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UniProtKB - P40225 (TPO_HUMAN)

Entry version 187 (02 Dec 2020)
Sequence version 1 (01 Feb 1995)
Previous versions | rss
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Protein

Thrombopoietin

Gene

THPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Hormone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P40225

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-76009, Platelet Aggregation (Plug Formation)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P40225

SIGNOR Signaling Network Open Resource

More...SIGNORi		P40225

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombopoietin
Alternative name(s):
C-mpl ligand
Short name:
ML
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
Short name:
MGDF
Myeloproliferative leukemia virus oncogene ligand
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THPO
Synonyms:MGDF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000090534.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:11795, THPO

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600044, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P40225

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Thrombocythemia 1 (THCYT1)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		7066

MalaCards human disease database

More...MalaCardsi		THPO
MIMi187950, phenotype

Open Targets

More...OpenTargetsi		ENSG00000090534

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		71493, Familial thrombocytosis
397692, Hereditary isolated aplastic anemia
329319, Thrombocythemia with distal limb defects

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36506

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P40225, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1293256

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		THPO

Domain mapping of disease mutations (DMDM)

More...DMDMi		730982

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000841122 – 353ThrombopoietinAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi22O-linked (GalNAc...) serine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 172
Disulfide bondi50 ↔ 106
Glycosylationi58O-linked (GalNAc...) threonine1 Publication1
Glycosylationi131O-linked (GalNAc...) threonine1 Publication1
Glycosylationi179O-linked (GalNAc...) threonine1 Publication1
Glycosylationi180O-linked (GalNAc...) threonine1 Publication1
Glycosylationi184O-linked (GalNAc...) serine1 Publication1
Glycosylationi197N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi206N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi213O-linked (GalNAc...) threonine1 Publication1
Glycosylationi234N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi255N-linked (GlcNAc...) (complex) asparagine1 Publication1
Glycosylationi265O-linked (GalNAc...) serine1 Publication1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P40225

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P40225

PeptideAtlas

More...PeptideAtlasi		P40225

PRoteomics IDEntifications database

More...PRIDEi		P40225

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55350 [P40225-1]
55351 [P40225-2]
55352 [P40225-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		592, 12 N-Linked glycans, 4 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P40225, 14 sites, 12 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P40225

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P40225

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P40225

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000090534, Expressed in right lobe of liver and 103 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P40225, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P40225, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000090534, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112922, 3 interactors

Database of interacting proteins

More...DIPi		DIP-5729N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P40225

Protein interaction database and analysis system

More...IntActi		P40225, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000204615

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P40225, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P40225

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi285 – 337Pro-richAdd BLAST53

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S9T0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006294

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40225

Identification of Orthologs from Complete Genome Data

More...OMAi		AHPHFQN

Database of Orthologous Groups

More...OrthoDBi		906192at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P40225

TreeFam database of animal gene trees

More...TreeFami		TF338084

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR019767, EPO/TPO_CS
IPR001323, EPO_TPO
IPR003978, Thrombopoietin

The PANTHER Classification System

More...PANTHERi		PTHR10560, PTHR10560, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00758, EPO_TPO, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01485, THROMBOPTN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47266, SSF47266, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00817, EPO_TPO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC 
        60         70         80         90        100
PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 
       110        120        130        140        150
QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL 
       160        170        180        190        200
SFQHLLRGKV RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS 
       210        220        230        240        250
GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI 
       260        270        280        290        300
HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP 
       310        320        330        340        350
TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS 

QEG
Length:353
Mass (Da):37,823
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0AB5449B72E5526
GO
Isoform 2 (identifier: P40225-2) [UniParc]FASTAAdd to basket
Also known as: TPO-2

The sequence of this isoform differs from the canonical sequence as follows:
     133-136: Missing.

Show »
Length:349
Mass (Da):37,387
Checksum:iC7348E1148DAA58C
GO
Isoform 3 (identifier: P40225-3) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     160-198: Missing.

