeneIDi3354888
KEGGidme:Dmel_CG12559

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3354888
FlyBaseiFBgn0003256, rl

Phylogenomic databases

eggNOGiKOG0660, Eukaryota
GeneTreeiENSGT00940000156771
InParanoidiP40417
OMAiDIYIVQC

Enzyme and pathway databases

BRENDAi2.7.11.24, 1994
ReactomeiR-DME-110056, MAPK3 (ERK1) activation
R-DME-112409, RAF-independent MAPK1/3 activation
R-DME-112411, MAPK1 (ERK2) activation
R-DME-1169408, ISG15 antiviral mechanism
R-DME-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-DME-170968, Frs2-mediated activation
R-DME-198753, ERK/MAPK targets
R-DME-202670, ERKs are inactivated
R-DME-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DME-2559580, Oxidative Stress Induced Senescence
R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-DME-2559585, Oncogene Induced Senescence
R-DME-2871796, FCERI mediated MAPK activation
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-375165, NCAM signaling for neurite out-growth
R-DME-437239, Recycling pathway of L1
R-DME-445144, Signal transduction by L1
R-DME-450341, Activation of the AP-1 family of transcription factors
R-DME-5654726, Negative regulation of FGFR1 signaling
R-DME-5654727, Negative regulation of FGFR2 signaling
R-DME-5654732, Negative regulation of FGFR3 signaling
R-DME-5654733, Negative regulation of FGFR4 signaling
R-DME-5663213, RHO GTPases Activate WASPs and WAVEs
R-DME-5673001, RAF/MAP kinase cascade
R-DME-5674135, MAP2K and MAPK activation
R-DME-5674499, Negative feedback regulation of MAPK pathway
R-DME-5675221, Negative regulation of MAPK pathway
R-DME-6798695, Neutrophil degranulation
R-DME-74749, Signal attenuation
R-DME-881907, Gastrin-CREB signalling pathway via PKC and MAPK
R-DME-9627069, Regulation of the apoptosome activity
R-DME-9634635, Estrogen-stimulated signaling through PRKCZ
R-DME-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SignaLinkiP40417

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3354888, 1 hit in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
rl, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3354888

Protein Ontology

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PROi
PR:P40417

Gene expression databases

BgeeiFBgn0003256, Expressed in embryo and 26 other tissues
ExpressionAtlasiP40417, baseline and differential
GenevisibleiP40417, DM

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR003527, MAP_kinase_CS
IPR008349, MAPK_ERK1/2
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PRINTSiPR01770, ERK1ERK2MAPK
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351, MAPK, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERKA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40417
Secondary accession number(s): A0A021WW06
, A8Y4W1, A8Y4W2, Q7PL59, Q9W5M2, Q9W5M3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 18, 2013
Last modified: February 10, 2021
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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