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UniProtKB - P40233 (CKI1_SCHPO)
Protein
Casein kinase I homolog 1
Gene
cki1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | ATP | 1 | |
Active sitei | 131 | Proton acceptor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | ATP | 9 |
GO - Molecular functioni
- ATP binding Source: PomBase
- magnesium ion binding Source: PomBase
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: PomBase
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: PomBase
GO - Biological processi
- endocytosis Source: GO_Central
- peptidyl-serine phosphorylation Source: GO_Central
- regulation of endocytosis Source: PomBase
- signaling Source: PomBase
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5613 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cki1 ORF Names:SPBC1347.06c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC1347.06c, cki1 |
VEuPathDBi | FungiDB:SPBC1347.06c |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: PomBase
Vacuole
- fungal-type vacuole Source: PomBase
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192861 | 1 – 446 | Casein kinase I homolog 1Add BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 329 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P40233 |
PaxDbi | P40233 |
PTM databases
iPTMneti | P40233 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 276168, 2 interactors |
IntActi | P40233, 1 interactor |
MINTi | P40233 |
STRINGi | 4896.SPBC1347.06c.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P40233 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P40233 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 274 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 263 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 308 – 430 | DisorderedSequence analysisAdd BLAST | 123 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 308 – 324 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 332 – 347 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 362 – 392 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 402 – 428 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
HOGENOMi | CLU_019279_1_0_1 |
InParanoidi | P40233 |
OMAi | RGWEASM |
PhylomeDBi | P40233 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P40233-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGQNNVVGV HYKVGRRIGE GSFGVIFEGT NLLNNQQVAI KFEPRRSDAP
60 70 80 90 100
QLRDEYRTYK LLAGCTGIPN VYYFGQEGLH NILVIDLLGP SLEDLLDLCG
110 120 130 140 150
RKFSVKTVAM AAKQMLARVQ SIHEKSLVYR DIKPDNFLIG RPNSKNANMI
160 170 180 190 200
YVVDFGMVKF YRDPVTKQHI PYREKKNLSG TARYMSINTH LGREQSRRDD
210 220 230 240 250
LEALGHVFMY FLRGSLPWQG LKAATNKQKY ERIGEKKQST PLRELCAGFP
260 270 280 290 300
EEFYKYMHYA RNLAFDATPD YDYLQGLFSK VLERLNTTED ENFDWNLLNN
310 320 330 340 350
GKGWQSLKSR NAETENQRSS KPPAPKLESK SPALQNHAST QNVVSKRSDY
360 370 380 390 400
EKPFAEPHLN SASDSAEPNQ NSLPNPPTET KATTTVPDRS GLATNQPAPV
410 420 430 440
DVHDSSEERV TREQVQNATK ETEAPKKKKS FWASILSCCS GSNEDT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 82 | I → V in AAA19019 (PubMed:8163505).Curated | 1 | |
Sequence conflicti | 310 | R → Q in AAA19019 (PubMed:8163505).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06929 mRNA Translation: AAA19019.1 CU329671 Genomic DNA Translation: CAB37437.1 |
PIRi | A53581 |
RefSeqi | NP_596698.1, NM_001022622.2 |
Genome annotation databases
EnsemblFungii | SPBC1347.06c.1; SPBC1347.06c.1:pep; SPBC1347.06c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06929 mRNA Translation: AAA19019.1 CU329671 Genomic DNA Translation: CAB37437.1 |
PIRi | A53581 |
RefSeqi | NP_596698.1, NM_001022622.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CSN | X-ray | 2.00 | A | 1-298 | [»] | |
1EH4 | X-ray | 2.80 | A/B | 1-298 | [»] | |
2CSN | X-ray | 2.50 | A | 2-298 | [»] | |
SMRi | P40233 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 276168, 2 interactors |
IntActi | P40233, 1 interactor |
MINTi | P40233 |
STRINGi | 4896.SPBC1347.06c.1 |
PTM databases
iPTMneti | P40233 |
Proteomic databases
MaxQBi | P40233 |
PaxDbi | P40233 |
Genome annotation databases
EnsemblFungii | SPBC1347.06c.1; SPBC1347.06c.1:pep; SPBC1347.06c |
Organism-specific databases
PomBasei | SPBC1347.06c, cki1 |
VEuPathDBi | FungiDB:SPBC1347.06c |
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
HOGENOMi | CLU_019279_1_0_1 |
InParanoidi | P40233 |
OMAi | RGWEASM |
PhylomeDBi | P40233 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5613 |
Miscellaneous databases
EvolutionaryTracei | P40233 |
PROi | PR:P40233 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CKI1_SCHPO | |
Accessioni | P40233Primary (citable) accession number: P40233 Secondary accession number(s): Q9UUL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families