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Protein

CD9 antigen

Gene

Cd9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion (By similarity).By similarity

GO - Molecular functioni

  • integrin binding Source: RGD

GO - Biological processi

Keywordsi

Biological processCell adhesion, Fertilization

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-1300652 Sperm:Oocyte Membrane Binding

Names & Taxonomyi

Protein namesi
Recommended name:
CD9 antigen
Alternative name(s):
CD_antigen: CD9
Gene namesi
Name:Cd9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2318 Cd9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 53ExtracellularSequence analysisAdd BLAST20
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 85CytoplasmicSequence analysisAdd BLAST11
Transmembranei86 – 109HelicalSequence analysisAdd BLAST24
Topological domaini110 – 193ExtracellularSequence analysisAdd BLAST84
Transmembranei194 – 219HelicalSequence analysisAdd BLAST26
Topological domaini220 – 226CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192081 – 226CD9 antigenAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi9S-palmitoyl cysteineBy similarity1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi76S-palmitoyl cysteineBy similarity1
Lipidationi77S-palmitoyl cysteineBy similarity1
Lipidationi85S-palmitoyl cysteineBy similarity1
Disulfide bondi150 ↔ 179PROSITE-ProRule annotation
Disulfide bondi151 ↔ 165PROSITE-ProRule annotation
Lipidationi216S-palmitoyl cysteineBy similarity1
Lipidationi217S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro) (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP40241
PRIDEiP40241

PTM databases

iPTMnetiP40241
PhosphoSitePlusiP40241

Expressioni

Tissue specificityi

Expressed in the peripheral nervous system.

Gene expression databases

BgeeiENSRNOG00000019556
ExpressionAtlasiP40241 baseline and differential
GenevisibleiP40241 RN

Interactioni

Subunit structurei

Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts with CD63. Identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8. Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3.By similarity

GO - Molecular functioni

  • integrin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026633

Structurei

3D structure databases

ProteinModelPortaliP40241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP40241
KOiK06460
OMAiEVFHNKF
OrthoDBiEOG091G0K9H
PhylomeDBiP40241
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

P40241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKGGSKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN
60 70 80 90 100
HSSFYTGVYI LIGAGALMML VGFLGCCGAV QESQCMLGLF FGFLLVIFAI
110 120 130 140 150
EIAAAVWGYT HKDEVIKELQ EFYKDTYQKL RNKDEPQRET LKAIHMALNC
160 170 180 190 200
CGIAGGVEQF ISDICPKKQV LESFQVKSCP DAIDEVFHSK FHIIGAVGIG
210 220
IAVVMIFGMI FSMILCCAIR RSREMV
Length:226
Mass (Da):25,215
Last modified:January 23, 2007 - v2
Checksum:i55E56BA0C595CF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76489 mRNA Translation: CAA54027.1
PIRiI56562 S39262
RefSeqiNP_444177.1, NM_053018.1
UniGeneiRn.2091

Genome annotation databases

EnsembliENSRNOT00000026633; ENSRNOP00000026633; ENSRNOG00000019556
GeneIDi24936
KEGGirno:24936
UCSCiRGD:2318 rat

Similar proteinsi

Entry informationi

Entry nameiCD9_RAT
AccessioniPrimary (citable) accession number: P40241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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