Show »
Length:314
Mass (Da):33,604
Checksum:i183A09670C9FAEE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5FBX8Q5FBX8_HUMAN
Thrombopoietin
THPO
319Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITS0A0A3B3ITS0_HUMAN
Thrombopoietin
THPO hCG_40497
493Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6L1F8W6L1_HUMAN
Thrombopoietin
THPO
286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y734A0A2R8Y734_HUMAN
Thrombopoietin
THPO
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46R → K in AAB03392 (Ref. 8) Curated1
Sequence conflicti46R → K in AAB03393 (Ref. 8) Curated1
Sequence conflicti46R → K in AAB03394 (Ref. 8) Curated1
Sequence conflicti76M → MSQ in AAA74083 (PubMed:7822271).Curated1
Sequence conflicti113Q → E in AAA50553 (PubMed:8020099).Curated1
Sequence conflicti131T → P in AAA74083 (PubMed:7822271).Curated1
Sequence conflicti277G → E in AAB03393 (Ref. 8) Curated1
Sequence conflicti277G → E in AAB03394 (Ref. 8) Curated1
Sequence conflicti346S → C in AAB03393 (Ref. 8) Curated1
Sequence conflicti346S → C in AAB03394 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01179514L → P. Corresponds to variant dbSNP:rs1042346Ensembl.1
Natural variantiVAR_011796116G → E. Corresponds to variant dbSNP:rs1126665Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001450133 – 136Missing in isoform 2. 1 Publication4
Alternative sequenceiVSP_001451160 – 198Missing in isoform 3. CuratedAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L33410 mRNA Translation: AAA59857.1
U11025 mRNA Translation: AAA50553.1
L36051 Genomic DNA Translation: AAC37568.1
L36052 mRNA Translation: AAC37566.1
D32046 Genomic DNA Translation: BAA06807.1
S76771 Genomic DNA Translation: AAB33390.1
D32047 mRNA Translation: BAA21930.1
U59493 mRNA Translation: AAB03392.1
U59494 mRNA Translation: AAB03393.1
U59495 mRNA Translation: AAB03394.1
U17071 Genomic DNA Translation: AAA74083.1
BC130322 mRNA Translation: AAI30323.1
BC136338 mRNA Translation: AAI36339.1
BC143982 mRNA Translation: AAI43983.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3265.1 [P40225-1]
CCDS54693.1 [P40225-2]

Protein sequence database of the Protein Information Resource

More...PIRi		G02729
I59281, I80105

NCBI Reference Sequences

More...RefSeqi		NP_000451.1, NM_000460.3 [P40225-1]
NP_001171068.1, NM_001177597.2 [P40225-2]
NP_001171069.1, NM_001177598.2
NP_001276926.1, NM_001289997.1
NP_001276927.1, NM_001289998.1 [P40225-1]
NP_001276932.1, NM_001290003.1
NP_001276951.1, NM_001290022.1 [P40225-2]
NP_001276955.1, NM_001290026.1
NP_001276956.1, NM_001290027.1
NP_001276957.1, NM_001290028.1 [P40225-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000445696; ENSP00000410763; ENSG00000090534 [P40225-2]
ENST00000647395; ENSP00000494504; ENSG00000090534 [P40225-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7066

UCSC genome browser

More...UCSCi		uc003fol.2, human [P40225-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33410 mRNA Translation: AAA59857.1
U11025 mRNA Translation: AAA50553.1
L36051 Genomic DNA Translation: AAC37568.1
L36052 mRNA Translation: AAC37566.1
D32046 Genomic DNA Translation: BAA06807.1
S76771 Genomic DNA Translation: AAB33390.1
D32047 mRNA Translation: BAA21930.1
U59493 mRNA Translation: AAB03392.1
U59494 mRNA Translation: AAB03393.1
U59495 mRNA Translation: AAB03394.1
U17071 Genomic DNA Translation: AAA74083.1
BC130322 mRNA Translation: AAI30323.1
BC136338 mRNA Translation: AAI36339.1
BC143982 mRNA Translation: AAI43983.1
CCDSiCCDS3265.1 [P40225-1]
CCDS54693.1 [P40225-2]
PIRiG02729
I59281, I80105
RefSeqiNP_000451.1, NM_000460.3 [P40225-1]
NP_001171068.1, NM_001177597.2 [P40225-2]
NP_001171069.1, NM_001177598.2
NP_001276926.1, NM_001289997.1
NP_001276927.1, NM_001289998.1 [P40225-1]
NP_001276932.1, NM_001290003.1
NP_001276951.1, NM_001290022.1 [P40225-2]
NP_001276955.1, NM_001290026.1
NP_001276956.1, NM_001290027.1
NP_001276957.1, NM_001290028.1 [P40225-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V7MX-ray2.51V/X22-184[»]
1V7NX-ray3.30V/X/Y/Z22-184[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112922, 3 interactors
DIPiDIP-5729N
ELMiP40225
IntActiP40225, 3 interactors
STRINGi9606.ENSP00000204615

Chemistry databases

ChEMBLiCHEMBL1293256

PTM databases

GlyConnecti592, 12 N-Linked glycans, 4 O-Linked glycans
GlyGeniP40225, 14 sites, 12 N-linked glycans (1 site)
iPTMnetiP40225
PhosphoSitePlusiP40225
UniCarbKBiP40225

Polymorphism and mutation databases

BioMutaiTHPO
DMDMi730982

Proteomic databases

MassIVEiP40225
PaxDbiP40225
PeptideAtlasiP40225
PRIDEiP40225
ProteomicsDBi55350 [P40225-1]
55351 [P40225-2]
55352 [P40225-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P40225, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19145, 598 antibodies

The DNASU plasmid repository

More...DNASUi		7066

Genome annotation databases

EnsembliENST00000445696; ENSP00000410763; ENSG00000090534 [P40225-2]
ENST00000647395; ENSP00000494504; ENSG00000090534 [P40225-1]
GeneIDi7066
KEGGihsa:7066
UCSCiuc003fol.2, human [P40225-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7066
DisGeNETi7066
EuPathDBiHostDB:ENSG00000090534.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		THPO
HGNCiHGNC:11795, THPO
HPAiENSG00000090534, Tissue enriched (liver)
MalaCardsiTHPO
MIMi187950, phenotype
600044, gene
neXtProtiNX_P40225
OpenTargetsiENSG00000090534
Orphaneti71493, Familial thrombocytosis
397692, Hereditary isolated aplastic anemia
329319, Thrombocythemia with distal limb defects
PharmGKBiPA36506

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S9T0, Eukaryota
GeneTreeiENSGT00390000006294
HOGENOMiCLU_039844_0_0_1
InParanoidiP40225
OMAiAHPHFQN
OrthoDBi906192at2759
PhylomeDBiP40225
TreeFamiTF338084

Enzyme and pathway databases

PathwayCommonsiP40225
ReactomeiR-HSA-76009, Platelet Aggregation (Plug Formation)
SignaLinkiP40225
SIGNORiP40225

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7066, 5 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		THPO, human
EvolutionaryTraceiP40225

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Thrombopoietin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7066
PharosiP40225, Tbio

Protein Ontology

More...PROi		PR:P40225
RNActiP40225, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000090534, Expressed in right lobe of liver and 103 other tissues
ExpressionAtlasiP40225, baseline and differential
GenevisibleiP40225, HS

Family and domain databases

InterProiView protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR019767, EPO/TPO_CS
IPR001323, EPO_TPO
IPR003978, Thrombopoietin
PANTHERiPTHR10560, PTHR10560, 1 hit
PfamiView protein in Pfam
PF00758, EPO_TPO, 1 hit
PRINTSiPR01485, THROMBOPTN
SUPFAMiSSF47266, SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00817, EPO_TPO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPO_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40225
Secondary accession number(s): A1L3Y0
, B7ZLR8, B9EGA8, Q13020, Q15790, Q15791, Q15792
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 2, 2020
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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