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Protein

Interferon alpha-inducible protein 27, mitochondrial

Gene

IFI27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.1 Publication

GO - Molecular functioni

  • lamin binding Source: MGI
  • RNA polymerase II activating transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 27, mitochondrial
Short name:
p27
Alternative name(s):
Interferon alpha-induced 11.5 kDa protein
Interferon-stimulated gene 12a protein
Short name:
ISG12(a)
Gene namesi
Name:IFI27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5397 IFI27
MIMi600009 gene
neXtProtiNX_P40305

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi3429
PharmGKBiPA29643

Polymorphism and mutation databases

BioMutaiIFI27
DMDMi116242590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000014737234 – 119Interferon alpha-inducible protein 27, mitochondrialAdd BLAST86

Proteomic databases

MaxQBiP40305
PaxDbiP40305
PeptideAtlasiP40305
PRIDEiP40305
ProteomicsDBi55359
TopDownProteomicsiP40305

PTM databases

iPTMnetiP40305
PhosphoSitePlusiP40305

Expressioni

Inductioni

Up-regulated by interferons.1 Publication

Gene expression databases

CleanExiHS_IFI27

Organism-specific databases

HPAiHPA028875

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109655, 2 interactors
IntActiP40305, 15 interactors
STRINGi9606.ENSP00000298902

Structurei

3D structure databases

ProteinModelPortaliP40305
SMRiP40305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JFVP Eukaryota
ENOG410Z2RX LUCA
HOGENOMiHOG000112988
HOVERGENiHBG099821
InParanoidiP40305
PhylomeDBiP40305
TreeFamiTF340510

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

P40305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAVPMVLSA
60 70 80 90 100
MGFTAAGIAS SSIAAKMMSA AAIANGGGVA SGSLVATLQS LGATGLSGLT
110
KFILGSIGSA IAAVIARFY
Length:119
Mass (Da):11,268
Last modified:October 17, 2006 - v3
Checksum:i242C9388FEF8FF9C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZF8A0A087WZF8_HUMAN
Interferon alpha-inducible protein ...
IFI27
79Annotation score:
Q9H4B1Q9H4B1_HUMAN
ISG12 protein
IFI27 P27
60Annotation score:
A8K0H0A8K0H0_HUMAN
Interferon alpha-inducible protein ...
IFI27 hCG_22330
122Annotation score:
A0A087WUJ8A0A087WUJ8_HUMAN
Interferon alpha-inducible protein ...
IFI27
96Annotation score:
A0A087WV79A0A087WV79_HUMAN
Interferon alpha-inducible protein ...
IFI27
65Annotation score:
A0A087X174A0A087X174_HUMAN
Interferon alpha-inducible protein ...
IFI27
112Annotation score:
A0A087WZR1A0A087WZR1_HUMAN
Interferon alpha-inducible protein ...
IFI27
119Annotation score:
G3V4U3G3V4U3_HUMAN
Interferon alpha-inducible protein ...
IFI27
40Annotation score:
A0A087X035A0A087X035_HUMAN
Interferon alpha-inducible protein ...
IFI27
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → VAMA in CAA47739 (PubMed:8358738).Curated1
Sequence conflicti86A → G in CAA47739 (PubMed:8358738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028066106S → F. Corresponds to variant dbSNP:rs2227974Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67325 mRNA Translation: CAA47739.1
BT006781 mRNA Translation: AAP35427.1
AM393107 mRNA Translation: CAL37985.1
BC015492 mRNA Translation: AAH15492.1
BN000227 mRNA Translation: CAE00394.1
CCDSiCCDS32148.1
PIRiI38081
RefSeqiNP_001123552.1, NM_001130080.2
NP_001275881.1, NM_001288952.1
NP_001275883.1, NM_001288954.1
NP_001275885.1, NM_001288956.1
NP_001275886.1, NM_001288957.1
NP_001275887.1, NM_001288958.1
NP_001275924.1, NM_001288995.1
NP_005523.3, NM_005532.4
UniGeneiHs.532634

Genome annotation databases

EnsembliENST00000298902; ENSP00000298902; ENSG00000165949
ENST00000555744; ENSP00000451956; ENSG00000165949
GeneIDi3429
KEGGihsa:3429

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFI27_HUMAN
AccessioniPrimary (citable) accession number: P40305
Secondary accession number(s): Q53YA6, Q6IEC1, Q96BK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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