Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase class 4 mu/sigma chain

Gene

ADH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Zinc 1; catalytic1
Metal bindingi80Zinc 1; catalytic1
Metal bindingi110Zinc 21
Metal bindingi113Zinc 21
Metal bindingi116Zinc 21
Metal bindingi124Zinc 21
Metal bindingi186Zinc 1; catalytic1
Binding sitei235NAD1 Publication1
Binding sitei240NAD1 Publication1
Binding sitei381NAD1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 216NAD1 Publication6
Nucleotide bindingi304 – 306NAD1 Publication3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-71384 Ethanol oxidation

Chemistry databases

SwissLipidsiSLP:000001879

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase
Gene namesi
Name:ADH7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000196344.11
HGNCiHGNC:256 ADH7
MIMi600086 gene
neXtProtiNX_P40394

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi131
OpenTargetsiENSG00000196344
PharmGKBiPA24577

Chemistry databases

ChEMBLiCHEMBL3867
DrugBankiDB00898 Ethanol
DB00157 NADH

Polymorphism and mutation databases

BioMutaiADH7
DMDMi292495000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606911 – 386Alcohol dehydrogenase class 4 mu/sigma chainAdd BLAST386

Proteomic databases

PaxDbiP40394
PeptideAtlasiP40394
PRIDEiP40394
ProteomicsDBi55365
55366 [P40394-2]

PTM databases

iPTMnetiP40394
PhosphoSitePlusiP40394

Expressioni

Tissue specificityi

Preferentially expressed in stomach.

Gene expression databases

BgeeiENSG00000196344 Expressed in 92 organ(s), highest expression level in esophagus mucosa
CleanExiHS_ADH7
ExpressionAtlasiP40394 baseline and differential
GenevisibleiP40394 HS

Organism-specific databases

HPAiHPA039695

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106643, 4 interactors
STRINGi9606.ENSP00000420269

Chemistry databases

BindingDBiP40394

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP40394
SMRiP40394
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40394

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP40394
KOiK13951
OMAiVCEMSGH
OrthoDBiEOG091G08N3
PhylomeDBiP40394
TreeFamiTF300429

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR028635 Zinc_ADH_IV
PANTHERiPTHR43880:SF2 PTHR43880:SF2, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFAEIQIQDK DRMGTAGKVI KCKAAVLWEQ KQPFSIEEIE VAPPKTKEVR
60 70 80 90 100
IKILATGICR TDDHVIKGTM VSKFPVIVGH EATGIVESIG EGVTTVKPGD
110 120 130 140 150
KVIPLFLPQC RECNACRNPD GNLCIRSDIT GRGVLADGTT RFTCKGKPVH
160 170 180 190 200
HFMNTSTFTE YTVVDESSVA KIDDAAPPEK VCLIGCGFST GYGAAVKTGK
210 220 230 240 250
VKPGSTCVVF GLGGVGLSVI MGCKSAGASR IIGIDLNKDK FEKAMAVGAT
260 270 280 290 300
ECISPKDSTK PISEVLSEMT GNNVGYTFEV IGHLETMIDA LASCHMNYGT
310 320 330 340 350
SVVVGVPPSA KMLTYDPMLL FTGRTWKGCV FGGLKSRDDV PKLVTEFLAK
360 370 380
KFDLDQLITH VLPFKKISEG FELLNSGQSI RTVLTF
Length:386
Mass (Da):41,481
Last modified:March 23, 2010 - v2
Checksum:iE34C959778ED6817
GO
Isoform 2 (identifier: P40394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MFAEIQIQDKDRMGTAGK → MKCLVSRHTVRETLDMVFQRMSVEAG

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):42,467
Checksum:i2EBC96FC412B6729
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG85A0A0C4DG85_HUMAN
Alcohol dehydrogenase class 4 mu/si...
ADH7
374Annotation score:
E9PFG0E9PFG0_HUMAN
Alcohol dehydrogenase class 4 mu/si...
ADH7
317Annotation score:
C9JP14C9JP14_HUMAN
Alcohol dehydrogenase class 4 mu/si...
ADH7
107Annotation score:

Sequence cautioni

The sequence AAA19002 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC51351 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG35707 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA53960 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA53961 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9D → E in AAA19002 (PubMed:8195208).Curated1
Sequence conflicti32Q → R AA sequence (PubMed:1592118).Curated1
Sequence conflicti83T → R AA sequence (PubMed:1592118).Curated1
Sequence conflicti110C → V in AAB38424 (PubMed:8824810).Curated1
Sequence conflicti150 – 151HH → GR AA sequence (PubMed:1592118).Curated2
Sequence conflicti160 – 161EY → VI in AAB38424 (PubMed:8824810).Curated2
Sequence conflicti169V → E in AAB38424 (PubMed:8824810).Curated1
Sequence conflicti175A → T in BAG35707 (PubMed:14702039).Curated1
Sequence conflicti217L → V in AAB38424 (PubMed:8824810).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02436492G → A. Corresponds to variant dbSNP:rs1573496Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430931 – 18MFAEI…GTAGK → MKCLVSRHTVRETLDMVFQR MSVEAG in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76342 mRNA Translation: CAA53961.1 Different initiation.
X76342 mRNA Translation: CAA53960.1 Different initiation.
U07821 mRNA Translation: AAA19002.1 Different initiation.
U16293
, U16286, U16287, U16288, U16289, U16290, U16291, U16292 Genomic DNA Translation: AAC51351.1 Different initiation.
AK301696 mRNA Translation: BAG63168.1
AK312854 mRNA Translation: BAG35707.1 Different initiation.
AP001960 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06101.1
BC131512 mRNA Translation: AAI31513.1
L33179 mRNA Translation: AAA59211.1
U09623 mRNA Translation: AAA82165.1
L47166 Genomic DNA Translation: AAB38424.1
S77168 mRNA Translation: AAB34478.1
CCDSiCCDS34034.1 [P40394-1]
CCDS54781.1 [P40394-2]
PIRiA55878 DEHUAS
RefSeqiNP_000664.2, NM_000673.4 [P40394-1]
NP_001159976.1, NM_001166504.1 [P40394-2]
UniGeneiHs.389

Genome annotation databases

EnsembliENST00000209665; ENSP00000209665; ENSG00000196344 [P40394-1]
ENST00000476959; ENSP00000420269; ENSG00000196344 [P40394-2]
GeneIDi131
KEGGihsa:131
UCSCiuc003huv.2 human [P40394-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76342 mRNA Translation: CAA53961.1 Different initiation.
X76342 mRNA Translation: CAA53960.1 Different initiation.
U07821 mRNA Translation: AAA19002.1 Different initiation.
U16293
, U16286, U16287, U16288, U16289, U16290, U16291, U16292 Genomic DNA Translation: AAC51351.1 Different initiation.
AK301696 mRNA Translation: BAG63168.1
AK312854 mRNA Translation: BAG35707.1 Different initiation.
AP001960 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06101.1
BC131512 mRNA Translation: AAI31513.1
L33179 mRNA Translation: AAA59211.1
U09623 mRNA Translation: AAA82165.1
L47166 Genomic DNA Translation: AAB38424.1
S77168 mRNA Translation: AAB34478.1
CCDSiCCDS34034.1 [P40394-1]
CCDS54781.1 [P40394-2]
PIRiA55878 DEHUAS
RefSeqiNP_000664.2, NM_000673.4 [P40394-1]
NP_001159976.1, NM_001166504.1 [P40394-2]
UniGeneiHs.389

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGNX-ray3.00A/B/C/D14-386[»]
1D1SX-ray2.50A/B/C/D14-386[»]
1D1TX-ray2.40A/B/C/D14-386[»]
ProteinModelPortaliP40394
SMRiP40394
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106643, 4 interactors
STRINGi9606.ENSP00000420269

Chemistry databases

BindingDBiP40394
ChEMBLiCHEMBL3867
DrugBankiDB00898 Ethanol
DB00157 NADH
SwissLipidsiSLP:000001879

PTM databases

iPTMnetiP40394
PhosphoSitePlusiP40394

Polymorphism and mutation databases

BioMutaiADH7
DMDMi292495000

Proteomic databases

PaxDbiP40394
PeptideAtlasiP40394
PRIDEiP40394
ProteomicsDBi55365
55366 [P40394-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209665; ENSP00000209665; ENSG00000196344 [P40394-1]
ENST00000476959; ENSP00000420269; ENSG00000196344 [P40394-2]
GeneIDi131
KEGGihsa:131
UCSCiuc003huv.2 human [P40394-1]

Organism-specific databases

CTDi131
DisGeNETi131
EuPathDBiHostDB:ENSG00000196344.11
GeneCardsiADH7
HGNCiHGNC:256 ADH7
HPAiHPA039695
MIMi600086 gene
neXtProtiNX_P40394
OpenTargetsiENSG00000196344
PharmGKBiPA24577
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP40394
KOiK13951
OMAiVCEMSGH
OrthoDBiEOG091G08N3
PhylomeDBiP40394
TreeFamiTF300429

Enzyme and pathway databases

ReactomeiR-HSA-71384 Ethanol oxidation

Miscellaneous databases

EvolutionaryTraceiP40394
GeneWikiiADH7
GenomeRNAii131
PROiPR:P40394
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196344 Expressed in 92 organ(s), highest expression level in esophagus mucosa
CleanExiHS_ADH7
ExpressionAtlasiP40394 baseline and differential
GenevisibleiP40394 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR028635 Zinc_ADH_IV
PANTHERiPTHR43880:SF2 PTHR43880:SF2, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH7_HUMAN
AccessioniPrimary (citable) accession number: P40394
Secondary accession number(s): A2RRB6
, A8MVN9, B2R760, B4DWV6, Q13713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again