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Entry version 156 (22 Apr 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Pyridoxine/pyridoxal/pyridoxamine kinase

Gene

pdxK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 Publication, Mg2+1 PublicationNote: Can use both zinc and magnesium that is complexed with ATP. However, magnesium seems to be the preferred metal used under physiological conditions.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Is activated by the monovalent cation potassium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 140 min(-1) for the phosphorylation of PL with MgATP. kcat is 120 min(-1) for the phosphorylation of PL with ZnATP. kcat is 20 min(-1) for the phosphorylation of PN with MgATP. kcat is 40 min(-1) for the phosphorylation of PM with MgATP. kcat is 25 min(-1) for the phosphorylation of PM with ZnATP (at pH 7.3 and 37 degrees Celsius) (PubMed:15249053). kcat is 250 min(-1) for the phosphorylation of PL with MgATP (at pH 7.3 and 37 degrees Celsius) (PubMed:16740960).2 Publications
  1. KM=100 µM for pyridoxal (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius)1 Publication
  2. KM=50 µM for pyridoxal (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius)1 Publication
  3. KM=190 µM for pyridoxal (in the presence of ZnATP, at pH 7.3 and 37 degrees Celsius)1 Publication
  4. KM=25 µM for pyridoxine (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius)1 Publication
  5. KM=30 µM for pyridoxamine (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius)1 Publication
  6. KM=10 µM for pyridoxamine (in the presence of ZnATP, at pH 7.3 and 37 degrees Celsius)1 Publication
  7. KM=600 µM for MgATP (at pH 7.3 and 37 degrees Celsius)1 Publication
  8. KM=450 µM for MgATP (at pH 7.3 and 37 degrees Celsius)1 Publication
  9. KM=2100 µM for MgATP (at pH 6.1 and 37 degrees Celsius)1 Publication
  10. KM=70 µM for ZnATP (in the presence of pyridoxal, at pH 7.3 and 37 degrees Celsius)1 Publication
  11. KM=45 µM for ZnATP (in the presence of pyridoxamine, at pH 7.3 and 37 degrees Celsius)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyridoxal 5'-phosphate salvage

    This protein is involved in step 1 of the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxal.1 Publication
    Proteins known to be involved in this subpathway in this organism are:
    1. Pyridoxal kinase PdxY (pdxY), Pyridoxine/pyridoxal/pyridoxamine kinase (pdxK), Pyridoxine/pyridoxal/pyridoxamine kinase (pdxK), Pyridoxal kinase PdxY (pdxY)
    This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxal, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

    Pathwayi: pyridoxal 5'-phosphate salvage

    This protein is involved in step 1 of the subpathway that synthesizes pyridoxine 5'-phosphate from pyridoxine.1 Publication
    Proteins known to be involved in this subpathway in this organism are:
    1. Pyridoxine/pyridoxal/pyridoxamine kinase (pdxK), Pyridoxine/pyridoxal/pyridoxamine kinase (pdxK)
    This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from pyridoxine, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

    Pathwayi: pyridoxal 5'-phosphate salvage

    This protein is involved in step 1 of the subpathway that synthesizes pyridoxamine 5'-phosphate from pyridoxamine.1 Publication
    Proteins known to be involved in this subpathway in this organism are:
    1. Pyridoxine/pyridoxal/pyridoxamine kinase (pdxK), Pyridoxine/pyridoxal/pyridoxamine kinase (pdxK)
    This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxamine 5'-phosphate from pyridoxamine, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei23SubstrateCombined sources1 Publication1
    Binding sitei59SubstrateCombined sources1 Publication1
    Binding sitei125ATPCombined sources1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi136Magnesium1 Publication1
    Binding sitei157ATP; via carbonyl oxygenCombined sources1 Publication1
    Metal bindingi162Magnesium1 Publication1
    Binding sitei162ATPCombined sources1 Publication1
    Binding sitei195ATPCombined sources1 Publication1
    Binding sitei231ATPCombined sources1 Publication1
    Binding sitei233SubstrateCombined sources1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi221 – 224ATPCombined sources1 Publication4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:PDXK-MONOMER
    ECOL316407:JW2411-MONOMER
    MetaCyc:PDXK-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.35 2026

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA01068;UER00298
    UPA01068;UER00299
    UPA01068;UER00300

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Pyridoxine/pyridoxal/pyridoxamine kinase2 Publications (EC:2.7.1.352 Publications)
    Short name:
    PN/PL/PM kinase1 Publication
    Alternative name(s):
    B6-vitamer kinase1 Publication
    Pyridoxal kinase 11 Publication
    Short name:
    PL kinase 11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:pdxK
    Synonyms:yfeI
    Ordered Locus Names:b2418, JW2411
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Cells lacking this gene lack pyridoxine kinase activity but still contain pyridoxal kinase activity (PubMed:8764513). Cells lacking this gene and cells lacking both pdxY and pdxK are not auxotrophs, meaning that the de novo pathway of PLP biosynthesis is functional. For PLP salvage, the pdxY single mutant can use both pyridoxine and pyridoxal, the pdxK single mutant can use pyridoxal but not pyridoxine, and the double mutant can no longer use both compounds (PubMed:9537380).2 Publications

