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Protein

Interferon alpha-inducible protein 27, mitochondrial

Gene

IFI27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).By similarity6 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • lamin binding Source: MGI
  • RNA polymerase II activating transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Apoptosis, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 27, mitochondrialCurated
Short name:
p27
Alternative name(s):
Interferon alpha-induced 11.5 kDa protein
Interferon-stimulated gene 12a protein1 Publication
Short name:
ISG12(a)1 Publication
Short name:
ISG12A1 Publication
Gene namesi
Name:IFI27Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000165949.12
HGNCiHGNC:5397 IFI27
MIMi600009 gene
neXtProtiNX_P40305

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 57HelicalSequence analysisAdd BLAST24
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56F → D: Increased pro-apoptotic activity; when associated with D-96. 1 Publication1
Mutagenesisi96A → D: Increased pro-apoptotic activity; when associated with D-56. 1 Publication1

Organism-specific databases

DisGeNETi3429
OpenTargetsiENSG00000165949
PharmGKBiPA29643

Polymorphism and mutation databases

BioMutaiIFI27
DMDMi116242590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33Mitochondrion1 PublicationAdd BLAST33
ChainiPRO_000014737234 – 122Interferon alpha-inducible protein 27, mitochondrialAdd BLAST89

Proteomic databases

MaxQBiP40305
PaxDbiP40305
PeptideAtlasiP40305
PRIDEiP40305
ProteomicsDBi55359

PTM databases

iPTMnetiP40305
PhosphoSitePlusiP40305

Expressioni

Inductioni

Up-regulated by type-I and type-II interferons.4 Publications

Gene expression databases

BgeeiENSG00000165949 Expressed in 227 organ(s), highest expression level in ectocervix
CleanExiHS_IFI27
ExpressionAtlasiP40305 baseline and differential

Organism-specific databases

HPAiHPA028875

Interactioni

Subunit structurei

Homodimer (PubMed:27673746). Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with SKP2; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with NR4A1 (PubMed:22427340). May interact with BCL2 (PubMed:27673746).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109655, 2 interactors
IntActiP40305, 15 interactors
STRINGi9606.ENSP00000298902

Structurei

3D structure databases

ProteinModelPortaliP40305
SMRiP40305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 122Mediates interaction with SKP2 and hepatitis C virus non-structural protein NS5A1 PublicationAdd BLAST47
Regioni103 – 112Required for hepatitis C virus non-structural protein NS5A degradation1 Publication10

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JFVP Eukaryota
ENOG410Z2RX LUCA
GeneTreeiENSGT00390000002592
HOGENOMiHOG000112988
HOVERGENiHBG099821
InParanoidiP40305
OMAiASMASNC
PhylomeDBiP40305
TreeFamiTF340510

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40305-2) [UniParc]FASTAAdd to basket
Also known as: ISG121 Publication, ISG12A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAMAAVPMV
60 70 80 90 100
LSAMGFTAAG IASSSIAAKM MSAAAIANGG GVASGSLVAT LQSLGATGLS
110 120
GLTKFILGSI GSAIAAVIAR FY
Length:122
Mass (Da):11,542
Last modified:October 10, 2018 - v4
Checksum:iA424B2EDEAA678A3
GO
Isoform 2 (identifier: P40305-1) [UniParc]FASTAAdd to basket
Also known as: ISG12delta1 Publication, ISG12Adelta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     43-45: Missing.

Show »
Length:119
Mass (Da):11,268
Checksum:i242C9388FEF8FF9C
GO
Isoform 3 (identifier: P40305-3) [UniParc]FASTAAdd to basket
Also known as: ISG12-S1 Publication, ISG12A-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: Major isoform in blood and cervix.1 Publication
Show »
Length:79
Mass (Da):7,451
Checksum:iA0E4077F6BFA7E56
GO
Isoform 4 (identifier: P40305-4) [UniParc]FASTAAdd to basket
Also known as: ISG12-Sdelta1 Publication, ISG12A-Sdelta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:74
Mass (Da):6,981
Checksum:i568D8A99D73466B9
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUJ8A0A087WUJ8_HUMAN
Interferon alpha-inducible protein ...
IFI27
96Annotation score:
A0A087WV79A0A087WV79_HUMAN
Interferon alpha-inducible protein ...
IFI27
65Annotation score:
A0A087WZR1A0A087WZR1_HUMAN
Interferon alpha-inducible protein ...
IFI27
119Annotation score:
A0A087X174A0A087X174_HUMAN
Interferon alpha-inducible protein ...
IFI27
112Annotation score:
G3V4U3G3V4U3_HUMAN
Interferon alpha-inducible protein ...
IFI27
40Annotation score:
A0A087X035A0A087X035_HUMAN
Interferon alpha-inducible protein ...
IFI27
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89A → G in CAA47739 (PubMed:8358738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028066109S → F. Corresponds to variant dbSNP:rs2227974Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0599071 – 48Missing in isoform 4. Add BLAST48
Alternative sequenceiVSP_0599081 – 43Missing in isoform 3. Add BLAST43
Alternative sequenceiVSP_05990943 – 45Missing in isoform 2. 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67325 mRNA Translation: CAA47739.1
BT006781 mRNA Translation: AAP35427.1
AK289535 mRNA Translation: BAF82224.1
AK312089 mRNA Translation: BAG35025.1
AM393107 mRNA Translation: CAL37985.1
AL079302 Genomic DNA No translation available.
AL121838 Genomic DNA No translation available.
KF573698 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81556.1
CH471061 Genomic DNA Translation: EAW81557.1
CH471061 Genomic DNA Translation: EAW81558.1
BC015492 mRNA Translation: AAH15492.1
AJ294851 mRNA Translation: CAC10503.2
AY126456 mRNA Translation: AAM95743.1
AY126457 mRNA Translation: AAM95744.1
AY126458 mRNA Translation: AAM95745.1
BN000227 mRNA Translation: CAE00394.1
CCDSiCCDS32148.1 [P40305-2]
PIRiI38081
RefSeqiNP_001123552.1, NM_001130080.2
NP_001275881.1, NM_001288952.1
NP_001275883.1, NM_001288954.1
NP_001275885.1, NM_001288956.1
NP_001275886.1, NM_001288957.1
NP_001275887.1, NM_001288958.1
NP_001275888.1, NM_001288959.1
NP_001275889.1, NM_001288960.1
NP_001275924.1, NM_001288995.1
NP_005523.3, NM_005532.4
UniGeneiHs.532634

