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Protein

B-cell antigen receptor complex-associated protein beta chain

Gene

CD79B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.3 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: CAFA
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • B cell differentiation Source: GO_Central
  • B cell receptor signaling pathway Source: GO_Central
  • immune response Source: ProtInc
  • protein homooligomerization Source: CAFA
  • signal transduction Source: ProtInc

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-5690714 CD22 mediated BCR regulation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP40259
SIGNORiP40259

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell antigen receptor complex-associated protein beta chain
Alternative name(s):
B-cell-specific glycoprotein B29
Ig-beta
Immunoglobulin-associated B29 protein
CD_antigen: CD79b
Gene namesi
Name:CD79B
Synonyms:B29, IGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000007312.12
HGNCiHGNC:1699 CD79B
MIMi147245 gene
neXtProtiNX_P40259

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 159ExtracellularSequence analysisAdd BLAST131
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 229CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Agammaglobulinemia 6, autosomal recessive (AGM6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
See also OMIM:612692
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057833137G → S in AGM6. 1 PublicationCorresponds to variant dbSNP:rs121912424Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi974
MalaCardsiCD79B
MIMi612692 phenotype
OpenTargetsiENSG00000007312
Orphaneti33110 Autosomal agammaglobulinemia
PharmGKBiPA26238

Polymorphism and mutation databases

BioMutaiCD79B
DMDMi728994

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001456029 – 229B-cell antigen receptor complex-associated protein beta chainAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 126PROSITE-ProRule annotation1 Publication
Disulfide bondi65 ↔ 122PROSITE-ProRule annotation1 Publication
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136Interchain (with C-119 in alpha chain)PROSITE-ProRule annotation1 Publication
Modified residuei196Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1
Modified residuei207Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP40259
MaxQBiP40259
PaxDbiP40259
PeptideAtlasiP40259
PRIDEiP40259
ProteomicsDBi55356
55357 [P40259-2]
TopDownProteomicsiP40259-2 [P40259-2]

PTM databases

iPTMnetiP40259
PhosphoSitePlusiP40259

Expressioni

Tissue specificityi

B-cells.

Gene expression databases

BgeeiENSG00000007312
CleanExiHS_CD79B
GenevisibleiP40259 HS

Organism-specific databases

HPAiCAB009751
HPA009178

Interactioni

Subunit structurei

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: CAFA

Protein-protein interaction databases

BioGridi107412, 110 interactors
DIPiDIP-59497N
ELMiP40259
IntActiP40259, 3 interactors
STRINGi9606.ENSP00000376544

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi47 – 49Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi61 – 66Combined sources6
Beta strandi75 – 84Combined sources10
Turni93 – 95Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi102 – 109Combined sources8
Turni114 – 116Combined sources3
Beta strandi118 – 125Combined sources8
Turni127 – 129Combined sources3
Beta strandi132 – 134Combined sources3
Beta strandi138 – 143Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KG5X-ray3.20A/B26-159[»]
ProteinModelPortaliP40259
SMRiP40259
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 138Ig-like V-typeAdd BLAST101
Domaini185 – 213ITAMPROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J02H Eukaryota
ENOG410Z4S5 LUCA
GeneTreeiENSGT00510000048811
HOGENOMiHOG000049137
HOVERGENiHBG050855
InParanoidiP40259
KOiK06507
OMAiDQTATYE
OrthoDBiEOG091G0O8L
PhylomeDBiP40259
TreeFamiTF336032

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00077 ITAM, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51055 ITAM_1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P40259-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP
60 70 80 90 100
RFIARKRGFT VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ
110 120 130 140 150
NESLATLTIQ GIRFEDNGIY FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ
160 170 180 190 200
LKQRNTLKDG IIMIQTLLII LFIIVPIFLL LDKDDSKAGM EEDHTYEGLD
210 220
IDQTATYEDI VTLRTGEVKW SVGEHPGQE
Length:229
Mass (Da):26,048
Last modified:February 1, 1995 - v1
Checksum:iC467175567D10883
GO
Isoform Short (identifier: P40259-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-144: Missing.

Show »
Length:125
Mass (Da):14,030
Checksum:i6CEE8C7A4F0AB1C0
GO
Isoform 3 (identifier: P40259-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: A → AA

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,119
Checksum:iFE9E79CA0CE5BBC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58G → A in AAB24822 (PubMed:8419481).Curated1
Sequence conflicti58G → R in AAA58387 (PubMed:1534761).Curated1
Sequence conflicti84E → A in AAB24822 (PubMed:8419481).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057833137G → S in AGM6. 1 PublicationCorresponds to variant dbSNP:rs121912424Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04722223A → AA in isoform 3. 1 Publication1
Alternative sequenceiVSP_00247741 – 144Missing in isoform Short. 2 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80461 mRNA Translation: AAA58387.1
M89957 mRNA Translation: AAA64459.1
S52229 mRNA Translation: AAB24822.2
L27587 Genomic DNA Translation: AAA72424.1
S79249 mRNA Translation: AAC60654.1
X83539 mRNA Translation: CAA58522.1
AK222954 mRNA Translation: BAD96674.1
AK223210 mRNA Translation: BAD96930.1
BC002975 mRNA Translation: AAH02975.2
BC032651 mRNA Translation: AAH32651.1
CCDSiCCDS11655.1 [P40259-1]
CCDS11656.1 [P40259-2]
CCDS42372.1 [P40259-3]
PIRiI54534 A46527
RefSeqiNP_000617.1, NM_000626.3 [P40259-1]
NP_001035022.1, NM_001039933.2 [P40259-3]
NP_067613.1, NM_021602.3 [P40259-2]
UniGeneiHs.89575

Genome annotation databases

EnsembliENST00000006750; ENSP00000006750; ENSG00000007312 [P40259-1]
ENST00000349817; ENSP00000245862; ENSG00000007312 [P40259-2]
ENST00000392795; ENSP00000376544; ENSG00000007312 [P40259-3]
GeneIDi974
KEGGihsa:974
UCSCiuc002jdp.2 human [P40259-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCD79B_HUMAN
AccessioniPrimary (citable) accession number: P40259
Secondary accession number(s): Q53FS2, Q9BU06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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