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Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.2 Publications

Miscellaneous

Present with 3250 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei393Glutathione; via amide nitrogenBy similarity1
Binding sitei445ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi469 – 480ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

  • iron import into the mitochondrion Source: SGD
  • iron ion homeostasis Source: UniProtKB-KW
  • iron-sulfur cluster assembly Source: SGD

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32967-MONOMER
ReactomeiR-SCE-1369007 Mitochondrial ABC transporters
R-SCE-2564818 Cytosolic iron-sulfur cluster assembly (yeast)

Protein family/group databases

TCDBi3.A.1.210.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
Synonyms:MDY
Ordered Locus Names:YMR301C
ORF Names:YM9952.03C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR301C
SGDiS000004916 ATM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 110Mitochondrial matrixAdd BLAST84
Transmembranei111 – 132HelicalAdd BLAST22
Topological domaini133 – 155Mitochondrial intermembraneAdd BLAST23
Transmembranei156 – 179HelicalAdd BLAST24
Topological domaini180 – 228Mitochondrial matrixAdd BLAST49
Transmembranei229 – 252HelicalAdd BLAST24
Topological domaini253Mitochondrial intermembrane1
Transmembranei254 – 274HelicalAdd BLAST21
Topological domaini275 – 340Mitochondrial matrixAdd BLAST66
Transmembranei341 – 359HelicalAdd BLAST19
Topological domaini360 – 374Mitochondrial intermembraneAdd BLAST15
Transmembranei375 – 396HelicalAdd BLAST22
Topological domaini397 – 690Mitochondrial matrixAdd BLAST294

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi475K → M: Loss of function; significant decrease in ATP-binding; no homodimerization. 1 Publication1
Mutagenesisi598E → A: Loss of function; slight decrease in ATP-binding. 1 Publication1
Mutagenesisi666 – 690Missing : Impairs protein stability. 1 PublicationAdd BLAST25

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000000025827 – 690Iron-sulfur clusters transporter ATM1, mitochondrialAdd BLAST664

Proteomic databases

MaxQBiP40416
PaxDbiP40416
PRIDEiP40416

PTM databases

iPTMnetiP40416

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-3181,EBI-3181

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi35481, 99 interactors
DIPiDIP-7617N
IntActiP40416, 14 interactors
MINTiP40416
STRINGi4932.YMR301C

Structurei

Secondary structure

1690
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi103 – 105Combined sources3
Helixi106 – 109Combined sources4
Helixi110 – 126Combined sources17
Helixi128 – 137Combined sources10
Helixi152 – 198Combined sources47
Helixi203 – 208Combined sources6
Helixi212 – 215Combined sources4
Turni216 – 228Combined sources13
Helixi229 – 234Combined sources6
Helixi236 – 254Combined sources19
Helixi256 – 303Combined sources48
Helixi305 – 310Combined sources6
Helixi315 – 366Combined sources52
Beta strandi367 – 370Combined sources4
Helixi373 – 382Combined sources10
Helixi383 – 385Combined sources3
Helixi387 – 389Combined sources3
Turni390 – 393Combined sources4
Helixi397 – 411Combined sources15
Turni412 – 414Combined sources3
Beta strandi430 – 432Combined sources3
Beta strandi436 – 443Combined sources8
Beta strandi451 – 459Combined sources9
Beta strandi464 – 468Combined sources5
Helixi475 – 477Combined sources3
Helixi478 – 482Combined sources5
Beta strandi489 – 495Combined sources7
Helixi500 – 502Combined sources3
Helixi505 – 510Combined sources6
Beta strandi512 – 515Combined sources4
Beta strandi523 – 525Combined sources3
Helixi526 – 530Combined sources5
Helixi531 – 533Combined sources3
Helixi539 – 548Combined sources10
Helixi552 – 557Combined sources6
Helixi561 – 563Combined sources3
Beta strandi565 – 567Combined sources3
Helixi575 – 589Combined sources15
Beta strandi592 – 598Combined sources7
Helixi605 – 618Combined sources14
Beta strandi620 – 623Combined sources4
Beta strandi625 – 631Combined sources7
Helixi633 – 636Combined sources4
Beta strandi640 – 646Combined sources7
Beta strandi649 – 654Combined sources6
Helixi656 – 661Combined sources6
Helixi666 – 690Combined sources25

3D structure databases

ProteinModelPortaliP40416
SMRiP40416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 401ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini436 – 672ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni280 – 284Glutathione binding5
Regioni343 – 346Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00440000033373
InParanoidiP40416
KOiK05663
OMAiYEAQRYD
OrthoDBiEOG092C3H79

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLPRCPVI GRIVRSKFRS GLIRNHSPVI FTVSKLSTQR PLLFNSAVNL
60 70 80 90 100
WNQAQKDITH KKSVEQFSSA PKVKTQVKKT SKAPTLSELK ILKDLFRYIW
110 120 130 140 150
PKGNNKVRIR VLIALGLLIS AKILNVQVPF FFKQTIDSMN IAWDDPTVAL
160 170 180 190 200
PAAIGLTILC YGVARFGSVL FGELRNAVFA KVAQNAIRTV SLQTFQHLMK
210 220 230 240 250
LDLGWHLSRQ TGGLTRAMDR GTKGISQVLT AMVFHIIPIS FEISVVCGIL
260 270 280 290 300
TYQFGASFAA ITFSTMLLYS IFTIKTTAWR THFRRDANKA DNKAASVALD
310 320 330 340 350
SLINFEAVKY FNNEKYLADK YNGSLMNYRD SQIKVSQSLA FLNSGQNLIF
360 370 380 390 400
TTALTAMMYM GCTGVIGGNL TVGDLVLINQ LVFQLSVPLN FLGSVYRDLK
410 420 430 440 450
QSLIDMETLF KLRKNEVKIK NAERPLMLPE NVPYDITFEN VTFGYHPDRK
460 470 480 490 500
ILKNASFTIP AGWKTAIVGS SGSGKSTILK LVFRFYDPES GRILINGRDI
510 520 530 540 550
KEYDIDALRK VIGVVPQDTP LFNDTIWENV KFGRIDATDE EVITVVEKAQ
560 570 580 590 600
LAPLIKKLPQ GFDTIVGERG LMISGGEKQR LAIARVLLKN ARIMFFDEAT
610 620 630 640 650
SALDTHTEQA LLRTIRDNFT SGSRTSVYIA HRLRTIADAD KIIVLDNGRV
660 670 680 690
REEGKHLELL AMPGSLYREL WTIQEDLDHL ENELKDQQEL
Length:690
Mass (Da):77,522
Last modified:February 1, 1996 - v2
Checksum:i009757811D331343
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23I → IRNHS in CAA57938 (PubMed:7828591).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82612 Genomic DNA Translation: CAA57938.1
X81715 Genomic DNA Translation: CAA57359.1
Z49212 Genomic DNA Translation: CAA89134.1
BK006946 Genomic DNA Translation: DAA10202.1
PIRiS54211
RefSeqiNP_014030.1, NM_001182810.1

Genome annotation databases

EnsemblFungiiYMR301C; YMR301C; YMR301C
GeneIDi855347
KEGGisce:YMR301C

Similar proteinsi

Entry informationi

Entry nameiATM1_YEAST
AccessioniPrimary (citable) accession number: P40416
Secondary accession number(s): D6W0C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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