Genome annotation databases

EnsembliENST00000612813; ENSP00000483430; ENSG00000165949 [P40305-2]
ENST00000612838; ENSP00000483932; ENSG00000275214 [P40305-2]
ENST00000613997; ENSP00000484089; ENSG00000275214 [P40305-2]
ENST00000615978; ENSP00000483291; ENSG00000275214 [P40305-3]
ENST00000616764; ENSP00000477753; ENSG00000165949 [P40305-2]
ENST00000618863; ENSP00000482635; ENSG00000165949 [P40305-3]
ENST00000621160; ENSP00000483498; ENSG00000165949 [P40305-2]
ENST00000627111; ENSP00000486608; ENSG00000275214 [P40305-2]
GeneIDi3429
KEGGihsa:3429

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67325 mRNA Translation: CAA47739.1
BT006781 mRNA Translation: AAP35427.1
AK289535 mRNA Translation: BAF82224.1
AK312089 mRNA Translation: BAG35025.1
AM393107 mRNA Translation: CAL37985.1
AL079302 Genomic DNA No translation available.
AL121838 Genomic DNA No translation available.
KF573698 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81556.1
CH471061 Genomic DNA Translation: EAW81557.1
CH471061 Genomic DNA Translation: EAW81558.1
BC015492 mRNA Translation: AAH15492.1
AJ294851 mRNA Translation: CAC10503.2
AY126456 mRNA Translation: AAM95743.1
AY126457 mRNA Translation: AAM95744.1
AY126458 mRNA Translation: AAM95745.1
BN000227 mRNA Translation: CAE00394.1
CCDSiCCDS32148.1 [P40305-2]
PIRiI38081
RefSeqiNP_001123552.1, NM_001130080.2
NP_001275881.1, NM_001288952.1
NP_001275883.1, NM_001288954.1
NP_001275885.1, NM_001288956.1
NP_001275886.1, NM_001288957.1
NP_001275887.1, NM_001288958.1
NP_001275888.1, NM_001288959.1
NP_001275889.1, NM_001288960.1
NP_001275924.1, NM_001288995.1
NP_005523.3, NM_005532.4
UniGeneiHs.532634

3D structure databases

ProteinModelPortaliP40305
SMRiP40305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109655, 2 interactors
IntActiP40305, 15 interactors
STRINGi9606.ENSP00000298902

PTM databases

iPTMnetiP40305
PhosphoSitePlusiP40305

Polymorphism and mutation databases

BioMutaiIFI27
DMDMi116242590

Proteomic databases

MaxQBiP40305
PaxDbiP40305
PeptideAtlasiP40305
PRIDEiP40305
ProteomicsDBi55359

Protocols and materials databases

DNASUi3429
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612813; ENSP00000483430; ENSG00000165949 [P40305-2]
ENST00000612838; ENSP00000483932; ENSG00000275214 [P40305-2]
ENST00000613997; ENSP00000484089; ENSG00000275214 [P40305-2]
ENST00000615978; ENSP00000483291; ENSG00000275214 [P40305-3]
ENST00000616764; ENSP00000477753; ENSG00000165949 [P40305-2]
ENST00000618863; ENSP00000482635; ENSG00000165949 [P40305-3]
ENST00000621160; ENSP00000483498; ENSG00000165949 [P40305-2]
ENST00000627111; ENSP00000486608; ENSG00000275214 [P40305-2]
GeneIDi3429
KEGGihsa:3429

Organism-specific databases

CTDi3429
DisGeNETi3429
EuPathDBiHostDB:ENSG00000165949.12
GeneCardsiIFI27
HGNCiHGNC:5397 IFI27
HPAiHPA028875
MIMi600009 gene
neXtProtiNX_P40305
OpenTargetsiENSG00000165949
PharmGKBiPA29643
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFVP Eukaryota
ENOG410Z2RX LUCA
GeneTreeiENSGT00390000002592
HOGENOMiHOG000112988
HOVERGENiHBG099821
InParanoidiP40305
OMAiASMASNC
PhylomeDBiP40305
TreeFamiTF340510

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Miscellaneous databases

ChiTaRSiIFI27 human
GeneWikiiIFI27
GenomeRNAii3429
PROiPR:P40305
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165949 Expressed in 227 organ(s), highest expression level in ectocervix
CleanExiHS_IFI27
ExpressionAtlasiP40305 baseline and differential

Family and domain databases

Gene3Di1.10.246.160, 1 hit
InterProiView protein in InterPro
IPR009311 IFI6/IFI27-like
IPR038213 IFI6/IFI27-like_sf
PANTHERiPTHR16932 PTHR16932, 1 hit
PfamiView protein in Pfam
PF06140 Ifi-6-16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFI27_HUMAN
AccessioniPrimary (citable) accession number: P40305
Secondary accession number(s): A0A087WZF8
, A8K0H0, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 10, 2018
Last modified: November 7, 2018
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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