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Protein

Carcinoembryonic antigen-related cell adhesion molecule 6

Gene

CEACAM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).8 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 6
Alternative name(s):
Non-specific crossreacting antigen
Normal cross-reacting antigen
CD_antigen: CD66c
Gene namesi
Name:CEACAM6
Synonyms:NCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000086548.8
HGNCiHGNC:1818 CEACAM6
MIMi163980 gene
neXtProtiNX_P40199

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38I → A: Loss of homodimerization and heterodimerization with CEACAM8. 1 Publication1
Mutagenesisi53L → A: No effect on homodimerization. Reduces heterodimerization with CEACAM8. 1 Publication1
Mutagenesisi55A → V: No effect on homophilic and heterophilic cell adhesion. 1 Publication1
Mutagenesisi61N → H: Inhibits homophilic and heterophilic cell adhesion. 1 Publication1
Mutagenesisi62R → L: No effect on homophilic cell adhesion. Reduces heterophilic cell adhesion. 1 Publication1
Mutagenesisi63I → F: No effect on homophilic cell adhesion. Inhibits heterophilic cell adhesion. 1 Publication1
Mutagenesisi66S → N: Inhibits homophilic cell adhesion. Reduces heterophilic cell adhesion. 1 Publication1
Mutagenesisi78L → Q: Inhibits homophilic cell adhesion. No effect on heterophilic cell adhesion. 1 Publication1
Mutagenesisi123Q → A: No effect on homodimerization. Reduces heterodimerization with CEACAM8. 1 Publication1
Mutagenesisi129L → A: Reduces homodimerization. Loss of heterodimerization with CEACAM8. 1 Publication1

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNETi4680
PharmGKBiPA26362

Polymorphism and mutation databases

BioMutaiCEACAM6
DMDMi296439410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 341 PublicationAdd BLAST34
ChainiPRO_000001456835 – 320Carcinoembryonic antigen-related cell adhesion molecule 6Add BLAST286
PropeptideiPRO_0000014569321 – 344Removed in mature formBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi111N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi115N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi167 ↔ 215PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi197N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi224N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi259 ↔ 299PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi288N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi292N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi309N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Lipidationi320GPI-anchor amidated glycineBy similarity1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP40199
MaxQBiP40199
PaxDbiP40199
PeptideAtlasiP40199
PRIDEiP40199
ProteomicsDBi55345

PTM databases

iPTMnetiP40199
PhosphoSitePlusiP40199

Expressioni

Tissue specificityi

Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051).3 Publications

Inductioni

Up-regulated in anoikis-resistant pancreatic adenocarcinoma cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000086548 Expressed in 167 organ(s), highest expression level in upper lobe of lung
CleanExiHS_CEACAM6
ExpressionAtlasiP40199 baseline and differential
GenevisibleiP40199 HS

Organism-specific databases

HPAiCAB008370
HPA011041

Interactioni

Subunit structurei

Homodimer; homodimerizes via its Ig-like V-type domain. Heterodimer with CEACAM8; heterodimerizes via its Ig-like V-type domain.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110760, 7 interactors
IntActiP40199, 33 interactors
STRINGi9606.ENSP00000199764

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP40199
SMRiP40199
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 142Ig-like V-typeBy similarityAdd BLAST108
Domaini145 – 232Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST88
Domaini240 – 314Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST75

Domaini

The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion.3 Publications

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP40199
KOiK06499
OrthoDBiEOG091G0AMM
PhylomeDBiP40199
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P40199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLAHNLPQ NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET
110 120 130 140 150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV NGQSLPVSPR LQLSNGNMTL
210 220 230 240 250
TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP TISPSKANYR
260 270 280 290 300
PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
310 320 330 340
AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI
Length:344
Mass (Da):37,195
Last modified:May 18, 2010 - v3
Checksum:i28469487A74C18A4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYD3M0QYD3_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM6
33Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138F → L in AAA59915 (PubMed:3220478).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034680239G → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs11548735Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA Translation: AAA59915.1
M18728 mRNA Translation: AAA59907.1
M18216 mRNA Translation: AAA51739.1
BT009774 mRNA Translation: AAP88776.1
AK312542 mRNA Translation: BAG35441.1
AC011513 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57061.1
BC005008 mRNA Translation: AAH05008.1
CCDSiCCDS12585.1
RefSeqiNP_002474.4, NM_002483.6
UniGeneiHs.466814

Genome annotation databases

EnsembliENST00000199764; ENSP00000199764; ENSG00000086548
GeneIDi4680
KEGGihsa:4680
UCSCiuc032hyc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA Translation: AAA59915.1
M18728 mRNA Translation: AAA59907.1
M18216 mRNA Translation: AAA51739.1
BT009774 mRNA Translation: AAP88776.1
AK312542 mRNA Translation: BAG35441.1
AC011513 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57061.1
BC005008 mRNA Translation: AAH05008.1
CCDSiCCDS12585.1
RefSeqiNP_002474.4, NM_002483.6
UniGeneiHs.466814

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHCX-ray2.71A/B34-141[»]
4WTZX-ray2.52A/B/C/D/E/F34-141[»]
4Y8AX-ray1.83A/B34-141[»]
4YIQX-ray1.85B/D34-141[»]
ProteinModelPortaliP40199
SMRiP40199
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110760, 7 interactors
IntActiP40199, 33 interactors
STRINGi9606.ENSP00000199764

PTM databases

iPTMnetiP40199
PhosphoSitePlusiP40199

Polymorphism and mutation databases

BioMutaiCEACAM6
DMDMi296439410

Proteomic databases

EPDiP40199
MaxQBiP40199
PaxDbiP40199
PeptideAtlasiP40199
PRIDEiP40199
ProteomicsDBi55345

Protocols and materials databases

DNASUi4680
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199764; ENSP00000199764; ENSG00000086548
GeneIDi4680
KEGGihsa:4680
UCSCiuc032hyc.2 human

Organism-specific databases

CTDi4680
DisGeNETi4680
EuPathDBiHostDB:ENSG00000086548.8
GeneCardsiCEACAM6
HGNCiHGNC:1818 CEACAM6
HPAiCAB008370
HPA011041
MIMi163980 gene
neXtProtiNX_P40199
PharmGKBiPA26362
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP40199
KOiK06499
OrthoDBiEOG091G0AMM
PhylomeDBiP40199
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCEACAM6 human
GeneWikiiCEACAM6
GenomeRNAii4680
PROiPR:P40199
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086548 Expressed in 167 organ(s), highest expression level in upper lobe of lung
CleanExiHS_CEACAM6
ExpressionAtlasiP40199 baseline and differential
GenevisibleiP40199 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM6_HUMAN
AccessioniPrimary (citable) accession number: P40199
Secondary accession number(s): Q13774, Q14920, Q53XP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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