UniProtKB - P40259 (CD79B_HUMAN)
B-cell antigen receptor complex-associated protein beta chain
CD79B
Functioni
GO - Molecular functioni
- identical protein binding Source: CAFA
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- B cell differentiation Source: GO_Central
- B cell receptor signaling pathway Source: GO_Central
- immune response Source: ProtInc
- response to bacterium Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P40259 |
Reactomei | R-HSA-5690714, CD22 mediated BCR regulation R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | P40259 |
SIGNORi | P40259 |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell antigen receptor complex-associated protein beta chainAlternative name(s): B-cell-specific glycoprotein B29 Ig-beta Immunoglobulin-associated B29 protein CD_antigen: CD79b |
Gene namesi | Name:CD79B Synonyms:B29, IGB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000007312.12 |
HGNCi | HGNC:1699, CD79B |
MIMi | 147245, gene |
neXtProti | NX_P40259 |
Subcellular locationi
Plasma membrane
Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- B cell receptor complex Source: GO_Central
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 159 | ExtracellularSequence analysisAdd BLAST | 131 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 181 – 229 | CytoplasmicSequence analysisAdd BLAST | 49 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Agammaglobulinemia 6, autosomal recessive (AGM6)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057833 | 137 | G → S in AGM6. 1 PublicationCorresponds to variant dbSNP:rs121912424EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 974 |
MalaCardsi | CD79B |
MIMi | 612692, phenotype |
OpenTargetsi | ENSG00000007312 |
Orphaneti | 33110, Autosomal agammaglobulinemia |
PharmGKBi | PA26238 |
Miscellaneous databases
Pharosi | P40259, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712852 |
DrugBanki | DB12240, Polatuzumab vedotin |
Polymorphism and mutation databases
BioMutai | CD79B |
DMDMi | 728994 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | 1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000014560 | 29 – 229 | B-cell antigen receptor complex-associated protein beta chainAdd BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 126 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 65 ↔ 122 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 136 | Interchain (with C-119 in alpha chain)PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 196 | Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 207 | Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P40259 |
jPOSTi | P40259 |
MassIVEi | P40259 |
MaxQBi | P40259 |
PaxDbi | P40259 |
PeptideAtlasi | P40259 |
PRIDEi | P40259 |
ProteomicsDBi | 55356 [P40259-1] 55357 [P40259-2] |
TopDownProteomicsi | P40259-2 [P40259-2] |
PTM databases
GlyGeni | P40259, 5 sites |
iPTMneti | P40259 |
PhosphoSitePlusi | P40259 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000007312, Expressed in lymph node and 194 other tissues |
Genevisiblei | P40259, HS |
Organism-specific databases
HPAi | ENSG00000007312, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.
Interacts with LYN (By similarity).
By similarityBinary interactionsi
Hide detailsP40259
With | #Exp. | IntAct |
---|---|---|
SGTA [O43765] | 6 | EBI-2873732,EBI-347996 |
SGTB [Q96EQ0] | 3 | EBI-2873732,EBI-744081 |
CD79B - isoform Long [P40259-1]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-15869023,EBI-15869023 |
GO - Molecular functioni
- identical protein binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 107412, 112 interactors |
DIPi | DIP-59497N |
ELMi | P40259 |
IntActi | P40259, 95 interactors |
STRINGi | 9606.ENSP00000376544 |
Miscellaneous databases
RNActi | P40259, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P40259 |
SMRi | P40259 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 138 | Ig-like V-typeAdd BLAST | 101 | |
Domaini | 185 – 213 | ITAMPROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S7X8, Eukaryota |
GeneTreei | ENSGT00940000154363 |
HOGENOMi | CLU_084230_0_0_1 |
InParanoidi | P40259 |
OMAi | YRGCGTE |
OrthoDBi | 1234092at2759 |
PhylomeDBi | P40259 |
TreeFami | TF336032 |
Family and domain databases
DisProti | DP01487 |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR039695, CD79a/CD79b IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR14334, PTHR14334, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51055, ITAM_1, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP
60 70 80 90 100
RFIARKRGFT VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ
110 120 130 140 150
NESLATLTIQ GIRFEDNGIY FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ
160 170 180 190 200
LKQRNTLKDG IIMIQTLLII LFIIVPIFLL LDKDDSKAGM EEDHTYEGLD
210 220
IDQTATYEDI VTLRTGEVKW SVGEHPGQE
The sequence of this isoform differs from the canonical sequence as follows:
41-144: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | G → A in AAB24822 (PubMed:8419481).Curated | 1 | |