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133421 – 283Pyridoxine/pyridoxal/pyridoxamine kinaseAdd BLAST283

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P40191

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P40191

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P40191

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4260568, 21 interactors
    851221, 4 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P40191, 6 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b2418

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1283
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P40191

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P40191

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4107XGF Bacteria
    COG2240 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_046496_3_1_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P40191

    KEGG Orthology (KO)

    More...
    KOi
    K00868

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P40191

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01173 pyridoxal_pyridoxamine_kinase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.1190.20, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01638 PdxK, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023479 PdxK
    IPR013749 PM/HMP-P_kinase-1
    IPR004625 PyrdxlKinase
    IPR029056 Ribokinase-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10534 PTHR10534, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08543 Phos_pyr_kin, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53613 SSF53613, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00687 pyridox_kin, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P40191-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSSLLLFNDK SRALQADIVA VQSQVVYGSV GNSIAVPAIK QNGLNVFAVP
    60 70 80 90 100
    TVLLSNTPHY DTFYGGAIPD EWFSGYLRAL QERDALRQLR AVTTGYMGTA
    110 120 130 140 150
    SQIKILAEWL TALRKDHPDL LIMVDPVIGD IDSGIYVKPD LPEAYRQYLL
    160 170 180 190 200
    PLAQGITPNI FELEILTGKN CRDLDSAIAA AKSLLSDTLK WVVVTSASGN
    210 220 230 240 250
    EENQEMQVVV VTADSVNVIS HSRVKTDLKG TGDLFCAQLI SGLLKGKALT
    260 270 280
    DAVHRAGLRV LEVMRYTQQH ESDELILPPL AEA
    Length:283
    Mass (Da):30,847
    Last modified:November 1, 1997 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DFEDADD2F589EA0
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U53700 Genomic DNA Translation: AAC44166.1
    U00096 Genomic DNA Translation: AAC75471.1
    AP009048 Genomic DNA Translation: BAA16292.1
    M21994 Genomic DNA No translation available.
    J02796 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A65016

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_416913.1, NC_000913.3
    WP_000096674.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC75471; AAC75471; b2418
    BAA16292; BAA16292; BAA16292

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    946881

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW2411
    eco:b2418

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.4313

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U53700 Genomic DNA Translation: AAC44166.1
    U00096 Genomic DNA Translation: AAC75471.1
    AP009048 Genomic DNA Translation: BAA16292.1
    M21994 Genomic DNA No translation available.
    J02796 Genomic DNA No translation available.
    PIRiA65016
    RefSeqiNP_416913.1, NC_000913.3
    WP_000096674.1, NZ_LN832404.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2DDMX-ray2.10A/B1-283[»]
    2DDOX-ray2.60A/B1-283[»]
    2DDWX-ray3.20A/B1-283[»]
    SMRiP40191
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi4260568, 21 interactors
    851221, 4 interactors
    IntActiP40191, 6 interactors
    STRINGi511145.b2418

    Proteomic databases

    jPOSTiP40191
    PaxDbiP40191
    PRIDEiP40191

    Genome annotation databases

    EnsemblBacteriaiAAC75471; AAC75471; b2418
    BAA16292; BAA16292; BAA16292
    GeneIDi946881
    KEGGiecj:JW2411
    eco:b2418
    PATRICifig|1411691.4.peg.4313

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB2519

    Phylogenomic databases

    eggNOGiENOG4107XGF Bacteria
    COG2240 LUCA
    HOGENOMiCLU_046496_3_1_6
    InParanoidiP40191
    KOiK00868
    PhylomeDBiP40191

    Enzyme and pathway databases

    UniPathwayiUPA01068;UER00298
    UPA01068;UER00299
    UPA01068;UER00300
    BioCyciEcoCyc:PDXK-MONOMER
    ECOL316407:JW2411-MONOMER
    MetaCyc:PDXK-MONOMER
    BRENDAi2.7.1.35 2026

    Miscellaneous databases

    EvolutionaryTraceiP40191

    Protein Ontology

    More...
    PROi
    PR:P40191

    Family and domain databases

    CDDicd01173 pyridoxal_pyridoxamine_kinase, 1 hit
    Gene3Di3.40.1190.20, 1 hit
    HAMAPiMF_01638 PdxK, 1 hit
    InterProiView protein in InterPro
    IPR023479 PdxK
    IPR013749 PM/HMP-P_kinase-1
    IPR004625 PyrdxlKinase
    IPR029056 Ribokinase-like
    PANTHERiPTHR10534 PTHR10534, 1 hit
    PfamiView protein in Pfam
    PF08543 Phos_pyr_kin, 1 hit
    SUPFAMiSSF53613 SSF53613, 1 hit
    TIGRFAMsiTIGR00687 pyridox_kin, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDXK_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40191
    Secondary accession number(s): P76964
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 1, 1997
    Last modified: April 22, 2020
    This is version 156 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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