UniProtKB - P40190 (IL6RB_RAT)
Interleukin-6 receptor subunit beta
Il6st
Functioni
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (By similarity).
In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity).
Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity).
Has a role in embryonic development (By similarity).
Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity).
Required for expression of TRPA1 in nociceptive neurons (By similarity).
Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity).
Required for normal trabecular bone mass and cortical bone composition (By similarity).
By similarityGO - Molecular functioni
- ciliary neurotrophic factor receptor activity Source: RGD
- ciliary neurotrophic factor receptor binding Source: RGD
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- growth factor binding Source: RGD
- identical protein binding Source: RGD
- scaffold protein binding Source: RGD
GO - Biological processi
- ciliary neurotrophic factor-mediated signaling pathway Source: RGD
- cytokine-mediated signaling pathway Source: RGD
- glycogen metabolic process Source: RGD
- interleukin-11-mediated signaling pathway Source: GOC
- interleukin-27-mediated signaling pathway Source: RGD
- interleukin-6-mediated signaling pathway Source: RGD
- intestinal epithelial cell development Source: RGD
- leukemia inhibitory factor signaling pathway Source: RGD
- negative regulation of cytosolic calcium ion concentration Source: RGD
- negative regulation of neuron apoptotic process Source: RGD
- oncostatin-M-mediated signaling pathway Source: RGD
- positive regulation of astrocyte differentiation Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of Notch signaling pathway Source: RGD
- positive regulation of osteoblast differentiation Source: RGD
- positive regulation of smooth muscle cell migration Source: RGD
- positive regulation of T cell proliferation Source: RGD
- positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
- regulation of hormone secretion Source: RGD
- regulation of Notch signaling pathway Source: RGD
- response to cytokine Source: RGD
- response to nutrient Source: RGD
- signal transduction Source: RGD
- triglyceride mobilization Source: RGD
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-RNO-1059683, Interleukin-6 signaling R-RNO-110056, MAPK3 (ERK1) activation R-RNO-112411, MAPK1 (ERK2) activation R-RNO-6788467, IL-6-type cytokine receptor ligand interactions R-RNO-9020956, Interleukin-27 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6 receptor subunit betaCuratedShort name: IL-6 receptor subunit beta Short name: IL-6R subunit beta Short name: IL-6R-beta Short name: IL-6RB Alternative name(s): Interleukin-6 signal transducer Membrane glycoprotein 130 Short name: gp130 Oncostatin-M receptor subunit alpha CD_antigen: CD130 |
Gene namesi | Name:Il6stImported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2903, Il6st |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- ciliary neurotrophic factor receptor complex Source: RGD
- external side of plasma membrane Source: RGD
- interleukin-6 receptor complex Source: RGD
- neuronal cell body membrane Source: RGD
- oncostatin-M receptor complex Source: RGD
Other locations
- cell body Source: RGD
- dendrite Source: RGD
- membrane raft Source: RGD
- neuronal cell body Source: RGD
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 618 | ExtracellularSequence analysisAdd BLAST | 596 | |
Transmembranei | 619 – 640 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 641 – 918 | CytoplasmicSequence analysisAdd BLAST | 278 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000010901 | 23 – 918 | Interleukin-6 receptor subunit betaAdd BLAST | 896 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 54 | By similarity | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 48 ↔ 103 | By similarity | ||
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 134 ↔ 144 | By similarity | ||
Glycosylationi | 157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 172 ↔ 181 | By similarity | ||
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 226 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 382 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 457 ↔ 465 | By similarity | ||
Glycosylationi | 477 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 552 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 660 | PhosphoserineBy similarity | 1 | |
Modified residuei | 666 | PhosphoserineBy similarity | 1 | |
Modified residuei | 781 | PhosphoserineBy similarity | 1 | |
Modified residuei | 788 | PhosphoserineBy similarity | 1 | |
Modified residuei | 828 | PhosphoserineBy similarity | 1 | |
Modified residuei | 838 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P40190 |
PTM databases
GlyGeni | P40190, 11 sites |
iPTMneti | P40190 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; associates with the complex IL6:IL6R but does not interact with IL6 (By similarity). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM. Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF.
Interacts with HCK (By similarity).
Interacts with INPP5D/SHIP1 (By similarity).
Interacts with SRC and YES (By similarity).
By similarityGO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: RGD
- cytokine binding Source: GO_Central
- growth factor binding Source: RGD
- identical protein binding Source: RGD
- scaffold protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018877 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 120 | Ig-like C2-typeAdd BLAST | 95 | |
Domaini | 125 – 215 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 223 – 323 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 328 – 418 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 422 – 516 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 518 – 612 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 659 – 679 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 720 – 754 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 773 – 795 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 817 – 842 | DisorderedSequence analysisAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 309 – 313 | WSXWS motif | 5 | |
Motifi | 650 – 658 | Box 1 motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 723 – 754 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QXEG, Eukaryota |
InParanoidi | P40190 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF06328, Lep_receptor_Ig, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 4 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS01353, HEMATOPO_REC_L_F2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSALRIWLMQ ALLIFLTTES IGQLVEPCGY IYPEFPVVQR GSNFTATCVL
60 70 80 90 100
KEKCLQVYSV NATYIVWKTN HVAVPKEQVT VINRTASSVT FTDVVFQNVQ
110 120 130 140 150
LTCNILSFGQ IEQNVYGITI LSGYPPDIPT NLSCIVNEGK NMLCQLDPGR
160 170 180 190 200
ETYLETNYTL KSEWATEKFP DCRTKHGTSS CMMGYTPIYF VNIEVWVEAE
210 220 230 240 250
NALGNVSSEP INFDPVDKVK PSPPHNLSVT NSEELSSILK LAWVNSGLDS
260 270 280 290 300
ILRLKSDIQY RTKDASTWIQ VPLEDTVSPR TSFTVQDLKP FTEYVFRIRS
310 320 330 340 350
IKENGKGYWS DWSEEASGTT YEDRPSKAPS FWYKVNANHP QEYRSARLIW
360 370 380 390 400
KTLPLSEANG KILDYEVVLT QSKSVSQTYT VNGTELIVNL TNNRYVASLA
410 420 430 440 450
ARNVVGKSPA TVLTIPGSHF KASHPVVDLK AFPKDNLLWV EWTPPSKPVN
460 470 480 490 500
KYILEWCVLS ENSPCIPDWQ QEDGTVNRTH LRGSLLESKC YLITVTPVFP
510 520 530 540 550
GGPGSPESMK AYLKQAAPSK GPTVRTKKVG KNEAVLEWDH LPVDVQNGFI
560 570 580 590 600
RNYSISYRTS VGKEMVVRVD SSHTEYTLSS LSSDTLYMVH MAAYTEEGGK
610 620 630 640 650
DGPEFTFTTL KFAQGEIEAI VVPVCLAFLL TTLLGVLFCF NKRDLIKKHI
660 670 680 690 700
WPNVPDPSKS HIAQWSPHTP PRHNFNSKDQ MYSDANFTDV SVVEIEANNK
710 720 730 740 750
KPCPDDLKSL DLFKKEKIST EGHSSGIGGS SCMSSSRPSI SSSEENESAQ
760 770 780 790 800
STASTVQYST VVHSGYRHQV PSVQVFSRSE STQPLLDSEE RPEDLQLVDS
810 820 830 840 850
VDSGDEILPR QQYFKQSCSQ PGASPDVSHF GRSSQVPSGS EEDFVRLKQQ
860 870 880 890 900
QVSDHISEPY GSEQRRLFQE GSVADALGTG TDGQIERFES VGMETAMDED
910
ISKSYLPQTV RQGGYMPQ
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7TQ89 | Q7TQ89_RAT | Ac1055 | Il6st | 1,010 | Annotation score: | ||
F1LPK1 | F1LPK1_RAT | Interleukin-6 receptor subunit beta | Il6st | 1,008 | Annotation score: | ||
A0A8I5Y7Q5 | A0A8I5Y7Q5_RAT | Interleukin-6 receptor subunit beta | Il6st rCG_44468 | 934 | Annotation score: | ||
A0A8I5ZSM2 | A0A8I5ZSM2_RAT | Interleukin-6 receptor subunit beta | Il6st | 328 | Annotation score: | ||
A0A8I5ZXR5 | A0A8I5ZXR5_RAT | Interleukin-6 receptor subunit beta | Il6st | 857 | Annotation score: | ||
A0A8I6A213 | A0A8I6A213_RAT | Interleukin-6 receptor subunit beta | Il6st | 203 | Annotation score: | ||
A0A8I6AAL6 | A0A8I6AAL6_RAT | Interleukin-6 receptor subunit beta | Il6st | 930 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92340 mRNA No translation available. |
PIRi | A44257 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92340 mRNA No translation available. |
PIRi | A44257 |
3D structure databases
AlphaFoldDBi | P40190 |
SMRi | P40190 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018877 |
PTM databases
GlyGeni | P40190, 11 sites |
iPTMneti | P40190 |
Proteomic databases
PaxDbi | P40190 |
Organism-specific databases
RGDi | 2903, Il6st |
Phylogenomic databases
eggNOGi | ENOG502QXEG, Eukaryota |
InParanoidi | P40190 |
Enzyme and pathway databases
Reactomei | R-RNO-1059683, Interleukin-6 signaling R-RNO-110056, MAPK3 (ERK1) activation R-RNO-112411, MAPK1 (ERK2) activation R-RNO-6788467, IL-6-type cytokine receptor ligand interactions R-RNO-9020956, Interleukin-27 signaling |
Miscellaneous databases
PROi | PR:P40190 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF06328, Lep_receptor_Ig, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 4 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS01353, HEMATOPO_REC_L_F2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL6RB_RAT | |
Accessioni | P40190Primary (citable) accession number: P40190 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families