THPO

Functionⁱ

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 8202159
hormone activity Source: UniProtKB-KW
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8202159
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 8202159
myeloid cell differentiation Source: Ensembl
positive regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
positive regulation of hematopoietic stem cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 21540074
positive regulation of megakaryocyte differentiation Source: UniProtKB
positive regulation of protein kinase B signaling Source: UniProtKB
positive regulation of protein phosphorylation Source: UniProtKB
thrombopoietin-mediated signaling pathway Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Hormone

Molecular function

Cytokine, Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-76009 Platelet Aggregation (Plug Formation)
SignaLinkⁱ	P40225
SIGNORⁱ	P40225

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thrombopoietin Alternative name(s): C-mpl ligand Short name: ML Megakaryocyte colony-stimulating factor Megakaryocyte growth and development factor Short name: MGDF Myeloproliferative leukemia virus oncogene ligand
Gene namesⁱ	Name:THPO Synonyms:MGDF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090534.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11795 THPO
MIMⁱ	600044 gene
neXtProtⁱ	NX_P40225

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Thrombocythemia 1 (THCYT1)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7066
MalaCards human disease database More...MalaCardsⁱ	THPO
MIMⁱ	187950 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000090534
Orphanetⁱ	71493 Familial thrombocytosis 397692 Hereditary isolated aplastic anemia 329319 Thrombocythemia with distal limb defects
PharmGKBⁱ	PA36506

Chemistry databases

ChEMBLⁱ	CHEMBL1293256

ChEMBLⁱ

CHEMBL1293256

Polymorphism and mutation databases

BioMutaⁱ	THPO
DMDMⁱ	730982

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Add BLAST		21
ChainⁱPRO_0000008411	22 – 353	ThrombopoietinAdd BLAST		332

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	22	O-linked (GalNAc...) serine1 Publication	1
Disulfide bondⁱ	28 ↔ 172
Disulfide bondⁱ	50 ↔ 106
Glycosylationⁱ	58	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	131	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	179	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	180	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	184	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	197	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Glycosylationⁱ	206	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Glycosylationⁱ	213	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	234	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Glycosylationⁱ	255	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Glycosylationⁱ	265	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	340	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	348	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P40225
PeptideAtlas More...PeptideAtlasⁱ	P40225
PRIDEⁱ	P40225
ProteomicsDBⁱ	55350 55351 [P40225-2] 55352 [P40225-3]

PTM databases

GlyConnectⁱ	592
iPTMnetⁱ	P40225
PhosphoSitePlusⁱ	P40225
UniCarbKBⁱ	P40225

Miscellaneous databases

PMAP-CutDBⁱ	P40225

PMAP-CutDBⁱ

P40225

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090534 Expressed in 85 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_THPO
ExpressionAtlasⁱ	P40225 baseline and differential
Genevisibleⁱ	P40225 HS

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 8202159
hormone activity Source: UniProtKB-KW
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112922, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-5729N
ELMⁱ	P40225
IntActⁱ	P40225, 3 interactors
STRINGⁱ	9606.ENSP00000204615

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	32 – 45	Combined sources	14
Helixⁱ	46 – 48	Combined sources	3
Beta strandⁱ	49 – 52	Combined sources	4
Beta strandⁱ	60 – 63	Combined sources	4
Helixⁱ	70 – 74	Combined sources	5
Helixⁱ	77 – 98	Combined sources	22
Turnⁱ	99 – 101	Combined sources	3
Beta strandⁱ	104 – 106	Combined sources	3
Helixⁱ	107 – 110	Combined sources	4
Helixⁱ	113 – 129	Combined sources	17
Beta strandⁱ	139 – 143	Combined sources	5
Helixⁱ	145 – 147	Combined sources	3
Helixⁱ	148 – 157	Combined sources	10
Turnⁱ	158 – 160	Combined sources	3
Helixⁱ	161 – 163	Combined sources	3
Beta strandⁱ	165 – 167	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P40225
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P40225

EvolutionaryTraceⁱ

P40225

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	285 – 337	Pro-richAdd BLAST		53

Domainⁱ

Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.

Sequence similaritiesⁱ

Belongs to the EPO/TPO family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVHV Eukaryota ENOG41116B9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006294
HOVERGENⁱ	HBG002468
InParanoidⁱ	P40225
KEGG Orthology (KO) More...KOⁱ	K06854
OMAⁱ	PLNGTHG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DW3
PhylomeDBⁱ	P40225
TreeFamⁱ	TF338084

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR019767 EPO/TPO_CS IPR001323 EPO_TPO IPR003978 Thrombopoeitin
PANTHERⁱ	PTHR10560 PTHR10560, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00758 EPO_TPO, 1 hit
PRINTSⁱ	PR01485 THROMBOPTN
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00817 EPO_TPO, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P40225-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC 
        60         70         80         90        100
PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 
       110        120        130        140        150
QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL 
       160        170        180        190        200
SFQHLLRGKV RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS 
       210        220        230        240        250
GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI 
       260        270        280        290        300
HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP 
       310        320        330        340        350
TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS 

QEG

Length:353

Mass (Da):37,823

Last modified:February 1, 1995 - v1

Checksum:ⁱF0AB5449B72E5526

GO

Isoform 2 (identifier: P40225-2) [UniParc]FASTA Add to basket

Also known as: TPO-2

The sequence of this isoform differs from the canonical sequence as follows:
133-136: Missing.

« Hide

        10         20         30         40         50
MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC 
        60         70         80         90        100
PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 
       110        120        130        140        150
QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQGRTTAHKD PNAIFLSFQH 
       160        170        180        190        200
LLRGKVRFLM LVGGSTLCVR RAPPTTAVPS RTSLVLTLNE LPNRTSGLLE 
       210        220        230        240        250
TNFTASARTT GSGLLKWQQG FRAKIPGLLN QTSRSLDQIP GYLNRIHELL 
       260        270        280        290        300
NGTRGLFPGP SRRTLGAPDI SSGTSDTGSL PPNLQPGYSP SPTHPPTGQY 
       310        320        330        340 
TLFPLPPTLP TPVVQLHPLL PDPSAPTPTP TSPLLNTSYT HSQNLSQEG

Show »

Length:349

Mass (Da):37,387

Checksum:ⁱC7348E1148DAA58C

GO

Isoform 3 (identifier: P40225-3) [UniParc]FASTA Add to basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
160-198: Missing.

« Hide

        10         20         30         40         50
MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC 
        60         70         80         90        100
PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 
       110        120        130        140        150
QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL 
       160        170        180        190        200
SFQHLLRGKT SGLLETNFTA SARTTGSGLL KWQQGFRAKI PGLLNQTSRS 
       210        220        230        240        250
LDQIPGYLNR IHELLNGTRG LFPGPSRRTL GAPDISSGTS DTGSLPPNLQ 
       260        270        280        290        300
PGYSPSPTHP PTGQYTLFPL PPTLPTPVVQ LHPLLPDPSA PTPTPTSPLL 
       310 
NTSYTHSQNL SQEG

Show »

Length:314

Mass (Da):33,604

Checksum:ⁱ183A09670C9FAEE4

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W6L1	F8W6L1_HUMAN	Thrombopoietin Thrombopoietin	THPO	286	Annotation score:
A0A2R8Y734	A0A2R8Y734_HUMAN	Thrombopoietin Thrombopoietin	THPO	12	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	46	R → K in AAB03392 (Ref. 8) Curated	1
Sequence conflictⁱ	46	R → K in AAB03393 (Ref. 8) Curated	1
Sequence conflictⁱ	46	R → K in AAB03394 (Ref. 8) Curated	1
Sequence conflictⁱ	76	M → MSQ in AAA74083 (PubMed:7822271).Curated	1
Sequence conflictⁱ	113	Q → E in AAA50553 (PubMed:8020099).Curated	1
Sequence conflictⁱ	131	T → P in AAA74083 (PubMed:7822271).Curated	1
Sequence conflictⁱ	277	G → E in AAB03393 (Ref. 8) Curated	1
Sequence conflictⁱ	277	G → E in AAB03394 (Ref. 8) Curated	1
Sequence conflictⁱ	346	S → C in AAB03393 (Ref. 8) Curated	1
Sequence conflictⁱ	346	S → C in AAB03394 (Ref. 8) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011795	14	L → P. Corresponds to variant dbSNP:rs1042346Ensembl.		1
Natural variantⁱVAR_011796	116	G → E. Corresponds to variant dbSNP:rs1126665Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001450	133 – 136	Missing in isoform 2. 1 Publication		4
Alternative sequenceⁱVSP_001451	160 – 198	Missing in isoform 3. CuratedAdd BLAST		39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L33410 mRNA Translation: AAA59857.1 U11025 mRNA Translation: AAA50553.1 L36051 Genomic DNA Translation: AAC37568.1 L36052 mRNA Translation: AAC37566.1 D32046 Genomic DNA Translation: BAA06807.1 S76771 Genomic DNA Translation: AAB33390.1 D32047 mRNA Translation: BAA21930.1 U59493 mRNA Translation: AAB03392.1 U59494 mRNA Translation: AAB03393.1 U59495 mRNA Translation: AAB03394.1 U17071 Genomic DNA Translation: AAA74083.1 BC130322 mRNA Translation: AAI30323.1 BC136338 mRNA Translation: AAI36339.1 BC143982 mRNA Translation: AAI43983.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3265.1 [P40225-1] CCDS54693.1 [P40225-2]
PIRⁱ	G02729 I59281 I80105
NCBI Reference Sequences More...RefSeqⁱ	NP_000451.1, NM_000460.3 [P40225-1] NP_001171068.1, NM_001177597.2 [P40225-2] NP_001171069.1, NM_001177598.2 NP_001276926.1, NM_001289997.1 NP_001276927.1, NM_001289998.1 [P40225-1] NP_001276932.1, NM_001290003.1 NP_001276951.1, NM_001290022.1 [P40225-2] NP_001276955.1, NM_001290026.1 NP_001276956.1, NM_001290027.1 NP_001276957.1, NM_001290028.1 [P40225-1]
UniGeneⁱ	Hs.1166 Hs.734657

Genome annotation databases

Ensemblⁱ	ENST00000204615; ENSP00000204615; ENSG00000090534 [P40225-1] ENST00000445696; ENSP00000410763; ENSG00000090534 [P40225-2] ENST00000645603; ENSP00000494281; ENSG00000090534 [P40225-1] ENST00000647395; ENSP00000494504; ENSG00000090534 [P40225-1]
GeneIDⁱ	7066
KEGGⁱ	hsa:7066
UCSC genome browser More...UCSCⁱ	uc003fol.2 human [P40225-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P40225	THPO isoform 1		PANTR		353	UniRef100_P40225
UPI0000EE22C7		HUMAN		493
P40225-2	THPO isoform 2		PANTR		349	UniRef100_A0A2J8M5P1
UPI0007DB99C6		PANTR		489

Protein	Similar proteins		Species	Score	Length	Source
P40225	THPO isoform 1		PANTR		353	UniRef90_P40225
Uncharacterized protein		PONAB		520
Uncharacterized protein		MACMU		353
Uncharacterized protein		MACFA		353
Uncharacterized protein		MACNE		353
+27

Protein	Similar proteins		Species	Score	Length	Source
P40225	Thrombopoietin		RAT		326	UniRef50_P40225
Thrombopoietin		MOUSE		356
THPO isoform 1		PANTR		353
Uncharacterized protein		PONAB		520
Uncharacterized protein		NOMLE		353
+63
P40225-3	thrombopoietin isoform X1		DELLE		324	UniRef50_P40225-3
Thrombopoietin		OTOGA		297
Thrombopoietin (Fragment)		HETGA		276
Thrombopoietin		COLAP		308
UPI0004BD96C7		EQUPR		290

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L33410 mRNA Translation: AAA59857.1 U11025 mRNA Translation: AAA50553.1 L36051 Genomic DNA Translation: AAC37568.1 L36052 mRNA Translation: AAC37566.1 D32046 Genomic DNA Translation: BAA06807.1 S76771 Genomic DNA Translation: AAB33390.1 D32047 mRNA Translation: BAA21930.1 U59493 mRNA Translation: AAB03392.1 U59494 mRNA Translation: AAB03393.1 U59495 mRNA Translation: AAB03394.1 U17071 Genomic DNA Translation: AAA74083.1 BC130322 mRNA Translation: AAI30323.1 BC136338 mRNA Translation: AAI36339.1 BC143982 mRNA Translation: AAI43983.1
CCDSⁱ	CCDS3265.1 [P40225-1] CCDS54693.1 [P40225-2]
PIRⁱ	G02729 I59281 I80105
RefSeqⁱ	NP_000451.1, NM_000460.3 [P40225-1] NP_001171068.1, NM_001177597.2 [P40225-2] NP_001171069.1, NM_001177598.2 NP_001276926.1, NM_001289997.1 NP_001276927.1, NM_001289998.1 [P40225-1] NP_001276932.1, NM_001290003.1 NP_001276951.1, NM_001290022.1 [P40225-2] NP_001276955.1, NM_001290026.1 NP_001276956.1, NM_001290027.1 NP_001276957.1, NM_001290028.1 [P40225-1]
UniGeneⁱ	Hs.1166 Hs.734657

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1V7M	X-ray	2.51	V/X	22-184	[»]
	1V7N	X-ray	3.30	V/X/Y/Z	22-184	[»]
ProteinModelPortalⁱ	P40225
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112922, 3 interactors
DIPⁱ	DIP-5729N
ELMⁱ	P40225
IntActⁱ	P40225, 3 interactors
STRINGⁱ	9606.ENSP00000204615

Chemistry databases

ChEMBLⁱ	CHEMBL1293256

ChEMBLⁱ

CHEMBL1293256

PTM databases

GlyConnectⁱ	592
iPTMnetⁱ	P40225
PhosphoSitePlusⁱ	P40225
UniCarbKBⁱ	P40225

Polymorphism and mutation databases

BioMutaⁱ	THPO
DMDMⁱ	730982

Proteomic databases

PaxDbⁱ	P40225
PeptideAtlasⁱ	P40225
PRIDEⁱ	P40225
ProteomicsDBⁱ	55350 55351 [P40225-2] 55352 [P40225-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7066
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000204615; ENSP00000204615; ENSG00000090534 [P40225-1] ENST00000445696; ENSP00000410763; ENSG00000090534 [P40225-2] ENST00000645603; ENSP00000494281; ENSG00000090534 [P40225-1] ENST00000647395; ENSP00000494504; ENSG00000090534 [P40225-1]
GeneIDⁱ	7066
KEGGⁱ	hsa:7066
UCSCⁱ	uc003fol.2 human [P40225-1]

Organism-specific databases

CTDⁱ	7066
DisGeNETⁱ	7066
EuPathDBⁱ	HostDB:ENSG00000090534.17
GeneCardsⁱ	THPO
HGNCⁱ	HGNC:11795 THPO
MalaCardsⁱ	THPO
MIMⁱ	187950 phenotype 600044 gene
neXtProtⁱ	NX_P40225
OpenTargetsⁱ	ENSG00000090534
Orphanetⁱ	71493 Familial thrombocytosis 397692 Hereditary isolated aplastic anemia 329319 Thrombocythemia with distal limb defects
PharmGKBⁱ	PA36506
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVHV Eukaryota ENOG41116B9 LUCA
GeneTreeⁱ	ENSGT00390000006294
HOVERGENⁱ	HBG002468
InParanoidⁱ	P40225
KOⁱ	K06854
OMAⁱ	PLNGTHG
OrthoDBⁱ	EOG091G0DW3
PhylomeDBⁱ	P40225
TreeFamⁱ	TF338084

Enzyme and pathway databases

Reactomeⁱ	R-HSA-76009 Platelet Aggregation (Plug Formation)
SignaLinkⁱ	P40225
SIGNORⁱ	P40225

Miscellaneous databases

ChiTaRSⁱ	THPO human
EvolutionaryTraceⁱ	P40225
GeneWikiⁱ	Thrombopoietin
GenomeRNAiⁱ	7066
PMAP-CutDBⁱ	P40225
Protein Ontology More...PROⁱ	PR:P40225
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090534 Expressed in 85 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_THPO
ExpressionAtlasⁱ	P40225 baseline and differential
Genevisibleⁱ	P40225 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR019767 EPO/TPO_CS IPR001323 EPO_TPO IPR003978 Thrombopoeitin
PANTHERⁱ	PTHR10560 PTHR10560, 1 hit
Pfamⁱ	View protein in Pfam PF00758 EPO_TPO, 1 hit
PRINTSⁱ	PR01485 THROMBOPTN
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00817 EPO_TPO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPO_HUMAN
Accessionⁱ	P40225Primary (citable) accession number: P40225 Secondary accession number(s): A1L3Y0 Q15792
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P40225 (TPO_HUMAN)

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Thrombopoietin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Thrombocythemia 1 (THCYT1)

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