UniProtKB - P40197 (GPV_HUMAN)
Protein
Platelet glycoprotein V
Gene
GP5
Organism
Homo sapiens (Human)
Status
Functioni
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
GO - Biological processi
- blood coagulation Source: Reactome
- blood coagulation, intrinsic pathway Source: Reactome
- cell adhesion Source: ProtInc
- platelet activation Source: Reactome
Keywordsi
Biological process | Blood coagulation, Cell adhesion, Hemostasis |
Enzyme and pathway databases
PathwayCommonsi | P40197 |
Reactomei | R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-430116, GP1b-IX-V activation signalling R-HSA-75892, Platelet Adhesion to exposed collagen R-HSA-76009, Platelet Aggregation (Plug Formation) R-HSA-9673221, Defective F9 activation |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet glycoprotein VShort name: GPV Alternative name(s): Glycoprotein 5 CD_antigen: CD42d |
Gene namesi | Name:GP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178732.5 |
HGNCi | HGNC:4443, GP5 |
MIMi | 173511, gene |
neXtProti | NX_P40197 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 523 | ExtracellularSequence analysisAdd BLAST | 507 | |
Transmembranei | 524 – 544 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 545 – 560 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2814 |
OpenTargetsi | ENSG00000178732 |
PharmGKBi | PA28823 |
Miscellaneous databases
Pharosi | P40197, Tbio |
Polymorphism and mutation databases
BioMutai | GP5 |
DMDMi | 729616 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000021361 | 17 – 560 | Platelet glycoprotein VAdd BLAST | 544 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 51 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 181 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Glycosylationi | 243 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Glycosylationi | 267 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 298 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 312 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 385 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 499 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The N-terminus is blocked.
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P40197 |
MassIVEi | P40197 |
PaxDbi | P40197 |
PeptideAtlasi | P40197 |
PRIDEi | P40197 |
ProteomicsDBi | 55341 |
PTM databases
GlyConnecti | 1968, 6 N-Linked glycans (2 sites) |
GlyGeni | P40197, 9 sites |
iPTMneti | P40197 |
PhosphoSitePlusi | P40197 |
Expressioni
Tissue specificityi
Platelets and megakaryocytes.
Gene expression databases
Bgeei | ENSG00000178732, Expressed in leukocyte and 34 other tissues |
Genevisiblei | P40197, HS |
Organism-specific databases
HPAi | ENSG00000178732, Tissue enhanced (lymphoid) |
Interactioni
Binary interactionsi
P40197
With | #Exp. | IntAct |
---|---|---|
GP9 [P14770] | 2 | EBI-10891395,EBI-1754109 |
Protein-protein interaction databases
BioGRIDi | 109076, 3 interactors |
ComplexPortali | CPX-114, Glycoprotein Ib-IX-V complex CPX-117, Glycoprotein Ib-IX-V-Filamin-A complex |
IntActi | P40197, 1 interactor |
STRINGi | 9606.ENSP00000383931 |
Miscellaneous databases
RNActi | P40197, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 50 | LRRNTAdd BLAST | 34 | |
Repeati | 75 – 96 | LRR 1Add BLAST | 22 | |
Repeati | 99 – 120 | LRR 2Add BLAST | 22 | |
Repeati | 123 – 144 | LRR 3Add BLAST | 22 | |
Repeati | 147 – 168 | LRR 4Add BLAST | 22 | |
Repeati | 171 – 193 | LRR 5Add BLAST | 23 | |
Repeati | 195 – 216 | LRR 6Add BLAST | 22 | |
Repeati | 219 – 240 | LRR 7Add BLAST | 22 | |
Repeati | 243 – 264 | LRR 8Add BLAST | 22 | |
Repeati | 267 – 288 | LRR 9Add BLAST | 22 | |
Repeati | 291 – 312 | LRR 10Add BLAST | 22 | |
Repeati | 340 – 361 | LRR 11Add BLAST | 22 | |
Repeati | 364 – 385 | LRR 12Add BLAST | 22 | |
Repeati | 388 – 409 | LRR 13Add BLAST | 22 | |
Domaini | 421 – 474 | LRRCTAdd BLAST | 54 |
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000162953 |
HOGENOMi | CLU_000288_18_6_1 |
InParanoidi | P40197 |
OMAi | VQLDHNQ |
OrthoDBi | 826997at2759 |
PhylomeDBi | P40197 |
TreeFami | TF351124 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 5 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 14 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P40197-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT
60 70 80 90 100
NLTHILLFGM GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL
110 120 130 140 150
KTLRLSRNKI THLPGALLDK MVLLEQLFLD HNALRGIDQN MFQKLVNLQE
160 170 180 190 200
LALNQNQLDF LPASLFTNLE NLKLLDLSGN NLTHLPKGLL GAQAKLERLL
210 220 230 240 250
LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR LPNLSSLTLS
260 270 280 290 300
RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT
310 320 330 340 350
QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG
360 370 380 390 400
LTALPDGLLR GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE
410 420 430 440 450
TLPGDVFGAL PRLTEVLLGH NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR
460 470 480 490 500
CAGPGAHAGL PLWALPGGDA ECPGPRGPPP RPAADSSSEA PVHPALAPNS
510 520 530 540 550
SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV FAMIKIGQLF
560
RKLIRERALG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | D → W AA sequence (PubMed:2350580).Curated | 1 | |
Sequence conflicti | 136 – 138 | GID → PGG AA sequence (PubMed:2350580).Curated | 3 | |
Sequence conflicti | 267 | N → H AA sequence (PubMed:2350580).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11238 mRNA Translation: AAA03069.1 Z23091 Genomic DNA Translation: CAA80637.1 GU138099 Genomic DNA Translation: ACZ44929.1 CH471052 Genomic DNA Translation: EAW78053.1 |
CCDSi | CCDS3307.1 |
PIRi | A48030, A60164 |
RefSeqi | NP_004479.1, NM_004488.2 |
Genome annotation databases
Ensembli | ENST00000401815; ENSP00000383931; ENSG00000178732 |
GeneIDi | 2814 |
KEGGi | hsa:2814 |
UCSCi | uc062rou.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11238 mRNA Translation: AAA03069.1 Z23091 Genomic DNA Translation: CAA80637.1 GU138099 Genomic DNA Translation: ACZ44929.1 CH471052 Genomic DNA Translation: EAW78053.1 |
CCDSi | CCDS3307.1 |
PIRi | A48030, A60164 |
RefSeqi | NP_004479.1, NM_004488.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109076, 3 interactors |
ComplexPortali | CPX-114, Glycoprotein Ib-IX-V complex CPX-117, Glycoprotein Ib-IX-V-Filamin-A complex |
IntActi | P40197, 1 interactor |
STRINGi | 9606.ENSP00000383931 |
PTM databases
GlyConnecti | 1968, 6 N-Linked glycans (2 sites) |
GlyGeni | P40197, 9 sites |
iPTMneti | P40197 |
PhosphoSitePlusi | P40197 |
Polymorphism and mutation databases
BioMutai | GP5 |
DMDMi | 729616 |
Proteomic databases
jPOSTi | P40197 |
MassIVEi | P40197 |
PaxDbi | P40197 |
PeptideAtlasi | P40197 |
PRIDEi | P40197 |
ProteomicsDBi | 55341 |
Protocols and materials databases
Antibodypediai | 56829, 153 antibodies |
DNASUi | 2814 |
Genome annotation databases
Ensembli | ENST00000401815; ENSP00000383931; ENSG00000178732 |
GeneIDi | 2814 |
KEGGi | hsa:2814 |
UCSCi | uc062rou.1, human |
Organism-specific databases
CTDi | 2814 |
DisGeNETi | 2814 |
EuPathDBi | HostDB:ENSG00000178732.5 |
GeneCardsi | GP5 |
HGNCi | HGNC:4443, GP5 |
HPAi | ENSG00000178732, Tissue enhanced (lymphoid) |
MIMi | 173511, gene |
neXtProti | NX_P40197 |
OpenTargetsi | ENSG00000178732 |
PharmGKBi | PA28823 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000162953 |
HOGENOMi | CLU_000288_18_6_1 |
InParanoidi | P40197 |
OMAi | VQLDHNQ |
OrthoDBi | 826997at2759 |
PhylomeDBi | P40197 |
TreeFami | TF351124 |
Enzyme and pathway databases
PathwayCommonsi | P40197 |
Reactomei | R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-430116, GP1b-IX-V activation signalling R-HSA-75892, Platelet Adhesion to exposed collagen R-HSA-76009, Platelet Aggregation (Plug Formation) R-HSA-9673221, Defective F9 activation |
Miscellaneous databases
BioGRID-ORCSi | 2814, 3 hits in 842 CRISPR screens |
GeneWikii | GP5 |
GenomeRNAii | 2814 |
Pharosi | P40197, Tbio |
PROi | PR:P40197 |
RNActi | P40197, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178732, Expressed in leukocyte and 34 other tissues |
Genevisiblei | P40197, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 5 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 14 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPV_HUMAN | |
Accessioni | P40197Primary (citable) accession number: P40197 Secondary accession number(s): D1MER9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries