UniProtKB - P40313 (CTRL_HUMAN)
Protein
Chymotrypsin-like protease CTRL-1
Gene
CTRL
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 75 | Charge relay systemBy similarity | 1 | |
Active sitei | 121 | Charge relay systemBy similarity | 1 | |
Active sitei | 214 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: GO_Central
- serine-type peptidase activity Source: GO_Central
GO - Biological processi
- protein catabolic process Source: GO_Central
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
PathwayCommonsi | P40313 |
Protein family/group databases
MEROPSi | S01.256 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CTRL Synonyms:CTRL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2524, CTRL |
MIMi | 118888, gene |
neXtProti | NX_P40313 |
VEuPathDBi | HostDB:ENSG00000141086.17 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1506 |
PharmGKBi | PA27025 |
Miscellaneous databases
Pharosi | P40313, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4873 |
Genetic variation databases
BioMutai | CTRL |
DMDMi | 729224 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000027660 | 19 – 33 | Activation peptideSequence analysisAdd BLAST | 15 | |
ChainiPRO_0000027661 | 34 – 264 | Chymotrypsin-like protease CTRL-1Add BLAST | 231 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 19 ↔ 141 | PROSITE-ProRule annotation | ||
Disulfide bondi | 60 ↔ 76 | PROSITE-ProRule annotation | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 155 ↔ 220 | PROSITE-ProRule annotation | ||
Disulfide bondi | 187 ↔ 201 | PROSITE-ProRule annotation | ||
Disulfide bondi | 210 ↔ 239 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | P40313 |
jPOSTi | P40313 |
MassIVEi | P40313 |
PaxDbi | P40313 |
PeptideAtlasi | P40313 |
PRIDEi | P40313 |
ProteomicsDBi | 55361 |
PTM databases
GlyGeni | P40313, 1 site |
iPTMneti | P40313 |
PhosphoSitePlusi | P40313 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141086, Expressed in pancreas and 117 other tissues |
ExpressionAtlasi | P40313, baseline |
Genevisiblei | P40313, HS |
Organism-specific databases
HPAi | ENSG00000141086, Tissue enriched (pancreas) |
Interactioni
Binary interactionsi
Hide detailsP40313
With | #Exp. | IntAct |
---|---|---|
CLDN5 [O00501] | 3 | EBI-7883667,EBI-18400628 |
FAM209A [Q5JX71] | 3 | EBI-7883667,EBI-18304435 |
FATE1 [Q969F0] | 3 | EBI-7883667,EBI-743099 |
Protein-protein interaction databases
BioGRIDi | 107886, 8 interactors |
IntActi | P40313, 7 interactors |
MINTi | P40313 |
STRINGi | 9606.ENSP00000458537 |
Chemistry databases
BindingDBi | P40313 |
Miscellaneous databases
RNActi | P40313, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 262 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 229 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000154494 |
HOGENOMi | CLU_006842_7_6_1 |
InParanoidi | P40313 |
OMAi | KFSTWIN |
OrthoDBi | 1522379at2759 |
PhylomeDBi | P40313 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P40313-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS
60 70 80 90 100
LQDSSGFHFC GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ
110 120 130 140 150
VLSVSRAITH PSWNSTTMNN DVTLLKLASP AQYTTRISPV CLASSNEALT
160 170 180 190 200
EGLTCVTTGW GRLSGVGNVT PAHLQQVALP LVTVNQCRQY WGSSITDSMI
210 220 230 240 250
CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN VRAPAVYTRV
260
SKFSTWINQV IAYN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L162 | I3L162_HUMAN | Chymotrypsin-like protease CTRL-1 | CTRL | 190 | Annotation score: | ||
I3NI28 | I3NI28_HUMAN | Chymotrypsin-like protease CTRL-1 | CTRL | 190 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051834 | 150 | T → I. Corresponds to variant dbSNP:rs11552953Ensembl. | 1 | |
Natural variantiVAR_021939 | 173 | H → R. Corresponds to variant dbSNP:rs1134760Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71874 Genomic DNA Translation: CAA50710.1 X71877 mRNA Translation: CAA50711.1 BC063475 mRNA Translation: AAH63475.1 |
CCDSi | CCDS10852.1 |
PIRi | I38136 |
RefSeqi | NP_001898.1, NM_001907.2 |
Genome annotation databases
Ensembli | ENST00000574481; ENSP00000458537; ENSG00000141086 |
GeneIDi | 1506 |
KEGGi | hsa:1506 |
UCSCi | uc002euw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71874 Genomic DNA Translation: CAA50710.1 X71877 mRNA Translation: CAA50711.1 BC063475 mRNA Translation: AAH63475.1 |
CCDSi | CCDS10852.1 |
PIRi | I38136 |
RefSeqi | NP_001898.1, NM_001907.2 |
3D structure databases
SMRi | P40313 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107886, 8 interactors |
IntActi | P40313, 7 interactors |
MINTi | P40313 |
STRINGi | 9606.ENSP00000458537 |
Chemistry databases
BindingDBi | P40313 |
ChEMBLi | CHEMBL4873 |
Protein family/group databases
MEROPSi | S01.256 |
PTM databases
GlyGeni | P40313, 1 site |
iPTMneti | P40313 |
PhosphoSitePlusi | P40313 |
Genetic variation databases
BioMutai | CTRL |
DMDMi | 729224 |
Proteomic databases
EPDi | P40313 |
jPOSTi | P40313 |
MassIVEi | P40313 |
PaxDbi | P40313 |
PeptideAtlasi | P40313 |
PRIDEi | P40313 |
ProteomicsDBi | 55361 |
Protocols and materials databases
Antibodypediai | 15944, 199 antibodies |
DNASUi | 1506 |
Genome annotation databases
Ensembli | ENST00000574481; ENSP00000458537; ENSG00000141086 |
GeneIDi | 1506 |
KEGGi | hsa:1506 |
UCSCi | uc002euw.4, human |
Organism-specific databases
CTDi | 1506 |
DisGeNETi | 1506 |
GeneCardsi | CTRL |
HGNCi | HGNC:2524, CTRL |
HPAi | ENSG00000141086, Tissue enriched (pancreas) |
MIMi | 118888, gene |
neXtProti | NX_P40313 |
PharmGKBi | PA27025 |
VEuPathDBi | HostDB:ENSG00000141086.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000154494 |
HOGENOMi | CLU_006842_7_6_1 |
InParanoidi | P40313 |
OMAi | KFSTWIN |
OrthoDBi | 1522379at2759 |
PhylomeDBi | P40313 |
Enzyme and pathway databases
PathwayCommonsi | P40313 |
Miscellaneous databases
BioGRID-ORCSi | 1506, 8 hits in 980 CRISPR screens |
ChiTaRSi | CTRL, human |
GeneWikii | CTRL_(gene) |
GenomeRNAii | 1506 |
Pharosi | P40313, Tchem |
PROi | PR:P40313 |
RNActi | P40313, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141086, Expressed in pancreas and 117 other tissues |
ExpressionAtlasi | P40313, baseline |
Genevisiblei | P40313, HS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTRL_HUMAN | |
Accessioni | P40313Primary (citable) accession number: P40313 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families