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UniProtKB - P40261 (NNMT_HUMAN)

Entry version 175 (25 May 2022)
Sequence version 1 (01 Feb 1995)
Previous versions | rss
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Protein

Nicotinamide N-methyltransferase

Gene

NNMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:8182091. PubMed:21823666, PubMed:23455543).

Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:26571212, PubMed:23455543, PubMed:31043742).

In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212).

Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD+ levels through the salvage pathway (By similarity).

Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity).

Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909).

By similarity6 Publications

Miscellaneous

Prominently expressed in the stroma of high-grade serous carcinomas (PubMed:31043742). In tumorigenesis, regulates the epigenetic reprograming of cancer cells associated with increased cell migration and metastasis (PubMed:23455543, PubMed:31043742).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inactivated by deimination on Arg-132.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.43 mM for nicotinamide (at pH 7.5 and 37 degrees Celsius)1 Publication
  2. KM=0.105 mM for nicotinamide (at pH 8.6 and 37 degrees Celsius)1 Publication
  3. KM=1.8 µM for S-adenosyl-L-methionine (at pH 7.5 and 37 degrees Celsius)1 Publication
  4. KM=5 µM for S-adenosyl-L-methionine (at pH 8.6 and 37 degrees Celsius)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Cofactor metabolism

This protein is involved in Cofactor metabolism.2 Publications
View all proteins of this organism that are known to be involved in Cofactor metabolism.

Pathwayi: Amino-acid degradation

This protein is involved in Amino-acid degradation.2 Publications
View all proteins of this organism that are known to be involved in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei20S-adenosyl-L-methionine2 Publications1
Binding sitei25S-adenosyl-L-methionine2 Publications1
Binding sitei63S-adenosyl-L-methionine; via carbonyl oxygen2 Publications1
Binding sitei69S-adenosyl-L-methionine2 Publications1
Binding sitei85S-adenosyl-L-methionine2 Publications1
Binding sitei90S-adenosyl-L-methionine2 Publications1
Binding sitei163S-adenosyl-L-methionine; via carbonyl oxygen2 Publications1
Binding sitei197Nicotinamide1 Publication1
Binding sitei213Nicotinamide1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P40261

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156581, Methylation
R-HSA-197264, Nicotinamide salvaging
R-HSA-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P40261

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nicotinamide N-methyltransferase1 Publication (EC:2.1.1.12 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NNMT1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7861, NNMT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600008, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P40261

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166741

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18R → K: Has no effect on N-methyltransferase activity. 1 Publication1
Mutagenesisi20Y → A: Loss of N-methyltransferase activity. 2 Publications1
Mutagenesisi20Y → F: Decreases N-methyltransferase activity. 1 Publication1
Mutagenesisi132R → K: Loss of N-methyltransferase activity like its citrullinated counterpart. 1 Publication1
Mutagenesisi181R → K: Has no effect on N-methyltransferase activity. 1 Publication1
Mutagenesisi197D → A: Loss of N-methyltransferase activity. 1 Publication1
Mutagenesisi201S → A: Has no effect on N-methyltransferase activity. 1 Publication1
Mutagenesisi213S → A: Has no effect on N-methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4837

Open Targets

More...OpenTargetsi		ENSG00000166741

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA251

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P40261, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2346486

Drug and drug target database

More...DrugBanki		DB00627, Niacin

DrugCentral

More...DrugCentrali		P40261

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NNMT

Domain mapping of disease mutations (DMDM)

More...DMDMi		730163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001597061 – 264Nicotinamide N-methyltransferaseAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Citrulline; alternate1 Publication1
Modified residuei39N6-acetyllysineCombined sources1
Modified residuei132Citrulline; alternate1 Publication1
Modified residuei181Citrulline; alternate1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Deiminated by PADI1 and PADI2.1 Publication

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P40261

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P40261

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P40261

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P40261

PeptideAtlas

More...PeptideAtlasi		P40261

PRoteomics IDEntifications database

More...PRIDEi		P40261

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55358

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P40261

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P40261, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P40261

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P40261

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P40261

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166741, Expressed in right lobe of liver and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P40261, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P40261, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166741, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110900, 8 interactors

Protein interaction database and analysis system

More...IntActi		P40261, 3 interactors

Molecular INTeraction database

More...MINTi		P40261

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000441434

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P40261

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P40261, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P40261

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P40261

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P40261

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 143S-adenosyl-L-methionine binding2 Publications2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4564, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_082526_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40261

Identification of Orthologs from Complete Genome Data

More...OMAi		YNFGSRH

Database of Orthologous Groups

More...OrthoDBi		1054662at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P40261

TreeFam database of animal gene trees

More...TreeFami		TF313114

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025820, NNMT/PNMT/TEMT_CS
IPR000940, NNMT_TEMT_trans
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR10867, PTHR10867, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01234, NNMT_PNMT_TEMT, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000384, PNMTase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01100, NNMT_PNMT_TEMT, 1 hit
PS51681, SAM_MT_NNMT_PNMT_TEMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC 
        60         70         80         90        100
LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK 
       110        120        130        140        150
EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG 
       160        170        180        190        200
AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK 
       210        220        230        240        250
SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE 
       260 
GLFSLVARKL SRPL
Length:264
Mass (Da):29,574
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i280B12748F4488AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U08021 mRNA Translation: AAA19904.1
U20971, U20970 Genomic DNA Translation: AAA93158.1
BC000234 mRNA Translation: AAH00234.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8368.1