Sequence conflicti | 58 | G → R in AAA58387 (PubMed:1534761).Curated | 1 | |
Sequence conflicti | 84 | E → A in AAB24822 (PubMed:8419481).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057833 | 137 | G → S in AGM6. 1 PublicationCorresponds to variant dbSNP:rs121912424EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047222 | 23 | A → AA in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_002477 | 41 – 144 | Missing in isoform Short. 2 PublicationsAdd BLAST | 104 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80461 mRNA Translation: AAA58387.1 M89957 mRNA Translation: AAA64459.1 S52229 mRNA Translation: AAB24822.2 L27587 Genomic DNA Translation: AAA72424.1 S79249 mRNA Translation: AAC60654.1 X83539 mRNA Translation: CAA58522.1 AK222954 mRNA Translation: BAD96674.1 AK223210 mRNA Translation: BAD96930.1 BC002975 mRNA Translation: AAH02975.2 BC032651 mRNA Translation: AAH32651.1 |
CCDSi | CCDS11655.1 [P40259-1] CCDS11656.1 [P40259-2] CCDS42372.1 [P40259-3] |
PIRi | I54534, A46527 |
RefSeqi | NP_000617.1, NM_000626.3 [P40259-1] NP_001035022.1, NM_001039933.2 [P40259-3] NP_067613.1, NM_021602.3 [P40259-2] |
Genome annotation databases
Ensembli | ENST00000006750; ENSP00000006750; ENSG00000007312 [P40259-1] ENST00000349817; ENSP00000245862; ENSG00000007312 [P40259-2] ENST00000392795; ENSP00000376544; ENSG00000007312 [P40259-3] |
GeneIDi | 974 |
KEGGi | hsa:974 |
UCSCi | uc002jdp.2, human [P40259-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
CD79Bbase CD79B mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80461 mRNA Translation: AAA58387.1 M89957 mRNA Translation: AAA64459.1 S52229 mRNA Translation: AAB24822.2 L27587 Genomic DNA Translation: AAA72424.1 S79249 mRNA Translation: AAC60654.1 X83539 mRNA Translation: CAA58522.1 AK222954 mRNA Translation: BAD96674.1 AK223210 mRNA Translation: BAD96930.1 BC002975 mRNA Translation: AAH02975.2 BC032651 mRNA Translation: AAH32651.1 |
CCDSi | CCDS11655.1 [P40259-1] CCDS11656.1 [P40259-2] CCDS42372.1 [P40259-3] |
PIRi | I54534, A46527 |
RefSeqi | NP_000617.1, NM_000626.3 [P40259-1] NP_001035022.1, NM_001039933.2 [P40259-3] NP_067613.1, NM_021602.3 [P40259-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KG5 | X-ray | 3.20 | A/B | 26-159 | [»] | |
BMRBi | P40259 | |||||
SMRi | P40259 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107412, 112 interactors |
DIPi | DIP-59497N |
ELMi | P40259 |
IntActi | P40259, 95 interactors |
STRINGi | 9606.ENSP00000376544 |
Chemistry databases
ChEMBLi | CHEMBL3712852 |
DrugBanki | DB12240, Polatuzumab vedotin |
PTM databases
GlyGeni | P40259, 5 sites |
iPTMneti | P40259 |
PhosphoSitePlusi | P40259 |
Polymorphism and mutation databases
BioMutai | CD79B |
DMDMi | 728994 |
Proteomic databases
EPDi | P40259 |
jPOSTi | P40259 |
MassIVEi | P40259 |
MaxQBi | P40259 |
PaxDbi | P40259 |
PeptideAtlasi | P40259 |
PRIDEi | P40259 |
ProteomicsDBi | 55356 [P40259-1] 55357 [P40259-2] |
TopDownProteomicsi | P40259-2 [P40259-2] |
Protocols and materials databases
ABCDi | P40259, 22 sequenced antibodies |
Antibodypediai | 2218, 958 antibodies |
Genome annotation databases
Ensembli | ENST00000006750; ENSP00000006750; ENSG00000007312 [P40259-1] ENST00000349817; ENSP00000245862; ENSG00000007312 [P40259-2] ENST00000392795; ENSP00000376544; ENSG00000007312 [P40259-3] |
GeneIDi | 974 |
KEGGi | hsa:974 |
UCSCi | uc002jdp.2, human [P40259-1] |
Organism-specific databases
CTDi | 974 |
DisGeNETi | 974 |
EuPathDBi | HostDB:ENSG00000007312.12 |
GeneCardsi | CD79B |
HGNCi | HGNC:1699, CD79B |
HPAi | ENSG00000007312, Group enriched (blood, lymphoid tissue) |
MalaCardsi | CD79B |
MIMi | 147245, gene 612692, phenotype |
neXtProti | NX_P40259 |
OpenTargetsi | ENSG00000007312 |
Orphaneti | 33110, Autosomal agammaglobulinemia |
PharmGKBi | PA26238 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7X8, Eukaryota |
GeneTreei | ENSGT00940000154363 |
HOGENOMi | CLU_084230_0_0_1 |
InParanoidi | P40259 |
OMAi | YRGCGTE |
OrthoDBi | 1234092at2759 |
PhylomeDBi | P40259 |
TreeFami | TF336032 |
Enzyme and pathway databases
PathwayCommonsi | P40259 |
Reactomei | R-HSA-5690714, CD22 mediated BCR regulation R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | P40259 |
SIGNORi | P40259 |
Miscellaneous databases
BioGRID-ORCSi | 974, 14 hits in 849 CRISPR screens |
ChiTaRSi | CD79B, human |
GeneWikii | CD79B |
GenomeRNAii | 974 |
Pharosi | P40259, Tbio |
PROi | PR:P40259 |
RNActi | P40259, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000007312, Expressed in lymph node and 194 other tissues |
Genevisiblei | P40259, HS |
Family and domain databases
DisProti | DP01487 |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR039695, CD79a/CD79b IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR14334, PTHR14334, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51055, ITAM_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD79B_HUMAN | |
Accessioni | P40259Primary (citable) accession number: P40259 Secondary accession number(s): Q53FS2, Q9BU06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries