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Entry version 145 (11 Dec 2019)
Sequence version 2 (01 Feb 1996)
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Protein

Protein SOK1

Gene

SOK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High copy suppressor of a cyclic AMP-dependent protein kinase mutant.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • protein kinase A signaling Source: SGD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-29628-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SOK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOK1
Ordered Locus Names:YDR006C
ORF Names:YD8119.12C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR006C

Saccharomyces Genome Database

More...
SGDi
S000002413 SOK1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720351 – 901Protein SOK1Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P40317

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P40317

PRoteomics IDEntifications database

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PRIDEi
P40317

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40317

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32059, 188 interactors

Database of interacting proteins

More...
DIPi
DIP-5173N

Protein interaction database and analysis system

More...
IntActi
P40317, 4 interactors

Molecular INTeraction database

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MINTi
P40317

STRING: functional protein association networks

More...
STRINGi
4932.YDR006C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40317 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP11 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001027

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P40317

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVHLCKV

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008862 Tcp11

The PANTHER Classification System

More...
PANTHERi
PTHR12832 PTHR12832, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05794 Tcp11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40317-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQPRTHSGP TTASNPAPSS TNSSSAPSAT NSKQERSSSS LSKPSSVVPS
60 70 80 90 100
KDSPDGDAIA KTQAAALKND MKSGDTSTLD GSSQNIIPNR ASMQKYIDQS
110 120 130 140 150
SDLLSRSSGV ITPSMSLNAS TNATNNDSSG NSANSSDLKI PIDRDNTIFK
160 170 180 190 200
TFDTKTGQFL KNDDNEEEIR RNNKVDSIPP KNIYTNINNP SPSPPPSSKQ
210 220 230 240 250
PPSASAPQLP PATEPHKEQA AQQQPPGNAS NFLRIFSNKK MRSHSVPTIL
260 270 280 290 300
HSSLRKLSSH NQYYRNQNIL LNHPTPSGIS KKKFSRNHHQ PYLHSNNPLS
310 320 330 340 350
SNPLSLKRAI FLNQQISGNA STNANNDNIN NSTATSMTNQ SFLSSSNFDL
360 370 380 390 400
TLEDRINYIK ATPTPVPFPP INLQGLKEID LQEILKNPQL RHDIIFDPLL
410 420 430 440 450
QFRPNLDGER GNKKRQLANI YWNDVQNEIY VYSKRPEIFQ YNRSRLVPLF
460 470 480 490 500
DTLRDVLLTI VPQKESPMIN NVLDTELNIQ ELLKGSLIMS NLSGWLADLF
510 520 530 540 550
KHHCAPMRDP WVDKMSNKFK EAERDSSLTR LIEGLRLVFQ ILETMKLDIA
560 570 580 590 600
NHQIRILRPA LLSNAVEFEK QYFNTLIASK RVNLNTSLLW FDKKFNENVT
610 620 630 640 650
AGLVRNPSSI TIPDVYNICI RSIINLLSCR KMVREYPTPL SFDHARLILL
660 670 680 690 700
RADIRQIVCI LVCRLLFQQL VANDPSMDKA TKEYVIHTYS TKRLKNEIIS
710 720 730 740 750
IITDEHGNCR WTKNTMSIAV HLCKVIDDLH REYDNNGSCE QARRPQLPSL
760 770 780 790 800
DNSKITFAKS WLSKQTQPLS EVYGVLENRV FKSLEDAIFN RSECTIDGRV
810 820 830 840 850
KQDFVYLYNT NNGNVGSTNT LSTTTDTASV KISPSLMSPS KTSTTTPTGN
860 870 880 890 900
AIASRGLFAA TELEEFENVY RHLYALINLH WSVFGPHYIE MLGDKVNKKG

I
Length:901
Mass (Da):101,082
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC900DF2889541B98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti645A → R in AAA56922 (PubMed:8065298).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12027 Genomic DNA Translation: AAA56922.1
Z48008 Genomic DNA Translation: CAA88066.1
BK006938 Genomic DNA Translation: DAA11854.1

Protein sequence database of the Protein Information Resource

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PIRi
S50987

NCBI Reference Sequences

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RefSeqi
NP_010289.3, NM_001180314.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR006C_mRNA; YDR006C; YDR006C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR006C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12027 Genomic DNA Translation: AAA56922.1
Z48008 Genomic DNA Translation: CAA88066.1
BK006938 Genomic DNA Translation: DAA11854.1
PIRiS50987
RefSeqiNP_010289.3, NM_001180314.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi32059, 188 interactors
DIPiDIP-5173N
IntActiP40317, 4 interactors
MINTiP40317
STRINGi4932.YDR006C

PTM databases

iPTMnetiP40317

Proteomic databases

MaxQBiP40317
PaxDbiP40317
PRIDEiP40317

Genome annotation databases

EnsemblFungiiYDR006C_mRNA; YDR006C; YDR006C
GeneIDi851569
KEGGisce:YDR006C

Organism-specific databases

EuPathDBiFungiDB:YDR006C
SGDiS000002413 SOK1

Phylogenomic databases

HOGENOMiHOG000001027
InParanoidiP40317
OMAiAVHLCKV

Enzyme and pathway databases

BioCyciYEAST:G3O-29628-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40317
RNActiP40317 protein

Family and domain databases

InterProiView protein in InterPro
IPR008862 Tcp11
PANTHERiPTHR12832 PTHR12832, 2 hits
PfamiView protein in Pfam
PF05794 Tcp11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOK1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40317
Secondary accession number(s): D6VRZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: December 11, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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