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Protein

T-complex protein 1 subunit zeta

Gene

CCT6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • unfolded protein binding Source: GO_Central
  • WD40-repeat domain binding Source: BHF-UCL

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • positive regulation of establishment of protein localization to telomere Source: BHF-UCL
  • positive regulation of protein localization to Cajal body Source: BHF-UCL
  • positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • protein folding Source: Reactome
  • protein stabilization Source: BHF-UCL

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
Acute morphine dependence-related protein 2
CCT-zeta-1
HTR3
Tcp20
Gene namesi
Name:CCT6A
Synonyms:CCT6, CCTZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146731.10
HGNCiHGNC:1620 CCT6A
MIMi104613 gene
neXtProtiNX_P40227

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi908
OpenTargetsiENSG00000146731
PharmGKBiPA26183

Polymorphism and mutation databases

BioMutaiCCT6A
DMDMi730922

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001283552 – 531T-complex protein 1 subunit zetaAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5N6-acetyllysineBy similarity1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei287N6-acetyllysineBy similarity1
Modified residuei365N6-acetyllysineCombined sources1
Modified residuei377N6-acetyllysineCombined sources1
Modified residuei388N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP40227
MaxQBiP40227
PaxDbiP40227
PeptideAtlasiP40227
PRIDEiP40227
ProteomicsDBi55353

2D gel databases

DOSAC-COBS-2DPAGEiP40227
REPRODUCTION-2DPAGEiIPI00027626
P40227
SWISS-2DPAGEiP40227
UCD-2DPAGEiP40227

PTM databases

iPTMnetiP40227
PhosphoSitePlusiP40227
SwissPalmiP40227

Expressioni

Gene expression databases

BgeeiENSG00000146731
CleanExiHS_CCT6A
ExpressionAtlasiP40227 baseline and differential
GenevisibleiP40227 HS

Organism-specific databases

HPAiHPA042996
HPA045576
HPA049949

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.1 Publication

GO - Molecular functioni

  • unfolded protein binding Source: GO_Central
  • WD40-repeat domain binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107346, 244 interactors
CORUMiP40227
DIPiDIP-33558N
IntActiP40227, 139 interactors
MINTiP40227
STRINGi9606.ENSP00000275603

Structurei

3D structure databases

ProteinModelPortaliP40227
SMRiP40227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
HOVERGENiHBG103725
InParanoidiP40227
KOiK09498
OMAiMQHKTDT
OrthoDBiEOG091G07CE
PhylomeDBiP40227
TreeFamiTF106333

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P40227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIT EGFEAAKEKA LQFLEEVKVS REMDRETLID
160 170 180 190 200
VARTSLRTKV HAELADVLTE AVVDSILAIK KQDEPIDLFM IEIMEMKHKS
210 220 230 240 250
ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE KTEVNSGFFY
260 270 280 290 300
KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF
310 320 330 340 350
SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN
410 420 430 440 450
AIDDGCVVPG AGAVEVAMAE ALIKHKPSVK GRAQLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD LNTGEPMVAA EVGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK G
Length:531
Mass (Da):58,024
Last modified:January 23, 2007 - v3
Checksum:i43ABCF548CC82B81
GO
Isoform 2 (identifier: P40227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):53,289
Checksum:i2B0A27299B03A08A
GO

Sequence cautioni

The sequence AAA58676 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BU540578 differs from that shown. Several sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301 – 303SLD → PLS in BAB61032 (Ref. 3) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052268229Y → C. Corresponds to variant dbSNP:rs33922584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04491868 – 112Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27706 mRNA Translation: AAA61061.1
AF385084 mRNA Translation: AAK61354.1
AB063318 mRNA Translation: BAB61032.1
AC092101 Genomic DNA Translation: AAS07451.1
AC092579 Genomic DNA No translation available.
BC106942 mRNA Translation: AAI06943.1
BU540578 mRNA No translation available.
M94083 mRNA Translation: AAA58676.1 Different initiation.
CCDSiCCDS34640.1 [P40227-2]
CCDS5523.1 [P40227-1]
PIRiS48087
RefSeqiNP_001009186.1, NM_001009186.1 [P40227-2]
NP_001753.1, NM_001762.3 [P40227-1]
UniGeneiHs.82916

Genome annotation databases

EnsembliENST00000275603; ENSP00000275603; ENSG00000146731 [P40227-1]
ENST00000335503; ENSP00000352019; ENSG00000146731 [P40227-2]
GeneIDi908
KEGGihsa:908
UCSCiuc003trl.2 human [P40227-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCPZ_HUMAN
AccessioniPrimary (citable) accession number: P40227
Secondary accession number(s): A6NCD2
, Q3KP28, Q75LP4, Q96S46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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