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UniProtKB - P40234 (CKI2_SCHPO)
Protein
Casein kinase I homolog 2
Gene
cki2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 131 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: PomBase
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- endocytosis Source: GO_Central
- peptidyl-serine phosphorylation Source: GO_Central
- regulation of endocytosis Source: PomBase
- signaling Source: PomBase
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5613 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cki2 ORF Names:SPBP35G2.05c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBP35G2.05c, cki2 |
VEuPathDBi | FungiDB:SPBP35G2.05c |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
- nucleus Source: GO_Central
Vacuole
- fungal-type vacuole membrane Source: PomBase
Other locations
- cytoplasm Source: PomBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192862 | 1 – 435 | Casein kinase I homolog 2Add BLAST | 435 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 361 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P40234 |
PaxDbi | P40234 |
PTM databases
iPTMneti | P40234 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 277852, 3 interactors |
STRINGi | 4896.SPBP35G2.05c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 282 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 271 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
HOGENOMi | CLU_019279_2_0_1 |
InParanoidi | P40234 |
OMAi | NSIIGTH |
PhylomeDBi | P40234 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P40234-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSQTSVVGV HYRVGRKIGE GSFGVIFDGM NLLNNQLIAI KFEPKKSEAP
60 70 80 90 100
QLRDEYRTYK LLVGNAGIPN VYYFGQEGLH NILVIDLLGP SLEDLFEWCG
110 120 130 140 150
RRFSVKTVAM TAKQMLSRVQ TIHEKNLVYR DIKPDNFLIG RPSSRNANMV
160 170 180 190 200
YMVDFGMAKY YRDPKTKQHI PYSERKSLSG TARYMSINTH LGREQSRRDD
210 220 230 240 250
LESLGHVFMY FLRGSLPWQG LKAANNKHKY EKISEKKQST SISELCAGFP
260 270 280 290 300
NEFSKYMTYV RSLEFDEEPD YAFLQELFDD VLRANGDTND GVYDWMLLND
310 320 330 340 350
GKGWESSSSH FSVVAMKRRK NYLGLNVVQN DDSRKKNSTL QTQNMRFKSS
360 370 380 390 400
YGVRGPRNYS SFDALPSKNA PLVRQEQSAS KKTIYAHSSR GYDRVRPMYV
410 420 430
SQPSNNAVGV NHPNDNSDSE AKGGFFDMIC CRCFS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 169 | H → Y in AAA19020 (PubMed:8163505).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06930 Genomic DNA Translation: AAA19020.1 CU329671 Genomic DNA Translation: CAB87367.1 |
PIRi | B53581 |
RefSeqi | NP_595380.1, NM_001021287.2 |
Genome annotation databases
EnsemblFungii | SPBP35G2.05c.1; SPBP35G2.05c.1:pep; SPBP35G2.05c |
GeneIDi | 2541341 |
KEGGi | spo:SPBP35G2.05c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06930 Genomic DNA Translation: AAA19020.1 CU329671 Genomic DNA Translation: CAB87367.1 |
PIRi | B53581 |
RefSeqi | NP_595380.1, NM_001021287.2 |
3D structure databases
SMRi | P40234 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 277852, 3 interactors |
STRINGi | 4896.SPBP35G2.05c.1 |
PTM databases
iPTMneti | P40234 |
Proteomic databases
MaxQBi | P40234 |
PaxDbi | P40234 |
Genome annotation databases
EnsemblFungii | SPBP35G2.05c.1; SPBP35G2.05c.1:pep; SPBP35G2.05c |
GeneIDi | 2541341 |
KEGGi | spo:SPBP35G2.05c |
Organism-specific databases
PomBasei | SPBP35G2.05c, cki2 |
VEuPathDBi | FungiDB:SPBP35G2.05c |
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
HOGENOMi | CLU_019279_2_0_1 |
InParanoidi | P40234 |
OMAi | NSIIGTH |
PhylomeDBi | P40234 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5613 |
Miscellaneous databases
PROi | PR:P40234 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CKI2_SCHPO | |
Accessioni | P40234Primary (citable) accession number: P40234 Secondary accession number(s): Q9P798 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | August 14, 2001 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families