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Protein

Carcinoembryonic antigen-related cell adhesion molecule 6

Gene

CEACAM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 6
Alternative name(s):
Non-specific crossreacting antigen
Normal cross-reacting antigen
CD_antigen: CD66c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEACAM6
Synonyms:NCA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000086548.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1818 CEACAM6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
163980 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P40199

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38I → A: Loss of homodimerization and heterodimerization with CEACAM8. 1 Publication1
Mutagenesisi53L → A: No effect on homodimerization. Reduces heterodimerization with CEACAM8. 1 Publication1
Mutagenesisi55A → V: No effect on homophilic and heterophilic cell adhesion. 1 Publication1
Mutagenesisi61N → H: Inhibits homophilic and heterophilic cell adhesion. 1 Publication1
Mutagenesisi62R → L: No effect on homophilic cell adhesion. Reduces heterophilic cell adhesion. 1 Publication1
Mutagenesisi63I → F: No effect on homophilic cell adhesion. Inhibits heterophilic cell adhesion. 1 Publication1
Mutagenesisi66S → N: Inhibits homophilic cell adhesion. Reduces heterophilic cell adhesion. 1 Publication1
Mutagenesisi78L → Q: Inhibits homophilic cell adhesion. No effect on heterophilic cell adhesion. 1 Publication1
Mutagenesisi123Q → A: No effect on homodimerization. Reduces heterodimerization with CEACAM8. 1 Publication1
Mutagenesisi129L → A: Reduces homodimerization. Loss of heterodimerization with CEACAM8. 1 Publication1

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26362

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEACAM6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439410

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 341 PublicationAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001456835 – 320Carcinoembryonic antigen-related cell adhesion molecule 6Add BLAST286
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000014569321 – 344Removed in mature formBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi111N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi115N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 215PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi197N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi224N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi259 ↔ 299PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi288N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi292N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi309N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi320GPI-anchor amidated glycineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P40199

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P40199

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40199

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P40199

PeptideAtlas

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PeptideAtlasi
P40199

PRoteomics IDEntifications database

More...
PRIDEi
P40199

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55345

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40199

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P40199

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in anoikis-resistant pancreatic adenocarcinoma cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000086548 Expressed in 167 organ(s), highest expression level in upper lobe of lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_CEACAM6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P40199 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P40199 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008370
HPA011041

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerizes via its Ig-like V-type domain. Heterodimer with CEACAM8; heterodimerizes via its Ig-like V-type domain.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110760, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P40199, 33 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000199764

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHCX-ray2.71A/B34-141[»]
4WTZX-ray2.52A/B/C/D/E/F34-141[»]
4Y8AX-ray1.83A/B34-141[»]
4YIQX-ray1.85B/D34-141[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P40199

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40199

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 142Ig-like V-typeBy similarityAdd BLAST108
Domaini145 – 232Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST88
Domaini240 – 314Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion.3 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFE1 Eukaryota
ENOG410YR1P LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233417

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007922

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40199

KEGG Orthology (KO)

More...
KOi
K06499

Database of Orthologous Groups

More...
OrthoDBi
998214at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P40199

TreeFam database of animal gene trees

More...
TreeFami
TF336859

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P40199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLAHNLPQ NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET
110 120 130 140 150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV NGQSLPVSPR LQLSNGNMTL
210 220 230 240 250
TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP TISPSKANYR
260 270 280 290 300
PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
310 320 330 340
AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI
Length:344
Mass (Da):37,195
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28469487A74C18A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYD3M0QYD3_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM6
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138F → L in AAA59915 (PubMed:3220478).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034680239G → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs11548735Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M29541 mRNA Translation: AAA59915.1
M18728 mRNA Translation: AAA59907.1
M18216 mRNA Translation: AAA51739.1
BT009774 mRNA Translation: AAP88776.1
AK312542 mRNA Translation: BAG35441.1
AC011513 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57061.1
BC005008 mRNA Translation: AAH05008.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12585.1

NCBI Reference Sequences

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RefSeqi
NP_002474.4, NM_002483.6

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.466814

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000199764; ENSP00000199764; ENSG00000086548

Database of genes from NCBI RefSeq genomes

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GeneIDi
4680

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4680

UCSC genome browser

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UCSCi
uc032hyc.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA Translation: AAA59915.1
M18728 mRNA Translation: AAA59907.1
M18216 mRNA Translation: AAA51739.1
BT009774 mRNA Translation: AAP88776.1
AK312542 mRNA Translation: BAG35441.1
AC011513 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57061.1
BC005008 mRNA Translation: AAH05008.1
CCDSiCCDS12585.1
RefSeqiNP_002474.4, NM_002483.6
UniGeneiHs.466814

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHCX-ray2.71A/B34-141[»]
4WTZX-ray2.52A/B/C/D/E/F34-141[»]
4Y8AX-ray1.83A/B34-141[»]
4YIQX-ray1.85B/D34-141[»]
ProteinModelPortaliP40199
SMRiP40199
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110760, 7 interactors
IntActiP40199, 33 interactors
STRINGi9606.ENSP00000199764

PTM databases

iPTMnetiP40199
PhosphoSitePlusiP40199

Polymorphism and mutation databases

BioMutaiCEACAM6
DMDMi296439410

Proteomic databases

EPDiP40199
jPOSTiP40199
MaxQBiP40199
PaxDbiP40199
PeptideAtlasiP40199
PRIDEiP40199
ProteomicsDBi55345

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4680
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199764; ENSP00000199764; ENSG00000086548
GeneIDi4680
KEGGihsa:4680
UCSCiuc032hyc.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4680
DisGeNETi4680
EuPathDBiHostDB:ENSG00000086548.8

GeneCards: human genes, protein and diseases

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GeneCardsi
CEACAM6
HGNCiHGNC:1818 CEACAM6
HPAiCAB008370
HPA011041
MIMi163980 gene
neXtProtiNX_P40199
PharmGKBiPA26362

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP40199
KOiK06499
OrthoDBi998214at2759
PhylomeDBiP40199
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEACAM6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CEACAM6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4680

Protein Ontology

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PROi
PR:P40199

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000086548 Expressed in 167 organ(s), highest expression level in upper lobe of lung
CleanExiHS_CEACAM6
ExpressionAtlasiP40199 baseline and differential
GenevisibleiP40199 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEAM6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40199
Secondary accession number(s): Q13774, Q14920, Q53XP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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