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Protein

CD82 antigen

Gene

Cd82

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
CD82 antigen
Alternative name(s):
C33 antigen
IA4
Inducible membrane protein R2
Metastasis suppressor Kangai-1 homolog
CD_antigen: CD82
Gene namesi
Name:Cd82
Synonyms:Kai1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104651 Cd82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 53ExtracellularSequence analysisAdd BLAST21
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 110HelicalSequence analysisAdd BLAST27
Topological domaini111 – 227ExtracellularSequence analysisAdd BLAST117
Transmembranei228 – 249HelicalSequence analysisAdd BLAST22
Topological domaini250 – 266CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192271 – 266CD82 antigenAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi157N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP40237
PaxDbiP40237
PeptideAtlasiP40237
PRIDEiP40237

PTM databases

iPTMnetiP40237
PhosphoSitePlusiP40237
SwissPalmiP40237

Expressioni

Tissue specificityi

Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.

Gene expression databases

BgeeiENSMUSG00000027215 Expressed in 275 organ(s), highest expression level in ileum
CleanExiMM_CD82
ExpressionAtlasiP40237 baseline and differential
GenevisibleiP40237 MM

Interactioni

Subunit structurei

Interacts directly with IGSF8.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028644

Structurei

3D structure databases

ProteinModelPortaliP40237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP40237
KOiK06509
OMAiFYNWTDN
OrthoDBiEOG091G0G4W
PhylomeDBiP40237
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P40237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS
60 70 80 90 100
SLQVGAYVFI GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV
110 120 130 140 150
TVGVLFYFNA DKLKKEMGNT VMDIIRNYTA NATSSREEAW DYVQAQVKCC
160 170 180 190 200
GWVSHYNWTE NEELMGFTKT TYPCSCEKIK EEDNQLIVKK GFCEADNSTV
210 220 230 240 250
SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI ELLGLFLSIC
260
LCRYIHSEDY SKVPKY
Length:266
Mass (Da):29,629
Last modified:February 1, 1995 - v1
Checksum:iCB4BE669E7C52D57
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AIJ1A2AIJ1_MOUSE
Tetraspanin
Cd82
179Annotation score:
A2AIJ2A2AIJ2_MOUSE
CD82 antigen
Cd82
146Annotation score:
A2AIJ3A2AIJ3_MOUSE
CD82 antigen
Cd82
88Annotation score:
A2AIJ4A2AIJ4_MOUSE
CD82 antigen
Cd82
21Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14883 mRNA Translation: BAA03602.1
CCDSiCCDS16454.1
PIRiI49561
RefSeqiNP_001129527.1, NM_001136055.2
NP_001258359.1, NM_001271430.1
NP_001258360.1, NM_001271431.1
NP_001258361.1, NM_001271432.1
NP_001258390.1, NM_001271461.1
NP_001258391.1, NM_001271462.1
NP_031682.1, NM_007656.5
UniGeneiMm.4261

Genome annotation databases

EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215
GeneIDi12521
KEGGimmu:12521
UCSCiuc008lfx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14883 mRNA Translation: BAA03602.1
CCDSiCCDS16454.1
PIRiI49561
RefSeqiNP_001129527.1, NM_001136055.2
NP_001258359.1, NM_001271430.1
NP_001258360.1, NM_001271431.1
NP_001258361.1, NM_001271432.1
NP_001258390.1, NM_001271461.1
NP_001258391.1, NM_001271462.1
NP_031682.1, NM_007656.5
UniGeneiMm.4261

3D structure databases

ProteinModelPortaliP40237
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028644

PTM databases

iPTMnetiP40237
PhosphoSitePlusiP40237
SwissPalmiP40237

Proteomic databases

EPDiP40237
PaxDbiP40237
PeptideAtlasiP40237
PRIDEiP40237

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215
GeneIDi12521
KEGGimmu:12521
UCSCiuc008lfx.2 mouse

Organism-specific databases

CTDi3732
MGIiMGI:104651 Cd82

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP40237
KOiK06509
OMAiFYNWTDN
OrthoDBiEOG091G0G4W
PhylomeDBiP40237
TreeFamiTF352892

Miscellaneous databases

ChiTaRSiCd82 mouse
PROiPR:P40237
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027215 Expressed in 275 organ(s), highest expression level in ileum
CleanExiMM_CD82
ExpressionAtlasiP40237 baseline and differential
GenevisibleiP40237 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD82_MOUSE
AccessioniPrimary (citable) accession number: P40237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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