Protein sequence database of the Protein Information Resource

More...PIRi		A54060

NCBI Reference Sequences

More...RefSeqi		NP_006160.1, NM_006169.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299964.4; ENSP00000299964.3; ENSG00000166741.8
ENST00000535401.5; ENSP00000441434.1; ENSG00000166741.8

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4837

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000299964.4; ENSP00000299964.3; NM_006169.3; NP_006160.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08021 mRNA Translation: AAA19904.1
U20971, U20970 Genomic DNA Translation: AAA93158.1
BC000234 mRNA Translation: AAH00234.1
CCDSiCCDS8368.1
PIRiA54060
RefSeqiNP_006160.1, NM_006169.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IIPX-ray2.05A/B/C/D1-264[»]
3RODX-ray2.72A/B/C/D1-264[»]
5YJFX-ray2.49A/B/C/D1-264[»]
6B1AX-ray2.30A/B/C/D1-264[»]
6CHHX-ray2.30A/B/C/D1-264[»]
6ORRX-ray2.25A/B/C/D1-264[»]
6PVEX-ray2.30A/B/C/D1-264[»]
6PVSX-ray2.58A/B/C/D1-264[»]
7BKGX-ray2.33A/B/C/D1-264[»]
7BLEX-ray2.81A/B/C/D1-264[»]
7EGUX-ray1.90A3-260[»]
7EHZX-ray2.50A3-260[»]
7NBJX-ray2.27A/B/C/D1-264[»]
7NBMX-ray2.69A/B/C/D1-264[»]
7NBQX-ray2.48A/B/C/D1-264[»]
AlphaFoldDBiP40261
SMRiP40261
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110900, 8 interactors
IntActiP40261, 3 interactors
MINTiP40261
STRINGi9606.ENSP00000441434

Chemistry databases

BindingDBiP40261
ChEMBLiCHEMBL2346486
DrugBankiDB00627, Niacin
DrugCentraliP40261

PTM databases

GlyGeniP40261, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP40261
MetOSiteiP40261
PhosphoSitePlusiP40261

Genetic variation databases

BioMutaiNNMT
DMDMi730163

Proteomic databases

EPDiP40261
jPOSTiP40261
MassIVEiP40261
PaxDbiP40261
PeptideAtlasiP40261
PRIDEiP40261
ProteomicsDBi55358
TopDownProteomicsiP40261

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18379, 486 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		4837

Genome annotation databases

EnsembliENST00000299964.4; ENSP00000299964.3; ENSG00000166741.8
ENST00000535401.5; ENSP00000441434.1; ENSG00000166741.8
GeneIDi4837
KEGGihsa:4837
MANE-SelectiENST00000299964.4; ENSP00000299964.3; NM_006169.3; NP_006160.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4837
DisGeNETi4837

GeneCards: human genes, protein and diseases

More...GeneCardsi		NNMT
HGNCiHGNC:7861, NNMT
HPAiENSG00000166741, Tissue enhanced (liver)
MIMi600008, gene
neXtProtiNX_P40261
OpenTargetsiENSG00000166741
PharmGKBiPA251
VEuPathDBiHostDB:ENSG00000166741

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4564, Eukaryota
GeneTreeiENSGT00390000011708
HOGENOMiCLU_082526_1_1_1
InParanoidiP40261
OMAiYNFGSRH
OrthoDBi1054662at2759
PhylomeDBiP40261
TreeFamiTF313114

Enzyme and pathway databases

BRENDAi2.1.1.1, 2681
PathwayCommonsiP40261
ReactomeiR-HSA-156581, Methylation
R-HSA-197264, Nicotinamide salvaging
R-HSA-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se
SignaLinkiP40261

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4837, 6 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NNMT, human
EvolutionaryTraceiP40261

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NNMT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4837
PharosiP40261, Tchem

Protein Ontology

More...PROi		PR:P40261
RNActiP40261, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166741, Expressed in right lobe of liver and 210 other tissues
ExpressionAtlasiP40261, baseline and differential
GenevisibleiP40261, HS

Family and domain databases

Gene3Di3.40.50.150, 1 hit
InterProiView protein in InterPro
IPR025820, NNMT/PNMT/TEMT_CS
IPR000940, NNMT_TEMT_trans
IPR029063, SAM-dependent_MTases
PANTHERiPTHR10867, PTHR10867, 1 hit
PfamiView protein in Pfam
PF01234, NNMT_PNMT_TEMT, 1 hit
PIRSFiPIRSF000384, PNMTase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS01100, NNMT_PNMT_TEMT, 1 hit
PS51681, SAM_MT_NNMT_PNMT_TEMT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNNMT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40261
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 25, 2022
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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