Interleukin-6 receptor subunit beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ciliary neurotrophic factor receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF."
    Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., Kallen K.J.
    J. Biol. Chem. 278:9528-9535(2003) [PubMed] [Europe PMC] [Abstract]
• ciliary neurotrophic factor receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex."
    Man D., He W., Sze K.H., Gong K., Smith D.K., Zhu G., Ip N.Y.
    J. Biol. Chem. 278:23285-23294(2003) [PubMed] [Europe PMC] [Abstract]
• cytokine binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cytokine receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma."
    Poussin K., Pilati C., Couchy G., Calderaro J., Bioulac-Sage P., Bacq Y., Paradis V., Leteurtre E., Sturm N., Ramos J., Guettier C., Bardier-Dupas A., Boulai A., Wendum D., Selves J., Izard T., Nault J.C., Zucman-Rossi J.
    Oncoimmunology 2:e27090-e27090(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• ciliary neurotrophic factor-mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF."
    Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., Kallen K.J.
    J. Biol. Chem. 278:9528-9535(2003) [PubMed] [Europe PMC] [Abstract]
• cytokine-mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and expression of an IL-6 signal transducer, gp130."
    Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T.
    Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
  • "Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction."
    Hilton D.J., Hilton A.A., Raicevic A., Rakar S., Harrison-Smith M., Gough N.M., Begley C.G., Metcalf D., Nicola N.A., Willson T.A.
    EMBO J. 13:4765-4775(1994) [PubMed] [Europe PMC] [Abstract]
• glycogen metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer."
    Kamiya A., Kinoshita T., Ito Y., Matsui T., Morikawa Y., Senba E., Nakashima K., Taga T., Yoshida K., Kishimoto T., Miyajima A.
    EMBO J. 18:2127-2136(1999) [PubMed] [Europe PMC] [Abstract]
• interleukin-11-mediated signaling pathway Source: GOC
• interleukin-27-mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27."
    Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan J.F., Phillips J.H., McClanahan T.K., de Waal Malefyt R., Kastelein R.A.
    J. Immunol. 172:2225-2231(2004) [PubMed] [Europe PMC] [Abstract]
• interleukin-6-mediated signaling pathway Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Role of interleukin-6 in chronic muscle hyperalgesic priming."
    Dina O.A., Green P.G., Levine J.D.
    Neuroscience 152:521-525(2008) [PubMed] [Europe PMC] [Abstract]
• leukemia inhibitory factor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF."
    Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., Kallen K.J.
    J. Biol. Chem. 278:9528-9535(2003) [PubMed] [Europe PMC] [Abstract]
  • "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity."
    Wang X.C., Qiu Y.H., Peng Y.P.
    Sheng Li Xue Bao 59:150-156(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interleukin-6-mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130."
    Narazaki M., Yasukawa K., Saito T., Ohsugi Y., Fukui H., Koishihara Y., Yancopoulos G.D., Taga T., Kishimoto T.
    Blood 82:1120-1126(1993) [PubMed] [Europe PMC] [Abstract]
• oncostatin-M-mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of astrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Astrocyte differentiation mediated by LIF in cooperation with BMP2."
    Nakashima K., Yanagisawa M., Arakawa H., Taga T.
    FEBS Lett. 457:43-46(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor."
    Derouet D., Rousseau F., Alfonsi F., Froger J., Hermann J., Barbier F., Perret D., Diveu C., Guillet C., Preisser L., Dumont A., Barbado M., Morel A., DeLapeyriere O., Gascan H., Chevalier S.
    Proc. Natl. Acad. Sci. U.S.A. 101:4827-4832(2004) [PubMed] [Europe PMC] [Abstract]
  • "Molecular cloning and expression of an IL-6 signal transducer, gp130."
    Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T.
    Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
  • "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Erices A., Conget P., Rojas C., Minguell J.J.
    Exp. Cell Res. 280:24-32(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smooth muscle cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "An essential role for gp130 in neointima formation following arterial injury."
    Wang D., Liu Z., Li Q., Karpurapu M., Kundumani-Sridharan V., Cao H., Dronadula N., Rizvi F., Bajpai A.K., Zhang C., Muller-Newen G., Harris K.W., Rao G.N.
    Circ. Res. 100:807-816(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27."
    Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan J.F., Phillips J.H., McClanahan T.K., de Waal Malefyt R., Kastelein R.A.
    J. Immunol. 172:2225-2231(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tyrosine phosphorylation of STAT protein Source: RGDInferred from sequence orthologyⁱ
  • "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27."
    Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan J.F., Phillips J.H., McClanahan T.K., de Waal Malefyt R., Kastelein R.A.
    J. Immunol. 172:2225-2231(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of hormone secretion Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells."
    Castro C.P., Giacomini D., Nagashima A.C., Onofri C., Graciarena M., Kobayashi K., Paez-Pereda M., Renner U., Stalla G.K., Arzt E.
    Endocrinology 144:693-700(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of Notch signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells."
    Chojnacki A., Shimazaki T., Gregg C., Weinmaster G., Weiss S.
    J. Neurosci. 23:1730-1741(2003) [PubMed] [Europe PMC] [Abstract]
• response to cytokine Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and expression of an IL-6 signal transducer, gp130."
    Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T.
    Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
  • "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
• response to nutrient Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Effects of protein malnutrition on IL-6-mediated signaling in the liver and the systemic acute-phase response in rats."
    Ling P.R., Smith R.J., Kie S., Boyce P., Bistrian B.R.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R801-8(2004) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: RGDInferred from sequence orthologyⁱ
  • "STAT3 down-regulates the expression of cyclin D during liver development."
    Matsui T., Kinoshita T., Hirano T., Yokota T., Miyajima A.
    J. Biol. Chem. 277:36167-36173(2002) [PubMed] [Europe PMC] [Abstract]
• triglyceride mobilization Source: RGDInferred from mutant phenotypeⁱ
  • "LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats."
    Nonogaki K., Pan X.M., Moser A.H., Shigenaga J., Staprans I., Sakamoto N., Grunfeld C., Feingold K.R.
    Am. J. Physiol. 271:E521-8(1996) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ciliary neurotrophic factor receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex."
    Man D., He W., Sze K.H., Gong K., Smith D.K., Zhu G., Ip N.Y.
    J. Biol. Chem. 278:23285-23294(2003) [PubMed] [Europe PMC] [Abstract]
• cytokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma."
    Poussin K., Pilati C., Couchy G., Calderaro J., Bioulac-Sage P., Bacq Y., Paradis V., Leteurtre E., Sturm N., Ramos J., Guettier C., Bardier-Dupas A., Boulai A., Wendum D., Selves J., Izard T., Nault J.C., Zucman-Rossi J.
    Oncoimmunology 2:e27090-e27090(2013) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSALRIWLMQ ALLIFLTTES IGQLVEPCGY IYPEFPVVQR GSNFTATCVL 
        60         70         80         90        100
KEKCLQVYSV NATYIVWKTN HVAVPKEQVT VINRTASSVT FTDVVFQNVQ 
       110        120        130        140        150
LTCNILSFGQ IEQNVYGITI LSGYPPDIPT NLSCIVNEGK NMLCQLDPGR 
       160        170        180        190        200
ETYLETNYTL KSEWATEKFP DCRTKHGTSS CMMGYTPIYF VNIEVWVEAE 
       210        220        230        240        250
NALGNVSSEP INFDPVDKVK PSPPHNLSVT NSEELSSILK LAWVNSGLDS 
       260        270        280        290        300
ILRLKSDIQY RTKDASTWIQ VPLEDTVSPR TSFTVQDLKP FTEYVFRIRS 
       310        320        330        340        350
IKENGKGYWS DWSEEASGTT YEDRPSKAPS FWYKVNANHP QEYRSARLIW 
       360        370        380        390        400
KTLPLSEANG KILDYEVVLT QSKSVSQTYT VNGTELIVNL TNNRYVASLA 
       410        420        430        440        450
ARNVVGKSPA TVLTIPGSHF KASHPVVDLK AFPKDNLLWV EWTPPSKPVN 
       460        470        480        490        500
KYILEWCVLS ENSPCIPDWQ QEDGTVNRTH LRGSLLESKC YLITVTPVFP 
       510        520        530        540        550
GGPGSPESMK AYLKQAAPSK GPTVRTKKVG KNEAVLEWDH LPVDVQNGFI 
       560        570        580        590        600
RNYSISYRTS VGKEMVVRVD SSHTEYTLSS LSSDTLYMVH MAAYTEEGGK 
       610        620        630        640        650
DGPEFTFTTL KFAQGEIEAI VVPVCLAFLL TTLLGVLFCF NKRDLIKKHI 
       660        670        680        690        700
WPNVPDPSKS HIAQWSPHTP PRHNFNSKDQ MYSDANFTDV SVVEIEANNK 
       710        720        730        740        750
KPCPDDLKSL DLFKKEKIST EGHSSGIGGS SCMSSSRPSI SSSEENESAQ 
       760        770        780        790        800
STASTVQYST VVHSGYRHQV PSVQVFSRSE STQPLLDSEE RPEDLQLVDS 
       810        820        830        840        850
VDSGDEILPR QQYFKQSCSQ PGASPDVSHF GRSSQVPSGS EEDFVRLKQQ 
       860        870        880        890        900
QVSDHISEPY GSEQRRLFQE GSVADALGTG TDGQIERFES VGMETAMDED 
       910 
ISKSYLPQTV RQGGYMPQ                                    

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families